Frontiers in Cellular and Infection MicrobiologyFrontiers in Cellular and Infection Microbiology 细胞与感染微生物学前沿
Frontiers in Cellular and Infection Microbiology(英文缩写 FRONT CELL INFECT MI),ISSN 2235-2988,eISSN 2235-2988,中文译名:Frontiers in Cellular and Infection Microbiology 细胞与感染微生物学前沿 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 6.073 | Q1 |
| 2022 | 5.700 | Q1 |
| 2023 | 4.600 | Q1 |
| 2024 | 4.800 | Q1 |
| 2025 | 5.500 | Q1 |
Frontiers in Cellular and Infection Microbiology 最新收录文献
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1. The single-cell immune atlas of bacterial pneumonia: from inflammatory cell infiltration to treatable cell states.
PMID:日期:2026-01-01Bacterial pneumonia remains a major cause of infectious mortality, and antimicrobial resistance has intensified interest in host-directed therapy (HDT). Recent bronchoalveolar lavage fluid (BALF) and peripheral blood atlases (2024-2025) provide single-cell evidence from human disease, but the main translational gap is prioritization rather than catalog expansion. In this review, we reorganize published datasets from bacterial pneumonia and related lung infection cohorts (>500,000 cells; 2020-2026) into a state-prioritization scheme termed "treatable cell states." Evidence is currently strongest for severity-linked expansion of indoleamine 2,3-dioxygenase 1-positive/programmed death-ligand 1-positive (IDO1+/PD-L1+) macrophages and pathological neutrophils; exhausted-like CD8+ T-cell states show emerging human transcriptomic and translational support but still require protein-level, functional, and longitudinal validation, whereas evidence for injured epithelium and repair-failed stromal states in bacterial pneumonia remains partly inferential and draws on adjacent lung-injury literature. We therefore treat the six proposed state categories as a ranked hypothesis set for macrophage-, neutrophil-, T-cell-, epithelial-, and stromal-directed interventions, not as validated clinical targets. Most proposed interventions still require longitudinal and functional validation before routine bedside use.
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2. {"_":"The association of the advanced lung cancer inflammation index with the risk of infection and mortality: a study of populations from two countries.","i":["Helicobacter pylori"]}
PMID:日期:2026-01-01() infection is strongly linked to multiple diseases. Inflammation and nutritional status are intricately intertwined with infection; however, most prior studies failed to integrate these two dimensions in a unified assessment. This study enrolled 3,718 eligible participants from the 1999-2000 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression was utilized to examine the association between the ALI and infection. Cox proportional hazards regression was employed to evaluate the association between ALI and all-cause mortality in -infected patients. Restricted cubic splines (RCS) were implemented to characterize potential nonlinear relationships. Subgroup analysis explores the consistency of the associations among different populations. An independent duplicate cohort from the Second Affiliated Hospital of Nanchang University was additionally incorporated. Elevated ALI emerged as a relevant factor for infection. Higher ALI levels were associated with improved survival prognosis. Beyond an inflection point (log2ALI=5.44) this negative association gradually diminished. Subgroup analyses revealed that the interaction test showed that no significant interaction was found for all stratification factors. The association between ALI and infection was consistent among the above subgroups. Independent duplicate cohort corroborated that as the level of logALI increases, the likelihood of infection showed a monotonous increasing trend. Higher ALI levels were positively associated with an increased risk of infection, and this association was consistent in an independent duplicate cohort. Among -infected individuals, higher ALI was related to reduced all-cause mortality, with the association most prominent at lower ALI ranges.
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3. Impact of clinical sample processing time on the performance and T-cell response of the T-SPOT.TB assay.
PMID:日期:2026-01-01T-SPOT., an interferon-gamma release assay (IGRA) for detecting Mycobacterium tuberculosis infection, requires blood processing within 4 hours, limiting clinical flexibility. T-Cell Xtend™ (TCX) extends permissible storage but is costly. This study evaluated delayed processing impacts on T-SPOT. consistency in a real-world setting. Outpatients undergoing T-SPOT. testing were prospectively enrolled. Samples were processed at standard timing (≤4 h), after 24-h delay with TCX, and after 24-h delay without TCX. Consecutive-day fresh samples served as within-subject reproducibility references. Among 443 patients, 282 underwent 24-h delayed testing. Agreement with standard-timing results was 93.3% without TCX (κ=0.859) and 93.0% with TCX (κ=0.860), comparable to fresh-sample reproducibility (95.0%; κ=0.840; all p<0.001). Multivariable analysis identified initial borderline results (OR = 15.21, p<0.001) and 24-h delay (p<0.05) as independent predictors of T-SPOT.TB reversion, regardless of TCX use. Antigen-well spot-forming cell (SFC) counts were significantly reduced after 24-h delay (p<0.001); TCX did not mitigate this decline (p=1.000). Positive-control SFC counts remained stable (p=0.602). A 24-h processing delay demonstrated high concordance with standard-timing T-SPOT. results, supporting clinical feasibility. Nevertheless, borderline results and delayed processing were independently associated with result discordance, warranting cautious clinical interpretation.
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4. {"_":"Gut microbiota and short-chain fatty acids in pregnant women with group B colonization and their impact on neonatal outcomes.","i":["Streptococcus"]}
PMID:日期:2026-01-01Group B (GBS) frequently colonizes the gastrointestinal and lower reproductive tracts in pregnant women. However, research has predominantly addressed its influence on the vaginal microbiota, leaving its effects on the gut ecosystem and the consequent implications for neonatal outcomes largely unexplored. In this prospective study, 87 pregnant women were enrolled at the Women and Children's Hospital of Xiamen University from March 2022 to October 2023 and divided into GBS-positive and GBS-negative cohorts according to their colonization status. Fecal samples were collected to complete 16S rRNA gene sequencing and fecal Short-chain fatty acids (SCFAs) content determination. The pregnancy outcomes and clinical prognosis information of the newborns were followed up. Intestinal microbiota composition and SCFAs levels were compared between GBS-positive and GBS-negative pregnant women, and their respective correlations with pregnancy and neonatal outcomes were evaluated. Significant differences in the genera , , and were observed between GBS-positive and GBS-negative group. SCFAs-targeted metabolomic analysis revealed that fecal butyrate concentration were significantly lower in GBS-positive group than in GBS-negative group. Association analysis revealed a significant positive correlation between intestinal butyrate concentration and the abundance of ( = 0.216, = 0.045). Spearman's correlation analysis showed that abundance and butyrate concentration were positively correlated with birth weight percentile-Fenton of newborn ( = 0.390, < 0.001; = 0.403, < 0.001) and negatively correlated with umbilical cord blood IL-6 level ( = -0.229, = 0.033; = -0.445, < 0.001). After adjusting for confounding factors including GBS colonization, regression analysis showed that increased butyrate concentration was an independent protective factor against elevated IL-6 (a: -27.823, 95%: -50.041~-5.606), whereas increased incidence of chorioamnionitis was an independent risk factor for elevated IL-6 (a: 30.155, 95%: 2.556~57.754). GBS colonization in late pregnancy is associated with disruptions in the gut microbiota and its metabolic profiles, particularly with lower abundance and diminished butyrate metabolism. Butyrate may lower neonatal inflammation through anti-inflammatory mechanisms. Therefore, targeting or the butyrate metabolic pathway should be viewed as a hypothesis-generating strategy to improve perinatal outcomes in GBS-colonized pregnant women.
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5. Urban wastewater and sewage sludge as environmental sources of antimicrobial resistance, potential pathogens, and selective agents: insights from three European wastewater treatment plants.
PMID:日期:2026-01-01Antimicrobial resistance (AMR) is a growing global human health threat, and it is increasingly recognized as a One Health issue, complicated by the complex interactions between humans, animals, and the environment. Wastewater treatment plants (WWTPs) link human activities with the environment and may act as a reservoir of AMR, facilitating environmental dissemination. This study investigated bacterial communities, antibiotic resistance genes (ARG), and antibiotic susceptibility in wastewater and digested sludge at three WWTPs in Norway and Greece, representing regions with low and high antibiotic consumption and clinical AMR prevalence. Antibiotic residues and potentially toxic metals were also quantified. Of 21 antibiotics analyzed, 13 were detected in at least one sample, with ciprofloxacin, cefotaxime, and meropenem occasionally exceeding predicted no-effect concentrations. Removal efficiencies varied, with limited removal at the Norwegian WWTPs compared with the Greek facility. Potentially toxic metals were detected at all sites, with exceeded minimum co-selective concentrations for Cu, Ni, Pb, and Zn. Bacterial community composition was influenced by location, sample type, and sampling time point (p<0.05), and was associated with antibiotic concentrations. Removal of fecal and environmental indicator bacteria was 3.1 ± 1.4 log CFU/100 mL at the Greek WWTP but negligible at the Norwegian WWTPs. Most ARGs (79%) were detected across all WWTPs, and clinically important resistance genes were also prevalent in outlet and digested sludge samples, suggesting considerable environmental spread. Antibiotic susceptibility testing revealed reduced susceptibility to all tested antibiotics, including 3 generation cephalosporins, meropenem, and last-resort antibiotics, although enumeration and susceptibility testing of environmental indicator bacteria was limited by methodological constraints. These findings demonstrate that WWTPs can contribute to the environmental dissemination of ARB and ARG in both high and low antibiotic consumption and clinical AMR regions, highlighting the need for effective wastewater treatment, improved environmental surveillance and integrated One Health approaches linking human and environmental AMR compartments.
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6. Advances in NLRP3 inflammasome research in viral infections: evolution, trends, and future directions.
PMID:日期:2026-01-01The NLRP3 inflammasome is a central innate immune sensor in virus-associated inflammation, yet the global research landscape of NLRP3 in viral infections remains unmapped. This study aimed to characterize its structure, evolution, research hotspots, and translational status. We performed a dual-database bibliometric analysis of publications from the Web of Science Core Collection (WoSCC) and Scopus through April 28, 2026, analyzing each database independently with cross-validation. Publication trends, collaboration networks, journal and co-citation patterns, citation bursts, keyword co-occurrence, and trend topics were examined using bibliometrix, VOSviewer, and CiteSpace. Publications from WoSCC (n = 1,544) and Scopus (n = 1,495) were analyzed independently and cross-validated. Annual output rose steadily from 2009 to a peak in 2025, expanding most steeply during 2019-2022. China and the United States dominated publication output, and cumulative all-affiliation output suggests that China overtook the United States around 2021-2022 despite its lower international collaboration ratio. The most productive institutions, led by the Chinese Academy of Sciences, shifted toward Chinese affiliations after 2018-2020. High-volume journals such as Frontiers in Immunology sustained routine output, whereas a small number of landmark papers in Nature dominated citation influence. Three recurrent hotspots emerged: viral triggers and NLRP3 activation mechanisms, the balance between antiviral defense and hyperinflammation, and NLRP3-associated cell death with therapeutic targeting. After 2022, trend topics shifted toward therapy, NRF2 regulation, diagnosis, and brain pathology, while clinical translation remained largely preclinical. This study delineates the advancements in NLRP3 inflammasome research related to viral infections by systematically mapping its evolutionary trajectory, core research trends, and priority future directions. The analysis outlines the structural and collaborative landscape of the field and may inform future mechanistic investigations, cross-institutional collaborations, and clinical research.
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7. Environmental circulation of multiple avian influenza subtypes and potential association with human infections in central China.
PMID:日期:2026-01-01Avian influenza viruses (AIVs) continue to circulate in live poultry markets (LPMs), posing potential risks for zoonotic exposure. This study investigated the environmental circulation of AIVs and their potential epidemiological associations with human infection in Henan Province, China. We analyzed 7,956 environmental samples collected from poultry-associated settings in Henan Province between 2020 and 2025. Multivariable logistic regression was used to identify factors associated with AIV detection. Serological surveillance was conducted among occupationally exposed individuals, and phylogenetic analyses were performed to characterize the genetic relationships between human-derived and environmental AIVs. A total of 1,460 samples (18.35%) tested positive for AIVs. LPMs were significantly associated with higher odds of AIV detection (OR = 7.211, 95% CI: 5.039-10.319, P < 0.001), and the odds of AIV detection increased over the surveillance period (OR = 1.254, 95% CI: 1.210-1.301, P < 0.001). Multiple AIV subtypes were detected, with H9N2 remaining predominant throughout the study period. Five human infections were identified, including H5N6 and H3N8 infections in 2022 and three H9N2 infections in 2025. Serological surveillance identified H9N2-seropositive and H3N8-reactive samples among occupationally exposed individuals. Phylogenetic analyses revealed genetic similarities between human-derived and environmental viruses. Three H3N8 viruses, including one isolated from a human case, formed a distinct phylogenetic cluster, with their internal genes closely related to co-circulating H9N2 viruses. These findings demonstrate sustained circulation of multiple AIV subtypes in poultry-associated environments and highlight the importance of integrated environmental and human surveillance for the early detection of viruses with zoonotic potential.
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9. Correction: Integrated microbial and transcriptomic profiling reveals distinct correlations in atrophic gastritis associated with liver cirrhosis.
PMID:日期:2026-01-01[This corrects the article DOI: 10.3389/fcimb.2026.1893991.].
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10. Heat stress-induced gut dysbiosis and multi-organ injury: mechanisms and therapeutic modulation.
PMID:日期:2026-01-01Heat stress (HS) is an increasingly prevalent environmental and exertional challenge. In severe cases, HS may progress to heatstroke, a life-threatening clinical syndrome characterized by severe hyperthermia, systemic inflammation, and multi-organ dysfunction. This review synthesizes evidence from laboratory rodent models and suggests that gut microbiota dysbiosis may act as a mediator and amplifier of HS-induced pathology. Across diverse rodent models, HS remodels the gut microbiota by reducing microbial diversity. These compositional changes are accompanied by decreased short-chain fatty acids, altered bile acid profiles, and increased lipopolysaccharide burden, although the specific metabolites affected vary across models. Causal evidence from fecal microbiota transplantation and gnotobiotic experiments supports microbiota-dependent amplification of intestinal barrier failure, hepatic inflammation, and neuroinflammation. In contrast, evidence for the gut-reproductive, gut-kidney, gut-heart, gut-muscle, and gut-adipose axes remains predominantly associative or derived from interventional correlations without formal causality testing. Targeting the gut-organ axis through probiotics, prebiotics, antioxidants, or functional amino acids offers promising but largely preclinical adjunctive strategies, with rapid cooling and supportive care remaining the foundation of heatstroke management. Future research should prioritize temporally resolved human studies, multi-omics integration, and causal validation to define the translational potential of microbiome-directed interventions.