口腔蕈样肉芽肿
Oral mycosis fungoides.
摘要(中文译文)
蕈样肉芽肿（MF）是皮肤T细胞淋巴瘤最常见的亚型。口腔表现罕见且高度多变，常提示疾病处于晚期阶段。一名70多岁的女性患者因持续6个月的疼痛性复发性腭部溃疡被转诊，该症状显著影响了她的生活质量。她已知患有MF，曾接受口服贝沙罗汀、电子束治疗及局部放疗。口腔检查发现两处浅表腭部溃疡，切开活检显示非典型间质及上皮内CD3+ T淋巴细胞浸润，以CD8+ T细胞为主；PCR显示T细胞受体基因重排，证实为单克隆细胞群，其图谱与近期皮肤活检中的结果一致，提示口腔MF。遗憾的是，患者在就诊于我们科室7个月后因疾病去世。本病例提示MF可出现口腔受累，并可对患者的生活质量产生显著影响。
Abstract
Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma. Oral presentation is both rare and highly variable, often denoting advanced disease stage. A female patient in her 70s was referred regarding painful recurrent palatal ulceration of 6 months' duration, which was significantly impacting her quality of life. She had known MF treated with oral bexarotene, electron beam therapy and localised radiotherapy. Oral examination revealed two shallow palatal ulcers, and incisional biopsy revealed an atypical stromal and intraepithelial CD3+ T lymphocyte population with a predominance of CD8+ T cells; PCR revealed T cell receptor gene rearrangements demonstrating a monoclonal population whose profile was identical to that in a recent skin biopsy, indicating oral MF. Unfortunately, the patient succumbed to her disease 7 months after presentation to our unit. This case highlights that oral involvement can develop in MF and can have a significant impact on a patient's quality of life.
如何引用
AMA
David Byrne, Sheila Galvin, Peter Molony, C M Healy. Oral mycosis fungoides.. BMJ case reports. 2026; doi:10.1136/bcr-2025-270779.
APA
David Byrne, Sheila Galvin, Peter Molony, C M Healy (2026). Oral mycosis fungoides.. BMJ case reports. https://doi.org/10.1136/bcr-2025-270779
GB/T 7714
David Byrne, Sheila Galvin, Peter Molony, C M Healy. Oral mycosis fungoides.[J]. BMJ case reports, 2026 doi:10.1136/bcr-2025-270779.
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