International Journal of Biological Macromolecules国际生物大分子杂志
International Journal of Biological Macromolecules(英文缩写 INT J BIOL MACROMOL),ISSN 0141-8130,eISSN 1879-0003,中文译名:国际生物大分子杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 8.025 | Q1 |
| 2022 | 8.200 | Q1 |
| 2023 | 7.700 | Q1 |
| 2024 | 8.500 | Q1 |
| 2025 | 8.700 | Q1 |
International Journal of Biological Macromolecules 最新收录文献
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1. A multifunctional quaternary chitosan/sericin composite sponge for antibiosis and hemostasis.
1. 一种用于抗菌和止血的多功能季铵化壳聚糖/丝胶蛋白复合海绵PMID:日期:2026-10-04Effective management of traumatic and infected wounds remains challenging because hemorrhage, bacterial contamination, and impaired early repair often occur simultaneously. This study designed a multifunctional composite sponge via physical cross-linking between quaternary chitosan (QCS) and silk sericin (SER), further loaded with dicresulene diammonium (Di). The QCS/SER/Di sponge was systematically evaluated for its physicochemical properties, biocompatibility and functional performance. The sponge formulations exhibited hemolysis ratios below 5%, while significantly enhancing fibroblast migration and proliferation. Furthermore, the QCS/SER/Di sponge reduced viable Staphylococcus aureus and Escherichia coli by more than 99% within 12 h and caused marked disruption of bacterial membrane integrity. During in vitro hemostasis tests, it induced complete whole-blood clotting within 2 min, compared with more than 8 min in the untreated control. In the rat tail-amputation model, the sponge reduced blood loss from 1656 ± 315.2 mg in untreated animals to approximately 204 mg, with comparable hemostatic benefits observed in the liver injury hemorrhage model. When applied to infected wounds, the sponges significantly reduced the bacterial load and were associated with greater wound-area reduction, re-epithelialization and collagen deposition, increased vascular structures, and changes in selected inflammation- and repair-associated markers during the 14-day observation period. This study presents a multifunctional composite sponge platform for complex wound management which integrates rapid hemostasis and strong antibacterial activity.
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2. Forsythiae Fructus polysaccharides mitigate DSS colitis by modulating gut microbiota-derived palmitic acid and PI3K/AKT pathway.
2. 连翘多糖通过调节肠道菌群衍生的棕榈酸和PI3K/AKT通路缓解DSS结肠炎PMID:日期:2026-10-04Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with limited therapeutic options, and the contribution of microbiota-associated metabolites to disease progression remains incompletely understood. Here, we demonstrate that Forsythia polysaccharides (FPs) exert protective effects against dextran sulfate sodium (DSS)-induced colitis through coordinated regulation of gut microbiota, microbial metabolism, and inflammatory signaling. FPs treatment markedly alleviated colonic injury and inflammation, restored intestinal barrier integrity, and remodeled the gut microbial community. Metabolomic analyses identified palmitic acid (PA) as a microbiota-associated metabolite that was elevated during colitis but reduced following FPs treatment and fecal microbiota transplantation from FPs-treated donors. Correlation analysis revealed significant associations between PA abundance and DSS-responsive microbial taxa, particularly Desulfovibrio. Mechanistically, PA enhanced neutrophil extracellular trap (NET) formation and activated PI3K/AKT signaling, whereas pharmacological inhibition of PI3K/AKT attenuated PA-induced NETs responses. Consistently, FPs treatment was accompanied by reduced colonic PA levels, suppression of PI3K/AKT signaling, and decreased NETs-associated inflammatory responses. Furthermore, PA supplementation partially counteracted the protective effects of FPs, while PI3K/AKT inhibition mitigated PA-associated disease exacerbation. Collectively, these findings support the involvement of a microbiota-associated PA-PI3K/AKT-NETs signaling network in DSS-induced colitis and highlight FPs as a promising microbiota-targeted therapeutic strategy for IBD.
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3. Corrigendum to "Green synthesis of mechanically robust and antibacterial chitosan colloidal hydrogels under near-neutral conditions for wound dressing" [Int. J. Biol. Macromol., volume 340, part 1, January 2026, article 150038].
3. 对“近中性条件下绿色合成机械稳健且抗菌的壳聚糖胶体水凝胶用于伤口敷料”的勘误[Int. J. Biol. Macromol.，第340卷，第1部分，2026年1月，文章150038]PMID:日期:2026-10-03该文献暂无摘要。
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4. Corrigendum to "Molecular simulation reveals spontaneous allosteric binding of BMS-357075 to human cyclin-dependent kinase 20" [Int. J. Biol. Macromol. 383 (2026) 154668].
4. 对“分子模拟揭示BMS-357075与人细胞周期蛋白依赖性激酶20的自发变构结合”的勘误 [Int. J. Biol. Macromol. 383 (2026) 154668]PMID:日期:2026-10-03该文献暂无摘要。
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5. Rhamnogalacturonan-I entrapped in insoluble plant cell wall networks: Structural basis, confinement mechanisms, and implications for targeted release: A review.
5. 鼠李糖半乳糖醛酸聚糖-I包埋于不溶性植物细胞壁网络中：结构基础、限制机制及靶向释放的意义：综述PMID:日期:2026-10-03Rhamnogalacturonan-I (RG-I) is a highly branched pectic polysaccharide whose recovery from plant-derived residues is often treated solely as an extraction problem. While the existing literature frequently investigates the physical and chemical behavior of total pectin, this review explicitly isolates the structural entrapment of the RG-I domain. We examine a complementary explanation: the retention of RG-I within insoluble plant cell wall networks. Evidence from solid-state nuclear magnetic resonance, selective extraction, enzymatic digestion, adsorption models, and compositional analyses is synthesized to assess interactions between RG-I, and where necessary, carefully extrapolated data from bulk pectic polysaccharides, and cellulose- and hemicellulose-rich regions. Its heterogeneous arabinan and galactan side chains may promote multivalent association, molecular crowding, steric restriction, and topological interpenetration. Covalent linkages, hydrogen bonding, van der Waals interactions, competitive adsorption, and pore-size constraints may contribute to this retention, although their relative importance varies among wall systems. These interactions also complicate extraction data: an increased RG-I proportion after concentrated alkali treatment may reflect preferential homogalacturonan loss rather than selective release of intact RG-I. Extraction performance should therefore be evaluated using yield together with molecular-size distribution, linkage integrity, side-chain preservation, and mass balance between soluble and residual fractions. Distinguishing true release from apparent enrichment is essential for comparing strategies and preserving structurally meaningful RG-I domains during processing.
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6. Actin filament and microtubule-centered cytoskeletal abnormalities are associated with intracellular structural disorder and cellular softening in keratoconus stromal fibroblasts.
6. 肌动蛋白丝和微管为中心的细胞骨架异常与圆锥角膜基质成纤维细胞内的结构紊乱和细胞软化相关PMID:日期:2026-10-03Keratoconus (KC) is characterized by progressive corneal thinning and biomechanical weakening, however, the cellular mechanobiological basis underlying stromal softening remains poorly understood. In this study, we investigated actin filament and microtubule-centered cytoskeletal abnormalities and their associations with intracellular structural disorder and cellular mechanics in primary stromal fibroblasts derived from corneas with KC and normal corneas. Confocal microscopy revealed disrupted actin filament orientation and altered microtubule coherency in KC stromal fibroblasts. Quantitative phase imaging demonstrated significantly increased intracellular disorder strength in KC (t = 5.597, p < 0.001), while atomic force microscopy revealed a reduced Young's modulus (t = 11.206, p < 0.001). Notably, disorder strength showed a strong negative correlation with cellular stiffness (r = -0.904, p < 0.001), indicating a close correlation between intracellular structural disorganization and cellular softening. Furthermore, KC stromal fibroblasts exhibited coordinated reductions in actin, tubulin, vimentin, and lamin A/C expression at both the mRNA and protein levels, suggesting broad alterations in cytoplasmic and nucleo-cytoskeletal components. To evaluate the functional contribution of cytoskeletal integrity to cellular mechanics, normal stromal fibroblasts were treated with cytochalasin D or nocodazole to disrupt actin filaments or microtubules, respectively. Both interventions reduced Young's modulus and were accompanied by increased MMP2 and MMP9 expression and decreased COL1A expression, suggesting changes in ECM-remodeling-related protein expression following cytoskeletal perturbation. Collectively, these findings provide multimodal cellular mechanobiological evidence demonstrating associations among cytoskeletal abnormalities, intracellular structural disorder, and altered cellular mechanics in KC, expanding the understanding of KC pathogenesis beyond collagen and extracellular matrix abnormalities.
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7. Lipid-mediated formation of amylose-lipid complexes in cold-stored mashed potatoes: Structural evidence and in vitro starch digestibility.
7. 冷藏马铃薯泥中脂质介导的直链淀粉-脂质复合物形成：结构证据与体外淀粉消化性PMID:日期:2026-10-03After gelatinization, amylose chains in starchy foods face two competing ordering pathways during cold storage: retrogradation-driven reassociation (RS3-type) and lipid-mediated inclusion complexation (RS5-type). This study examined whether mayonnaise-derived lipids modulate starch reassembly in mashed potatoes during storage. Mashed potatoes with or without mayonnaise (105 g potato: 24 g mayonnaise) were stored at 0 °C and 10 °C for up to 72 h. Starch structural evolution was characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, and differential scanning calorimetry, while digestion behavior was evaluated using the INFOGEST 2.0 in vitro model. Storage alone promoted retrogradation-associated ordering in the control samples, particularly at 0 °C. Mayonnaise incorporation promoted the formation of B + V-type crystalline structures and thermally stable amylose-lipid complexes, indicating that lipid-mediated complexation supplemented the dominant retrogradation process with an additional RS5-type ordering pathway. Consistently, mayonnaise-containing samples exhibited lower rapidly digestible starch and higher resistant starch after storage, with the strongest effect observed in LCCT-M (over 59% RS). Overall, mayonnaise acted as a food-grade emulsion that diverted part of starch reorganization during cold storage from the dominant RS3-type retrogradation route toward RS5-type amylose-lipid complexation, offering a simple, mechanism-based strategy for designing slow-digesting starchy foods under cold-chain conditions.
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8. Characterization of glycosaminoglycan modifications and a related galactosyltransferase B4GALT7 in Bombyx mori.
8. 家蚕中糖胺聚糖修饰及相关半乳糖基转移酶B4GALT7的表征PMID:日期:2026-10-03Glycosaminoglycan (GAG) modifications mediate multiple biological processes, yet the GAG modification landscape remains poorly characterized, especially in invertebrates. The silkworm Bombyx mori is an important economic insect, a lepidopteran model species, and a promising bioreactor for recombinant protein production. Herein, we profiled the GAG modifications in Bombyx mori and identified 21 chondroitin sulfate (CS)-modified proteoglycans. Bioinformatic analyses indicate that several of these proteoglycans participate in cytoskeletal organization, cell adhesion, and immune response, whereas the majority still lack sufficient functional annotation or reference information from homologs. We further characterized silkworm B4GALT7, a core enzyme participating in the biosynthesis of the tetrasaccharide linkage of GAG, and demonstrated that B4GALT7 could positively regulate global GAG modification levels in silkworm cells. Silkworm B4GALT7 localizes to the Golgi apparatus and displays broad substrate tolerance toward several sugar donors and diverse acceptors including xylose, pNP-sugars and phenolic compounds, exhibiting enzymatic features distinct from its human and Drosophila homologs. Its optimal catalytic conditions were defined as 25 °C, pH 7.0, and 1 mM Ca. This study establishes the first CS-proteoglycan profiles in B. mori, and characterized a GAG biosynthetic enzyme, B4GALT7, providing a fundamental basis for further exploration of the structures and functions of GAG modification in this model insect.
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9. Effect of chitosan-functionalized ferritin-riboflavin nanoparticles as a novel vitamin delivery system on Pickering emulsions: Rheology, stability, and in vitro release kinetics.
9. 壳聚糖功能化铁蛋白-核黄素纳米颗粒作为一种新型维生素递送系统对Pickering乳液的影响：流变学、稳定性及体外释放动力学PMID:日期:2026-10-03This work aimed to investigate the feasibility and delivery capacity of Pickering emulsions stabilized by chitosan-modified self-assembled ferritin-riboflavin nanoparticles (BRC-NPs). Results showed that after the modification of nanoparticles with chitosan, the size of BRC-NPs was 56.99 nm. The structure, thermal and functional properties of the BRC-NPs were significantly improved through the electrostatic interaction between chitosan and ferritin. Rheological properties, emulsifying properties and stability of the Pickering emulsion were modulated by BRC-NPs concentration. When the BRC-NPs concentration was 0.4%, the Pickering emulsion had better viscosity, viscoelasticity and creep properties. Moreover, 0.4% BRC-NPs can increase the storage and light stability of the emulsion and delay its lipid oxidation. In vitro digestion results showed that ferritin digestion and lipid oxidation in the emulsion were delayed as the concentration of BRC-NPs increased, achieving sustainable release of riboflavin and improving its bioavailability. This study opens new avenues for using Pickering emulsions stabilized by active nanoparticles as novel delivery systems.
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10. Mismetallation reveals metal tolerance and enhanced stability of human deoxyhypusine hydroxylase.
10. 错配金属化揭示了人类脱氧羟腐胺羟化酶的金属耐受性和增强的稳定性PMID:日期:2026-10-03Hypusination is a unique post-translational modification found exclusively in eukaryotic translation factor 5A (eIF5A). In this reaction, a specific lysine residue in eIF5A is converted into hypusine residue. The modification comprises two enzymatic steps: a NAD-dependent deoxyhypusine synthase (DHS) transfers the 4-aminobutyl moiety from spermidine to form a deoxyhypusine residue, and an iron-dependent deoxyhypusine hydroxylase (DOHH) hydroxylates this intermediate to generate a hypusine residue and fully functional eIF5A. Although DOHH is a key enzyme concluding the hypusination pathway, obtaining stable, well-diffracting crystals has remained challenging, limiting mechanistic studies and inhibitor screening. We therefore explored whether replacing the native iron ions with those of alternative metals could yield a more thermostable and structurally robust analogue suitable for crystallography. We show that several non-native metals markedly increase DOHH thermal stability and support our observation by crystal structures of human DOHH with either nickel or cobalt ions substituted for native iron ions (at 2.16 and 1.81 Å resolution, respectively), providing the first structural characterization of mismetallated human DOHH analogues. X-ray fluorescence and anomalous scattering confirmed direct incorporation of metal ions into the active site. While adopting a distinct metal coordination environment, the mismetallated enzymes retain the overall fold of the native Fe-bound form. Their enhanced stability highlights their value as reliable surrogates for structural and mechanistic studies.