Bioactive Materials生物活性材料
Bioactive Materials(英文缩写 BIOACT MATER),ISSN 2452-199X,eISSN 2452-199X,中文译名:生物活性材料 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
Bioactive Materials 最新收录文献
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1. An endoplasmic reticulum-enriched nanogel couples ferroptotic tumor damage with macrophage reprogramming for triple-negative breast cancer immunotherapy.
PMID:日期:2027-02-01Triple-negative breast cancer (TNBC) is characterized by severely immunosuppressive tumor microenvironment (TME), which leads to tumor ferroptosis resistance and dominant protumor M2 macrophages, restraining innate-to-adaptive antitumor immune cascade. Herein, an endoplasmic reticulum (ER)-enriched pH/redox-sensitive SPIONS@P-CpG-DOX nanogel was constructed to realize dual ER-targeted manipulation on TNBC cells and tumor-associated macrophages (TAMs) to elicit an ER-centered innate-to-adaptive immune amplification axis. In TNBC cells, nanogel-induced ER stress inhibits the GSH-GPX4 axis and accelerates lipid peroxidation, triggering ER-originated ferroptosis and immunogenic cell death (ICD) to release antigens and damage-associated molecular patterns (DAMPs) for immune priming. In macrophages, nanogel activates ER-dependent STING/NF-κB pathways without ferroptosis, facilitating M2-to-M1 polarization and inflammatory TME remodeling. The dual ER-initiated pathways synergistically facilitate dendritic cell (DC) maturation, enhance intratumoral CD4 and CD8 T-cell infiltration and build long-term systemic immune memory. In 4T1 TNBC models, the nanogel efficiently inhibits primary tumor growth, postoperative recurrence, distant rechallenge and lung metastasis with favorable biosafety. This work validates ER as a core regulatory hub linking tumor ferroptosis and macrophage reprogramming, providing an organelle-targeted strategy for durable TNBC immunotherapy.
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2. A designable twist-densification route to bioactive collagen hydrogel yarns approaching tendon-like mechanics.
PMID:日期:2027-02-01Reconstituted collagen hydrogels offer the bioactivity that load-bearing tissue engineering requires, but their Pascal to low-kPa moduli have confined them to non-structural roles, and the synthetic and hybrid strategies that close the mechanical gap typically forfeit that bioactivity. We show that a twist-induced densification process resolves this tradeoff in a controllable way, converting soft collagen hydrogel fibers into superhelical hydrogel yarns whose mechanics can be prescribed from fabrication parameters. A parameter-free model drawn from fiber-network mechanics predicts the modulus enhancement from densification, fibril alignment, and helical fiber architecture, and the same surface helix angle independently predicts the nonlinear strain-stiffening response. The resulting yarns exhibit modulus, strength, and toughness approaching the lower range reported for native tendons, representing enhancements of two to three orders of magnitude over the as-fabricated collagen hydrogels. Importantly, they remain amenable to braiding, knitting, and weaving into two- and three-dimensional constructs, including tubular architectures that recover elastically under repeated compression. Short-term cytocompatibility is preserved despite the severe compaction: encapsulated fibroblasts retain over 90% viability, exhibit pronounced alignment within the yarns, and transduce externally applied strain. Twist densification thus provides a designable route to living, load-bearing protein textiles.
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3. Dynamic coordination engineering of gallium biomaterials: A biological accessibility framework for therapeutic biofunction.
PMID:日期:2027-02-01Gallium (Ga)-based biomaterials have emerged as versatile therapeutic platforms owing to the iron-mimicking properties and broad biological activities of gallium. Coordination engineering regulates Ga speciation, stability, transport, and therapeutic activation; however, optimizing individual physicochemical properties does not necessarily improve biological performance. Excessive coordination stability may restrict ligand exchange and therapeutic activation, whereas insufficient stability may cause premature dissociation, nonspecific exposure, and reduced target delivery. In this Review, we propose Biological Accessibility as a multidimensional, time-dependent property describing the spatiotemporal availability of biologically active gallium species to relevant biological environments, cells, and molecular or tissue targets throughout the therapeutic lifecycle. We first examine ligand chemistry, coordination thermodynamics, ligand-exchange kinetics, gallium speciation under physiological conditions, and disease-responsive coordination evolution. We then review representative coordination-engineered gallium platforms and their applications in antibacterial therapy, immunomodulation, cancer treatment, bone regeneration, bioimaging, and theranostics, highlighting coordination-regulated transport, localization, cellular accessibility, activation, retention, and clearance. Building on these advances, we develop a dynamic framework linking continuous coordination evolution with Biological Accessibility across systemic, pathological, and intracellular environments. We further discuss Therapeutic and Off-target Accessibility, disease-specific accessibility windows, mechanistic attribution of biological functions, quantitative evaluation, coordination evolution, predictive modeling, artificial intelligence-assisted design, biosafety, and clinical translation. This framework provides a conceptual basis for accessibility-guided design of next-generation gallium biomaterials and broader coordination-engineered therapeutic systems.
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4. A bioactivity-enhanced thermosensitive amnion-derived hydrogel with sustained IGF-1 release: A multitargeted and efficient strategy for corneal injury repair.
PMID:日期:2027-02-01Corneal alkali burn (CAB) remains difficult to treat because rapid tear clearance limits topical drug exposure, while the injured cornea develops a complex microenvironment involving inflammation, neovascularization, fibrosis, epithelial barrier loss, and impaired nerve repair. Here, we developed a human amniotic membrane-derived thermosensitive hydrogel (hAMgel) and loaded it with insulin-like growth factor-1 (IGF-1) to create a bioactive sustained-release system (IGF1@hAMgel) for CAB repair. The hAMgel transformed from a flowable precursor into a semi-transparent film on the ocular surface within 1-2 min and IGF1@hAMgel released approximately 90% of loaded IGF-1 over 24 h, with corneal IGF-1 concentration peaking at 2 h post-dose (378.5 pg/mg protein) and remaining detectable over 24 h, supporting sustained topical exposure. In a rat CAB model, IGF1@hAMgel accelerated epithelial healing, reducing the fluorescein-stained area from 31.34 ± 2.83% in controls to 16.78 ± 2.87% at day 1. By day 14, IGF1@hAMgel reduced corneal opacity (0.67 ± 0.52 vs. 4.00 ± 0.00), resolved edema with central corneal thickness approaching baseline (187.7 ± 16.31 μm vs. 178.3 ± 5.89 μm), suppressed neovascularization (CD31-positive area 4.46 ± 1.69% vs. 24.33 ± 2.07%), and promoted corneal nerve regeneration. Proteomic analysis showed that hAMgel retained abundant extracellular matrix(ECM) components, including collagens, Lumican, and fibronectin, together with repair-related and immunomodulatory proteins. These findings identify IGF1@hAMgel as a sutureless, eye-drop-like bioactive ECM platform that integrates growth-factor delivery with amnion-derived reparative cues for multitargeted ocular surface repair.
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5. Antifibrotic hydrogel strategies for scarless tissue regeneration: mechanisms, design, and application.
PMID:日期:2027-02-01Tissue repair is a highly coordinated process, yet dysregulated fibrosis often diverts healing toward scar formation, resulting in permanent structural and functional impairment. Achieving scarless regeneration requires precise modulation of the wound microenvironment to support functional tissue reconstruction. Hydrogels, owing to their biocompatibility, tunable mechanics, and controllable delivery capabilities, have emerged as promising platforms for regenerative therapy. Recent multifunctional hydrogels can regulate tissue repair through microstructural engineering, mechanical modulation, immune regulation, pro-angiogenic stimulation, and dynamic extracellular matrix remodeling, thereby suppressing fibrotic progression. However, current reviews mainly focus on accelerating wound closure and lack systematic discussion of antifibrotic hydrogel design across different tissues. In this review, we summarize the key mechanisms underlying scar formation and propose design principles for hydrogel-mediated scarless regeneration. We further highlight recent advances in multiple tissues, including skin, tendon, cornea, urethra, nerve, endometrium, liver, myocardium, emphasizing both shared principles and tissue-specific requirements. Finally, we discuss translational challenges and future opportunities, particularly AI-driven hydrogel design for functional regeneration.
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6. A self-crosslinkable, adhesive intestine-derived extracellular matrix hydrogel enhances organoid retention and restores intestinal barrier integrity.
PMID:日期:2027-02-01Disruption of the intestinal barrier impairs essential functions of the gastrointestinal tract and triggers severe inflammation. Accordingly, transplantation of intestinal organoids restores the integrity of the injured intestinal barrier by promoting regeneration. However, the dynamic mucosal microenvironment of the intestine hinders effective retention of transplanted organoids, thereby limiting their therapeutic efficacy. To address this challenge, this study introduces a pyrogallol (PG)-conjugated intestine-derived extracellular matrix (IEM) (IEM-PG) as a scaffold for effective organoid transplantation. The dual crosslinking of IEM-based fibrillogenesis and oxidative PG coupling enabled IEM-PG to form a robust hydrogel scaffold without crosslinking agents under physiological conditions. Moreover, the IEM-PG hydrogel exhibited enhanced mechanical properties, superior bio-adhesion, and greater resistance to enzymatic degradation than the pristine IEM. The IEM-PG hydrogel was also highly biocompatible and did not adversely affect the viability and development of colonic organoids. The solution-type IEM-PG was readily injected into colonic tissue, thus allowing IEM-PG to initially spread along the intestinal lining. Transplantation of colonic organoids using IEM-PG in a mouse colonic ulcer model demonstrated effective cell retention in the intestinal tract, thereby restoring the structural integrity and function of the intestinal barrier. The study further demonstrated that the patch-type IEM-PG hydrogel was effective for the transplantation of colonic assembloids and the treatment of colonic perforation. Overall, this study presents the IEM engineered with an adhesive motif as a self-crosslinking hydrogel platform for organoid/assembloid transplantation and intestinal tissue repair.
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7. A bladder microenvironment-adaptive ceria nanozyme hydrogel enables urea-responsive intravesical chemo-immunotherapy.
PMID:日期:2027-02-01Bladder cancer intravesical therapy remains limited by rapid urinary washout, insufficient penetration across the bladder mucosal barrier, and an immunosuppressive tumor microenvironment. Here, we developed a bladder microenvironment-adaptive chemo-immunotherapy system, Gel/UCeNZ/Gem/CpG, to improve local bladder cancer treatment. In this system, urease-modified CeO nanozymes (UCeNZ), gemcitabine (Gem), and CpG oligodeoxynucleotide (CpG ODN) were incorporated into an injectable thermosensitive adhesive hydrogel. After intravesical administration, the hydrogel rapidly formed a mucosa-adherent depot, thereby prolonging bladder residence and enabling sustained therapeutic release. Meanwhile, UCeNZ responded to endogenous urinary urea to enhance particle transport and mucosal penetration, improving local drug exposure beyond passive instillation. Functionally, CeO-mediated redox regulation amplified Gem-induced oxidative stress, mitochondrial dysfunction, apoptosis, and immunogenic cell death-associated signaling, as evidenced by HMGB1 translocation/release, calreticulin exposure, and intracellular ATP dysregulation. CpG ODN further promoted dendritic cell maturation and strengthened T cell-mediated antitumor immunity. In an orthotopic bladder cancer model, Gel/UCeNZ/Gem/CpG significantly suppressed tumor progression, prolonged survival, increased CD8 T cell infiltration, reduced regulatory T cells and M2-like macrophages, and enhanced memory/effector-like T cell activation without obvious systemic toxicity. Transcriptomic analysis further revealed coordinated regulation of oxidative stress, apoptosis, antigen presentation, cytokine signaling, T cell activation, PD-1/PD-L1 checkpoint signaling, and p53-related tumor-suppressive pathways. Overall, this study presents a bladder-adaptive intravesical chemo-immunotherapy strategy that integrates mucosal retention, urea-responsive penetration, redox-amplified immunogenic chemotherapy, and immune microenvironment remodeling for bladder cancer treatment.
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8. Immuno-resolving nitric oxide-generating stents for coordinated vascular healing.
PMID:日期:2027-02-01Delayed endothelialization and persistent inflammation remain key challenges for long-term vascular healing after stent implantation. Here, we develop a temporally coordinated immunoregenerative coating (C15-NOGC) that couples sustained nitric oxide (NO) generation with C15-associated immunomodulation. The coating is fabricated via re-crosslinking of Cu-DOTA-modified polyamine within a polydopamine coating, followed by bioorthogonal immobilization of the pro-resolving peptide chemerin-15 (C15), yielding a mechanically robust interface with stable peptide presentation and physiological-level NO release. Functionally, immobilized C15 promotes a pro-resolving macrophage phenotype associated with increased ChemR23 expression, enhances phagocytic activity, and reduces pro-inflammatory responses. Concurrently, continuous NO generation provides antithrombotic activity, promotes endothelial regeneration, and modulates smooth muscle cell phenotype and vascular remodeling. Following stent implantation in ApoE rats, C15-NOGC significantly enhances early re-endothelialization, is associated with a reduced neointimal area, and shows favorable local vascular remodeling responses compared with bare metal and drug-eluting stents. PCR-array and proteomic analyses further reveal complementary molecular signatures associated with inflammatory regulation, vascular remodeling, and reparative processes, providing molecular context for the observed vascular responses. Together, these findings support a temporally coordinated strategy that integrates C15-associated immunomodulation with endothelial-mimetic NO generation for pro-healing vascular stent design.
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9. {"_":"Dismantling the eDNA-mediated HS barrier with biohybrids against refractory biofilm infections.","sub":["2"]}
PMID:日期:2027-02-01The spatiotemporal distribution of gaseous mediators is critical for maintaining physiological functions. Biofilms both contain gas-producing bacteria and possess complex architectures that reshape gaseous mediator distribution. However, whether biofilm pathogenicity is linked to such gaseous regulation remains unclear. In this study, we reveal that extracellular DNA (eDNA) within the biofilm matrix contributes to the local retention and enrichment of HS. This enrichment stabilizes eDNA, strengthens biofilm barriers, impedes gas clearance, promotes bacterial persistence, and induces macrophage immunosuppression, creating a reciprocally protective defensive loop. To dismantle this defense, we engineered a stepwise-responsive biohybrid system in which probiotic-derived engineered minicells actively target hypoxic biofilm regions, while HS-triggered nanoparticle degradation enables deeper matrix penetration and concurrent HS scavenging. The retained minicells then catalyze glucose oxidation to generate HO, which, together with Fe-mediated Fenton-like reactions, degrades eDNA and collapses the biofilm. This strategy eradicates persistent bacteria, reverses immunosuppression, and provides a therapeutic strategy to reduce recurrence and optimize refractory infection treatments.
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10. A programmable spatiotemporal bioelectrical conduit promotes peripheral nerve regeneration by suppressing ferroptosis through modulation of ER-mitochondria coupling in Schwann cells.
PMID:日期:2027-02-01Following peripheral nerve injury, abnormal endoplasmic reticulum-mitochondria coupling and activation of ferroptosis in Schwann cells are important causes of impaired myelination and regenerative failure. Based on this, we developed a multiscale anisotropic electroactive nerve conduit. The outer layer consists of a BaTiO-loaded GelMA piezoelectric hydrogel for ultrasound-triggered acoustic-electric conversion, while the inner layer is formed by rolling an aligned gelatin/PLA/G conductive fiber membrane into a tubular structure to provide directional conductive support and biomimetic topographical guidance. Together, this bilayer architecture forms a programmable spatiotemporal bioelectrical instruction system capable of generating localized, tunable, and directional bioelectrical output. The results showed that this conduit exhibited good biocompatibility and significantly promoted Schwann cell migration, polarized alignment, recovery of myelin-related phenotypes, and secretion of neurotrophic factors, while also enhancing neurite outgrowth of DRG neurons. Mechanistic studies further demonstrated that directional bioelectrical stimulation suppressed GRP75 expression, inhibited abnormal MAM formation mediated by the IP3R1-GRP75-VDAC1 complex, restored mitochondrial oxidative phosphorylation and energy metabolism, and ultimately attenuated ferroptosis in Schwann cells. In vivo experiments further showed that this conduit markedly promoted ordered nerve fiber regeneration, myelin maturation, neurovascular network reconstruction, and recovery of target muscle function, with repair outcomes approaching those of autologous nerve grafting. These findings establish a proof-of-concept engineered strategy for peripheral nerve regeneration and provide a basis for further preclinical evaluation in long-gap peripheral nerve defect models.