POWDER TECHNOLOGY粉体技术
POWDER TECHNOLOGY(英文缩写 POWDER TECHNOL),ISSN 0032-5910,eISSN 1873-328X,中文译名:粉体技术 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.640 | Q1 |
| 2022 | 5.200 | Q1 |
| 2023 | 4.500 | Q2 |
| 2024 | 4.600 | Q2 |
| 2025 | 5.500 | Q2 |
POWDER TECHNOLOGY 最新收录文献
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1. Spray freeze dried niclosamide nanocrystals embedded dry powder for high dose pulmonary delivery.
1. 喷雾冷冻干燥的氯硝柳胺纳米晶体嵌入式干粉用于高剂量肺部递送PMID:日期:2022-12-13Based on the drug repositioning strategy, niclosamide (NCL) has shown potential applications for treating COVID-19. However, the development of new formulations for effective NCL delivery is still challenging. Herein, NCL-embedded dry powder for inhalation (NeDPI) was fabricated by a novel spray freeze drying technology. The addition of Tween-80 together with 1,2-Distearoyl-sn-glycero-3-phosphocholine showed the synergistic effects on improving both the dispersibility of primary NCL nanocrystals suspended in the feed liquid and the spherical structure integrity of the spray freeze dried (SFD) microparticle. The SFD microparticle size, morphology, crystal properties, flowability and aerosol performance were systematically investigated by regulating the feed liquid composition and freezing temperature. The addition of leucine as the aerosol enhancer promoted the microparticle sphericity with greatly improved flowability. The optimal sample (SF D-NLDT) showed the highest fine particle fraction of ∼47.83%, equivalently over 3.8 mg NCL that could reach the deep lung when inhaling 10 mg dry powders.
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2. A CFD-DEM investigation of powder transport and aerosolization in ELLIPTA® dry powder inhaler.
PMID:日期:2022-09We have performed Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) simulations of air and particles in a commercial ELLIPTA® inhaler. We simulated the fluidization, deagglomeration and transport of carrier and API particles, with two realistic inhalation profiles that are representative of moderate asthma and very severe COPD patients, and three different mouthpiece designs. In each of the ten cases simulated, we determined the fine particle fraction (FPF) in the stream leaving the mouthpiece, the temporal evolution of the spatial distribution of the particles, the mean air (slip) velocity seen by the carrier particles, and the average numbers and normal impact velocities of carrier-carrier and carrier-wall collisions inside the inhaler. In the cases examined, the air-carrier and carrier-carrier interactions affected the FPF, while the carrier-wall interactions were too infrequent to have a substantial effect. The simulations revealed the benefit of loading both blisters even when only a single medication needs to be delivered.
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3. Targeted delivery of inhalable drug particles in a patient-specific tracheobronchial tree with moderate COVID-19: A numerical study.
3. 中度COVID-19患者特异性气管支气管树中可吸入药物颗粒的靶向递送：一项数值研究PMID:日期:2022-05-17The coronavirus disease 2019 (COVID-19) pandemic has led to severe social and economic disruption worldwide. Although currently no consent has been reached on a specific therapy that can treat COVID-19 effectively, several inhalation therapy strategies have been proposed to inhibit SARS-CoV-2 infection. These strategies include inhalations of antiviral drugs, anti-inflammatory drugs, and vaccines. To investigate how to enhance the therapeutic effect by increasing the delivery efficiency (DE) of the inhaled aerosolized drug particles, a patient-specific tracheobronchial (TB) tree from the trachea up to generation 6 (G6) with moderate COVID-19 symptoms was selected as a testbed for the in silico trials of targeted drug delivery to the lung regions with pneumonia alba, i.e., the severely affected lung segments (SALS). The 3D TB tree geometry was reconstructed from spiral computed tomography (CT) scanned images. The airflow field and particle trajectories were solved using a computational fluid dynamics (CFD) based Euler-Lagrange model at an inhalation flow rate of 15 L/min. Particle release maps, which record the deposition locations of the released particles, were obtained at the inlet according to the particle trajectories. Simulation results show that particles with different diameters have similar release maps for targeted delivery to SALS. Point-source aerosol release (PSAR) method can significantly enhance the DE into the SALS. A C++ program has been developed to optimize the location of the PSAR tube. The optimized simulations indicate that the PSAR approach can at least increase the DE of the SALS by a factor of 3.2× higher than conventional random-release drug-aerosol inhalation. The presence of the PSAR tube only leads to a 7.12% change in DE of the SALS. This enables the fast design of a patient-specific treatment for reginal lung diseases.
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4. Automatic 3D cluster modelling of COVID-19 through voxel-based redistribution.
PMID:日期:2021-05-25Computational analysis of virus dynamics provides a non-contact environment for the study of the vital object. Cluster modelling is an essential step to investigate the properties of a group of viruses, and an automatic approach is required for massive 3D data processing. The morphological complexity of individual virus limits the application of smooth function algorithms with a regular-shaped assumption. This paper proposed a voxel-based redistribution approach to generate the virus cluster with COVID-19 input automatically. Representative elementary volume analysis was performed to address the statistical influence from the digital sample size. Coordination number analysis and surface density measurement were conducted with COVID-19 input and spherical input for comparison. The proposed approach is in natural compatibility with the lattice Boltzmann method for fluid dynamics analysis. A virtual permeation simulation was performed with the COVID-19 cluster and spherical cluster to demonstrate the necessity to include spike protein structure in the cluster modelling.
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5. Fragmentation dynamics of single agglomerate-to-wall impaction.
5. 单个团聚体与壁面碰撞的破碎动力学PMID:日期:2021-01-22The de-agglomeration characteristics of single agglomerate-wall impaction are examined using high-resolution shadowgraph imaging. Experiments are performed to investigate the effects of constituent particle size (D from 3-7 m) and air velocity on the individual size and velocity of de-agglomerated fragments at conditions relevant to dry powder inhalation systems. De-agglomerated fragment area and trajectories were used to differentiate between pseudo-elastic and inelastic collisions during de-agglomeration. Advanced image processing techniques have enabled provision of joint population distributions of fragment area and aspect ratio, which identify a bimodal dispersion of fragments during de-agglomeration. The bimodality is destroyed with increasing air velocity and also generally diminishes with time after impact. The experiment presented forms a platform for the detailed quantitative characterisation of de-agglomeration behaviour and can be useful towards the development and validation of related computational models for pharmaceutical dry powder inhalers.
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6. Erratum to "Fragmentation dynamics of single agglomerate-to-wall impaction" [Powder Technology 378 (2021) 561-575, DOI: 10.1016/j.powtec.2020.10.021].
6. 勘误：“单个团聚体撞击壁面的破碎动力学” [《粉末技术》378 (2021) 561-575，DOI:PMID:日期:2021-01-10[This corrects the article PMC8724865.].
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7. Atomic Force Microscopy to Identify Dehydration Temperatures for Small Volumes of Active Pharmaceutical Ingredients.
7. 原子力显微镜用于识别小体积活性药物成分的脱水温度PMID:日期:2019-09-16The environmental conditions associated with changing the hydration state of active pharmaceutical ingredients (API) are crucial to understanding their stability, bioperformance, and manufacturability. Identifying the dehydration event using < 1μg of material is an increasingly important challenge. Atomic Force Microscopy indentation mapping is implemented at controlled temperatures between 25-100°C, for nanoscale volumes of hydrated APIs exhibiting distinct dehydration behavior and anhydrous APIs as controls. For caffeine hydrate and azithromycin dihydrate, the relative mechanical modulus increases ~10-fold at dehydration temperatures. These are confirmed by conventional macroscopic measurements including Variable Temperature Powder X-ray Diffraction, Thermogravimetric Analysis, and Differential Scanning Calorimetry. Conversely, no such mechanical transition is observed for anhydrous ibuprofen or a proprietary anhydrous compound. AFM-based mechanical mapping is therefore demonstrated for small-volume determination of temperature-induced solid-state dehydration events, which may enable spatially or temporally mapping for future studies of dehydration mechanisms and kinetics, as a function of commercially relevant nanoscale heterogeneities.
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8. Computational Fluid Dynamics Analysis of the Venturi Dustiness Tester.
8. 文丘里粉尘测试仪的计算流体动力学分析PMID:日期:2017-05Dustiness quantifies the propensity of a finely divided solid to be aerosolized by a prescribed mechanical stimulus. Dustiness is relevant wherever powders are mixed, transferred or handled, and is important in the control of hazardous exposures and the prevention of dust explosions and product loss. Limited quantities of active pharmaceutical powders available for testing led to the development (at University of North Carolina) of a Venturi-driven dustiness tester. The powder is turbulently injected at high speed ( ~ 2 × 10) into a glass chamber; the aerosol is then gently sampled ( ~ 2 × 10) through two filters located at the top of the chamber; the dustiness index is the ratio of sampled to injected mass of powder. Injection is activated by suction at an Extraction Port at the top of the chamber; loss of powder during injection compromises the sampled dustiness. The present work analyzes the flow inside the Venturi Dustiness Tester, using an Unsteady Reynolds-Averaged Navier-Stokes formulation with the Shear Stress Transport turbulence model. The simulation considers single-phase flow, valid for small particles (Stokes number <1). Results show that ~ 24% of fluid-tracers escape the tester before the Sampling Phase begins. Dispersion of the powder during the Injection Phase results in a uniform aerosol inside the tester, even for inhomogeneous injections, satisfying a necessary condition for the accurate evaluation of dustiness. Simulations are also performed under the conditions of reduced Extraction-Port flow; results confirm the importance of high Extraction-Port flow rate (standard operation) for uniform distribution of fluid tracers. Simulations are also performed under the conditions of delayed powder injection; results show that a uniform aerosol is still achieved provided 0.5 s elapses between powder injection and sampling.
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9. The effect of operating conditions on resistance parameters of filter media and limestone dust cake for uniformly loaded needle felts in a pilot scale test facility at ambient conditions.
9. 在环境条件下的中试规模试验设施中，操作条件对均匀加载针刺毡的滤料和石灰石粉尘滤饼阻力参数的影响PMID:日期:2012-09Resistance parameters are essential for the prediction of pressure drop in bag filters. The reported values for limestone dust differ in magnitude and also depend on operating parameters. In this work, experimental data is provided from a pilot scale pulse-jet regenerated bag filter test facility for three types of needle felts using air and limestone dust at ambient conditions. Results reveal that specific resistance of filter media is independent of velocity while the specific resistance of filter cake increases linearly with filtration velocity. Residual pressure drop is almost constant, independent of upper pressure drop limit. The cake resistance at constant velocity fits to a second degree polynomial whereas it increases linearly with the velocity. A linear relation is reported here for all the cases. The resistance of filter cake decreases at higher upper pressure drop limit.
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10. Influence of operating parameters on cake formation in pilot scale pulse-jet bag filter.
10. 操作参数对中试规模脉冲喷吹袋式除尘器滤饼形成的影响PMID:日期:2012-07Bag filters are commonly used for fine particles removal in off-gas purification. There dust laden gas pervades through permeable filter media starting at a lower pressure drop limit leaving dust (called filter cake) on the filter media. The filter cakeformation is influenced by many factors including filtration velocity, dust concentration, pressure drop limits, and filter media resistance. Effect of the stated parameters is investigated experimentally in a pilot scale pulse-jet bag filter test facility where lime stone dust is separated from air at ambient conditions. Results reveal that filtration velocity significantly affects filter pressure drop as well as cake properties; cake density and specific cake resistance. Cake density is slightly affected by dust concentration. Specific resistance of filter cake increases with velocity, slightly affected by dust concentration, changes inversely with the upper pressure drop limit and decreases over a prolonged use (aging). Specific resistance of filter media is independent of upper pressure drop limit and increases linearly over a prolonged use.