Tirzepatide和钙补充引起的高钙血症：病例报告
Hypercalcemia Induced by Tirzepatide and Calcium Supplementation: A Case Report.
摘要(中文译文)
替尔泊肽是一种胰高血糖素样肽-1受体（GLP-1R）激动剂和葡萄糖依赖性促胰岛素多肽受体（GIPR）激动剂，用于治疗糖尿病和减重。常见不良反应包括恶心、呕吐等胃肠道症状、胰腺炎和急性肾损伤。高钙血症在文献中罕有报道，此前曾在同时使用噻嗪类利尿剂或外源性钙补充剂的GLP-1R激动剂使用者中报道。我们报告一例70岁女性，患有阻塞性睡眠呼吸暂停，于就诊前三个月开始使用替尔泊肽，因骨质疏松服用钙补充剂，并有肥胖症，出现恶心和呕吐。检查发现其患有症状性中度高钙血症，伴低钾血症、代谢性碱中毒和急性肾损伤，经静脉补液后纠正。此前尚无文献描述替尔泊肽使用联合钙补充剂所致的高钙血症。其机制最可能涉及替尔泊肽对骨转换的影响以及同时摄入钙补充剂导致的吸收增加。临床医生在患者开始使用替尔泊肽时需密切监测其电解质，尤其是钙。尚需进一步研究以揭示替尔泊肽在钙代谢方面的机制。
Abstract
Tirzepatide is a glucagon-like peptide-1 receptor (GLP-1R) agonist and glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist that is used for diabetes mellitus and weight loss. Common adverse effects include gastrointestinal symptoms such as nausea and vomiting, pancreatitis, and acute kidney injury. Hypercalcemia is rarely reported in the literature and has previously been reported in patients taking GLP-1R agonists with concomitant thiazide diuretic or exogenous calcium supplement. We report a 70-year-old female with obstructive sleep apnea started on tirzepatide three months prior to presentation, osteoporosis on calcium supplements, and obesity, who developed nausea and vomiting. She was found to have symptomatic moderate hypercalcemia with hypokalemia, metabolic alkalosis, and acute kidney injury that corrected after intravenous hydration. No prior literature describes hypercalcemia from tirzepatide use and calcium supplementation. The mechanism most likely involves tirzepatide's effect on bone turnover and concomitant increased absorption from calcium supplement ingestion. Clinicians need to closely monitor patients' electrolytes, especially calcium, when initiating patients on tirzepatide. Further research is warranted to reveal tirzepatide's mechanism regarding calcium metabolism.
如何引用
AMA
Edward Nguyen, Megan Kawamura, Irwin Munoz, Gary Ahn. Hypercalcemia Induced by Tirzepatide and Calcium Supplementation: A Case Report.. Cureus. 2026; doi:10.7759/cureus.108061.
APA
Edward Nguyen, Megan Kawamura, Irwin Munoz, Gary Ahn (2026). Hypercalcemia Induced by Tirzepatide and Calcium Supplementation: A Case Report.. Cureus. https://doi.org/10.7759/cureus.108061
GB/T 7714
Edward Nguyen, Megan Kawamura, Irwin Munoz, Gary Ahn. Hypercalcemia Induced by Tirzepatide and Calcium Supplementation: A Case Report.[J]. Cureus, 2026 doi:10.7759/cureus.108061.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出