水凝胶医疗材料伤口愈合 hydrogel medical materials wound healing - PubMed 文献
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关于 水凝胶医疗材料伤口愈合
水凝胶医疗材料伤口愈合（hydrogel medical materials wound healing）是生物医学工程与再生医学的交叉领域，聚焦于以亲水性三维网络结构的水凝胶作为伤口敷料或组织修复支架，促进急慢性创面愈合。水凝胶（hydrogel）是一类能吸收大量水分而不溶解的高分子材料，其网络可由天然多糖（如海藻酸、壳聚糖、透明质酸）或合成聚合物（如聚乙二醇、聚乙烯醇）交联形成。该领域涉及材料科学、生物化学、临床医学等多学科，近义词包括水凝胶敷料（hydrogel dressing）、创面修复材料（wound repair materials）、生物活性水凝胶（bioactive hydrogel）等。其核心目标是通过模拟细胞外基质微环境，调控炎症、增殖与重塑阶段，实现功能性皮肤再生。
该方向的研究热点涵盖多功能水凝胶设计，如抗菌、抗氧化、自愈合、可注射及刺激响应型材料；经典议题包括水凝胶的力学性能与降解速率匹配、生长因子或药物控释、以及宿主免疫反应调控。代表性期刊有《Biomaterials》《Acta Biomaterialia》《Advanced Healthcare Materials》等，学者如Ali Khademhosseini、Jennifer Elisseeff等在相关领域有系统性工作。研究常结合体外细胞实验与动物模型，评估水凝胶对成纤维细胞、角质形成细胞及巨噬细胞极化的影响，并探索慢性糖尿病溃疡、烧伤等难愈创面的治疗策略。
PubMed增强版为关注水凝胶伤口愈合的研究者提供高效支持：一键获取英文文献的中文翻译，降低语言门槛；展示期刊影响因子与分区，辅助快速筛选高影响力研究；集成PDF下载链接，方便获取全文；AI阅读功能可自动提炼摘要核心结论与实验方法，节省文献调研时间。这些工具帮助临床医生、材料科学家及研究生更系统地追踪该领域进展，优化实验设计或临床决策。
水凝胶医疗材料伤口愈合 的 PubMed 搜索结果
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1. Almond Gum/Gelatin-Based Multifunctional Nanocomposite Hydrogel: A Synergistic Hybrid Platform for Wound Healing.
1. 杏仁胶/明胶基多功能纳米复合水凝胶：一种用于伤口愈合的协同混合平台PMID:日期:2025-12-04[中文摘要] 伤口管理面临诸多关键临床限制，凸显了对能够最大化愈合过程并促进组织再生的改良伤口敷料的需求。本研究建立了一种简单、绿色且可规模化的方法，利用植物源和动物源聚合物，即杏仁胶和明胶，并负载具有生物活性的L-薄荷醇和Ae-ZnONPs（MeZ@ALGEL），制备多功能纳米复合水凝胶，通过其杀菌、活性氧（ROS）调节和组织再生能力强化伤口环境，从而改善伤口愈合。MeZ@ALGEL具有必要的物理化学和力学性能以及显著的抗菌和抗氧化活性，使其适合局部给药并有利于加速伤口修复。在体外条件下，MeZ@ALGEL对成纤维细胞表现出高度生物相容性，在类伤口情况下积极促进其迁移，并显示羟脯氨酸含量改善，基因表达分析揭示、和基因上调，以及基因下调。使用作为初步伤口模型的体内研究表明，MeZ@ALGEL水凝胶在浓度高达125 μg/mL时无毒，促进玻璃棉介导的伤口愈合，表现出强抗菌活性，并通过涉及细菌清除、ROS调节和刺激胶原合成的多层面途径加速伤口修复，最终增强模型生物体的伤口愈合。基于这些发现，这种简便合成的纳米复合水凝胶通过利用各组分之间的协同相互作用，为开发天然来源的多功能水凝胶开辟了可能性，并在伤口护理领域具有巨大潜力。
[英文摘要] Management of wounds unveils various crucial clinical constraints, emphasizing the demand for transformed wound dressings that maximize the healing process and facilitate tissue regeneration. Here, a simple, green yet scalable approach was established to fabricate a multifunctional nanocomposite hydrogel employing plant- and animal-derived polymers, specifically almond gum and gelatin, enhanced with bioactive L-menthol and Ae-ZnONPs (MeZ@ALGEL), to improve wound healing by reinforcing the wound environment with its bactericidal, reactive oxygen species (ROS) regulation, and tissue regeneration abilities. MeZ@ALGEL exhibits necessary physicochemical and mechanical properties and significant antibacterial and antioxidant activities, making it ideal for topical administration and beneficial in accelerating wound repair. Under in vitro conditions, MeZ@ALGEL demonstrates a high degree of biocompatibility with fibroblast cells, actively promotes their migration in wound-like cases, and indicates improved hydroxyproline content with upregulation of , , genes, and downregulation of the gene revealed in gene expression analysis. In vivo studies using as a preliminary wound model reveal that the MeZ@ALGEL hydrogel is nontoxic up to the concentration of 125 μg/mL, promotes healing of glass wool-mediated wounds, exhibits strong antimicrobial activity, and accelerates wound repair through a multifaceted approach involving bacterial eradication, regulation of ROS, and stimulation of collagen synthesis, ultimately enhancing wound healing in the model organism. By these findings, the facilely synthesized nanocomposite hydrogel opens up the possibilities for developing multifunctional hydrogels of natural origin by utilizing the synergistic interaction of components and offers great potential in the wound care sector.
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2. By Endowing Polyglutamic Acid/Polylysine Composite Hydrogel with Super Intrinsic Characteristics to Enhance its Wound Repair Potential.
2. 通过赋予聚谷氨酸/聚赖氨酸复合水凝胶超强内在特性以增强其伤口修复潜力PMID:日期:2021-03-03[中文摘要] 本研究通过复合技术，以聚谷氨酸和聚赖氨酸为前驱体，酪蛋白为发泡剂，钙离子为凝固剂，制备了多功能多孔复合水凝胶。结果表明，所制备的水凝胶具有高孔隙率和高吸水率，以及良好的力学性能、固有抗菌性能和生物黏附性能。结果表明，所制备水凝胶的高吸水率、生物黏附性和孔隙率能够有效浓缩血液成分并更好地封闭伤口。所制备水凝胶中钙离子的释放能够激活凝血因子。这两种因素均可在止血中发挥重要作用。所制备水凝胶优异的吸水性、保湿性、黏附性和固有抗菌性能可为伤口愈合创造湿润、无菌且封闭的微环境。深部皮肤缺损模型的实验结果验证了其良好的促进伤口修复效果。这些固有的优异性能可赋予所制备水凝胶广泛的应用价值。
[英文摘要] In this study, multifunctional porous composite hydrogels are prepared via composite technology and using poly(glutamic acid) and (polylysine) as precursors, casein as foaming agent, and calcium ions as coagulant. The results show that the as-prepared hydrogels have high porosity and water absorbency, and good mechanical, inherent antibacterial, and bioadhesive properties. The results show such high water absorption, bioadhesion, and porosity of the as-prepared hydrogel can effectively concentrate blood components and seal wounds better. The release of calcium ions in the as-prepared hydrogels can activate coagulation factors. Both factors can play an important role in hemostasis. The excellent hydroscopicity, moisture retention, adhesion, and inherent antibacterial properties of the as-prepared hydrogel can create a moist, sterile, and closed microenvironment for the wound healing. The experimental results of a deep skin defect model have verified its good effect of promoting wound repair. These inherent excellent properties can endow the as-prepared hydrogel with a wide range of application values.
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3. Ascorbic acid-loaded gellan-g-poly(ethylene glycol) methacrylate matrix as a wound-healing material.
3. 负载抗坏血酸的马尾藻胶-g-聚(乙二醇)甲基丙烯酸酯基质作为伤口愈合材料PMID:日期:2023-08-13[中文摘要] 抗坏血酸（AA）是参与伤口愈合各阶段的重要生物分子之一。本研究旨在开发一种新型水凝胶系统，可在伤口护理管理过程中实现抗坏血酸的局部递送。在本研究中，我们将聚乙二醇甲基丙烯酸酯接枝到可再生生物聚合物结冷胶上，所形成的接枝共聚物（GPMA）通过共价交联和离子交联形成网络，并用作向伤口递送AA的基质。通过接枝和交联过程，结冷胶的力学性能较力学性能较弱的天然结冷胶提高了数倍。体外细胞毒性评价表明，GPMA对成纤维细胞无细胞毒性。GPMA水凝胶基质可实现AA的持续释放。当AA被掺入GPMA中时，在使用角质形成细胞进行的划痕伤口实验中观察到伤口闭合显著改善。由于AA在胶原合成中作为辅因子发挥作用，向伤口微环境受控递送AA有利于colα1基因表达的上调。本研究表明，在体外实验中，浓度为150 μM的抗坏血酸对伤口愈合具有有利影响。总体结果表明，GPMA基质可能是用于伤口愈合应用的一种有前景的材料。
[英文摘要] Ascorbic acid (AA) is one of the important biomolecules involved in all phases of wound healing. The aim of this study was to develop a new hydrogel system that offers topical delivery of ascorbic acid to wounds during wound care management. In this work, we grafted poly (ethylene glycol) methacrylate onto a renewable biopolymer gellan, and the graft copolymer (GPMA) formed was crosslinked covalently and ionically, and used as a matrix for delivering AA to the wounds. By the processes of grafting and crosslinking, the mechanical properties of the gellan increased several fold compared to mechanically weak native gellan. In vitro cytotoxicity evaluation showed that GPMA was non-cytotoxic to fibroblast cells. GPMA hydrogel matrix allowed the sustained release of AA. When AA was incorporated in GPMA, a significant improvement in wound closure was observed in scratch wound assay performed with keratinocytes. Since AA acts as a cofactor in collagen synthesis, the controlled delivery of AA to the wound microenvironment favors the up-regulation of colα1 gene expression. This study revealed that ascorbic acid, at a concentration of 150 μM, has a favorable impact on wound healing when tested in vitro. Overall results indicate that the GPMA matrix could be a promising material for wound healing applications.
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4. Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing.
4. 基于透明质酸的水凝胶用于糖尿病伤口愈合的最新进展PMID:日期:2025-02-07[中文摘要] 糖尿病创面愈合是一个复杂的生物学难题，常因细胞过程紊乱和炎症失调而受阻，进而导致慢性创面和难愈性创面。鉴于其给患者和医疗系统带来的沉重负担，亟需先进的治疗策略。基于透明质酸（HA）的水凝胶因其生物相容性、生物可降解性和独特的生理功能，已成为一种有前景的解决方案。本综述旨在全面概述基于HA的水凝胶的最新进展，重点阐述其在解决糖尿病创面并发症方面的潜力。具体而言，本文探讨了高血糖诱导的氧化应激以及复杂的糖尿病创面微环境中细胞信号传导受损等挑战。此外，本综述还探讨了HA的组成与特性，包括其黏附能力以及在减少手术创伤中的作用。文中还讨论了各种交联策略和功能化修饰，以赋予基于HA的水凝胶抗氧化、抗菌及释放生长因子的能力。通过总结最新研究并指出有待进一步探索的领域，本综述有助于开发更有效的基于HA的水凝胶制剂用于糖尿病创面愈合。
[英文摘要] Diabetic wound healing represents a complex biological challenge, often impeded by disrupted cellular processes and dysregulated inflammation, which can lead to chronic and non-healing wounds. Given the significant burden on patients and the healthcare system, there is an urgent need for advanced therapeutic strategies. Hyaluronic acid (HA)-based hydrogels have emerged as a promising solution due to their biocompatibility, biodegradability, and unique physiological functions. This review aims to provide a comprehensive overview of recent advances in HA-based hydrogels, highlighting their potential in addressing diabetic wound complications. Specifically, it examines challenges such as hyperglycemia-induced oxidative stress and impaired cellular signaling within the intricate diabetic wound microenvironment. Moreover, the review explores the composition and properties of HA, including its adhesive capabilities and role in reducing surgical trauma. Various crosslinking strategies and functional modifications are also discussed to endow HA-based hydrogels with antioxidant, antimicrobial, and growth factor-releasing capabilities. By summarizing the latest research and identifying areas for further exploration, this review contributes to the development of more effective HA-based hydrogel formulations for diabetic wound healing.
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5. Biomimetic gradient hydrogel with fibroblast spheroids for full-thickness skin regeneration.
5. 具有成纤维细胞球体的仿生梯度水凝胶用于全层皮肤再生PMID:日期:2024-12-16[中文摘要] 基于水凝胶的支架因其在组织工程中加速组织再生的应用而受到广泛研究。然而，复制具有适当生物学线索的组织生理微环境仍然具有挑战性。近年来，梯度水凝胶的进展通过提供模拟天然组织细胞外基质的精确结构，改变了组织工程研究。与传统的均一结构水凝胶不同，梯度水凝胶通过调控多种细胞行为（如增殖、迁移和分化），为慢性伤口治疗中的联合细胞疗法提供了更好的仿生微环境。在此，我们将L929小鼠成纤维细胞球体整合到梯度水凝胶中以模拟真皮硬度微环境，并研究了其对全层皮肤再生的影响。通过使用双注射泵系统，调节不同甲基丙烯酰化程度的甲基丙烯酰化透明质酸（HA-MA）浓度，实现了硬度梯度。将L929球体包封于梯度水凝胶中，促进了皮肤细胞以层级有序的构型组织化，从而在大鼠模型中实现了比未处理组快1.53倍的全层伤口愈合。本研究为探究梯度水凝胶在多种组织工程和再生应用中的潜在作用提供了一种方法。
[英文摘要] Hydrogel-based scaffolds have been widely investigated for their use in tissue engineering to accelerate tissue regeneration. However, replicating the physiological microenvironments of tissues with appropriate biological cues remains challenging. Recent advances in gradient hydrogels have transformed tissue-engineering research by providing precise structures that mimic the extracellular matrix of natural tissues. Unlike conventional homogeneously structured hydrogels, gradient hydrogels provide a better bio-mimicking microenvironment for combined cell therapies in chronic wound treatment by regulating various cell behaviors, such as proliferation, migration, and differentiation. Here, we present the integration of L929 mouse fibroblast spheroids into gradient hydrogels to mimic the dermal stiffness microenvironment and we investigated their impact on full-thickness skin regeneration. A stiffness gradient was achieved by modulating the concentration of methacrylated hyaluronic acid (HA-MA) with varying degrees of methacrylation, using a dual-syringe pump system. The encapsulation of L929 spheroids with gradient hydrogel facilitated skin cell organization in a hierarchically ordered configuration, leading to full-thickness wound healing that was 1.53 times faster than the untreated group in a rat model. This study provides a method for investigating the potential role of gradient hydrogels in various tissue engineering and regeneration applications.
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6. A DNA-inspired injectable adhesive hydrogel with dual nitric oxide donors to promote angiogenesis for enhanced wound healing.
6. 一种受DNA启发的可注射粘附水凝胶，具有双一氧化氮供体以促进血管生成从而增强伤口愈合PMID:日期:2024-01-24[中文摘要] 慢性糖尿病创面是糖尿病的严重并发症，常导致高额治疗费用和高截肢率。大量研究表明，一氧化氮（NO）疗法是一种有前景的选择，因为它有利于创面血管再生。在此，我们利用腺嘌呤和胸腺嘧啶修饰的壳聚糖（CSA和CST）制备了基于碱基配对的注射型黏附水凝胶（CAT）。通过进一步引入S-亚硝基谷胱甘肽（GSNO）和二元L-精氨酸（bArg），我们获得了一种更适合慢性创面治疗的NO缓释水凝胶（CAT/bArg/GSON）。结果表明，CAT/bArg/GSON组中HIF-1α和VEGF表达上调，并观察到血管再生改善，表明NO发挥了重要作用。此外，研究结果还显示，经CAT/bArg/GSON水凝胶处理后，金黄色葡萄球菌和大肠杆菌的存活率分别降至14 ± 2 %和6 ± 1 %。同时，创面微环境得到改善，表现为DPPH清除率达60 ± 1 %。特别是，组织学检查和免疫组化染色结果显示，经CAT/bArg/GSNO处理的创面表现出更密集的新生血管形成、更快的上皮组织再生和更厚的胶原沉积。总体而言，本研究提出了一种制备具有双NO供体的注射型水凝胶敷料的有效策略。CAT/bArg/GSON的功能已在慢性创面血管再生的研究中得到充分证实，表明CAT/bArg/GSON可能成为促进慢性创面愈合的一种潜在选择。意义声明：本文利用互补碱基配对原理制备了一种壳聚糖水凝胶，其具有多种优势，包括良好的黏附性、生物相容性和流动性能，使其成为创面敷料的良好材料。负载的GSNO和bArg可通过凝胶降解稳定释放NO和L-精氨酸。随后，释放的L-精氨酸不仅具有抗氧化特性，还能在NOS的作用下继续生成少量NO。该设计实现了创面部位NO的持续稳定供应，最大限度地发挥了NO促进血管生成和抗菌的作用。在再生组织中观察到更多的新生血管形成和丰富的胶原。本研究为糖尿病创面提供了一种有效的修复水凝胶材料。
[英文摘要] Chronic diabetic wounds are a severe complication of diabetes, often leading to high treatment costs and high amputation rates. Numerous studies have revealed that nitric oxide (NO) therapy is a promising option because it favours wound revascularization. Here, base-paired injectable adhesive hydrogels (CAT) were prepared using adenine- and thymine-modified chitosan (CSA and CST). By further introducing S-nitrosoglutathione (GSNO) and binary l-arginine (bArg), we obtained a NO sustained-release hydrogel (CAT/bArg/GSON) that was more suitable for the treatment of chronic wounds. The results showed that the expression of HIF-1α and VEGF was upregulated in the CAT/bArg/GSON group, and improved blood vessel regeneration was observed, indicating an important role of NO. In addition, the research findings revealed that following treatment with the CAT/bArg/GSON hydrogel, the viability of Staphylococcus aureus and Escherichia coli decreased to 14 ± 2 % and 6 ± 1 %, respectively. Moreover, the wound microenvironment was improved, as evidenced by a 60 ± 1 % clearance of DPPH. In particular, histological examination and immunohistochemical staining results showed that wounds treated with CAT/bArg/GSNO exhibited denser neovascularization, faster epithelial tissue regeneration, and thicker collagen deposition. Overall, this study proposes an effective strategy to prepare injectable hydrogel dressings with dual NO donors. The functionality of CAT/bArg/GSON has been thoroughly demonstrated in research on chronic wound vascular regeneration, indicating that CAT/bArg/GSON could be a potential option for promoting chronic wound healing. STATEMENT OF SIGNIFICANCE: This article prepares a chitosan hydrogel utilizing the principle of complementary base pairing, which offers several advantages, including good adhesion, biocompatibility, and flow properties, making it a good material for wound dressings. Loaded GSNO and bArg can steadily release NO and l-arginine through the degradation of the gel. Then, the released l-arginine not only possesses antioxidant properties but can also continue to generate a small amount of NO under the action of NOS. This design achieves a sustained and stable supply of NO at the wound site, maximizing the angiogenesis-promoting and antibacterial effects of NO. More neovascularization and abundant collagen were observed in the regenerated tissues. This study provides an effective repair hydrogel material for diabetic wound.
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7. Thymol enriched bacterial cellulose hydrogel as effective material for third degree burn wound repair.
7. 富含百里酚的细菌纤维素水凝胶作为三度烧伤创面修复的有效材料PMID:日期:2018-10-29[中文摘要] 细菌纤维素因其优越的性能而在生物医学应用中有着卓越的贡献。然而，其缺乏抗菌性能限制了其在伤口愈合中的应用。为解决三度烧伤中的并发症问题，本研究开发了富含百里香酚的细菌纤维素水凝胶（BCT）。通过傅里叶变换红外光谱（FTIR）、热重分析（TGA）和差示扫描量热法（DSC）分别研究了百里香酚掺入细菌纤维素后所产生的化学和热学变化。抗菌研究表明，BCT对烧伤特异性病原体具有优异的杀菌活性。体外生物相容性研究在小鼠3T3成纤维细胞中进行。BCT水凝胶促进了成纤维细胞的生长，表现出低毒性，并提高了细胞活力。采用雌性白化Wistar大鼠体内实验检测了BCT水凝胶的烧伤创面愈合效率。组织病理学研究显示，经BCT水凝胶处理的创面比细菌纤维素组和对照组愈合更快。以上所有研究结果表明，BCT水凝胶可作为一种资源丰富且天然的烧伤创面敷料材料。
[英文摘要] Bacterial cellulose is well known for its excellent contributions in biomedical applications due to its superior properties. However the lack of antimicrobial property restricts its use in wound healing. To address the complications in third degree burns, thymol enriched bacterial cellulose hydrogel (BCT) was developed in this study. The incorporation of thymol into bacterial cellulose along with its chemical and thermal changes were investigated by FTIR, TGA and DSC respectively. Antimicrobial studies revealed that BCT possess excellent biocidal activity against burn specific pathogens. The in vitro biocompatibility studies were carried out in mouse 3T3 fibroblast cells. The BCT hydrogel facilitated the growth of fibroblast cells, exhibiting low toxicity, and increased cell viability. The burn wound healing efficiency of the BCT hydrogel was examined in vivo using female albino Wistar rats. Histopathological studies reveal that the wound treated with BCT hydrogel showed faster wound closure than BC and control groups. All these findings, suggest that BCT hydrogel can be used as resourceful and natural burn wound dressing material.
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8. Citric acid-modified chitosan hydrogel loaded with shikonin promotes skin wound healing.
8. 负载紫草素的柠檬酸改性壳聚糖水凝胶促进皮肤伤口愈合PMID:日期:2025-09-10[中文摘要] 尽管药理学治疗和纱布敷料在皮肤伤口愈合领域取得了进展，但这些方法仍存在诸多局限性。因此，开发一种能够高效促进皮肤伤口愈合的多功能材料尤为关键。本研究通过冻融法制备了负载紫草素（SK）的柠檬酸（CA）修饰壳聚糖（CS）水凝胶（CA-CS-SK）。通过傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、旋转流变仪、溶胀实验、降解率分析及药物释放实验对水凝胶的物理性能进行了表征。此外，通过溶血实验、CCK-8细胞毒性检测及活/死细胞染色综合评价了水凝胶的生物相容性。在体外测定了水凝胶对大肠杆菌和金黄色葡萄球菌的抗菌活性，并最终通过H&E染色和酶联免疫吸附测定（ELISA）在小鼠全层皮肤缺损模型中验证了其治疗效果。CA-CS-SK水凝胶表现出适宜的流变学性能、溶胀率、降解率及药物释放速率。它能有效抑制大肠杆菌和金黄色葡萄球菌的增殖，且抑菌效果优于CA-CS水凝胶和单独使用SK。此外，该水凝胶对人真皮成纤维细胞无明显毒性，也未引起红细胞破裂。动物模型实验表明，与棉纱布、CA-CS水凝胶和SK相比，CA-CS-SK水凝胶可降低伤口部位TNF-α和IL-6水平，减轻炎症反应，并促进伤口愈合。CA-CS-SK水凝胶具有高抗菌活性、优异的生物相容性及高效的伤口愈合促进能力，是一种极具应用前景的皮肤伤口治疗材料。
[英文摘要] Despite the advancements of pharmacological treatments and gauze dressings in the field of skin wound healing, these methods present numerous limitations. Therefore, developing a multifunctional material capable of efficiently promoting skin wound healing is particularly crucial. Citric acid (CA)-modified chitosan (CS) loaded with Shikonin (SK) (CA-CS-SK) hydrogel was prepared via the freeze-thaw method. The physical properties of the hydrogel were profiled through FTIR, SEM, rotational rheometry, swelling experiment, degradation rate analysis, and drug release experiments. Furthermore, the biocompatibility of the hydrogel was comprehensively evaluated through hemolysis assay, CCK-8 cytotoxicity detection, and live/dead cell staining. Antimicrobial activity against E. coli and S. aureus of the hydrogel was gauged in vitro, and its therapeutic performance was ultimately validated in a mouse full-thickness wound model through H&E staining and ELISA. The CA-CS-SK hydrogel exhibited appropriate rheological properties, swelling ratio, degradation rate, and drug release rate. It effectively suppressed the proliferation of E. coli and S. aureus, with superior inhibitory effects compared to CA-CS hydrogel and SK alone. Additionally, the hydrogel showed no significant toxicity to human dermal fibroblasts and did not cause erythrocyte rupture. Animal model experiments demonstrated that, compared to cotton gauze, CA-CS hydrogel, and SK, the CA-CS-SK hydrogel reduced levels of TNF-α and IL-6 at the wound site, alleviated the inflammatory response, and promoted wound healing. The CA-CS-SK hydrogel possesses high antibacterial activity, excellent biocompatibility, and efficient wound healing promotion capabilities, making it a highly promising material for skin wound treatment.
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9. A versatile LTF-GO/gel hydrogel with antibacterial and antioxidative attributes for skin wound healing.
9. 一种具有抗菌和抗氧化特性的多功能LTF-GO/凝胶水凝胶用于皮肤伤口愈合PMID:日期:2023-12-27[中文摘要] 皮肤结构损伤后，皮肤伤口愈合将成为一个紧迫而棘手的问题。尤其是持续性伤口，更易受到细菌感染，从而促进持续性皮肤炎症的发生。因此，开发一种既能促进伤口愈合又具有抗菌性能的伤口敷料至关重要。在本研究中，通过将氧化石墨烯（GO）和乳铁蛋白引入明胶水凝胶中，开发了一种通过酶交联形成的多功能生物活性水凝胶。此外，通过引入乳铁蛋白，该复合水凝胶在体外表现出优异的抗菌性和生物相容性。细胞实验表明，LTF-GO/Gel水凝胶可通过增强L929细胞迁移来促进伤口愈合。有趣的是，在近红外光照射下，LTF-GO/Gel水凝胶可增加单线态氧（O）和羟自由基（-OH）的生成，使该水凝胶体系具有优异的抗氧化和抗菌能力，这些结果表明LTF-GO/Gel水凝胶作为伤口愈合敷料具有临床前景。体内实验明确证实了LTF-GO/Gel水凝胶具有加速伤口愈合和减轻炎症的能力。因此，该水凝胶在伤口愈合应用中具有巨大潜力。
[英文摘要] Skin wound healing will become a pressing and difficult problem following injury to the skin structure. Persistent wounds, in particular, become more vulnerable to bacterial infections, which can contribute to persistent skin inflammation. Therefore, it is critical to create a wound dressing that promotes wound healing while also being antimicrobial. In the present work, a multifunctional biological activity hydrogel formed by enzymatic cross-linking was developed by introducing graphene oxide (GO) and lactoferrin to gelatin hydrogel. Furthermore, by incorporating lactoferrin, the composite hydrogels exhibit excellent in vitro antibacterial and biocompatibility. According to cell experiments, the LTF-GO/Gel hydrogel can improve wound healing by enhancing L929 cell migration. Interestingly, under near-infrared light, LTF-GO/Gel hydrogel increases the generation of singlet oxygen (O) and hydroxyl radical (-OH), making the hydrogel system excellent antioxidant and antibacterial capabilities, these results demonstrate that the LTF-GO/Gel hydrogel has clinical promise as a wound dressing for wound healing. In vivo experiments unequivocally establish the capacity of the LTF-GO/Gel hydrogel to expedite wound healing and mitigate inflammation. This hydrogel, therefore, harbors immense potential for applications in wound healing.
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10. Smart Bioresponsive Hydrogels for Chronic Wound Healing: Design, Therapeutic Functionalization, and Emerging Digital Health Integration.
10. 智能生物响应性水凝胶用于慢性伤口愈合：设计、治疗功能化及新兴数字健康整合PMID:日期:2026-06[中文摘要] 智能生物响应水凝胶已成为慢性伤口管理的一种变革性解决方案，如糖尿病足溃疡、静脉性腿部溃疡和压疮，这些伤口常因持续性炎症、感染和生化失调而复杂化。与传统敷料不同，这些先进材料被设计为能够响应伤口内源性刺激，如pH、活性氧（ROS）、葡萄糖和酶活性，从而实现空间和时间可控的药物释放。本综述全面审视了刺激响应水凝胶背后的设计原理、生化触发因素和功能化策略。我们探讨了多种水凝胶类别，包括单一和多刺激系统，以及深度功能增强，如抗菌剂、血管生成生长因子和自愈合黏附机制。重点强调了与数字健康平台的新兴整合，如可穿戴生物传感器、可植入系统和人工智能驱动的伤口分析，这些平台能够实现实时监测和闭环药物递送。讨论了学术原型与现有商业产品之间的比较分析，以及涉及临床试验、监管挑战和制造可扩展性的转化障碍。综述最后展望了人工智能个性化、多功能一体化水凝胶系统的未来路线图，该系统将生物材料与生物传感和远程医疗能力相结合。本手稿为寻求弥合水凝胶创新与临床影响之间差距的研究人员、临床医生和生物工程师提供了详细且及时的资源。
[英文摘要] Smart bioresponsive hydrogels have emerged as a transformative solution for the management of chronic wounds, such as diabetic foot ulcers, venous leg ulcers, and pressure sores, which are often complicated by persistent inflammation, infection, and biochemical dysregulation. Unlike traditional dressings, these advanced materials are engineered to respond to intrinsic wound stimuli such as pH, reactive oxygen species (ROS), glucose, and enzymatic activity, enabling spatially and temporally controlled drug release. This review comprehensively examines the design principles, biochemical triggers, and functionalization strategies behind stimuli responsive hydrogels. We explore diverse hydrogel classes, including single and multi-stimuli systems, and in-depth functional augmentations, such as antibacterial agents, angiogenic growth factors, and self-healing adhesion mechanisms. A major emphasis is placed on emerging integration with digital health platforms such as wearable biosensors, implantable systems, and AI driven wound analytics, which enable real time monitoring and closed loop drug delivery. Comparative analyses between academic prototypes and existing commercial products are discussed alongside translational barriers related to clinical trials, regulatory challenges, and manufacturing scalability. The review concludes by outlining a prospective roadmap for AI personalized, multifunctional all-in-one hydrogel systems that integrate biomaterials with biosensing and telemedicine capabilities. This manuscript provides a detailed and timely resource for researchers, clinicians, and bioengineers seeking to bridge the gap between hydrogel innovation and clinical impact.