药食同源物质中靶向肠道菌群的自然化合物在脂质代谢紊乱中的治疗潜力
Therapeutic potential of natural compounds from medicinal and food homology substances targeting gut microbiota in lipid metabolism disorders.
摘要(中文译文)
血脂异常（dyslipidemia）可促进非酒精性脂肪性肝病（NAFLD）、2型糖尿病（T2DM）和肥胖等慢性疾病的发生。新出现的证据强调，肠道菌群失调（gut dysbiosis）是脂质代谢异常的关键驱动因素。本综述探讨了药食同源（MFH）物质中的天然生物活性化合物如何通过调节肠道微生物组来调控脂质代谢。本文总结了关于药食同源物质中天然化合物对微生物群-脂质代谢轴的调节作用的证据，并讨论了其应用的局限性以及在预防和治疗代谢性疾病方面的前景。通过利用这些微生物群介导的效应，天然化合物有望成为调节脂质代谢的有益天然资源。
Abstract
Dyslipidemia contributes to chronic diseases such as non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2DM), and obesity. Emerging evidence highlights gut dysbiosis as a key driver of abnormal lipid metabolism. This review examines how natural bioactive compounds from medicinal and food homology (MFH) substances regulate lipid metabolism by modulating the gut microbiome. It summarizes evidence on the modification of the microbiota-lipid metabolism axis by natural compounds from MFH substances and discusses the limitations of applications and their promise for preventing and treating metabolic diseases. By capitalizing on these microbiota-mediated effects, natural compounds may serve as a beneficial natural resource for adjusting lipid metabolism.
如何引用
AMA
Qinjing Xia, Jixuan Xin, Yue Mu, Mingquan Li, Juan Yao, Xijingyi Xiao, et al. Therapeutic potential of natural compounds from medicinal and food homology substances targeting gut microbiota in lipid metabolism disorders.. Frontiers in microbiology. 2026; doi:10.3389/fmicb.2026.1809114.
APA
Qinjing Xia, Jixuan Xin, Yue Mu, Mingquan Li, Juan Yao, Xijingyi Xiao, et al (2026). Therapeutic potential of natural compounds from medicinal and food homology substances targeting gut microbiota in lipid metabolism disorders.. Frontiers in microbiology. https://doi.org/10.3389/fmicb.2026.1809114
GB/T 7714
Qinjing Xia, Jixuan Xin, Yue Mu, Mingquan Li, Juan Yao, Xijingyi Xiao, et al. Therapeutic potential of natural compounds from medicinal and food homology substances targeting gut microbiota in lipid metabolism disorders.[J]. Frontiers in microbiology, 2026 doi:10.3389/fmicb.2026.1809114.
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