Nature Synthesis自然·合成
Nature Synthesis(英文缩写 NAT SYNTH),ISSN 2731-0582,eISSN 2731-0582,中文译名:自然·合成 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
Nature Synthesis 最新收录文献
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1. {"_":"Engineering de novo formatotrophy in the non-model yeast .","i":["Y. lipolytica"]}
PMID:日期:2026-01-01Formate is an exciting potential microbial feedstock as it can be derived from CO and electricity. Despite this, limited progress has been made in engineering formatotrophy in yeasts, and no yeasts grow using formate naturally. Here we use metabolic modelling to find two potential formatotrophy pathways in . We then use C13 tracer analysis and computationally guided growth experiments to show that wild-type possesses strong formate dissimilation and a cyclical C1 pathway with similar architecture to the synthetic serine-threonine cycle, which it uses to co-assimilate formate and glycerol. Messenger RNA sequencing shows that formate exposure results in increased oxidative stress and changes in the tricarboxylic acid cycle, redox and C1 metabolism. Following this, we use model-guided adaptive laboratory evolution to produce a formatotrophic strain of using the eukaryotic serine-threonine cycle. We then use further messenger RNA sequencing to show that formatotrophy is supported by changes in adenosine triphosphate and reactive oxygen species metabolism. Subsequently, we engineer nicotinamide adenine dinucleotide phosphate (NADPH) and reactive oxygen species metabolism to create a strain with substantially improved growth. This strain reaches about 10% of the theoretical maximum biomass yield, highlighting its potential for additional engineering approaches. Finally, we show that beta-carotene production from formate is possible in our engineered strain, opening the door to formatotrophic eukaryote bioprocesses.
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2. Handle-free attachment of small molecules on single-walled carbon nanotubes.
PMID:日期:2026-01-01Few chemical methods controllably generate defects on single-walled carbon nanotubes, and fewer still create quantum wells that localize excitons and enhance near-infrared emission. Here we describe an aqueous, nanotube-catalysed Fenton reaction that enables the conjugation of an extensive range of small molecules lacking traditional single-walled carbon nanotube conjugation handles, generating quantum well defects with tunable electro-optical properties. We demonstrate the attachment of over 150 unique small molecules, including alcohols, amines, carbonyls, acrylates, amino acids and peptides. The resulting optical properties are governed by the electronic structure of the attached group, which determines the relative configuration of defects ( or ) within the graphitic lattice. Time-dependent density functional theory calculations confirm the assignment of the observed emission peaks to specific defect configurations. These molecularly driven effects enable precise control over the optical properties of the nanotubes, broadening the design space of rationally engineered quantum well-bearing nanomaterials.
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3. Breaking the 'rule-of-five' to access bridged bicyclic heteroaromatic bioisosteres.
PMID:日期:2026-01-01Bioisosteric replacement of aromatic and heteroaromatic rings with bridged bicyclic hydrocarbons is an important strategy in drug discovery. Intramolecular [2+2] cycloadditions of unconjugated dienes can provide a route to such motifs but are governed by the 'rule-of-five', which dictates that five-membered rings are preferentially formed, limiting access to alternative ring sizes. Here we introduce a visible-light-mediated intramolecular [2 + 2] cycloaddition of aza-1,6-dienes that leverages radical stabilization strategies to enable the selective formation of bridged bicycles over typically favoured fused bicycles. This approach generates previously elusive 6-azabicyclo[3.1.1]heptanes with facile substitution at every position around the ring. Exit vector analysis and comparison of the physicochemical and pharmacological properties of a 6-azabicyclo[3.1.1]heptane analogue of a piperazine-based drug demonstrate the potential application of this scaffold in medicinal chemistry. The methodology enables access to new chemical space, with implications for drug discovery and beyond.
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4. Electrochemical oxidation enables aromatic C-H amination with dual mechanisms.
PMID:日期:2026-01-01The selective amination of aromatic C-H bonds is a powerful strategy to access aryl amines, which offer functionalities used in many pharmaceuticals and agrochemicals. Despite advances in the field, a general platform for the direct, selective C-H amination of electronically diverse arenes, particularly electron-deficient (hetero)arenes, remains an unaddressed challenge. In addition, many (hetero)arenes are reluctant to undergo common selective prefunctionalization reactions, including halogenation, borylation and silylation. Here we report an electrochemical method for the selective C-H amination of a range of (hetero)arenes. Key to this strategy is mechanistic flexibility with convergent outcomes between anodic generation of electrophilic nitrogen radical dications from DABCOnium salts (DABCO = 1,4-diazabicyclo[2.2.2]octane) and arene radical cations from electron-rich arenes. Notably, oxidative conditions allow the electrocatalytic regeneration of DABCOnium salts that can participate in the functionalization of electron-deficient (hetero)arenes. This platform allows anodically generated N-radical cations to engage in aromatic C-H amination instead of well-reported hydrogen-atom transfer. This electrochemical DABCOylation reaction yields aryl DABCOnium salts that provide access to many complex drug-like aryl piperazines with high functionality tolerance, broad scope and site selectivity. Moreover, these salts can engage in catalytic functionalization reactions to form C-C, C-P and C-B bonds.
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5. Mechanically interlocked monolayer and bilayer two-dimensional polymers with high elastic modulus.
PMID:日期:2026-01-01Two-dimensional polymers (2DPs), comprising mono- or multilayer covalent polymeric networks with long-range order in two orthogonal directions, are of considerable interest due to their unique physicochemical properties. However, achieving precise thickness control from monolayer to bilayer, crucial for exploring proximity effect-driven phenomena beyond the monolayer limit, remains synthetically challenging. Here we report the on-water surface synthesis of crystalline mechanically interlocked monolayer and bilayer 2DP (MI-M2DP and MI-B2DP) films by embedding macrocyclic molecules with one and two cavities into 2DP backbones. The incorporation of bulky macrocyclic molecules introduces periodic mechanical bonds that precisely control interlayer interlocking, enabling selective monolayer or bilayer 2DP formation. Both MI-M2DP and MI-B2DP exhibit homogeneous, large-area films with ordered hexagonal pores and high modulus. MI-B2DP demonstrates an exceptionally high effective Young's modulus of 151 ± 16 GPa (indentation method), surpassing MI-M2DP (90 ± 14 GPa), van der Waals-stacked MI-M2DPs (46 ± 11 GPa) and other reported multilayer 2DPs (<50 GPa). Modelling confirms that the mechanical interlocking minimizes interlayer sliding and reinforces the structure.
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6. Oxygen migration into carbon-carbon single bonds by photochemical oxidation.
PMID:日期:2026-01-01The editing of organic molecules through single-atom modification is an enabling capability for medicinal chemistry. Although several examples of single-atom insertions into the carbon-carbon double bonds of unsaturated aromatic ring systems have been reported, heteroatom insertions into chemically inert carbon-carbon single bonds are comparatively rare. Here we report a photochemical strategy for the formal migration of oxygen atoms into carbon-carbon single bonds. This protocol is based on the ability of copper(II) salts to induce photochemical homolytic cleavage of carbon-carbon bonds adjacent to alcohols and to mediate oxidative coupling reactions of the resulting organoradical intermediates. Application of this method to cyclic alcohol substrates results in oxygen atom insertions into saturated carbocyclic rings, and its extension to linear alcohol substrates enables atomic permutation of hydroxymethyl functionalities into methyl ethers.
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7. Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion.
PMID:日期:2026-01-01Radical chain initiation strategies are fundamental to the synthesis of small molecule drugs and macromolecular materials. Modern methods for initiation through one-electron reduction are largely dominated by photo- and electrochemistry but the large-scale industrial application of these methods is often hampered by scalability challenges. Here we report a general, thermally driven and scalable method for the reductive initiation of radical chains that involves reacting an inexpensive azo initiator with a formate salt to form a carbon dioxide radical anion. Substoichiometric quantities of this initiator system were used to form C( )-C( ), C( )-S, C( )-H, C( )-B and C( )-P bonds from complex (hetero)aryl halides, with high chemoselectivity and under transition-metal-free conditions. The developed initiator system was also used to probe the mechanism of other radical reactions.
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8. Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes.
PMID:日期:2026-01-01Here we present the ambiphilic reactivity of alkyl sulfonyl fluorides in the stereoselective synthesis of diverse cyclopropanes from olefins, under palladium(II) catalysis. The sulfonyl fluoride functionality serves as both an acidifying group and an internal oxidant within the ambiphile, enabling successive carbopalladation and oxidative addition steps in the catalytic cycle, respectively. The transformation grants access to -substituted cyclopropanes and exhibits broad compatibility with various alkyl sulfonyl fluorides, including those bearing -CN, -COR, isoxazolyl, pyrazolyl and aryl groups. With internal alkene substrates, 1,2,3-trisubstituted cyclopropanes that are otherwise challenging to synthesize are formed in good-to-moderate yields and predictable diastereoselectivity. Detailed mechanistic insights from reaction progress kinetic analysis and density functional theory calculations reveal that the S2-type C-SOF oxidative addition is the turnover-limiting and diastereoselectivity-determining step.
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9. Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp3)-H bonds with dihaloarenes using palladium catalysis.
PMID:日期:2025-12-01Methylene-selective C-H functionalization at distal positions is a challenge that remains to be addressed in the field of Pd(II) catalysis. We have previously reported a ligand enabled , -C-H coupling with dihaloarenes for the synthesis of benzocyclobutenes (BCBs) as a promising class of scaffolds in drug discovery. Herein, we report a Pd(II)-catalyzed , -methylene C-H activation of free aliphatic acids and subsequent coupling with dihaloarenes, which offers an efficient route for the synthesis of diversely functionalized benzocyclobutenes (BCBs). The development of a carboxyl-pyridone ligand is crucial for the remote C(sp)-H activation. Notably, previous , -methylene C-H activation reactions of -aliphatic acids are uniformly limited to carbocyclic substrates. The site selective activation of , -C-H bonds allows the installation of the BCB pharmacophores that are one more carbon further away from the carboxyl group which could serve as hydrogen bond donor or acceptor. Such alternation of distance between two interactions can significantly impact bioactivity.
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10. Iron-catalysed radical difunctionalization of alkenes.
10. 铁催化的烯烃自由基双官能化PMID:日期:2025-09-01Transition metal-catalysed difunctionalization of alkenes enables the rapid construction of complex molecules by converting a flat C( )-C( ) -fragment to form a three-dimensional structure with neighbouring -hybridized carbons and two new C( )-G bonds (G = carbon, heteroatom, halogen and so on) in a single step. Iron catalysis is attractive because of its lower cost, higher Earth abundance, lower mining carbon footprint and lower toxicity in comparison to traditional transition metal catalysts, but lags behind nickel and palladium in terms of synthetic applications and mechanistic understanding. Here we present an overview of recent reaction development progress and unmet challenges in iron-catalysed difunctionalization reactions, with a focus on three-component radical cross-coupling processes that use commercially available iron salts in combination with readily available ligands. For each case, we highlight the mechanistic insights gained from (in)organic synthesis, computational modelling and spectroscopic techniques that advance our understanding and guide the development of new transformations.