MACROMOLECULAR BIOSCIENCE大分子生物科学
MACROMOLECULAR BIOSCIENCE(英文缩写 MACROMOL BIOSCI),ISSN 1616-5187,eISSN 1616-5195,中文译名:大分子生物科学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.859 | Q1 |
| 2022 | 4.600 | Q1 |
| 2023 | 4.400 | Q1 |
| 2024 | 4.100 | Q2 |
| 2025 | 4.200 | Q2 |
MACROMOLECULAR BIOSCIENCE 最新收录文献
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1. Bacterial Nanocellulose as a Platform for Three-Dimensional Colon Cancer Cultures: Physicochemical Characterization and Biocompatibility Evaluation.
PMID:日期:2026-103D in vitro cancer models provide a more physiologically relevant representation of tumor architecture and cell-matrix interactions than conventional monolayer cultures. This study evaluated bacterial nanocellulose (BNC) as a scaffold for the 3D culture of colorectal cancer cells. BNC scaffolds were produced using paraffin spheres as porogens and subsequently characterized in terms of morphology, chemical structure, thermal stability, and mechanical properties. Human colorectal cancer cell lines SW480 and SW620, along with CHO-K1 cells, were exposed to BNC leachates and cultured on 2D and 3D BNC matrices. Cells grown on 2D BNC exhibited typical monolayer proliferation, whereas 3D matrices allowed cell infiltration and volumetric distribution, supporting multicellular organization and the formation of spheroid-like aggregates. Cell viability remained in both leachate and direct scaffold cultures. Genotoxicity assays showed low levels of DNA damage, with most cells displaying no detectable genotoxic effects, and mutagenicity tests revealed no significant differences compared to controls (p > 0.05). Overall, the results demonstrate that 3D BNC supports cell viability, multicellular organization, and genomic safety, highlighting its suitability as a biocompatible scaffold for in vitro 3D colon cancer models.
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2. Drug-in-Cyclodextrin-in-Liposome Hybrid Systems for Hydrophobic Drug Delivery: A Comprehensive Review.
PMID:日期:2026-10Delivering hydrophobic active pharmaceutical ingredients remains a major challenge due to poor aqueous solubility, limited bioavailability, and chemical instability. Drug-in-cyclodextrin-in-liposome (DCL) technology combines cyclodextrin inclusion complexation with liposomal encapsulation to address these limitations. In this hybrid approach, the hydrophobic drug is first incorporated into the apolar cyclodextrin cavity, and the resulting complex is subsequently encapsulated within the aqueous compartment of liposomes. This review provides a comprehensive, data-driven analysis of DCL technology, covering its conceptual development, cyclodextrin properties, lipid composition, vesicle architecture, and preparation methods. Quantitative parameters, including encapsulation efficiency, particle size, zeta potential, and drug release, are compared with conventional liposomes and cyclodextrin complexes. DCL systems demonstrated 2 to 11 fold higher encapsulation efficiency than conventional liposomes, together with sustained release, improved vesicle stability, and enhanced protection of labile drugs against degradation. Preclinical evidence indicates potential therapeutic benefits, although in vivo validation remains limited. Molecular docking and molecular dynamics further provide mechanistic insights into drug-cyclodextrin and cyclodextrin-membrane interactions. Emerging strategies include surface modification, stimuli-responsive systems, dual-drug loading, green manufacturing, and computational design, supporting the future clinical translation of DCL technology.
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3. Ferritin-Based Nanomotors for Deep Glioblastoma Penetration and Enhanced Drug Delivery.
PMID:日期:2026-09-30Poor penetration into tumor tissue remains a major barrier to effective nanomedicine delivery, particularly in glioblastoma multiforme (GBM). Here, nanoparticle transport was computationally studied to rationally design an ultrasmall chemotactic nanomotor that improves penetration into dense tumor tissue. The nanomotor comprises a targeting human heavy-chain ferritin (HFn) nanocage and a catalytic cerium oxide (CeO) component. Leveraging transferrin receptor‑1 overexpression on brain microvascular endothelial cells and GBM cells, HFn enables transport across an in vitro blood-brain barrier (BBB) model and accumulation in GBM spheroids. The CeO domain catalyzes hydrogen peroxide decomposition in the tumor‑mimicking microenvironment, generating oxygen and imparting directional propulsion along HO gradients. In chemotaxis assays, the nanomotors actively migrated toward localized HO sources and GBM cells embedded in Matrigel. In large U87 spheroids (>400 µm), HFn@CeO nanomotors penetrated deeply and distributed throughout the spheroid core, whereas non‑propelled HFn nanocarriers remained confined mainly to the periphery. Doxorubicin‑loaded nanomotors (HFn@CeODOX) achieved substantially enhanced intratumoral DOX distribution and reduced IC (0.33 µM) compared with HFn-DOX (1.13 µM) and free DOX (1.75 µM) in GBM spheroids. These results provide a promising basis for future in vivo evaluation in brain tumor therapy.
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4. Advances in Microneedle-Based Technology for Disease Detection via Interstitial Fluid.
4. 基于微针技术的组织间液疾病检测进展PMID:日期:2026-09Conventional blood-based diagnostics provide essential clinical information but can be less suitable for frequent or continuous biomarker monitoring because they generally require repeated invasive sampling and laboratory-based analysis. Microneedle platforms provide minimally invasive access to dermal interstitial fluid (ISF) and can couple transdermal sampling with on-needle or in situ sensing. This review critically summarizes the microneedle diagnostic systems by comprehensively considering the microneedle architecture, material and polymer properties, mechanical design, sensing modality, disease-specific biomarker requirements and translational performance. Solid, hollow, coated, dissolving, and hydrogel microneedles are discussed together with recent advances in polymer structure-property engineering and 3D-printed microneedle platforms. Electrical/electrochemical, optical, and Raman-based sensing strategies are comparatively evaluated, followed by their applications in metabolic, oncological, inflammatory, allergic, stress-related, and renal disorders. Particular attention is given to the trade-offs among mechanical reliability, ISF transport, analytical sensitivity, biofouling, signal stability, manufacturing reproducibility, and clinical validation. Finally, scalable manufacturing, regulatory translation, wearable integration, and artificial-intelligence-assisted analysis are discussed as key requirements for moving microneedle diagnostics from proof-of-concept devices toward reliable personalized and decentralized healthcare.
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5. {"_":"Fabrication and Healing Potential of Polylactic Acid /Clay/NdO Nanocomposite Fibers in Diabetic Wound Therapy.","sub":["2","3"]}
PMID:日期:2026-09Chronic diabetic wounds are difficult to heal due to impaired neovascularization, dysregulated tissue repair, and prolonged inflammation. To address these challenges, PLA/nanoclay/NdO nanocomposite fiber mats were fabricated by electrospinning. Structural and morphological analyses confirmed successful incorporation and uniform dispersion of nanoclay and NdO within the PLA matrix. Nanoclay modulated the scaffold surface, while NdO enhanced mechanical strength. The intercalated nanoclay network further improved load transfer, reduced fiber diameter, and enhanced surface wettability, supporting cellular interactions. The scaffold showed more than 90% cell viability across all tested samples, demonstrating good cytocompatibility. The optimized scaffold exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The enhanced vascular density of the scaffolds in the chick chorioallantoic membrane (CAM) assay confirms their angiogenic potential. The scaffold also demonstrated controlled degradation, with 8.1 ± 0.5% weight loss after 28 days in simulated body fluid. In vivo evaluation using a diabetic rat wound model showed accelerated wound contraction, complete reepithelialization, neovascularization and minimal inflammatory response by day 21. The findings of this study suggest that PLA/Clay/NdO bioactive nanofibrous scaffolds have considerable potential for diabetic wound-healing applications.
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6. Fabrication of Gelatin Nanofibrous Sponges Incorporating Mesoporous Silica Nanoparticles with Enhanced Capacity to Promote Blood Coagulation and Accelerate Wound Healing.
PMID:日期:2026-09Effective bleeding control and accelerated wound healing are crucial for patient survival. Conventional dressings often have structural limitations that hinder their effectiveness in controlling hemorrhages and promoting skin tissue regeneration. Here, a gelatin-based nanofibrous sponge incorporating mesoporous silica nanoparticles (MSNs) was developed by transforming two-dimensional nanofiber membranes into three-dimensional structures via electrospinning, gas foaming, and freeze-drying techniques. The sponges were characterized using SEM, EDS, and FTIR. Their swelling, degradation behavior, and mechanical properties showed improved permeability and fluid absorption. Incorporating MSNs significantly enhanced the compressive strength of sponges, making them suitable for deep wounds and creating a favorable microenvironment for cellular activity, despite reduced elastic recovery. In vitro tests confirmed good cytocompatibility and low hemolysis ratios. In vivo experiments on a mouse model of full-thickness skin defects showed that the sponge with a combination of (6%) MSNs effectively accelerated wound healing, with a markedly higher re-epithelialization than the control group, achieving nearly complete healing by Day 14. Additionally, this composite sponge facilitated rapid hemostasis with minimal blood loss. These results highlight the potential of the gelatin-based porous nanofibrous sponge combined with MSNs as a promising candidate for clinical applications, serving as an effective wound dressing and an absorbable hemostatic agent.
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7. Tamoxifen Loaded Conjugate of Self-Assembled Fluorescent Organic Nanoparticle and Vesicle for p53-Activated Breast Cancer Therapy.
PMID:日期:2026-09Fluorescent organic nanoparticles (FONPs) with intrinsic fluorescence and self-assembled vesicles (VES) are receiving widespread interest in biomedicine. Both FONPs and VES have individual drawbacks like cytotoxicity of FONPs while VES gets eliminated through reticuloendothelial system impeding their applications. Development of nanoconjugates through amalgamation of individual nanocarrier with complementing features would find greater significance by overcoming individual hurdles. Herein, we report design and synthesis of FONP-VES nanoconjugate by combining naphthalimide-based pH-responsive hydrazone moiety containing FONP (NIHYDH) and cholesterol-based vesicle (CBAV) via electrostatic interaction. FONP, VES and FONP-VES conjugate were characterized by spectroscopy and microscopy. Orange emitting NIHYDH-CBAV nanoconjugate was utilised in bioimaging and as delivery vehicle which demonstrated targeted transport of tamoxifen (TAM) to (ER+) MCF7 cells through pH-responsive dissipation of nanoconjugate owing to cleavage of hydrazone bond under acidic pH gradient. TAM has demonstrated clinical drug resistance along with limited bioavailability. Upon encapsulation within nanoconjugate, NIHYDH-CBAV-TAM offered ∼2.8-fold higher cytotoxicity toward MCF7 cells compared to normal NIH3T3 cells alongside demonstrating ∼2.1-fold reduction in the size of MCF7 3D tumour spheroids. TAM loaded nanoconjugate was ∼2.2-3.4-fold more cytotoxic than TAM loaded individual nanocarrier. Cytotoxicity of NIHYDH-CBAV-TAM got enhanced due to increased intracellular oxidative stress that triggered p53 upregulated cell apoptotic pathway.
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8. "Artificial Lighthouse" Overcomes Tumor Microenvironment Heterogeneity's "Sea Fog": Pre-Targeted Strategy-Mediated Nanomedicine Enables Tumor Body Fluid Detection, In Vivo Imaging, and Multitherapy Treatment.
PMID:日期:2026-09Nanomedicine has broad prospects in tumor diagnosis and treatment, but its clinical translation has long been limited by targeted delivery efficiency. The heterogeneity of the tumor microenvironment is like a "sea fog" that hinders precision medicine. This makes it difficult for traditional active targeting that relies on natural targets to achieve precise delivery. For this difficulty, this review summarizes the constraints of tumor microenvironment heterogeneity on nanomaterials in terms of time and space. Pre-targeting strategies enhance delivery efficiency by constructing an "artificial lighthouse." According to the source of the target and the mode of specific binding, this review divides pre-targeting strategies into two categories: biomolecular recognition-mediated and bioorthogonal click chemistry-mediated. On this basis, this review comprehensively introduces recent progress in pre-targeting-enabled nanomedicine in body fluid-based detection, in vivo imaging, and multi-therapies. Furthermore, this review is the first to summarize the synergistic mechanisms of pre-targeting with prodrugs, insitu self-assembly, and dual-targeting strategies. This review systematically summarizes the complete framework of pre-targeting strategies, from mechanisms and classifications to applications and expansions. It aims to provide inspiration for the development of nanomedicine in the field of oncology for effective cancer diagnosis and treatment.
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9. Targeting LGALS1 via CAF-Derived Extracellular Vesicles Synergizes With αPD-1 to Reverse Immunosuppression and Sensibilize Chemo-Immunotherapy for Colorectal Cancer.
PMID:日期:2026-09Colorectal cancer (CRC) exhibits intrinsic resistance to conventional therapeutic regimens. By integrating single-cell and bulk transcriptomic data from CRC cohorts, we demonstrate that proliferative capacity alone constitutes an inadequate prognostic predictor. Instead, an immunosuppressive tumor microenvironment (TME) emerges as the dominant driver of disease progression. Galectin-1 (LGALS1), highly upregulated in metastatic CRC, correlates with robust infiltration of regulatory T cells (Tregs) and M2 macrophages to facilitate immune evasion and poor clinical outcomes, thereby serving as a promising therapeutic target for anti-tumor immunotherapy. The stromal barrier mediated by cancer-associated fibroblasts (CAFs) restricts intratumoral penetration of antitumor agents and diminishes therapeutic efficacy. To overcome this physical barrier, we constructed a CAF extracellular vesicle-based co-delivery platform termed CEV@Comb, encapsulating the LGALS1 inhibitor OTX008 and 5-fluorouracil (5-FU). CEV@Comb selectively accumulates in tumors, suppresses growth in vitro and in vivo, and remodels the immunosuppressive TME by boosting M1 macrophages and cytotoxic CD8 T cells while reducing intratumoral Tregs. Combination therapy with CEV@Comb and anti‑programmed death‑1 antibody (αPD-1) further amplifies anti-tumor immunity in the Apc, Kras, Trp53, Smad4(AKPS) CRC mouse model. This study identifies LGALS1 as a core immunosuppressive mediator and provides an innovative chemoimmunotherapeutic strategy to improve clinical outcomes for patients with advanced CRC.
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10. Fabrication and Application of Injectable Bpei/Graphene Oxide/Silver Nanoparticle Hydrogel for Wound Healing.
PMID:日期:2026-09Acute full‑thickness skin wounds represent a significant clinical challenge due to tissue loss, risk of bacterial contamination, and the need for rapid and effective regeneration. Injectable thermosensitive hydrogels incorporating antibacterial nanomaterials represent a promising strategy for advanced wound care. In this study, a multifunctional hydrogel composed of Graphene oxide (GO), branched polyethyleneimine (BPEI), and silver nanoparticles (AgNPs) dispersed in Pluronic F127 was developed and evaluated for wound healing applications. The GO-BPEI-AgNP nanocomposite was synthesized via amidation and microwave-assisted methods and characterized using DLS, UV-vis, FTIR, XRD, and SEM-EDX analyses. Biocompatibility was assessed in HaCaT keratinocytes using the Alamar Blue assay, while scratch assays and antibacterial activity against. In vivo wound healing efficacy and histopathological changes were evaluated in a rat full-thickness skin wound model, together with qRT-PCR analysis of wound-healing-related genes. The hydrogel exhibited favorable injectability, nanoscale morphology, and high biocompatibility (IC: 246.7 µg/mL). It significantly enhanced keratinocyte migration and demonstrated antibacterial activity. In vivo findings revealed accelerated wound closure, enhanced epidermal regeneration, and modulation of PDGFA, VEGFC, COL1A1, TIMP1, and MMP9 expression. Collectively, the GO‑BPEI‑AgNP hydrogel shows strong potential as an injectable antibacterial biomaterial for acute full‑thickness wound repair, with potential relevance to infection‑associated wound environments.