在感染风险高且对高级治疗反应不足的中度活动性溃疡性结肠炎患者中，使用Guselkumab实现快速缓解：病例报告
Achieving Rapid Remission With Guselkumab in a Moderately Active Ulcerative Colitis Patient With High Infectious Risk and Inadequate Response to Advanced Therapy: A Case Report.
摘要(中文译文)
溃疡性结肠炎（UC）对先前先进治疗应答不足（AT-IR）且需要住院的患者管理尤为困难，尤其是在感染高风险限制免疫抑制剂使用的情况下。一名32岁男性广泛结肠型UC患者对糖皮质激素、英夫利西单抗和他克莫司难治。其临床过程并发感染性休克和侵袭性念珠菌病。抗真菌治疗因药物相互作用限制了乌帕替尼的使用。在实现感染控制后，开始静脉注射古塞奇尤单抗（200 mg）。患者大便频率恢复正常，便血在两周内消失。患者达到临床缓解，随后出院。总之，古塞奇尤单抗使一名活动性UC伴AT-IR、感染风险高且其他先进治疗受限的患者达到了临床缓解。
Abstract
Ulcerative colitis (UC) with prior inadequate response to advanced therapy (AT-IR) that requires hospitalization is particularly challenging to manage, especially in cases where a high risk of infection limits the use of immunosuppressive agents. A 32-year-old male patient with pancolitis-type UC was refractory to glucocorticosteroids, infliximab, and tacrolimus. His clinical course was complicated by septic shock and invasive candidiasis. Antifungal therapy limited the use of upadacitinib due to drug-drug interactions. After achieving infection control, intravenous guselkumab (200 mg) was initiated. The patient's stool frequency normalized, and hematochezia resolved within two weeks. The patient achieved clinical remission, and he was then discharged. In conclusion, guselkumab achieved clinical remission in a patient with active UC with AT-IR, in whom the risk of infection was high and other advanced therapies were restricted.
如何引用
AMA
Nozomi Furuichi, Yuki Itoi, Keiichi Oshima, Yoji Takeuchi, Toshio Uraoka. Achieving Rapid Remission With Guselkumab in a Moderately Active Ulcerative Colitis Patient With High Infectious Risk and Inadequate Response to Advanced Therapy: A Case Report.. Cureus. 2026; doi:10.7759/cureus.107908.
APA
Nozomi Furuichi, Yuki Itoi, Keiichi Oshima, Yoji Takeuchi, Toshio Uraoka (2026). Achieving Rapid Remission With Guselkumab in a Moderately Active Ulcerative Colitis Patient With High Infectious Risk and Inadequate Response to Advanced Therapy: A Case Report.. Cureus. https://doi.org/10.7759/cureus.107908
GB/T 7714
Nozomi Furuichi, Yuki Itoi, Keiichi Oshima, Yoji Takeuchi, Toshio Uraoka. Achieving Rapid Remission With Guselkumab in a Moderately Active Ulcerative Colitis Patient With High Infectious Risk and Inadequate Response to Advanced Therapy: A Case Report.[J]. Cureus, 2026 doi:10.7759/cureus.107908.
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