Communications Biology通讯生物学
Communications Biology(英文缩写 COMMUN BIOL),ISSN 2399-3642,eISSN 2399-3642,中文译名:通讯生物学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
Communications Biology 最新收录文献
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1. Fermented protein foods as modulators of the gut-muscle axis: mechanisms, evidence, and future directions.
PMID:日期:2026-09-25Skeletal muscle has a profound influence on metabolic health, functional capacity and resilience across the lifespan. Beyond dietary protein and physical activity, the gut microbiome may have the capacity to impact skeletal muscle mass and function through the bidirectional network termed the gut-muscle axis (GMA). Fermented protein foods (FPFs) are protein rich matrices transformed by microbial activity that integrate modified protein structures, bioactive peptides, and live microorganisms, or components thereof, which could modulate skeletal muscle physiology. Here, we review mechanistic, preclinical and human evidence concerning the potential of FPFs to influence skeletal muscle health through GMA modulation. Although emerging human studies suggest favourable effects on metabolic regulation, inflammatory pathways and gut microbial ecology, direct evidence that FPFs impact muscle protein synthesis, muscle mass or function remains limited. Furthermore, the literature is characterised by considerable heterogeneity in interventions and outcome measures. Studies integrating comprehensive microbiome characterisation, multi-omics approaches and direct skeletal muscle phenotyping are needed to determine whether FPFs confer advantages over conventional protein foods or more established microbiome targeted strategies such as probiotic supplementation. Such studies will be essential to elucidate their role in targeted nutritional strategies for ageing, metabolic disease, muscle atrophy, and physical performance.
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2. How mitochondrial heterogeneity fuels a dynamic organelle ecosystem.
PMID:日期:2026-09-24Mitochondria are traditionally viewed as a homogeneous network supporting cellular energy production. However, increasing evidence reveals substantial heterogeneity across biological scales, from intramitochondrial microdomains to specialised mitochondrial populations within cells and tissues. These subpopulations differ in morphology, metabolism, bioenergetics, and spatial organisation, reflecting adaptation to local functional demands. In this Review, we discuss the mechanisms underlying mitochondrial heterogeneity, the emerging concept of mitochondrial subclasses, their functional integration within cellular metabolism, and the challenge of distinguishing stable subclasses from transient states. We propose a shift from a network-based view toward a dynamic mitochondrial ecosystem with important implications for physiology and disease.
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3. Two coinfecting archaeal viruses provide insights into virus-virus interactions.
PMID:日期:2026-09-24Virus-virus interactions can profoundly shape viral ecology and evolution, yet they remain poorly understood, particularly in haloarchaea. Upon characterization of a spindle-shaped virus, Tebenquiche spindle-shaped virus 1 (Tebi-SV1), isolated from Halorubrum strain TLS-6, we detected the presence of a second virus, Tebenquiche pleomorphic virus 1 (Tebi-PV1), that coinfects host cells. Gene sharing network analysis revealed several genomes related to Tebi-SV1 in public databases, most of which also co-occur with pleolipoviruses in their host genomes. Attempts to separate the two viruses were unsuccessful, suggesting a symbiotic relationship between Tebi-SV1 and Tebi-PV1. We discovered that virus abundances may be regulated through a shared operator sequence allowing Tebi-PV1 to keep Tebi-SV1 copy numbers low without excluding Tebi-SV1 from the host genome. Additionally, Tebi-PV1 encodes and expresses a type-4-pilin, that likely plays a role in regulating the interactions between the host and the viruses. Our findings highlight the complexity of virus-virus interactions and that resident viruses are important regulators of virus-host interactions.
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4. Evolutionary dynamics of plant cell wall-degrading enzymes reflects feeding ecology in weevils.
PMID:日期:2026-09-23Many herbivorous beetles depend on plant cell wall-degrading enzymes (PCWDEs) to access the nutritious plant cell content. However, the evolution of PCWDEs in weevils, the most diverse lineage of herbivores, remains poorly understood. Using transcriptomic and genomic analyses of 45 weevil species spanning the majority of existing subfamilies, we identified a total of 13 different PCWDE families, revealing high variability between species. Interestingly, the PCWDE repertoires tracked dietary specialization, with convergent reductions in fungivorous taxa. Furthermore, PCWDE gene family dynamics were driven by both larval and adult specialized herbivory on different plant organs. Despite this complex evolutionary history, phylogenetic analyses place core PCWDE functionalities at the base of the Phytophaga (weevils, leaf beetles, and longhorn beetles) and reveal subsequent horizontal gene transfer (HGT) events from various donors during early Phytophaga diversification. These findings demonstrate that HGTs, gene duplications, and losses shaped PCWDE diversity and facilitated the ecological success of weevils.
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5. Molecular mechanism of complement interference by Streptococcus pyogenes nuclease A.
PMID:日期:2026-09-23Bacteria deploy virulence factors to subvert host immunity; yet the molecular details of these interactions often remain limited. Here, we reveal the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterize the structure and dynamics of SpnA using hydrogen-deuterium exchange mass spectrometry and single-particle electron cryo microscopy, yielding the first structural insights to SpnA. This allowed us to identify an additional oligonucleotide-binding domain, whose flexible structure may play an important function in nucleolytic activity. Affinity-pulldown mass spectrometry identified the complement system membrane attack complex (MAC) C5b67 components as key interactors. Cross-linking mass spectrometry combined with integrative modeling identified the binding interfaces between SpnA and C5b67. These interfaces are conserved among genetically diverse S. pyogenes strains. Interaction between SpnA and C5b67 is suggested to prevent the assembly of a functional MAC. Our findings uncover a novel function of SpnA in complement inhibition, and identifies new potential targets to prevent and treat S. pyogenes infections.
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6. A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal inhibitor that binds the peptidyl transferase center.
PMID:日期:2026-09-23Translation inhibitors are invaluable for probing ribosome function and therapeutic applications, but systematic discovery in human systems is limited by the lack of scalable, screening-compatible cell-free platforms. Here, we establish a robust high-throughput screening using human lysates that bypasses cellular cytotoxic effects. After screening ~28,000 small molecules, we identified known and a novel translation inhibitor, including NT-2, a trichothecene mycotoxin produced by the pathogenic Fusarium sporotrichioides. NT-2 suppressed protein synthesis in human cells and yeast lysates, while sparing translation in bacteria and intact yeast cells. Cryo-EM at 1.76 Å revealed NT-2 bound at the peptidyl transferase center of the human 60S ribosome. In addition, cryoEM classification of NT-2 treated cells shows ribosomes in an inactive eEF2/SERBP1-bound dormant state. Together, these results expose NT-2 as a previously unrecognized environmental inhibitor of mammalian protein synthesis and demonstrate the power of cell-free translation screening to reveal new inhibitors with unexpected ribosome fates.
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7. Linguistic information may compensate for age-related decline in attentional filtering.
PMID:日期:2026-09-22As we age, understanding speech in social situations imposes an increasingly difficult challenge to the auditory system. However, the attentional mechanisms underlying age-related speech comprehension difficulties in multitalker situations remain unclear. We collected EEG signals while 63 normal hearing participants (35 women) from 19 to 71 years performed a speech comprehension task involving a multitalker paradigm at individually adjusted target-to-distractor ratios. Combining trial-resolved multivariate temporal response function modeling with detailed behavioral comprehension responses, we provide a window into lower-level impairments and possible higher-level compensatory mechanisms across the adult life span. We show that reduced behavioral performance in late adulthood is associated with increased distractor representation. This points towards increased distractibility as a potential mechanism underlying age-related speech comprehension deficits. Additionally, at the behavioral and neural levels, we show that older adults rely more on higher-level linguistic information. Finally, we show that an increased reliance on word-level linguistic information may compensate for increased distractor tracking and adaptively support comprehension performance across the adult life span. Thus, an increased reliance on higher-level processing could attenuate age-related impairments in attentional filtering.
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8. Plant heteropolysaccharides and their bioadhesion to animal glycocalyx visualized at the nanoscale.
PMID:日期:2026-09-22The plant-derived biopolymer pectin has been explored as sealant in lung surgery. Interpenetration of pectin's heteropolysaccharide chains with sugar-chains on components of the mesothelial glycocalyx is thought to mediate adhesion. To visualize a potential adhesion complex, we first establish a method to preserve pectin ultrastructure by limiting hydration during sample preparation for electron microscopy. Depending on actual hydration states and pectic domains selected we find distinct morphologies: Citrus pectic polysaccharides, combining both, smooth homogalacturonan and hairy rhamnogalacturonan domains, form a loose network of thin filaments. Rhamnogalacturonan and xylogalacturonan domains from soy show a denser mesh, while pectic galactan from potato or pectic arabinan from sugar beet display more globular aspects. As proof of concept, we finally apply the filamentous lemon pectin to the surface of murine lung in a surgical setting. Ultrastructural visualization of the sealant-tissue assembly shows tight association between the carbohydrate fibers, possibly driven by polymer-typical chain interactions.
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9. Citizen science reveals temporally structured insect attraction and mitigation efficacy under artificial light at night.
PMID:日期:2026-09-21Artificial light at night (ALAN) is an anthropogenic disturbance with negative effects on nocturnal flying insects, yet most studies treat "night-time" as a uniform exposure period. However, nocturnal insects exhibit pronounced temporal niche partitioning, suggesting that attraction to artificial light and the effectiveness of mitigation measures may vary over the night. Using a citizen science framework, we show how insect attraction along a lakeside road varies across five nightly intervals, comparing conventional high pressure sodium with tailored and shielded LED road lights. Complementary UV ground traps showed marked shifts in local insect abundance and taxonomic composition, with peak attraction occurring during late evening and midnight hours (09.30pm-11.30pm-00.30am). Road lights closely followed this temporal trend. Tailored and shielded LED luminaires reduced total insect attraction, with the strongest effects during peak activity, but limited efficacy during twilight and late-night periods. Both total abundances and taxonomic composition showed significant time-by-treatment interactions, demonstrating that incorporating temporal dynamics can greatly improve targeted mitigation strategies.
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10. Harnessing microfluidics for microbiology: from bacteria-host interactions to emerging cancer therapies.
PMID:日期:2026-09-21Microfluidics has emerged as a powerful technology for precisely controlling mechanical and chemical environments across a wide range of biological systems, from single cells to complex co-cultures. In microbiology, the microscale dimensions of bacteria pose experimental challenges that microfluidic systems have effectively addressed, offering compatibility with live imaging and enabling quantitative investigations of bacterial behaviors and host-bacteria interactions. Historical microfluidic designs are now routinely used to quantify bacterial growth and lineage with unprecedented temporal-spatial resolution and precise control of external conditions. In parallel, organ-on-chip technologies are increasingly applied in microbiology to study host-bacteria interactions within physiologically relevant and well-controlled microenvironments. Recently, cancer tissues have been recognized as unexpected hosts for bacteria, with mounting impactful evidence showing that intratumoral microbes can influence cancer progression and response to therapy. Despite growing interest, the application of microfluidics to cancer-bacteria interactions remains limited. Addressing this gap requires the development of appropriate methodological tools that replicate the relevant tumor microenvironment features and allow the quantification of both cellular responses and bacterial colonization dynamics upon the bacterial-host interaction. In this review, we first outline the foundational applications of microfluidics in microbiology from single-cell to collective behavior studies. We then describe how organ-on-chip technology enables the fine-tuned formation of organ-specific conditions, which are critical for modeling the complex tumor microenvironment. We further examine recent findings on intratumoral bacteria across cancer types and discuss how microfluidics, especially tumor-on-chip approaches, can advance this emerging field, from mechanistic insights to therapeutic development.