PAIN疼痛
PAIN(英文缩写 PAIN),ISSN 0304-3959,eISSN 1872-6623,中文译名:疼痛 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 7.926 | Q1 |
| 2022 | 7.400 | Q1 |
| 2023 | 5.900 | Q1 |
| 2024 | 5.500 | Q1 |
| 2025 | 5.800 | Q1 |
PAIN 最新收录文献
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1. Reply to Alcántara Montero: the definition of regional pain should be agnostic to potential underlying mechanisms.
PMID:日期:2026-10-01该文献暂无摘要。
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2. Reframing regional pain: integrating central mechanisms and phenotypic complexity.
PMID:日期:2026-10-01该文献暂无摘要。
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3. Low-income and middle-income countries as engines of discovery in pain research.
PMID:日期:2026-10-01该文献暂无摘要。
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4. Quantifying nociceptive state across the neuraxis with in vivo fiber photometry: methodological foundations, constraints, and future directions.
PMID:日期:2026-10-01In vivo fiber photometry has become an effective approach for quantifying nociceptive state dynamics in defined neural populations across the brain and spinal cord (ie, neuraxis) in rodent models. By enabling longitudinal recordings with cell-type specificity during freely moving behavior, photometry is well-suited for pain research. Rigorous inference from photometry demands explicit attention to what the signal represents and to sources of systematic error that are amplified in nociception assays. Changes in fluorescence represent a manifestation of integrated activity across a heterogeneous sampling volume, conflate somatic and neuropil signals, and are shaped by indicator kinetics that blur rapid spiking. Moreover, pain-evoked movements and autonomic shifts can introduce nonneural fluctuations through motion, photobleaching, changes in optical coupling, and hemodynamic absorption, producing signal components that can masquerade as neural responses if not controlled for. Here, we synthesize methodological foundations and constraints that are particularly consequential for nociception paradigms, emphasizing experimental design, reference-channel strategies, artifact detection and correction, behavioral alignment across relevant timescales, and transparent reporting of preprocessing and normalization choices. In addition, we highlight several ascending systems of nociception and pain processing as potential targets for research (ie, parabrachial nucleus, periaqueductal gray, anterior cingulate cortex). We emphasize emerging standards aimed at enhancing reproducibility and cross-study comparability, and outline future directions, including multisite and multicolor recordings, expanded sensor repertoires for neuromodulators and voltage, integration with perturbations and electrophysiology, and scalable analysis pipelines coupled to high-resolution behavioral quantification to advance mechanistic understanding of pain circuitry in vivo.
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5. All that glows is not pain: a call for rigorous interpretation of fiber photometry signals in pain research.
PMID:日期:2026-10-01该文献暂无摘要。
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7. Centrally mediated pain features predict persistent pain in early inflammatory arthritis: a 2-year prospective study.
PMID:日期:2026-10-01Patients with inflammatory arthritis (IA) often report pain not necessarily coupled to active inflammation. We previously demonstrated that a significant subset of patients with newly diagnosed IA report features of centrally mediated pain. In this prospective study following the same IA cohort, we tracked the relative contributions of inflammatory/noninflammatory mechanisms to pain over 2 years. We used patient-reported outcome measures (PROMs), clinical data (including ultrasound), and standardised quantitative sensory testing. Mixed-effects regression models examined longitudinal associations. We recruited 66 patients. At 6, 12, and 24 months, 62%, 57%, and 49% of individuals, respectively, reported persistent pain (numerical rating scale ≥3). Using factor-derived composite scores, baseline and longitudinal inflammation was not associated with subsequent pain ( b -0.05, P = 0.87), whereas higher centrally mediated pain markers predicted less pain reduction ( b 1.41, 95%, P < 0.001). Baseline PROMs of centrally mediated pain (fibromyalgia severity average marginal effect [AME]: 0.94, P < 0.001, painDETECT AME: 1.03, P < 0.001) and mental health (eg, Generalised Anxiety Disorder-7 AME: 1.08, P < 0.001) were the strongest predictors of persistent pain. Baseline trapezius pressure pain threshold (PPT) and conditioned pain modulation (CPM) pain detection threshold (PDT) effect showed modest association (trapezius PPT AME: -0.51, P = 0.054, CPM PDT effect AME: -0.49, P = 0.051) whereas temporal summation of pain (AME: 0.09, P = 0.756) and CPM pain tolerance threshold effect (AME: -0.01, P = 0.964) did not. In our cohort, persistent pain was associated with higher baseline and longitudinal scores for centrally mediated pain according to PROMs rather than inflammation according to joint ultrasound. In IA, early identification and treatment of features of centrally mediated pain may improve pain-related outcomes.
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9. Deep FLASH-seq profiling of purified canine sensory neurons uncovers species-specific signatures relevant to pain and itch.
PMID:日期:2026-10-01Naturally occurring pain and itch disorders in the domestic dog represent an important and underexploited opportunity for translational sensory neuroscience. These conditions largely mirror human disease, highlighting the need for detailed comparative understanding of canine somatosensory neurobiology. Here, we present a single-cell transcriptomic characterisation of the canine dorsal root ganglion (DRG), providing molecular insights into sensory neuron diversity in a species of direct veterinary and biomedical relevance. We develop a novel mechanical dissociation and fluorescence-activated cell sorting strategy enabling purification of intact whole neurons from adult canine DRG, followed by deep, full-length RNA sequencing using FLASH-seq. This approach yields high-quality transcriptional profiles with molecular depth analogous to deep neuronal profiling in human DRG, enabling resolution of neuronal identities and subtype-specific gene programs. Using these data, we identify canine sensory neuron clusters conforming to conserved principles of DRG molecular organization observed across species, including peptidergic and noncanonical peptidergic nociceptors, low-threshold mechanoreceptors, proprioceptors, and thermosensory populations. Cross-species comparisons with human and mouse DRG datasets reveal broad conservation of pain- and itch-relevant pathways and therapeutic targets, alongside biologically meaningful divergence. We further identify species-specific differences in subtype-restricted expression of the pharmacologically relevant receptors IL31RA and SSTR2 , which we validate using in situ hybridization and contextualize with human spatial transcriptomic data. Finally, we provide evidence that domestication-associated genes are nonrandomly enriched in specific sensory neurons, suggesting that evolutionary history may have shaped somatosensory function. These data represent a resource for comparative sensory neuroscience and inform translational interpretation of pain and itch therapeutics across species.
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10. Identification of high-impact chronic pain in adolescents with musculoskeletal pain.
PMID:日期:2026-10-01High-impact chronic pain (HICP) describes pain that interferes substantially with daily functioning and is associated with diminished quality of life, yet brief tools to identify and track HICP in adolescents are lacking. The 3-item Pain, Enjoyment, and General Activity (PEG) scale derived from the Brief Pain Inventory offers a promising rapid measure, but its psychometric properties and an empirically derived HICP cut-off score based on PEG have not been established in pediatric chronic pain. The present study examined convergent validity, classification accuracy, and a PEG cut-off for HICP in 263 adolescents (10-18 years; 84.4% female) with chronic musculoskeletal pain receiving tertiary pain care. The PEG was strongly associated with primary clinical variables: functional disability ( r = 0.63), quality of life ( r = -0.56), and pain intensity and unpleasantness ( r = 0.58, 0.61), and strongly-to-moderately associated with secondary clinical variables: fatigue ( r = 0.53), depression ( r = 0.49), and pain catastrophizing ( r = 0.49), with modest associations with sleep and anxiety ( r = -0.31, 0.25). Receiver operating characteristic analysis indicated that across all 4 primary clinical variables, the PEG demonstrated the strongest discrimination of upper-tertile functional disability scores (Functional Disability Inventory ≥28, area under the curve = 0.81, sensitivity 0.75, specificity 0.76, positive predictive value 0.64, Youden index 0.51, PEG score cut-off 6) and was cross-validated against pain intensity, pain unpleasantness, and quality-of-life variables. The PEG represents a promising brief monitoring and clinical status tool to support risk-stratified care and clinical research in pediatric chronic musculoskeletal pain.