TRANSPLANTATION移植
TRANSPLANTATION(英文缩写 TRANSPLANTATION),ISSN 0041-1337,eISSN 1534-6080,中文译名:移植 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.385 | Q1 |
| 2022 | 6.200 | Q1 |
| 2023 | 5.300 | Q1 |
| 2024 | 5.000 | Q1 |
| 2025 | 4.900 | Q1 |
TRANSPLANTATION 最新收录文献
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8. Mapping Unmet Need: The Global Chasm Between Liver Disease Burden and Transplant Capacity.
PMID:日期:2026-10-01该文献暂无摘要。
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9. From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation.
PMID:日期:2026-10-01The persistent shortage of human organs for transplantation has intensified efforts to develop alternative sources, specifically xenotransplantation and exogenesis. Xenotransplantation uses genetically engineered pigs to provide organs, tissues, and cells for clinical use. Significant progress has occurred in developing multigene-modified pigs that lack glycan xenoantigens while expressing human complement and coagulation regulators. These modifications have successfully mitigated hyperacute, antibody-mediated, and cellular rejection in preclinical nonhuman primate models. Recent compassionate-use cases in humans have demonstrated the feasibility of heart, kidney, and liver xenotransplantation, although achieving long-term survival remains a challenge. Complementing this approach, exogenesis aims to generate human-compatible organs within animal hosts through interspecies chimerism. Although advances in establishing organ niches and overcoming xeno-barriers have yielded preliminary success in heart, pancreas, and muscle development, formidable immune and developmental hurdles remain. Together, these approaches offer promising strategies to expand the donor organ pool and address the growing global demand for transplantation. Further advances in genetic engineering, immune modulation, and developmental biology, supported by rigorous preclinical and clinical evaluation, will be critical for widespread translation. This review outlines the current progress, major challenges, and future directions in xenogeneic and exogenic organ generation.
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10. Gut Microbiota-Associated Lysophosphatidylcholine Aggravates Donation After Circulatory Death Liver Injury via Lysosomal Dysregulation During Normothermic Regional Perfusion.
PMID:日期:2026-10-01Normothermic regional perfusion (NRP) is increasingly used in donation after circulatory death liver transplantation, yet the impact of the accompanying intestinal ischemia/reperfusion injury and gut microbiota dysbiosis on liver grafts remains unclear. A rat model of donation after circulatory death followed by NRP was established. Intestinal microbiota composition was characterized by 16S rRNA gene sequencing, and the contribution of microbiota alterations to liver injury during NRP was assessed using antibiotic-treated rats and fecal microbiota transplantation. Untargeted metabolomics of intestinal contents was subsequently performed to identify candidate metabolites potentially involved in microbiota-associated liver injury. Lysophosphatidylcholine (LPC) was further investigated in vivo and in vitro by transcriptomic analysis and studies of lysosomal function and autophagic flux. NRP induced intestinal microbiota dysbiosis. Antibiotic treatment attenuated liver injury, whereas fecal microbiota transplantation from NRP donors aggravated liver injury. Untargeted metabolomics identified LPC as a markedly increased metabolite during NRP, with elevated levels in intestinal contents, portal venous plasma, and liver tissue. Transcriptomic analysis and complementary in vivo and in vitro experiments showed that increased LPC exposure exacerbated hepatocellular injury and was associated with lysosomal dysfunction and impaired autophagic flux. NRP induced gut microbiota dysbiosis and alterations in the intestinal metabolome. LPC was increased during NRP and aggravated liver injury, accompanied by lysosomal dysfunction and impaired autophagic flux, suggesting that modulation of the intestinal microenvironment and LPC-targeted intervention may offer potential strategies to mitigate liver injury during NRP.