对埃塞俄比亚全国乙型肝炎病毒感染负担的总体审查：呼吁在疫苗接种、安全血液和感染预防方面采取行动
An umbrella review navigating the nationwide burden of hepatitis B virus infection in Ethiopia: A call for action on vaccination, safe blood, and infection prevention.
摘要(中文译文)
乙型肝炎病毒（HBV）是病毒性肝炎的主要病因之一，感染可持续存在并导致并发症，包括肝硬化、肝功能失代偿和肝癌。已有多项关于埃塞俄比亚人群HBV感染的系统评价和荟萃分析，但研究结果不一致。本伞状综述旨在评估埃塞俄比亚人群HBV感染的合并患病率及其相关因素。检索了PubMed、Scopus、HINARI和Google Scholar等数据库中所有已发表和未发表的系统评价与荟萃分析研究。采用系统评价质量评估工具（AMSTAR）对纳入研究进行批判性评价。使用STATA软件17版进行分析。采用I²检验确定异质性，采用漏斗图和Egger回归检验评估发表偏倚。采用随机效应模型合并HBV感染患病率，并以森林图呈现。本伞状综述共纳入12项系统评价和荟萃分析，涉及997,264名参与者。埃塞俄比亚人群HBV感染的合并患病率为5.78%（95% CI：5.33，6.23）。男性、有多个性伴侣、有流产史、有文身、有拔牙史、共用锐器，以及与卫生系统相关的因素如既往住院史和输血史，是埃塞俄比亚人群HBV感染相关的显著危险因素。本研究强调，根据世界卫生组织分类，埃塞俄比亚人群HBV感染患病率处于相对中度地方性流行水平。通过综合既往综述的证据，本研究为临床医生和决策者提供了最新的具体信息，有助于设计循证公共卫生策略并指导未来研究，从而实现HBV感染的预防、控制和消除。PROSPERO注册号：CRD420251160887。
Abstract
The Hepatitis B virus (HBV) is one of the major causes of viral hepatitis that may persist and lead to complications, including cirrhosis, hepatic decompensation, and liver cancer. Numerous systematic reviews and meta-analysis have been conducted on HBV infection among people in Ethiopia, showing inconsistent findings. This umbrella review aimed to assess the pooled prevalence of HBV infection and its associated factors among people in Ethiopia. All published and unpublished systematic review and meta-analysis studies were searched on databases such as PubMed, Scopus, HINARI and Google Scholar. A measurement tool to assess systematic reviews was used for critical appraisal of the included studies. STATA software version 17 was used to conduct the analysis. I2 test were used to determine heterogeneity, whereas funnel plots and Egger's regression tests were used to assess publication bias. To pool the prevalence of HBV infection, a random-effects model was used and presented using a forest plot. Twelve systematic reviews and meta-analysis with 997,264 participants were included in this umbrella review. The pooled prevalence of the HBV infection among people in Ethiopia was 5.78% (95% CI: 5.33, 6.23). Being male, having multiple sexual partners, having a history of abortion, having body tattoos, having a history of tooth extraction, sharing sharp material, and linked to health system such as having a history of hospital admission, and blood transfusion were significant risk factors associated with HBV infection among people in Ethiopia. This study highlights that the prevalence of HBV infection among people in Ethiopia was relatively moderate endemicity as per WHO classification. By synthesizing evidence of prior review, this study provides specific up-to-date information for clinicians and policymakers to design evidence-based public health strategies and guide future research that enable the prevention, control, and eliminate infection of HBV. PROSPERO Registration: CRD420251160887.
如何引用
AMA
Abel Desalegn Demeke, Aboma Tsegaye, Alem Bayable, Takla Tamir, Biazin Yenealem Mekuriaw, Behailu Taye Gebremeskele, et al. An umbrella review navigating the nationwide burden of hepatitis B virus infection in Ethiopia: A call for action on vaccination, safe blood, and infection prevention.. PloS one. 2026; doi:10.1371/journal.pone.0352169.
APA
Abel Desalegn Demeke, Aboma Tsegaye, Alem Bayable, Takla Tamir, Biazin Yenealem Mekuriaw, Behailu Taye Gebremeskele, et al (2026). An umbrella review navigating the nationwide burden of hepatitis B virus infection in Ethiopia: A call for action on vaccination, safe blood, and infection prevention.. PloS one. https://doi.org/10.1371/journal.pone.0352169
GB/T 7714
Abel Desalegn Demeke, Aboma Tsegaye, Alem Bayable, Takla Tamir, Biazin Yenealem Mekuriaw, Behailu Taye Gebremeskele, et al. An umbrella review navigating the nationwide burden of hepatitis B virus infection in Ethiopia: A call for action on vaccination, safe blood, and infection prevention.[J]. PloS one, 2026 doi:10.1371/journal.pone.0352169.
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