儿童和青少年牙龈炎的低强度激光治疗：基于体外、体内和临床研究的叙述性综述
Low-Level Laser Therapy for Gingival Inflammation in Children and Adolescents: A Narrative Review Based on In Vitro, In Vivo and Clinical Studies.
摘要(中文译文)
牙龈炎是儿科人群中最常见的炎症性疾病之一，在全球范围内构成重大的口腔健康负担。除传统方法外，低水平激光治疗（LLLT）等新兴辅助疗法（又称光生物调节）日益受到关注。本综述旨在评估关于LLLT在儿童和青少年牙龈炎症管理中临床相关性及潜在医疗保健意义的现有证据。本研究进行了结构化叙述性文献综述，纳入2005年至2025年间发表的实验研究、动物研究和临床研究。研究筛选和筛查由两名评审人员独立完成。对纳入的儿科临床研究的方法学特征进行了定性评估，重点关注随机化、盲法、随访报告和不良事件监测。实验研究表明，LLLT可促进牙龈细胞增殖并调节炎症反应，而抗菌效果尚不一致。动物研究表明，当LLLT与常规治疗联合使用时，可减轻牙龈炎症和牙槽骨丧失。儿科人群的临床研究报告牙龈指数和牙周治疗需求有所改善，且未观察到不良反应。LLLT似乎是一种安全、非侵入性的辅助疗法，具有改善儿科人群口腔健康结局的潜力。其临床适用性和较高的患者接受度支持其可能整合到更广泛的口腔保健策略中。然而，仍需进一步开展设计良好、方案标准化且具有长期随访的临床试验。
Abstract
Gingivitis is one of the most prevalent inflammatory conditions in pediatric populations and represents a significant oral health burden worldwide. In addition to conventional approaches, emerging adjunctive therapies such as low-level laser therapy (LLLT), also known as photobiomodulation, have gained increasing attention. This review aims to evaluate current evidence regarding the clinical relevance and potential healthcare implications of LLLT in the management of gingival inflammation in children and adolescents. A structured narrative literature review was conducted, including experimental, animal, and clinical studies published between 2005 and 2025. Study selection and screening were performed independently by two reviewers. Methodological characteristics of the included pediatric clinical studies were qualitatively assessed, focusing on randomization, blinding, follow-up reporting, and adverse event monitoring. Experimental studies demonstrate that LLLT enhances gingival cell proliferation and modulates inflammatory responses, while antimicrobial effects remain inconsistent. Animal studies indicate reductions in gingival inflammation and alveolar bone loss when LLLT is used adjunctively with conventional therapy. Clinical studies in pediatric populations report improvements in gingival indices and periodontal treatment needs, with no adverse effects observed. LLLT appears to be a safe, non-invasive adjunctive therapy with potential to improve oral health outcomes in pediatric populations. Its clinical applicability and high patient acceptability support its potential integration into broader oral healthcare strategies. However, further well-designed clinical trials with standardized protocols and long-term follow-up are required.
如何引用
AMA
Mădălina-Ștefania Stancu, Mihaela Tănase, Aneta Munteanu, Ion-Victor Feraru, Carmen Nicoleta Novac, Anca Andreea Boboc, et al. Low-Level Laser Therapy for Gingival Inflammation in Children and Adolescents: A Narrative Review Based on In Vitro, In Vivo and Clinical Studies.. Healthcare (Basel, Switzerland). 2026; doi:10.3390/healthcare14111533.
APA
Mădălina-Ștefania Stancu, Mihaela Tănase, Aneta Munteanu, Ion-Victor Feraru, Carmen Nicoleta Novac, Anca Andreea Boboc, et al (2026). Low-Level Laser Therapy for Gingival Inflammation in Children and Adolescents: A Narrative Review Based on In Vitro, In Vivo and Clinical Studies.. Healthcare (Basel, Switzerland). https://doi.org/10.3390/healthcare14111533
GB/T 7714
Mădălina-Ștefania Stancu, Mihaela Tănase, Aneta Munteanu, Ion-Victor Feraru, Carmen Nicoleta Novac, Anca Andreea Boboc, et al. Low-Level Laser Therapy for Gingival Inflammation in Children and Adolescents: A Narrative Review Based on In Vitro, In Vivo and Clinical Studies.[J]. Healthcare (Basel, Switzerland), 2026 doi:10.3390/healthcare14111533.
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