眼眶和颅骨转移是携带MET外显子14跳跃突变的肺腺癌的初始表现
Orbital and skull metastases as the initial presentation of lung adenocarcinoma harbouring a MET exon 14 skipping mutation.
摘要(中文译文)
一位70多岁的男性因右眼疼痛、视力障碍、前额肿胀及左侧髂部疼痛就诊。影像学检查发现右侧眶额部大型肿块伴颅骨受累、右上肺叶空洞性病变及左侧髂部病变。组织学和分子分析证实为伴MET外显子14跳跃突变的肺腺癌。初始治疗以症状控制为主，对眶部及髂部病变行姑息性放疗，症状迅速缓解。分子学确诊后，开始使用tepotinib——一种选择性MET酪氨酸激酶抑制剂。治疗后患者临床状况稳定，原发肺部病灶影像学上略有缩小。本病例突出了MET突变非小细胞肺癌眶部转移的非典型临床表现，强调了对于表现为非典型转移部位的患者，及时进行组织学诊断和分子分型的临床必要性，以便及时启动靶向全身治疗。
Abstract
A man in his 70s presented with right ocular pain, visual disturbance, forehead swelling and left iliac pain. Diagnostic imaging revealed a large right orbital-frontal mass with skull involvement, a cavitary lesion in the right upper lobe and a left iliac lesion. Histological and molecular analyses confirmed lung adenocarcinoma with a MET exon 14 skipping mutation. Initial management focused on symptom control via palliative radiotherapy to the orbital and iliac lesions which achieved rapid relief. Following molecular confirmation, tepotinib-a selective MET tyrosine kinase inhibitor-was initiated. This resulted in clinical stability and a slight radiographic reduction of the primary lung lesion. This case highlights an atypical clinical manifestation of orbital metastasis in MET-mutated non-small-cell lung cancer. It underscores the clinical necessity of prompt tissue diagnosis and molecular profiling in patients presenting with atypical metastatic sites to facilitate the timely initiation of targeted systemic therapies.
如何引用
AMA
Eiji Ando, Yuri Hayashi, Yasuhiro Matsuo, Hideo Saka. Orbital and skull metastases as the initial presentation of lung adenocarcinoma harbouring a MET exon 14 skipping mutation.. BMJ case reports. 2026; doi:10.1136/bcr-2025-270013.
APA
Eiji Ando, Yuri Hayashi, Yasuhiro Matsuo, Hideo Saka (2026). Orbital and skull metastases as the initial presentation of lung adenocarcinoma harbouring a MET exon 14 skipping mutation.. BMJ case reports. https://doi.org/10.1136/bcr-2025-270013
GB/T 7714
Eiji Ando, Yuri Hayashi, Yasuhiro Matsuo, Hideo Saka. Orbital and skull metastases as the initial presentation of lung adenocarcinoma harbouring a MET exon 14 skipping mutation.[J]. BMJ case reports, 2026 doi:10.1136/bcr-2025-270013.
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