Chemical Biology Letters
Chemical Biology Letters(英文缩写 CHEM BIOL LETT),ISSN 2347-9825,eISSN 2347-9825 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
Chemical Biology Letters 最新收录文献
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1. Global Cancer Etiology: Molecular Signatures, Therapeutic Disparities, and the role of Socio-economic Determinants.
1. 全球癌症病因学：分子特征、治疗差异及社会经济决定因素的作用PMID:日期:2026-04-16The global burden of cancer is increasingly shaped by socio-economic determinants that extend beyond geographic incidence patterns. While historically considered a disease of affluence, cancer now reflects a divergence between high-income countries (HICs) and low- and middle-income countries (LMICs), driven by distinct environmental, occupational, and structural exposures. This narrative review examines how socio-economic conditions act as primary determinants of cancer etiology by linking epidemiological trends to molecular evidence. A comprehensive literature search was conducted (2006-2026), focusing on cancer etiology, environmental carcinogenesis, mutational signatures, and health disparities. Three domains of socio-economic influence emerged from search. First, harmful exposures, including asbestos, aflatoxin B1, arsenic, heavy metals, and air pollution, are disproportionately concentrated in under-regulated populations. Second, these exposures produce distinct mutational signatures; aflatoxin-related hepatocellular carcinoma is associated with TP53 R249S and COSMIC Signature 24, while cancers in HICs often involve PI3K/AKT/mTOR pathway alterations. Third, disparities in screening infrastructure create "screening deserts," increasing mortality gaps. Socio-economic context fundamentally shapes cancer biology, incidence, and outcomes. Reducing disparities requires expanded genomic capacity in LMICs, targeted prevention strategies, and equitable access to precision oncology.
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2. Cyclic-Linear Hybrid Peptides as Molecular Transporters of Chemotherapeutic Agents.
2. 环状-线性杂合肽作为化疗药物的分子转运体PMID:日期:2026-02-02Arginine/tryptophan-rich peptides are amphipathic, enabling membrane interaction, cargo transport, and antimicrobial activity. To enhance these properties, we synthesized and evaluated hybrid peptide [RW]K-AH135 (), combining the antimicrobial α-helical peptide AH135 (AMP) with the cell-penetrating peptide (CPP) [RW]K, and [RW]K-AH135 (), combining AH135 with another AMP [RW]K. Peptides were synthesized by Fmoc solid-phase peptide synthesis and cyclization in solution phase, purified by HPLC, and characterized by MALDI-TOF. While AH135 and [RW] showed antimicrobial activity (MICs 3.1-6.2 μg/mL), both hybrids were inactive (MIC ≥ 50 μg/mL). In contrast, the hybrids functioned as molecular transporters in cancer cells. [RW]-AH135 enhanced the activity of multiple chemotherapeutics in MDA-MB-231 and SK-OV-3 cells, improving growth inhibition by approximately 15-47% at 72 h, and improved doxorubicin efficacy by approximately 37% in resistant MES-SA cells. Both hybrids promoted the intracellular delivery of green fluorescent protein (50 nM), as confirmed by flow cytometry and confocal microscopy (p < 0.001). [RW]K-AH135 showed higher uptake in both lines in a dose- and time-dependent manner. [RW]K-AH135 acted as a chemotherapeutic agent sensitizer, whereas [RW]K-AH135 was a superior carrier. Thus, these hybrids act as molecular transporters and represent promising platforms for drug conjugation and intracellular delivery.