腹膜后成熟畸胎瘤恶性转化为结直肠表型腺癌和卵巢转移
Retroperitoneal mature teratoma with malignant transformation to colorectal phenotype adenocarcinoma and ovarian metastasis.
摘要(中文译文)
腹膜后畸胎瘤占所有畸胎瘤的5%~15%，恶性转化发生率为3%~6%，最常见转化为鳞状细胞癌。结直肠表型的腺癌极为罕见，文献报道约15例，其中三分之一出现转移。卵巢转移此前未见文献记载；我们报告首例已知病例。一名30多岁经产妇被诊断为成熟性腹膜后畸胎瘤，该肿瘤恶性转化为结肠型腺癌并伴有腹主动脉旁淋巴结转移。她接受了手术切除，包括左肾切除术和淋巴结清扫术，随后接受卡培他滨联合奥沙利铂（CAPEOX）辅助化疗。六个月后，她出现卵巢转移，需要再次手术。在1年随访时她仍无病生存。本病例说明了腹膜后畸胎瘤伴腺癌转化的侵袭性行为。由于其罕见性，治疗借鉴黏液性卵巢癌和结直肠癌的方案。最佳管理包括手术和全身治疗，长期监测对于发现复发或延迟转移至关重要。
Abstract
Retroperitoneal teratomas constitute 5%-15% of all teratomas, with malignant transformation occurring in 3%-6% of cases, most commonly to squamous cell carcinoma. Adenocarcinoma of colorectal phenotype is exceedingly rare, with roughly 15 reported cases, one-third of which showed metastasis. Ovarian metastasis has not been previously documented; we report the first known case. A multiparous woman in her late 30s was diagnosed with a mature retroperitoneal teratoma that underwent malignant transformation into colonic-type adenocarcinoma with para-aortic lymph node metastases. She underwent surgical resection, including left nephrectomy and lymph node dissection, followed by adjuvant capecitabine plus oxaliplatin (CAPEOX) chemotherapy. Six months later, she developed ovarian metastasis, requiring additional surgery. She remains disease-free at the 1-year follow-up. This case illustrates the aggressive behaviour of retroperitoneal teratomas with adenocarcinoma transformation. Owing to its rarity, treatment is extrapolated from mucinous ovarian and colorectal cancer protocols. Optimal management includes surgery and systemic therapy, with long-term surveillance critical for detecting recurrence or delayed metastasis.
如何引用
AMA
Amy Jose, Khushbu Badami, Sridevi Veluswami, Anand Raja. Retroperitoneal mature teratoma with malignant transformation to colorectal phenotype adenocarcinoma and ovarian metastasis.. BMJ case reports. 2026; doi:10.1136/bcr-2025-270701.
APA
Amy Jose, Khushbu Badami, Sridevi Veluswami, Anand Raja (2026). Retroperitoneal mature teratoma with malignant transformation to colorectal phenotype adenocarcinoma and ovarian metastasis.. BMJ case reports. https://doi.org/10.1136/bcr-2025-270701
GB/T 7714
Amy Jose, Khushbu Badami, Sridevi Veluswami, Anand Raja. Retroperitoneal mature teratoma with malignant transformation to colorectal phenotype adenocarcinoma and ovarian metastasis.[J]. BMJ case reports, 2026 doi:10.1136/bcr-2025-270701.
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