多酚自组装递送系统的多尺度理性构建策略：从纳米尺度到微米尺度
Multiscale rational construction strategy for polyphenol self-assembled delivery systems: from nanoscale to microscale.
摘要(中文译文)
天然多酚因其独特的生物活性功能，如抗氧化、抗炎、抗肿瘤和抗菌特性，在制药、食品和化妆品领域受到了广泛关注。多酚分子中的多个酚羟基（邻苯二酚和没食子酰基部分）使其能够通过非共价相互作用与多种物质形成动态络合，包括氢键、疏水相互作用、静电相互作用和配位键合。多酚优异的自组装和界面特性使其能够构建从纳米尺度到微米尺度的多尺度、多功能递送系统。微米尺度递送系统在疾病治疗中发挥着不可替代的作用，基于多酚的微米尺度递送系统的研究正日益受到重视。本综述系统描述了多种基于多酚的微米尺度递送系统，包括凝聚层液滴、Pickering乳液、微胶囊、微粒以及多酚修饰的微生物和细胞，并讨论了它们的自组装机制、制备方法、功能特性和治疗应用。最后，我们概述了多酚自组装递送系统的研究进展，并讨论了下一代多酚基生物材料发展的未来方向。
Abstract
Natural polyphenols have garnered significant attention in pharmaceuticals, food, and cosmetics due to their unique bioactive functions such as antioxidant, anti-inflammatory, antitumor, and antibacterial properties. The multiple phenolic hydroxyl groups in polyphenol molecules (catechol and galloyl moieties) enable dynamic complexation with various substances through non-covalent interactions, including hydrogen bonding, hydrophobic interactions, electrostatic interactions and coordination bonding. The excellent self-assembly and interfacial properties of polyphenols enable the construction of multiscale and multifunctional delivery systems, ranging from nanoscale to microscale. Microscale delivery systems play an irreplaceable role in disease treatment, and research on polyphenol-based microscale delivery systems is gaining momentum. This review systematically describes various polyphenol-based microscale delivery systems, including coacervate droplets, Pickering emulsions, microcapsules, microparticles, and polyphenol-modified microbes and cells, and discusses their self-assembly mechanisms, preparation methods, functional characteristics and therapeutic applications. Finally, we outline the research advances in polyphenol self-assembled delivery systems and discuss future directions for the development of next-generation polyphenol-based biomaterials.
如何引用
AMA
Qi Xie, Haoyu Zhang, Yuan Gao, Hongbing Lan, Ling Tang, Jinying Lv, et al. Multiscale rational construction strategy for polyphenol self-assembled delivery systems: from nanoscale to microscale.. Materials today. Bio. 2026; doi:10.1016/j.mtbio.2026.103400.
APA
Qi Xie, Haoyu Zhang, Yuan Gao, Hongbing Lan, Ling Tang, Jinying Lv, et al (2026). Multiscale rational construction strategy for polyphenol self-assembled delivery systems: from nanoscale to microscale.. Materials today. Bio. https://doi.org/10.1016/j.mtbio.2026.103400
GB/T 7714
Qi Xie, Haoyu Zhang, Yuan Gao, Hongbing Lan, Ling Tang, Jinying Lv, et al. Multiscale rational construction strategy for polyphenol self-assembled delivery systems: from nanoscale to microscale.[J]. Materials today. Bio, 2026 doi:10.1016/j.mtbio.2026.103400.
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