肝移植 liver transplantation - PubMed 文献(第 4 页)
PubMed 共收录约 150,227 篇相关文献，本站只列出其中相关度最高的前 50 篇（共 5 页）；要看全部结果、按影响因子 / 分区 / 年份筛选，请前往完整搜索。
本页是「肝移植（liver transplantation）」PubMed 检索结果的第 4 页，列出第 31–40 篇相关文献；主题介绍见第 1 页。
肝移植 的 PubMed 搜索结果(第 4 页)
-
Can liver transplantation be applied for the treatment of liver cancer? 肝移植能否用于肝癌的治疗？
Unfavourable results and shortage of donor organs have led to restricted indication of liver transplantation for irresectable hepatocellular carcinoma. This review analyses the current state of experience in order to work out criteria for a more differentiated multimodal treatment including liver transplantation. New techniques of extended liver resection under hypothermic perfusion have to be considered in some conventionally irresectable tumors. Split-liver transplantation is a donor organ saving option which preserves the chance of transplantation in individual tumor patients without disadvantage for patients with benign diseases.
-
Liver transplantation in the era of cost constraints. 成本约束时代的肝移植
The issue of containing cost has had a significant impact on organ transplantation. After our institution's 500th liver transplant, we critically examined the impact of the changing health care environment on liver transplantation. We retrospectively analyzed 500 consecutive liver transplants done in the period of 1989 to 1998. Comparing the first 100 liver transplants to the last 100, patient demographics did not change significantly; however, mean waiting times increased significantly, from 30.4 days to 146.7 days, and median hospital stay decreased from 20.2 days to 10.9 days. One-year patient and graft survivals were not significantly different, 93.6% versus 96.5% and 88.0% versus 95.7%, respectively. Despite transplants in patients at higher risk and discharging patients sooner after transplantation, surgical results and patient survivals remained excellent. This was accomplished through improvements and modification of immunosuppression, outpatient treatment of uncomplicated acute rejection, and emphasis on close outpatient follow-up.
-
Liver Transplantation in 2016: An Update. 2016年肝移植：最新进展
Liver transplantation is a lifesaving intervention for patients with decompensated cirrhosis, certain malignancies, and genetic disorders associated with disordered liver metabolism. This commentary will discuss the indications for liver transplantation, the evaluation of liver transplant candidates, prioritization of candidates on the waiting list, and post-transplant care.
-
[Development of an orthotopic hepatic transplantation technique in rats: what should the researcher's objectives be?]. [大鼠原位肝移植技术的发展：研究者的目标应该是什么？]
The development of liver transplantation in man emphasises the need for more work in the field of experimental liver transplantation. For this purpose the model of orthotopic liver transplantation in the rat is very useful but difficult to establish as a safe and reproducible technique. The aim of this study concerning acquisition of the orthotopic liver transplantation model in the rat was to define precise objectives for future investigators. Two investigators without experience in microsurgery each performed 75 orthotopic liver transplantations, which were divided into five consecutive series. In each series survival times of the recipients after transplantation were analysed according to the mean duration of the operative procedure and the mean portal vein clamping time. For each investigator, mean duration of the operative procedure progressively decreased to reach a minimum at the 45th graft. From that time on, the portal vein clamping time became less than 17 minutes and a significant increase in the post operative survival time of the recipient was observed. However it was only from the sixtieth transplantation on, with stable portal vein clamping time but technical mistakes fewer that a high success rate was observed.
-
Minimalization of immunosuppression in liver transplantation: steps from 'how' to 'now'. Interview by Emily Reeve. 肝移植中免疫抑制的最小化：从“如何”到“现在”的步骤。Emily Reeve访谈
From the very start of his surgical career, Jan Lerut was involved in organ transplantation. This interest resulted in transplantation fellowships at the University Paris-Sud - Centre Hépatobiliaire under the lead of Professor Bismuth and at the Pittsburgh Medical Center under the lead of Professor Starzl. He was director of the abdominal transplant program at the Inselspital University of Bern from 1987 to 1991. Currently, he is Professor of Surgery, Director of the Starzl Abdominal Transplant Unit of the University Hospitals Saint Luc of the Université Catholique de Louvain and director of the Université Catholique de Louvain Transplant Center in Brussels. He is also director of the department of Abdominal and Transplantation Surgery at the same university. He has served as president of the Belgian Society of Transplantation, chairman of the Eurotransplant Liver Allocation Committee and president of the European Society for Organ Transplantation. Under his presidency over the Eurotransplant Liver Allocation Committee, the Model for End stage Liver Disease system was introduced. His presidency at the European Society for Organ Transplantation was devoted to the broadening of the European transplant community and to the development of a master educational program in the field of transplantation. He has published over 250 peer-reviewed articles, authored 24 book chapters and 24 scientific films. His research interests focus on the development of technical refinements in liver transplantation and on the use of minimal immunosuppression and tolerance induction in liver transplantation.
-
New-onset diabetes and hypertension as complications of liver transplantation. 新发糖尿病和高血压作为肝移植的并发症
Among the many complications that can occur after liver transplantation are diabetes and hypertension. In this study, we evaluated the overall prevalence of and identified predictors for post-transplantation diabetes and hypertension. This study was retrospective. We collected the data of the patients from the database in the liver transplant unit. Incidence of new-onset diabetes after transplantation (NODAT) was 25% and incidence of post-transplantation hypertension was 20%. No predictors were found for NODAT. Predictors of post-transplantation hypertension were body mass index and use of cyclosporine. Diabetes and hypertension are common after liver transplantation. Predictors of post-transplantation hypertension are high body mass index and use of cyclosporine.
-
Malignancies after liver transplantation: Value of contrast-enhanced ultrasound (CEUS). 肝移植后恶性肿瘤：超声造影（CEUS）的价值
To evaluate the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) in the diagnosis of malignancies after liver transplantation. A total of 23 patients with suspicious liver masses after liver transplantation with initial imaging series between September 2006 and September 2015 were statistically analysed. CEUS and CT were compared in their diagnosis of malignancy with CT being the gold standard. Out of 23 patients 9 patients showed malignant masses in CT, which could also be detected in 7 out 9 of cases using CEUS. CEUS showed a sensitivity of 77.8%, a specificity of 100.0%, a positive predictive value (PPV) of 100.0% and a negative predictive value (NPV) of 87,5% in comparison with CT being the gold standard. In 2 cases CT showed a malignancy, contrary to the CEUS examination that was reported as normal. CEUS seems to be an alternative option for the evaluation of malignant masses in liver transplant patients. CEUS shows a high specificity and PPV in the detection of malignant liver masses.
-
[Can the quality of a modest liver transplantation program compare to international standards? Results in Inselspital Berne]. [一个规模适中的肝移植项目的质量能否与国际标准相比？伯尔尼Inselspital的结果]
Today, orthotopic liver transplantation is the treatment of choice for the endstage of various liver diseases, and a 1-year survival rate of over 80% is reported in international surveys. The liver transplant program of the Inselspital is very small compared to international centers and this may raise questions about the results and the justification for such a program. In a 24-month period, 20 liver transplants (including 2 retransplants) have been performed in 18 patients at the Inselspital. 2 patients (11%) died 20 and 268 days respectively after transplantation. 2 patients (11%) had significant morbidity 502 and 529 days respectively after transplantation. After a median follow-up of 11.5 months postoperatively, 14 (80% of all patients) lived an independent life. 9 (50%) were fully reintegrated in the household or in their profession and 5 others (30%) were working part time. We conclude that even a small liver transplant program based only on routine resources can achieve results comparable to international standards.
-
Liver transplantation and rejection: an overview. 肝移植与排斥反应：概述
Liver transplantation has offered a new avenue for study and understanding of splanchnic and hepatic hemodynamics. This overview presents some of the issues highlighted to date, but emphasizes that this field is open to further study.
-
Unfreezing What's Hot in Liver Transplantation: A Review of Current Trends. 解冻肝移植中的热点：当前趋势综述
Liver transplantation has been underway for several decades, becoming a curative and life-prolonging treatment for individuals experiencing acute liver failure, end-stage liver disease, and/or hepatocellular carcinoma. Several trends have emerged to better select recipients and identify indicators for successful transplantation in light of the shortage of available organs relative to the number of people awaiting transplantation. In addition, different perfusion approaches have been studied to better understand how to achieve favorable outcomes during and after liver transplantation.