PROGRESS IN LIPID RESEARCH脂质研究进展
PROGRESS IN LIPID RESEARCH(英文缩写 PROG LIPID RES),ISSN 0163-7827,eISSN 1873-2194,中文译名:脂质研究进展 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 14.673 | Q1 |
| 2022 | 13.600 | Q1 |
| 2023 | 14.000 | Q1 |
| 2024 | 14.900 | Q1 |
| 2025 | 18.100 | Q1 |
PROGRESS IN LIPID RESEARCH 最新收录文献
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2. Diet, microbiota, and lipidomics: How fatty acids shape the endocannabinoidome and host metabolism.
PMID:日期:2026-07-07The endocannabinoidome (eCBome) is a complex lipid signaling network that integrates metabolic, immune, and neurobehavioral processes in response to environmental cues. Dietary lipids and gut microbiota have emerged as major modulators of its activity and signaling tone. Intake of specific fatty acids, including the monounsaturated oleic acid, the omega-6 polyunsaturated linoleic acid, and omega-3 polyunsaturated fatty acids, influences the eCBome not only by serving as structural precursors of bioactive lipid mediators, but also by altering the relative abundance of these mediators through changes in substrate availability, enzymatic competition, and receptor-mediated feedback loops. Concurrently, gut microbiota shape host eCBome signaling by regulating lipid metabolism, inflammatory tone, and intestinal barrier integrity, while eCBome mediators reciprocally modulate microbial composition and function. Dysregulation of this complex diet-microbiota-eCBome interplay has been implicated in the pathogenesis of metabolic disorders, chronic inflammation, and neuropsychiatric conditions. In this review, we critically examine the molecular mechanisms underlying the interactions between dietary lipid composition, gut microbial ecology, and eCBome signaling. We discuss the implications for human health and highlight emerging diet-based therapeutic strategies targeting this axis.
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3. Iron and lipid dysregulation as key determinants of ferroptosis in cardiometabolic disease.
PMID:日期:2026-07-01Cardiometabolic diseases (CMD) are a major global health threat. Given their multifactorial pathogenesis, understanding the interconnected mechanisms driving disease progression is essential. Ferroptosis, an iron-dependent form of regulated cell death characterized by iron accumulation, lipid peroxidation, and compromised antioxidant defenses, is emerging as a promising target for therapeutic intervention in CMD. Growing evidence underscores the intricate interplay among iron metabolism, redox homeostasis, and lipid metabolism in regulating ferroptosis and CMD. Notably, we propose the concept of an "iron paradox" as an integrative framework to synthesize these observations. Despite representing opposite systemic iron states, both iron deficiency and iron overload can converge on ferroptotic vulnerability by disrupting subcellular iron trafficking, mitochondrial function, lipid remodeling, and antioxidant defense. This framework emphasizes that ferroptosis risk in CMD is not primarily governed directly by absolute iron abundance, but more so the interaction between redox-active iron, PUFA-containing phospholipids and lipid peroxide detoxification systems. We then describe the molecular regulation of ferroptosis, with a focus on disruptions in iron and lipid homeostasis as drivers of lipid peroxidation. The contribution of these cellular changes to CMD pathophysiology is then described. Finally, we summarize preclinical evidence supporting ferroptosis-targeted interventions and outline future directions for translational research and therapeutic innovation.
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4. 5,6-epoxycholestanols metabolism and functions: Defining the epoxycholestanoid (EChA) family.
4. 5,6-环氧胆甾醇的代谢和功能：定义环氧胆甾醇（EChA）家族PMID:日期:2026-05-26The oxidation of cholesterol at the Δ double bond generates 5,6-epoxycholestanols (5,6-ECs), which exist as two diastereoisomers, 5,6α-EC and 5,6β-EC. These metabolites define a distinct branch of sterol metabolism that integrates redox chemistry with receptor signaling. Once considered artefactual autoxidation products, 5,6-ECs are now recognized as regulated intermediates arising from enzymatic, oxidative, and environmental sources, and yielding structurally and functionally diverse metabolites, here termed the epoxycholestanoid (EChA) family. Cholesterol-5,6-epoxide hydrolase (ChEH; EBP/DHCR7 complex) converts 5,6-ECs into cholestane-3β,5α,6β-triol (CT), which is subsequently oxidized by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) to form 6-oxocholestan-3β,5α-diol (OCDO), a glucocorticoid receptor (GR)-biased agonist that promotes tumor growth. In parallel, 5,6α-EC undergoes stereoselective conjugation with histamine to generate dendrogenin A (DDA), an endogenous liver X receptor β (LXRβ)-biased agonist that displays tumor suppressive and neurostimulating functions. These opposing OCDO-GR and DDA-LXRβ pathways are embedded in enzyme-coupled feedback loops that link oxidative stress, sterol metabolism, and transcriptional control. This review integrates lipidomics, enzymology, receptor pharmacology, and disease biology to define the EChA family as a conserved redox-responsive signaling network at the interface of cholesterol metabolism, inflammation, ageing, and disease, offering new opportunities for biomarker discovery and therapeutic intervention.
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5. Oxysterols and bile acids - From intertwined biosynthesis to combined quantification.
PMID:日期:2026-04-14Oxysterols and bile acids, historically viewed as cholesterol byproducts, are now a center of research interest for their roles in physiological and pathological processes. Here we explore the complexities of oxysterol metabolism and bile acid biosynthesis, highlighting the intricate interplay of enzymes in the oxysterome and the network of intermediates in bile acid synthesis. The biological importance of these compounds has led to the development of methods for quantifying them. As discussed here, while these methods provide useful information for biological studies, future methods for the combined analysis of oxysterols and bile acids would further accelerate research in the field, and enable a better understanding of bile acid pathways and the associated diseases. This review provides an overview of the current understanding of oxysterol metabolism and bile acid biosynthesis, highlighting metabolic pathways, analytical challenges, and their relevance to inherited disorders of bile acid metabolism.
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6. Plasma membrane lipids at plant-pathogen interfaces: Regulators of immunity and susceptibility.
PMID:日期:2026-03-21Plants in their natural habitats encounter abiotic and biotic stress factors, making sensing and responding to stresses integral components of their lifestyle. The ability to respond to environmental cues is essential for plant fitness, and thus, plants have evolved molecular mechanisms to cope with these challenges. This review updates recent advances in understanding how plasma membrane (PM) biology contributes to plant responses against biotic stresses. Emphasis is placed on the dynamic roles of membrane lipids, which play crucial roles in defining protein composition and function of the PM at the plant-pathogen interface. Emerging insights into PM nanostructure and lipid-mediated signaling reveal how rapid, dynamic and localized lipid remodeling supports effective defense activation during pathogen attack. Evidence from various plant models suggests that multi-layered regulatory mechanisms control the lipid composition of the PM, enabling plants to manage intrinsic PM properties and hence, processes that minimize the susceptibility to pathogen exploitation. From the pathogens' perspective, successful infection requires subverting plant defenses and manipulating host PM function for colonization. A deeper understanding of plant PM dynamics during pathogen challenge will provide knowledge for crop improvement strategies, opening novel avenues to enhance resistance at the frontline of plant-pathogen interactions.
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7. Nature, functions and trafficking of membrane lipids to support autophagosome formation in plant cells.
PMID:日期:2026-03-21Throughout development and in response to fluctuating environmental conditions, plants rely on autophagy to degrade and recycle cytoplasmic material thereby maintaining cellular homeostasis. This pathway is characterized by the de novo formation of double-membrane vesicles, the autophagosomes, that selectively sequester and deliver cargo to the vacuole for degradation. The biogenesis of these specialized structures is driven by intense membrane remodelling events of which both lipid quantity and quality are emerging key actors. Recent advances have unraveled the singular lipid composition of autophagic membranes, provided mechanistic insights into the functions of membrane lipids during autophagy and highlighted critical determinants of lipid transport for membrane expansion during autophagosome formation. In this review, we synthesize current knowledge on the nature, functions and trafficking of membrane lipids during autophagy with a particular focus on the model plant Arabidopsis thaliana. We further discuss outstanding questions regarding lipids dynamics and lipid-protein cooperation in autophagic membranes and compare lipid-related mechanisms in plants to that of other organisms. Together, these advances expand the conceptual framework of autophagy and underscore lipids as key regulators of plant acclimation and survival.
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8. State-of-the-art on absorption mechanisms and factors affecting the bioavailability of preformed vitamin A.
PMID:日期:2026-03-17Vitamin A deficiency remains a major health issue in many countries. Two types of vitamin A are naturally present in our diet, provitamin A carotenoids from plant sources and preformed vitamin A, mainly retinyl esters and retinol, found in animal products, fortified foods and supplements. The objective was to review current knowledge and gaps in understanding the mechanism and factors influencing preformed vitamin A bioavailability. The results show that the fate of retinyl esters in the intestine is well described, but that of retinol deserves further investigation. Preformed vitamin A present in liver, oil, sugar, and milk is well absorbed (70 to 99%), but data for other important matrices like eggs and fortified flours is lacking. The impact of the type and quantity of dietary lipids is unclear, especially whether low levels in a meal would be sufficient for optimal vitamin A absorption. Further research is needed to evaluate the effect of plant proteins and dietary fibers for which results are conflicting. The impact of host related factors like age is limited, and largely unknown for gender and genetic/epigenetic factors. It is well established that inflammation and other metabolic disorders affect vitamin A status, yet further study could help to distinguish absorption issues from other metabolic processes. An interesting avenue is the possible role of microbiota and probiotics on vitamin A absorption, as it could represent a complementary approach to food fortification. Further clinical research should prioritize the use of tracers to better quantify absorption under various nutritional conditions.
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9. Oxylipin profile data analysis: Current methodologies, challenges, and future directions.
PMID:日期:2026-03-06Oxylipins are bioactive lipid mediators derived from the enzymatic and non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). They play diverse and potent roles in biological processes, with increasing relevance to a wide range of diseases and dietary interventions. While significant advances have been made in oxylipin profiling using targeted mass spectrometry-based techniques, challenges remain in the interpretation, integration, and visualization of these complex datasets. This review critically evaluates current methodologies, highlighting the application of classical statistical tests, regression models, and multivariate statistical methods (MSMs). MSMs, such as principal component analysis, partial least squares discriminant analysis, and non-metric multidimensional scaling, offer key advantages for exploring high-dimensional, collinear oxylipin datasets and are well-suited for both cross-sectional and time-course study designs. Newer approaches, including machine learning and deep learning models, are emerging as powerful tools but are currently constrained by data availability. We also review the integration of oxylipins into multi-omics frameworks and pathway-based analyses, highlighting opportunities and limitations in bioinformatics infrastructure. Finally, we propose future directions to enhance the biological interpretability of oxylipin data through pathway enrichment tools and incorporation into established omics platforms. Together, these developments will strengthen the understanding of oxylipin roles in systems biology and translational lipid research.
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10. Nutrigenomics of fat-soluble vitamins and micronutrients in hepatocyte lipotoxicity and MASLD.
10. 脂溶性维生素和微量营养素在肝细胞脂毒性和MASLD中的营养基因组学PMID:日期:2026-03-06Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent liver disorder deriving from the chronic exposure to hepatocyte steatosis and its lipotoxicity effects, as mitochondrial dysfunction, overactivation of stress response and inflammatory genes, and cell death signaling. Genomics and post-genomic disciplines are now offering unprecedent opportunities in disease mechanisms characterization, precision diagnostics, and treatment. These disciplines include nutrigenomics, i.e. the use of genomics techniques to study the health effects of the interaction between diet/nutrients and the genome. Its applications can be particularly useful to study lifestyle and dietary modifications, and to assess the efficacy of nutritional interventions through the criteria of precision medicine. Specific examples include interventions with fat-soluble vitamins and other lipid nutrients as omega-3 fatty acids, which have shown cytoprotective properties and molecular effects useful in modulating key steps of the hepatocellular lipotoxicity process, such as lipid biosynthesis, lipid peroxidation inflammatory gene activation and cell death signaling. Other applications of nutrigenomics concern drug discovery and preclinical studies to explore therapeutic mechanisms, efficacy and safety of new vitamin products and nutraceuticals. This review discusses current evidence on hepatocyte lipotoxicity and its nutrigenomic exploration to identify disease mechanisms, nutritional defects and intervention strategies with these lipid nutrients. Their properties, limitations, and potential for translation in the prevention and clinical management of MASLD are critically evaluated.