大脑中动脉峰值收缩速度与新生儿血红蛋白作为胎儿贫血标志物的相关性
Correlation Between Middle Cerebral Artery Peak Systolic Velocity and Neonatal Haemoglobin as a Marker of Fetal Anaemia.
摘要(中文译文)
胎儿贫血是围产期发病和死亡的重要原因。经多普勒超声测量的大脑中动脉收缩期峰值流速（MCA-PSV）已成为评估胎儿贫血的可靠无创工具。然而，其与血红蛋白水平在异质性临床人群中的相关性仍需进一步评估。本研究旨在评估MCA-PSV与脐血血红蛋白之间的相关性，并评价MCA-PSV在预测出生时贫血方面的诊断价值。本前瞻性观察研究在一家三级医疗中心开展，为期六个月，纳入100例单胎妊娠。采用标准化多普勒技术测量MCA-PSV，并以中位数倍数（MoM）表示。出生后24小时内测量脐血血红蛋白。采用Pearson相关系数评估MCA-PSV与血红蛋白之间的相关性。通过灵敏度、特异度和预测值评价MCA-PSV MoM≥1.5的诊断效能。观察到MCA-PSV与脐血血红蛋白之间存在显著的中度负相关（r=-0.42，p<0.001）。出生时贫血者86例（86%），其中中重度贫血52例（52%）。贫血新生儿的MCA-PSV及MoM值显著更高（p<0.001）。MCA-PSV MoM随贫血严重程度增加而升高（p<0.001）。以≥1.5 MoM为阈值显示出极好的特异度（100%）和阳性预测值（100%），但灵敏度较低（8.1%）。MCA-PSV与血红蛋白水平呈显著负相关，是胎儿贫血有用的无创标志物。尽管其特异度高，但灵敏度低限制了其作为筛查工具的作用，强调需要结合临床综合评估。
Abstract
Fetal anaemia is an important cause of perinatal morbidity and mortality. Middle cerebral artery peak systolic velocity (MCA-PSV) measured by Doppler ultrasound has emerged as a reliable non-invasive tool for its assessment. However, its correlation with haemoglobin levels in heterogeneous clinical populations requires further evaluation. This study aimed to evaluate the correlation between MCA-PSV and cord blood haemoglobin and to assess the diagnostic utility of MCA-PSV in predicting anaemia at birth. This prospective observational study was conducted over six months at a tertiary care centre and included 100 singleton pregnancies. MCA-PSV was measured using standardised Doppler techniques and expressed as multiples of the median (MoM). Cord blood haemoglobin was measured within 24 hours of birth. Correlation between MCA-PSV and haemoglobin was assessed using Pearson's correlation coefficient. Diagnostic performance of MCA-PSV MoM ≥1.5 was evaluated using sensitivity, specificity, and predictive values. A significant moderate inverse correlation was observed between MCA-PSV and cord blood haemoglobin (r = -0.42, p < 0.001). Anaemia at birth was present in 86 (86%) cases, with moderate-to-severe anaemia in 52 (52%). MCA-PSV and MoM values were significantly higher in anemic neonates (p < 0.001). MCA-PSV MoM increased with the severity of anaemia (p < 0.001). A threshold of ≥1.5 MoM showed excellent specificity (100%) and positive predictive value (100%) but low sensitivity (8.1%). MCA-PSV demonstrates a significant inverse correlation with haemoglobin levels and is a useful non-invasive marker for fetal anaemia. While highly specific, its low sensitivity limits its role as a screening tool, emphasising the need for integrated clinical assessment.
如何引用
AMA
Ravindra S Pukale, Manikonda B SatyaSri Alekhya. Correlation Between Middle Cerebral Artery Peak Systolic Velocity and Neonatal Haemoglobin as a Marker of Fetal Anaemia.. Cureus. 2026; doi:10.7759/cureus.109456.
APA
Ravindra S Pukale, Manikonda B SatyaSri Alekhya (2026). Correlation Between Middle Cerebral Artery Peak Systolic Velocity and Neonatal Haemoglobin as a Marker of Fetal Anaemia.. Cureus. https://doi.org/10.7759/cureus.109456
GB/T 7714
Ravindra S Pukale, Manikonda B SatyaSri Alekhya. Correlation Between Middle Cerebral Artery Peak Systolic Velocity and Neonatal Haemoglobin as a Marker of Fetal Anaemia.[J]. Cureus, 2026 doi:10.7759/cureus.109456.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出