微生物组-行为耦合塑造了婴儿对早期母体不可预测性的适应
Microbiome-behavior coupling shapes infant adaptation to early maternal unpredictability.
摘要(中文译文)
有些人类婴儿如何适应环境挑战，而另一些则不能？我们研究了婴儿对母亲不可预测性的行为反应是否预测早期抑制控制，并与肠道微生物群落组成和神经活性代谢潜力相关联。母亲不可预测性以母婴互动期间感觉信号转换的熵来量化（=255；2-6个月），预测婴儿在19-28个月时抑制控制较差。然而，在高不可预测性下表现出高视觉定向行为（VOB）的婴儿 later 表现出与暴露于低不可预测性的婴儿相当的抑制控制，提示一种适应性行为缓冲策略。在婴儿子集（=87）中，我们检验了婴儿年龄、性别、分娩方式、喂养、母亲教育程度和母亲不可预测性是否解释肠道微生物群落多样性的变异。只有喂养状态和VOB与分类学和功能微生物谱均显著相关。VOB与沿某轴和某轴的分类学和功能变异以及微生物色氨酸和谷氨酸合成基因的富集相关。尽管喂养组在α多样性上存在差异，但VOB与喂养状态无关，提示喂养不是观察到的VOB-微生物组特征的主要驱动因素。神经活性基因功能的交互模型揭示，微生物特征在VOB和母亲不可预测性的不同组合间存在差异，提示在不同水平的环境不可预测性下，微生物对部署视觉注意策略的支持不同。总之，这些发现支持一个框架，即婴儿行为策略与肠道微生物组成和代谢基因潜力的变异相关。
Abstract
How do some human infants adapt to environmental challenges while others do not? We examined whether infant behavioral responses to maternal unpredictability predict early inhibitory control and are linked to gut microbial community composition and neuroactive metabolic potential. Maternal unpredictability, quantified as the entropy of sensory signal transitions during mother-infant interaction ( = 255; 2-6 months), predicted poorer infant inhibitory control at 19-28 months. However, infants who exhibited high visual orienting behavior (VOB) under high unpredictability showed later inhibitory control comparable to infants exposed to low unpredictability, suggesting an adaptive behavioral buffering strategy. In a subset of infants ( = 87), we tested whether infant age, sex, delivery mode, feeding, maternal education, and maternal unpredictability explained variation in gut microbial community diversity. Only feeding status and VOB were significantly associated with both taxonomic and functional microbial profiles. VOB was associated with taxonomic and functional variation along a and axis and enrichment of microbial tryptophan and glutamate synthesis genes. Although feeding groups differed in alpha diversity, VOB was not associated with feeding status, suggesting that feeding is not the primary driver of the observed VOB-microbiome signatures. Interaction models of neuroactive gene functions revealed that microbial signatures vary across combinations of VOB and maternal unpredictability, suggesting that the microbial support for deploying visual attentional strategies differs under distinct levels of environmental unpredictability. Together, these findings support a framework in which infant behavioral strategy is associated with variation in gut microbial composition and metabolic gene potential.
如何引用
AMA
Dima Amso, Guilherme Fahur Bottino, Tess T Forest, Kevin S Bonham, Michal R Zieff, Fadheela Patel, et al. Microbiome-behavior coupling shapes infant adaptation to early maternal unpredictability.. Frontiers in microbiology. 2026; doi:10.3389/fmicb.2026.1830339.
APA
Dima Amso, Guilherme Fahur Bottino, Tess T Forest, Kevin S Bonham, Michal R Zieff, Fadheela Patel, et al (2026). Microbiome-behavior coupling shapes infant adaptation to early maternal unpredictability.. Frontiers in microbiology. https://doi.org/10.3389/fmicb.2026.1830339
GB/T 7714
Dima Amso, Guilherme Fahur Bottino, Tess T Forest, Kevin S Bonham, Michal R Zieff, Fadheela Patel, et al. Microbiome-behavior coupling shapes infant adaptation to early maternal unpredictability.[J]. Frontiers in microbiology, 2026 doi:10.3389/fmicb.2026.1830339.
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