Advanced Science先进科学
Advanced Science(英文缩写 ADV SCI),ISSN 2198-3844,eISSN 2198-3844,中文译名:先进科学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
Advanced Science 最新收录文献
-
1. Unlocking Li/Mg-Based Photochemical Nitration Platforms for Anticancer Drug Discovery.
PMID:日期:2026-09-25The low toxicity and cost-effectiveness of light main-group metal photochemical systems render them highly suitable for drug development, while the redox inertness of light main-group metals significantly hinders this goal. Herein, through the in situ assembly of readily available lithium nitrate, methoxyacetic acid, and aniline substrates, an unprecedented, mild lithium-based photochemical system capable of producing valuable nitro radicals is established. This system enables selective C(sp)-H (di-)nitration of anilines for synthesizing nitro-aromatic compounds as potential antitumor candidates. Further, replacing lithium nitrate with magnesium nitrate makes the reaction conditions milder, allowing lower-energy green-light irradiation for the (di-)nitration. The two main-group metal photochemical systems also enable direct late-stage functionalization of complex drug molecules, eliminating the risk of transition metal residue and drastically simplifying the workup procedures of pharmaceutical manufacturing processes.
-
2. Synergistic Effects in Multistate Black Electro-Thermochromic Smart Windows for Energy-Efficient Modulation of Solar Heating.
PMID:日期:2026-09-23Electrochromic and thermochromic smart windows are mature technologies that offer complementary strategies for regulating solar transmittance. To enhance their overall performance and mitigate key limitations associated with each approach, we present hybrid electro-thermochromic (ETC) smart windows. By integrating a black electrochromic layer composed of three complementarily-colored, redox-matched viologen molecules with a paraffin-particle-based thermochromic film, these hybrid devices deliver multiple synergistic functionalities: voltage-controlled, multimodal operation enabling both passive and active solar modulation; photothermal-assisted activation of the thermochromic layer driven by the strong solar absorption of the colored electrochromic state; efficient regulation of solar heat gain with a ten-fold reduction in electrical energy consumption for the electrochromic component; and near-complete suppression of sunlight transmission by simultaneous activation of both layers thanks to their complementary spectral responses. In energy-saving experiments in hot days, ETC windows achieved a maximum reduction of 8.5°C in solar heat gain relative to clear glass, in agreement with building-energy simulations predicting up to a 23% decrease in annual energy usage in low-latitude regions (e.g., Honolulu). Collectively, these results demonstrate the practical energy-saving potential of ETC smart windows, which offer a versatile and energy-efficient solution for dynamic solar control across diverse climatic conditions.
-
3. A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence.
PMID:日期:2026-09-23Endometrial cancer (EC) recurrence is strongly associated with enhanced tumor stemness. While lactate-a major tumor-derived metabolite-is known to promote immunosuppression across cancers, its contribution to EC stemness and recurrence remains poorly understood. In this study, we show that elevated protein lactylation in EC correlates with heightened tumor stemness and unfavorable prognosis. Mechanistically, a lactate-enriched microenvironment induces lactylation of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), thereby stabilizing and upregulating the protein. This modification enhances EC stemness by enabling IGF2BP3 to stabilize HMGA2 mRNA via an m6A-dependent pathway, activating downstream stemness-related transcriptional programs. This effect requires lysine 280 (K280) lactylation mediated by alanyl-tRNA synthetase 1 (AARS1), as either AARS1 depletion or IGF2BP3-K280 mutation abolishes lactylation and attenuates stemness. Both genetic and pharmacologic inhibition of IGF2BP3 lactylation markedly suppress tumor growth and stem-like properties in vitro and in vivo. Clinically, IGF2BP3-K280 lactylation correlates with aggressive clinicopathological features and poor survival, outperforming conventional biomarkers in recurrence prediction. Integration of IGF2BP3-K280 lactylation into a clinical nomogram substantially improved recurrence-risk stratification across multi-center cohorts. Collectively, these findings uncover a metabolic-epigenetic mechanism linking lactate metabolism to m6A-mediated stemness regulation, establishing IGF2BP3-K280 lactylation as both a therapeutic vulnerability and a precision biomarker for EC recurrence.
-
4. Towards a Compositional Framework for Describing Human Phenotypes.
PMID:日期:2026-09-22Deep phenotyping increasingly spans scales from macro to micro, yet heterogeneity in measurement and documentation still constrains standardization and limits comparability across cohorts. This study introduces a compositional framework that integrates the Phenotype Assembly Method (PhenoAM), Phenome Data Elements (PhenoDE), and a suite of large language model (LLM)-based PhenoAgents to support systematic, interpretable, and scalable phenotype standardization with quality assessment. PhenoAM decomposes phenotype descriptions into features and qualifiers to enable component-level mapping, while PhenoDE provides standardized representations of 58 371 phenotype data elements across 22 measurement platforms of the International Human Phenome Project (IHPP); pooled mapping coverage was 98.1% within the 18-platform analysis set and 99.8% across all 22 platforms. Using this representation, analyses of illustrative phenotypes from IHPP, National Health and Nutrition Examination Survey (NHANES), and the UK Biobank show that differences in features or qualifiers can influence data distributions and analytic outcomes, underscoring the importance of explicit measurement context in cross-cohort studies. PhenoAgents support semantic parsing, terminology candidate retrieval, and data-quality review through curator-assisted modules. PhenoDEs and their statistical distributions within IHPP are accessible on the PhenoDE Portal.
-
5. Self-Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease.
PMID:日期:2026-09-22Dry eye disease (DED) is a common ocular surface disorder closely associated with mitochondrial dysfunction and excessive accumulation of reactive oxygen species (ROS). However, existing treatments are limited by ocular surface barriers. This study developed an integrated nanomotor-based eye drop system (HPB@Lip@AB) combining self-propulsion, mitochondrial repair, and multiple antioxidant functions. The nanomotor consists of a hollow Prussian blue (HPB) nanozyme core loaded with ammonia borane (AB) as a molecular hydrogen (H) precursor, encapsulated within a liposomal shell to form a core-shell structure. In the DED microenvironment, HPB catalyzes the decomposition of hydrogen peroxide (HO) to generate oxygen bubbles, propelling the nanomotors to rapidly penetrate the tear film barrier. Following cellular uptake, AB is proposed to generate H in acidic intracellular environments, potentially acting synergistically with HPB to exert antioxidant, anti-apoptotic, and anti-inflammatory effects. This restores tear secretion, stabilizes the tear film, and repairs the corneal epithelium. H-related effects were associated with increased aldehyde dehydrogenase 1 family member L2 (ALDH1L2) expression, improved mitochondrial function, and reduced apoptosis and inflammation. Our nanomotor strategy enables efficient DED treatment through combined mechanisms, offering a promising platform for high-penetration ocular drug delivery.
-
6. Beyond Conventional: A Review of Phytochemical-Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management.
PMID:日期:2026-09-21Chronic wounds represent a global healthcare challenge, characterized by persistent inflammation, microbial infection, and compromised tissue regeneration, often refractory to conventional therapies. Natural phytochemicals, with their inherent diverse bioactivities, provide a multi-target approach to modulate inflammation and accelerate tissue repair, overcoming the limitations of single-agent interventions. However, their clinical utility is frequently limited by poor physicochemical stability, low bioavailability, and insufficient retention at the wound site. Advanced hydrogel platforms serve as effective delivery systems, capable of encapsulating these potent compounds to ensure localized, sustained, and on-demand release, addressing critical translational barriers. This review examines the wound-healing mechanisms and molecular targets of key phytochemical classes, critically analyzing their physicochemical limitations. We then discuss the rational design principles of phytochemical hydrogel systems, encompassing stimuli-responsive networks, externally triggered release modalities, and 3D-printed scaffolds for precise spatial drug distribution. We also highlight the emerging role of artificial intelligence in accelerating this field, from predicting hydrogel characteristics and screening novel phytochemicals to optimizing formulation strategies. Finally, we propose a strategic translational roadmap, addressing crucial aspects such as botanical standardization, scalable manufacturing, and regulatory pathways, to support the clinical translation of these systems.
-
7. {"_":"Wood Carbon Sponge/SiO Aerogel Composites with Anisotropic Broadband Microwave Absorption, Elastic Resilience, and Thermal Insulation.","sub":["2"]}
PMID:日期:2026-09-21Biomass-derived carbon aerogels have attracted considerable interest for lightweight microwave-absorption owing to their hierarchical porosity and renewability. While the structural anisotropy of natural wood is well recognized, its consequences for electromagnetic response remain largely unexplored. Herein, we utilize SiO aerogel-incorporated wood-derived carbon sponge as a model system to investigate its electromagnetic anisotropy in the axial, radial, and tangential directions. Governed by the aligned cellular architecture, a robust permittivity ordering (tangential > radial > axial) is revealed. Notably, the composite exhibits pronounced anisotropic absorption: the tangential direction achieves a minimum reflection loss of -64.1 dB, the radial direction delivers an ultra-broadband effective absorption bandwidth of 11.6 GHz (covering the entire X and Ku bands) at a thickness of only 4.95 mm, and the axial direction also maintains strong absorption, with the overall performance surpassing most biomass-derived carbon aerogels at comparable thicknesses. The composite also reveals a low thermal conductivity of ∼0.04 W/(m·K) and anisotropic compressibility. This work clarifies the intrinsic structure-electromagnetic-mechanical-thermal correlations in anisotropic wood carbon sponges and offers a bioinspired paradigm for advanced lightweight stealth materials with concurrent thermal insulation.
-
8. Ribonucleotides Amplify Mitochondrial DNA-Driven cGAS-STING Activation via FdUMP-ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy.
PMID:日期:2026-09-21Intracellular nucleotide imbalance between ribonucleotides and deoxyribonucleotides can trigger cytosolic mitochondrial DNA (mtDNA) release and subsequent activation of the cGAS-STING pathway. However, fluoropyrimidine-induced nucleotide imbalance is constrained by their metabolic instability. Here, we leverage ribonucleotides to amplify floxuridine (FUDR)-induced mtDNA release and cGAS-STING activation for enhanced cancer chemoimmunotherapy. We identified that cytidine monophosphate (CMP) significantly enhances FUDR-mediated activation of the mtDNA-driven cGAS-STING pathway, inducing over 300-fold upregulation of the interferon gene Ifnb1 and initiating STING-dependent antitumor immunity. Genome-wide CRISPR-Cas9 screening identified five pyrimidine-metabolizing enzymes (CMPK1, CMPK2, TYMP, UPP1, and UPP2) that are responsible for the metabolic instability of floxuridine monophosphate (FdUMP). CMP and its intracellular metabolites can metabolically block these enzymes, thereby increasing the peak intracellular concentration of FdUMP by over 500-fold and extending its half-life by more than 20-fold, which in turn promotes sustained intracellular nucleotide imbalance. To translate this mechanism into therapy, we co-encapsulated FdUMP and CMP into hybrid lipid nanoparticles (FC-NPs). FC-NPs robustly activated STING-dependent antitumor immunity, achieving remarkable therapeutic efficacy in multiple murine colorectal cancer (CRC) models. Our study not only addresses the long-standing issue of fluoropyrimidine metabolic instability but also reveals a novel ribonucleotide-mediated immunomodulatory mechanism, providing a promising strategy to potentiate chemoimmunotherapy in CRC.
-
9. Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer.
PMID:日期:2026-09-21Intrinsic resistance to anti-PD-1 immunotherapy remains a major obstacle in treating metastatic gastric cancer (GC), particularly in tumors harboring concurrent YAP hyperactivation and TP53 loss. Here, using a genetically engineered mouse model with conditional YAP hyperactivation and Tp53 deletion in gastric Atp4b cells (AYP), we show this "double-hit" alone suffices to recapitulate human refractory GC, including histopathological heterogeneity, multi-organ metastasis, and intrinsic PD-1 resistance. We identified BST2 as a direct YAP-TEAD transcriptional target. In human GC, BST2-high tumor correlates with poor anti-PD-1 response. Mechanistically, tumor cell-derived BST2 engages the inhibitory receptor PIRA2 on neutrophils and liver Kupffer cells, instructing an immunosuppressive, pro-metastatic phenotype that inhibits T cells antitumor response and confers PD-1 resistance. Therapeutically, dual BST2/PD-1 blockade in the AYP model suppresses primary tumor growth and eradicates established liver metastases. Thus, YAP activation, cooperating with TP53 loss, fuels metastatic GC and immunotherapy resistance via BST2 induction.
-
10. {"_":"Dual-Targeted Biomimetic MoSe Nanozymes for Enhancing Peri-Implant Soft Tissue Integration.","sub":["2"]}
PMID:日期:2026-09-21Peri-implant diseases (PID) remain major threats to titanium implant longevity, largely due to insufficient soft tissue integration (STI), which weakens the biological seal and promotes a pathogenic-immunological amplification loop involving early Staphylococcus aureus colonization and oxidative stress-induced macrophage dysfunction. Here, we developed a dual-targeting biomimetic nanozyme platform by camouflaging molybdenum diselenide (MoSe) nanoflowers with membranes derived from S. aureus-pre-stimulated macrophages (SPMM). This biomimetic design couples S. aureus-targeting of SPMM with the photothermal activity of MoSe to achieve targeted contact-enhanced bacterial eradication, while integrating macrophage-targeting of SPMM with reactive oxygen species (ROS)-scavenging activity of MoSe to alleviate oxidative stress in macrophages. By disrupting the pathogenic-immunological amplification loop, MoSe@SPMM reshaped a pro-regenerative peri-implant immune microenvironment. In a rat implantation model, near-infrared (NIR)-triggered MoSe@SPMM suppressed bacterial colonization, promoted macrophage reprogramming, and preserved endothelial and fibroblast functions, thereby enhancing angiogenesis, matrix remodeling, connective tissue attachment, and integrin-mediated tissue-implant adhesion. This biomimetic nanozyme strategy provides a rational framework for coordinating pathogen control and immune regulation to promote peri-implant STI.