YONSEI MEDICAL JOURNAL延世医学杂志
YONSEI MEDICAL JOURNAL(英文缩写 YONSEI MED J),ISSN 0513-5796,eISSN 1976-2437,中文译名:延世医学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.052 | Q2 |
| 2022 | 2.400 | Q3 |
| 2023 | 2.600 | Q1 |
| 2024 | 2.800 | Q1 |
| 2025 | 3.100 | Q1 |
YONSEI MEDICAL JOURNAL 最新收录文献
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1. Urinary Albumin-to-Creatinine Ratio and Risk of Incident Cardiovascular Disease in the KoGES-ARIRANG Community-Based Cohort.
PMID:日期:2026-10-01We aimed to assess whether low-grade albuminuria, characterized by a low urinary albumin-to-creatinine ratio (UACR) within the normal range (<30 mg/g), could predict cardiovascular disease (CVD) risk in a low-risk general population, with an emphasis on sex- and menopause-specific differences. We analyzed data from 1327 participants from the Korean Genome and Epidemiology Study, excluding individuals with known CVD or major chronic illnesses, who were followed up for a median of 6.37 years. The UACR was measured from spot urine samples and treated as a continuous variable. The cardiovascular outcomes included stroke, myocardial infarction, and angina. Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between UACR and incident CVD, stratified by sex and menopausal status. No significant association was observed between UACR and CVD in men or premenopausal women. However, in postmenopausal women, UACR was significantly associated with incident CVD (adjusted hazard ratio 1.09; 95% confidence interval: 1.01-1.18 per 1 mg/g increase). Spline analyses revealed a clear dose-response relationship in postmenopausal women, whereas no such pattern was observed in the other subgroups. Covariate-stratified analyses suggested a potential interaction effect of body mass index, blood pressure, and lipid profile. Low-grade albuminuria may serve as an early biomarker of cardiovascular risk in otherwise healthy individuals, particularly in subgroups susceptible to hormonal or metabolic changes. Routine UACR screening may be a practical tool for early risk stratification and prevention of CVD.
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2. Real-World Impact of Cardiac Rehabilitation Education and Therapy on Clinical Outcomes after Acute Myocardial Infarction: A Korean Cohort Analysis.
PMID:日期:2026-10-01Cardiac rehabilitation (CR) is central to tertiary prevention after acute myocardial infarction (AMI), but the prognostic impact of different education and therapy patterns in Asian real world practice is uncertain. Using Korean National Health Insurance Service claims (2018-2022), we identified patients aged ≥40 years hospitalized for AMI who underwent thrombolysis, percutaneous coronary intervention, or coronary artery bypass grafting. CR exposure was classified into six groups by structured education and the number of supervised therapy sessions, and outcomes over 2 years included all cause readmission, readmission and emergency room (ER) visits for MI or unstable angina (UA), all cause mortality, repeat revascularization, and stroke. Multivariable Cox models estimated adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Among 92968 patients, 85.5% received no CR, 3.2% had education only, and 11.3% received any therapy. Education only participants had the lowest crude rates of mortality, cardiovascular readmission, and repeat revascularization. All CR exposed groups showed lower all cause mortality, with the greatest benefit in education plus ≥4 therapy sessions (HR 0.257, 95% CI 0.123-0.539) and ≥4 therapy sessions without education (HR 0.291, 95% CI 0.203-0.417). Education focused CR was additionally associated with lower cardiovascular readmission and repeat revascularization, whereas readmission and ER visits varied across therapy intensive groups. In this nationwide Korean AMI cohort, CR participation, especially with education, was associated with substantial mortality reduction, suggesting structured education as a pragmatic cornerstone of tertiary prevention, with supervised therapy providing incremental benefit when available.
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3. Achieving Correction and Mitigating Complications in Adult Spinal Deformity through an Anterior-Posterior Combined Approach.
PMID:日期:2026-10-01To evaluate whether incorporating an anterior stage into adult spinal deformity (ASD) correction surgery with apical segment interbody fusion can reduce surgical invasiveness and enhance radiologic correction compared to a posterior-only approach. A retrospective review was conducted using a prospectively collected database from a single institution. A total of 150 ASD patients who underwent surgery between January 2014 and May 2021 and were followed for at least 2 years were included. Among them, 108 underwent a posterior-only approach (P group), and 42 underwent a combined anterior-posterior approach (AP group). Radiologic outcomes, bone fusion rates, clinical outcomes, and complications were assessed at baseline, immediately postoperatively, and at 2 years postoperatively. The AP group received an average of 2.2±0.6 levels of interbody fusion at the deformity apex. Compared to the P group, the AP group had significantly lower Schwab grade of posterior osteotomy, reduced total blood loss, and shorter posterior operative time. The AP group demonstrated a significantly greater coronal correction of the major Cobb angle. Regarding sagittal balance, the AP group also achieved more harmonious alignment across most parameters throughout the 2-year follow-up, although the differences were not statistically significant. Clinical outcomes, complication rates, and fusion rates were comparable between the two groups. Adding an anterior stage of apical segment interbody fusion to spinal deformity correction can achieve reduced surgical invasiveness and better spinal alignment without increasing the risk of major complications.
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4. Association between Early-Onset Metabolic Diseases and Adverse Mental Health Conditions: A Nationwide Cross-Sectional Study.
PMID:日期:2026-10-01Though metabolic diseases increasingly affect younger populations, their mental health implications remain poorly understood. We examined associations between age at metabolic disease diagnosis and mental health conditions, comparing early-onset (age <40 years) and late-onset (age ≥40 years) cases. We analyzed the 2014-2023 Korea National Health and Nutrition Examination Survey. Participants reported physician-diagnosed hypertension, diabetes, or dyslipidemia, with age at diagnosis. Mental health conditions included depression, perceived stress, and suicidality. Depression was assessed using the Patient Health Questionnaire-9, perceived stress through self-reported daily experiences, and suicidality as the presence of suicidal ideation, planning, or attempts within the past year. Associations were examined using multiple logistic regression with Bonferroni correction. Early-onset hypertension [odds ratio (OR)=2.67; 95% confidence interval (CI): 1.91-3.74] and dyslipidemia (OR=2.55; 95% CI: 1.71-3.79) showed higher odds of depression compared to undiagnosed and late-onset cases (-diff.<0.001 and -diff.=0.001, respectively). Early-onset hypertension (OR=1.41; 95% CI: 1.21-1.66) and dyslipidemia (OR=1.90; 95% CI: 1.59-2.26) showed higher odds of perceived stress compared to undiagnosed and late-onset cases (both -diff.<0.001). Early-onset diabetes (OR=2.76; 95% CI: 1.79-4.25) showed higher odds of suicidality compared to undiagnosed and late-onset cases (-diff.<0.001). Early-onset metabolic diseases showed stronger associations with adverse mental health conditions than late-onset cases, with patterns suggesting these associations were not primarily explained by disease duration. While the cross-sectional design limits causal inference, mental health screening in early-onset metabolic disease care could be considered.
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5. Medical Expulsive Therapy after Extracorporeal Shock Wave Lithotripsy: A Systematic Review and Network Meta-Analysis.
PMID:日期:2026-10-01Medical expulsive therapy (MET) after extracorporeal shock wave lithotripsy (ESWL) remains a subject of debate. We aimed to evaluate the comparative efficacy and safety of various pharmacological interventions using a network meta-analysis (NMA) of 21 randomized controlled trials (RCTs). A systematic search of PubMed, EMBASE, and the Cochrane Library was conducted through 2024 (Open Science Framework registered). We included only purely pharmacological RCTs, strictly excluding non-randomized studies and device-assisted trials. A Bayesian NMA was performed to estimate odds ratios and the surface under the cumulative ranking curve (SUCRA) for stone-free rates and complications. Twenty-one RCTs involving 3262 patients were analyzed. The tamsulosin-tadalafil combination was identified as the most effective strategy (SUCRA: 93.8%), followed by tamsulosin-corticosteroid (78.2%) and boron supplementation (67.9%). Notably, while silodosin is often superior for single intact stones, it ranked relatively low in the post-ESWL setting (SUCRA: 20.9%). All agents showed acceptable safety profiles without significant serious adverse events compared to controls. The tamsulosin-tadalafil combination represents the optimal pharmacological adjunct to ESWL. Our findings suggest that effective post-ESWL MET requires a broad therapeutic approach targeting multi-segmental ureteral relaxation and inflammation to clear fragment "showers," distinguishing it from the management of solitary ureteral stones.
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6. Incidence and Outcomes of Bloodstream Infections in Critically Ill Patients with COVID-19: A Nationwide Multicenter Study in South Korea.
PMID:日期:2026-10-01Coronavirus disease 2019 (COVID-19) increases the risk of bloodstream infections (BSI), but associated risk factors remain incompletely characterized. We aimed to evaluate BSI risk factors in patients admitted to the intensive care unit for COVID-19. This nationwide multicenter study, conducted across 22 university-affiliated hospitals in South Korea, included COVID-19 patients treated with high-flow nasal cannula (HFNC) therapy or mechanical ventilation. Baseline characteristics were compared between patients who developed BSI within 30 days and those who did not. Pathogens were analyzed, risk factors were evaluated using multivariable logistic regression, and supplementary Cox proportional hazards analyses were performed to address time-dependent outcomes. Of 573 included patients, 206 (35.9%) developed at least one BSI episode. species were the most frequent isolates. Gram-negative bacteria became increasingly prevalent over time, while fungal infections were associated with prolonged hospitalization. Multivariable analysis identified chronic neurological disease, higher baseline Sequential Organ Failure Assessment score, mechanical ventilation, prone positioning, and extracorporeal membrane oxygenation (ECMO) use prior to infection as independent BSI predictors. Notably, although crude in-hospital mortality was significantly higher in the BSI group (41.5% vs. 31.7%, =0.012), BSI was not an independent predictor of in-hospital mortality in either logistic regression or Cox analyses. In critically ill patients with COVID-19, high baseline severity, chronic neurological disease, and pre-infection advanced life support (mechanical ventilation and ECMO) were independent predictors of BSI. Rather than acting as an independent cause of death, BSI primarily serves as a clinical marker of extreme illness severity and prolonged invasive interventions.
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7. Borderline Personality Disorder in South Korea: A Narrative Review of Clinical Research and Future Directions.
PMID:日期:2026-10-01South Korea has one of the highest suicide rates among developed countries, with suicide being the leading cause of death among individuals in their teens to 40s. Despite this serious situation, systematic interventions for suicide prevention remain limited, particularly concerning borderline personality disorder (BPD), which is strongly associated with suicidality. This narrative review examines 11 empirical studies involving clinically diagnosed BPD samples in South Korea, focusing on the prevalence, clinical characteristics, and treatment challenges of BPD within the Korean sociocultural context. The available evidence suggests that BPD is substantially underrecognized in South Korea, with a prevalence rate considerably lower than international estimates and a relatively older mean age of onset, likely reflecting the impact of mental health stigma and barriers to care. Korean individuals with BPD also demonstrate marked functional impairment and a strong association with suicidality, with sociocultural factors further complicating treatment engagement and outcomes. These findings highlight the need for earlier identification and timely diagnosis, broader implementation of evidence-based treatments, and greater dissemination of generalist treatment models and basic training for frontline clinicians. Such coordinated efforts may also contribute to suicide prevention efforts in the country.
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8. Erratum to "Pharmacogenetic Risk Factors for Thiopurine-Induced Leukopenia in Patients with Inflammatory Bowel Disease" by Boo EK, et al. (Yonsei Med J 2026;67(8):603-615).
PMID:日期:2026-09-01This corrects the article on p. 603 in vol. 67, PMID: 42494268.
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9. Predicting Functional Prognosis in Supratentorial Stroke Using [¹⁸F]Fluoro-2-deoxy-D-glucose Positron Emission Tomography.
PMID:日期:2026-09-01Cerebral metabolic activity following stroke plays a crucial role in neurological recovery. This study aimed to investigate whether decreased cerebral metabolic activity, quantified by the asymmetry index (AI) using [¹⁸F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET), predicts functional prognosis at 3 and 6 months in patients with supratentorial stroke. Forty patients with a first-time supratentorial stroke were enrolled. Neurological status was quantified using the National Institutes of Health Stroke Scale (NIHSS) and the Motricity Index (MI) at baseline (time of PET acquisition), and at 3 and 6 months after stroke onset. Using PET imaging, metabolic AI was calculated for both the cerebral and cerebellar hemispheres. Correlations between AI and neurologic outcomes were analyzed according to the timing of PET acquisition, classified as the acute (1-14 days) or subacute (15-60 days) phases. In the subacute group, cerebral AI showed significant correlations with NIHSS scores at baseline (r=0.511, <0.01) and with both NIHSS (r=0.589, <0.01) and MI (r=-0.479, <0.01) at 3 months. These correlations strengthened at 6 months for both NIHSS (r=0.724, <0.01) and MI (r=-0.744, <0.01). However, no significant correlations were found between cerebral AI and neurological outcomes in the acute group. Cerebellar AI did not correlate with functional outcomes at any time point. Cerebral metabolic asymmetry measured during the subacute phase of supratentorial stroke is a significant predictor of long-term neurological outcomes at 3 and 6 months.
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10. Effect of a Tinnitus Sound Therapy Application on Tinnitus Relief.
PMID:日期:2026-09-01This study aimed to evaluate the effectiveness of a smartphone-based sound therapy application in patients with chronic subjective tinnitus. A total of 121 participants were recruited, and 72 were included in the final analysis. Participants were instructed to use a sound therapy application on their personal smartphones for 6 months. Assessments were conducted at baseline, 3 months, and 6 months. Outcome measures included tinnitogram, Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI), tinnitus-related subjective measures (loudness, annoyance, and stress), and two-channel electroencephalography (EEG). The mean age of participants was 53.36±11.79 years, with an average tinnitus duration of 49-58 months. Significant improvements were observed over time. THI scores decreased significantly (=0.006), as did BDI scores (=0.002). Among subjective measures, right-ear annoyance and stress levels significantly decreased (both =0.001), whereas tinnitogram loudness matching and subjective loudness did not show significant changes. EEG analysis demonstrated significant reductions in theta (=0.004) and alpha power (=0.015), with more pronounced decreases in mid-beta, high-beta, and gamma bands (all <0.001). Gamma power declined from 5.57 at baseline to 4.56 at 6 months, while low-beta power showed no significant change (=0.319). Smartphone-based sound therapy may reduce tinnitus-related distress and psychological symptoms. Further studies are needed to confirm long-term effects and generalizability.