原发性直肠印戒细胞癌
Primary signet ring cell carcinoma of the rectum.
摘要(中文译文)
印戒细胞癌（SRCC）是结直肠癌的一种罕见亚型，其组织学定义为≥50%的肿瘤细胞含有丰富的胞质内黏液，细胞核被推向周边，形成印戒样形态。SRCC在年轻成人中的诊断比例异常偏高，且与弥漫浸润性生长、腹膜播散以及较传统腺癌更差的预后相关。我们报告一例30岁出头的男性，因直肠狭窄导致急性肠梗阻就诊。由于活检取材表浅且无诊断价值，缺乏提示恶性肿瘤的强烈临床病史，且癌胚抗原处于正常范围，最初考虑为炎症性病因。诊断仅在剖腹探查时才得以明确，随后的组织病理学检查证实为原发性直肠SRCC。本病例说明，SRCC作为结直肠癌的一种罕见亚型，尽管其生物学行为预后不良，却可伪装为炎症性疾病，并逃避表浅活检和标准生物标志物的检测。
Abstract
Signet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer, defined histologically when ≥50% of tumour cells contain abundant intracytoplasmic mucin with a peripherally displaced nucleus, producing signet ring morphology. SRCC is disproportionately diagnosed in younger adults and is associated with diffuse infiltrative growth, peritoneal dissemination and poorer outcomes than conventional adenocarcinoma.We report a man in his early 30s who presented with acute bowel obstruction due to a rectal stricture. An inflammatory aetiology was initially considered because biopsies were superficial and non-diagnostic, there was no strong clinical history to suggest malignancy, and carcinoembryonic antigen was within the normal range. The diagnosis became apparent only at laparotomy, with subsequent histopathology confirming primary rectal SRCC. This case illustrates how SRCC, a rare subtype of colorectal cancer, can masquerade as an inflammatory disease and evade superficial biopsies and standard biomarkers despite its poor-prognosis biology.
如何引用
AMA
Tanya Bhalla, Anuj Bhalla, Chiranjiv Singh Gill. Primary signet ring cell carcinoma of the rectum.. BMJ case reports. 2026; doi:10.1136/bcr-2025-270048.
APA
Tanya Bhalla, Anuj Bhalla, Chiranjiv Singh Gill (2026). Primary signet ring cell carcinoma of the rectum.. BMJ case reports. https://doi.org/10.1136/bcr-2025-270048
GB/T 7714
Tanya Bhalla, Anuj Bhalla, Chiranjiv Singh Gill. Primary signet ring cell carcinoma of the rectum.[J]. BMJ case reports, 2026 doi:10.1136/bcr-2025-270048.
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