Chem化学
Chem(英文缩写 CHEM-US),ISSN 2451-9294,eISSN 2451-9294,中文译名:化学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 25.832 | Q1 |
| 2022 | 23.500 | Q1 |
| 2023 | 19.100 | Q1 |
| 2024 | 19.600 | Q1 |
| 2025 | 19.100 | Q1 |
Chem 最新收录文献
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1. Skeletal editing by iron-catalyzed carbene insertion of trichloromethanes.
PMID:日期:2026-08-13Direct interchange between five- and six-membered nitrogen heterocycles by skeletal editing is valuable in drug discovery. Specifically, inserting a carbon atom into oxidatively prone indole affords metabolically stable quinoline. However, tailored reagents for this transformation are limited by safety, availability, and generality. Here, we introduce a C-insertion method that employs stable, commercially abundant trichloromethanes (as chlorocarbene precursors) and simple iron catalysts (FeCl) to directly transform indoles to diverse quinolines. This highly practical method allows rare access to direct C-H and C-D insertion (essential analogs in medicinal chemistry) and many other pharmacophores. Mechanistic studies show key differences in rate, reactivity, and selectivity of this iron carbene versus metal-free carbenes. In addition, the skeletal editing of several drug-like molecules is presented, including a one-step synthesis of a quinoline analog of the psychedelic indole lysergic acid diethylamide (LSD). This analog exhibits lower potency and efficacy for activating 5-HT2A receptors, suggesting therapeutic potential with reduced hallucinogenic properties.
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2. The Influence of Heterometals on Dinitrogen Binding at Synthetic Iron-Sulfur Clusters.
PMID:日期:2026-07-30Of the three nitrogenase isozymes (Mo, V, and Fe-only), the Mo nitrogenase is the most efficient at catalyzing N reduction. To better understand the chemical basis for this difference in reactivity, we herein study how the identity of M in an isostructural series of synthetic [MFeS] clusters (M = V, Cr, Fe, Mo, or W) impacts the ability of neighboring Fe sites to bind N. We find that only for M = Mo or W does reduction of the chloride-bound clusters result in formation of an N complex; those clusters with M = V, Cr, or Fe instead undergo bimolecular reactivity, with no evidence for N binding. We argue that the divergent N chemistry between clusters with 4d or 5d "heterometals" and those comprised only of 3d ions can be ascribed to electronic structure differences, and that such differences may underlie the higher efficiency of the Mo nitrogenase.
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3. Exploration of protein degradability enables fully endogenous MrTAC degraders.
PMID:日期:2026-07-09Small molecules can induce protein degradation by hijacking natural degrons, but most degraders rely on the same proteasome-targeting degron. Motivated by the need for chemically exploitable degrons, this study leverages the lysosome-targeting methylarginine degron for the development of methylarginine-targeting chimeras (MrTACs). First, lysosomal-capture proteomics identify substrates naturally modified by methylarginine degrons. Next, a tag-based protein library is used for understanding the characteristics that affect degradation by MrTACs, which induces methylarginine degrons by recruiting protein arginine methyltransferases (PRMTs). MrTACs degrade proteins regardless of their native proteolytic route, including targets that have eluded classic degrader modalities, across multiple PRMTs. We leverage this for endogenous MrTACs that recruit PRMTs with repurposed inhibitors, which can be transformed into silent recruiters via group-transfer chemistry. MrTACs drive <95% target degradation across disease-linked proteins at nanomolar doses. Overall, this study integrates native and chemically induced degradation to establish a platform for fully endogenous, therapeutically viable degraders.
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4. Proton-Coupled Electrochemical Reduction of a Phosphine Oxide.
PMID:日期:2026-07-09The two-proton/two-electron electrochemical reduction of a phosphine oxide with elimination of water as the sole byproduct (P(V)=O + 2H + 2e → P(III) + HO) is reported. Under electrochemical (constant current electrolysis) conditions, reduction of 5-phenylphospholo[]dipyridine -oxide ( ) in the presence of a proton donor gives the corresponding phosphine () in up to 90% yield and 95% conversion. Electrokinetic data and simulations are consistent with an mechanism, in which an initial one-electron reduction brings about rate-limiting protonation of the phosphoryl bond. A regioisomeric phosphine oxide (9-phenylphospholo[]dipyridine -oxide, ) shows reversible electron transfer (ET) behavior but does not lead to proton-coupled electron transfer (PCET) P=O reduction. These results introduce the electronic design of π-substituents as a tunable mode by which to access previously challenging proton-coupled reduction of the strong P=O bond.
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5. A radical-polar crossover approach to complex nitrogen heterocycles via the triplet state.
PMID:日期:2026-07-09The transition from radical to ionic reactivity is a key design feature of many photochemical reactions, enabling complex transformations not possible under either mechanistic regime alone. Ground-state alkenes are common substrates in existing methods of this type, serving as radical acceptors to generate open-shell intermediates from which the radical-polar crossover (RPC) event is oxidatively or reductively triggered by a photocatalyst. Here, we describe an alternative RPC mechanism proceeding via an alkene triplet diradical. In this transformation, an iodine radical liberated during a homolytic aromatic substitution step functions as a single-electron oxidant to generate an iminium electrophile that can be intercepted en route to complex natural-product-like amines. An enantioselective variant of the reaction, enabled by an oxidatively installed sulfinyl leaving group, points to the generality of this underdeveloped pattern of diradical reactivity, paving the way for other triplet-state reactions that incorporate both one- and two-electron bond-forming processes.
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6. PCET-Enabled Decarboxylative Oxygenation Promoted by Photoexcited Nitroarenes.
PMID:日期:2026-06-11The valorization of feedstock chemicals is a central objective of synthetic chemistry. We report that tuning the aromatic substituents of photoexcited nitroarenes enables selective decarboxylative oxygenation of carboxylic acids proton-coupled electron transfer (PCET). The direct engagement of carboxylic acids constitutes a new reactivity for photoexcited nitroarenes, which are known to act as potent and selective HAT agents for thermodynamically accessible, hydridic C-H bonds. The mechanistic details of the transformation were elucidated through experimental and theoretical studies that support both stepwise and concerted PCET-type mechanisms dependent on the oxidation potentials of substrates. The selectivity reported herein for PCET reactivity with O-H bonds in the presence of weaker C-H bonds reveals the tunability of photoexcited nitroarene reagents, as well as their utility in transformations involving the single-electron activation of thermodynamically challenging heteroatom-H bonds.
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7. Radical "Link-and-Lose" Strategies for Iterative C-F Functionalization of Polyfluoroarenes.
PMID:日期:2026-06-11The selective activation of carbon-fluorine bonds represent a longstanding challenge in organic synthesis due to their exceptional strength and inertness. Recent work by Wang and co-workers introduces a pyridine-boryl radical-mediated "link-and-lose" strategy for iterative C-F bond functionalization of polyfluoroarenes, enabling selective transformation of the second, third, and even fourth C-F bonds and affording diverse fluorinated scaffolds with significant relevance to medicinal chemistry.
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8. Geometric Divergence in Nanostructural Fates of Coassembled Peptides Leads to Broadening of Morphology-Based Optoelectronic Property Outcomes.
PMID:日期:2026-05-08Sequence-defined hierarchical structure critically governs the function and emergent properties of biomacromolecules. However, introducing functional yet bulky π-conjugated synthetic units imposes geometric constraints that complicate the rational prediction of structuremorphology correlations for engineered biomacromolecules. Here, we report an intriguing coassembly behavior of a sequence-matched peptide pair bearing energy-transporting π-electron donor/acceptor cores (DDD-4T/DDD-PDI). Individually, DDD-4T forms twisted 1-D chiral nanofibers, whereas DDD-PDI assembles into achiral 2-D bundle-like nanostructures. Upon coassembly, heterotypic interactions between a more torsionally compliant donor core and comparatively rigid acceptor core produce hybrid chiral nanostructures distinct from either pristine state. These variations in nanostructure dimensionality and local chirality result in differential photophysical and optoelectronic properties. Thermal annealing and kinetic control of acidification further direct assemblies into alternative local minima, underscoring pathway-dependent supramolecular interactions. Collectively, we present a design principle for bioelectronic materials whereby broadening property-defining morphological fates could be driven by torsional mismatch between supramolecular units.
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9. Oxygen Tolerant Green Light Photopolymerizations with Type I Boron-Alkylated BODIPYs: The Power of a Methylene.
PMID:日期:2026-04-23Conventional Type I photoinitiators require high-energy UV light to generate radicals, while most visible-light systems rely on slower, oxygen-sensitive Type II photoredox pathways. We report boron-alkylated BODIPYs as visible-light Type I photoinitiators that operate efficiently under green LEDs and ambient conditions. Ethyl substitution, relative to methyl, at the boron site accelerates photolysis, lowers the B-C bond dissociation energy, and suppresses oxygen sensitization. Consequently, the ethyl derivative doubles the polymerization rate and decreases oxygen inhibition times over an order of magnitude compared to the methyl analogue. Relative to Ivocerin, a leading blue-light Type I photoinitiator, the BODIPY system achieves a higher external quantum yield due to stronger absorption. As proof of concept, the ethyl derivative enabled rapid ambient green-light DLP 3D printing of commercial acrylate resins, achieving 2.5 s exposures per 50 μm layer at 3 mW cm. This oxygen-tolerant platform provides a practical, sustainable route for photocurable technologies.
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10. Integrated transient chromophores for efficient photo-induced radiofluorination.
PMID:日期:2026-04-09Photoredox catalysis has emerged as a powerful tool in organic synthesis, enabling substrate activation via visible light in the presence of an external photocatalyst. However, reliance on bimolecular interactions between the photoexcited catalyst and substrate limits efficiency, a critical drawback for applications such as radiolabeling. To address this challenge, we report a molecular design strategy that bypasses this constraint by integrating a transient chromophore directly into the substrate. This approach eliminates diffusion-dependent activation, achieving highly efficient transformations through a self-correcting mechanism: reactive intermediates either engage nucleophilic addition or revert to the ground state via decay, minimizing side reactions. The transient chromophore additionally acts as a charged leaving group, enabling facile purification of the neutral labeled product. We demonstrate this strategy in radiofluorination reactions, achieving superior yields and simplicity compared with conventional photoredox methods. Its utility is highlighted by the synthesis of positron emission tomography (PET) tracers for oncology, neurology, and cardiology.