Annual Review of Analytical Chemistry分析化学年度综述
Annual Review of Analytical Chemistry(英文缩写 ANNU REV ANAL CHEM),ISSN 1936-1327,eISSN 1936-1335,中文译名:分析化学年度综述 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 12.400 | Q1 |
| 2022 | 8.000 | Q1 |
| 2023 | 5.900 | Q1 |
| 2024 | 7.500 | Q1 |
| 2025 | 8.300 | Q1 |
Annual Review of Analytical Chemistry 最新收录文献
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1. Immunometabolomics Applied to Physical Exercise: Accomplishments and New Directions for Health Improvement.
PMID:日期:2026-05-01Immunometabolomics is a multidisciplinary field that explores how metabolic pathways regulate immune cell function, using metabolomics-the large-scale analysis of small molecules (metabolites)-to map these interactions in health and disease. Emerging evidence highlights that metabolic shifts are not merely by-products but key drivers of exercise-induced immune adaptations, with significant implications for performance, recovery, and disease prevention. This narrative review summarizes the latest findings on how exercise shapes immune responses through metabolic pathways. We discuss how key metabolites, such as succinate, itaconate, lactate, short-chain fatty acids, and kynurenine, act as molecular links between energy metabolism and immune regulation during and after exercise. We also investigate the effects of physical exercise on immunometabolic profiles within distinct tissues, elucidating their roles in promoting either proinflammatory or anti-inflammatory adaptations. Methodological advances in metabolomics and multi-omics are also addressed. Our review highlights robust evidence from human trials that physical exercise reprograms immunometabolic pathways in a time-, tissue-, and modality-specific manner, supporting its role in both health maintenance and clinical interventions.
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2. Carbon Nanofibers for Mass-Producible Electrochemical Transducers for Point-of-Care Testing.
PMID:日期:2026-05-01Carbon nanofibers (CNFs) possess inherent 3D-porous architecture that facilitates the development of highly sensitive electrochemical transducers. Their fabrication via laser-induced carbonization provides advantages such as mass production capability, outstanding electroanalytical performance, and preserved full beneficial features even when integrated into miniaturized systems. Moreover, the overall manufacturing cost is relatively low in comparison to conventional techniques, making the laser-generated CNFs favorable as electrochemical transducers in point-of-care testing (POCT). This review highlights the key studies representing the formation of CNF electrodes and their functional hybrids realized from laser-carbonization technology, which reflect a clear new trend in the field. The morphologies of laser-generated CNF electrodes from various substrates, how they can be conveniently integrated into POCT devices, and their superior analytical performance are discussed. The mass-producible 3D-porous CNF electrodes via laser carbonization will pave the way for efficient translation into the next generation of POCT devices, not only for sensing but also for self-powering devices.
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3. {"_":"Application of Ambient Ionization Mass Spectrometry to the Analysis of .","i":["Cannabis"]}
PMID:日期:2026-05-01To circumvent multiple challenges associated with analysis by conventional methods such as gas chromatography (GC), liquid chromatography (LC), and hyphenated techniques such as GC and LC mass spectrometry (MS), there is increasing interest in the application of ambient ionization mass spectrometry (AIMS) for its chemical characterization, as this approach can in principle address several of the issues associated with interrogation of -derived complex matrix samples. Among the advantages that these methods confer are rapid analysis times; limited or no need for sample pretreatment steps; detection of a range of compound classes in a single analysis, including cannabinoids, terpenes, flavonoids, and pesticides; avoidance of nuanced method development tailored to particular analyte classes; and the ability to analyze samples in their native forms. This review highlights the progress thus far in the nascent area of application of AIMS approaches to and -derived materials, and the further developments required in order for AIMS methods to be more widely adopted for routine analysis.
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4. From Function to Single Cells: Analytical Innovations in Islet Biology and Diabetes Research.
PMID:日期:2026-05-01Islets of Langerhans are the endocrine portion of the pancreas, which release different peptide hormones to control blood glucose. Release of these hormones is perturbed in a number of metabolic diseases, highlighting the necessity for understanding the biology of this tissue. Several notable analytical approaches have been developed to study islets and their secreted hormones, including the Nobel Prize-winning discovery of insulin, the determination of its amino acid sequence, and the development of the radioimmunoassay. Advances in islet research are propelled by progress in analytical methodologies; new tools and technologies are continually being refined by emerging biological insights, creating an ideal environment for discovery. In this article, we provide a critical review of analytical advances in the analysis of islets of Langerhans over the past 5 years. Topics include advances in functional testing, proteomics, metabolomics, mass spectrometry imaging, single-cell -omics, and multimodal detection.
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5. Quantum Cascade Laser-Based Vibrational Circular Dichroism Imaging for Chiral Biosensing.
PMID:日期:2026-05-01Vibrational circular dichroism (VCD) is an established chiroptical technique that probes molecular handedness via differential IR absorption of left- and right-circularly polarized light. Quantum cascade lasers (QCLs) have revitalized VCD spectroscopy by delivering high-power, narrowband mid-IR sources that, combined with polarization-modulation strategies, have dramatically improved VCD sensitivity and speed-enabling imaging that was not previously attainable. We review the instrumental design of QCL-based VCD imaging and demonstrate its application to spatially resolved chiral biosensing. By mapping VCD signals with micrometer resolution, one can detect and differentiate protein secondary structures, monitor enantiomeric purity in pharmaceutical compounds, and visualize pathological tissue features without labels. We discuss practical challenges, including cell-window birefringence, polarization-sensitive detection, and data processing, and propose optimized configurations for robust imaging. Finally, we outline future directions for QCL-VCD systems and their integration with nonlinear chiroptical techniques, highlighting the potential of QCL-VCD imaging to transform chiral analysis in biological and clinical contexts.
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6. Ion-Ion Chemistry for the Analysis of Biomolecular Ions via Tandem Mass Spectrometry: A Tutorial Review.
PMID:日期:2026-05-01Gas-phase ion-ion reactions lead to well-defined changes in mass and charge that are readily detected via mass spectrometry. They have unusually large cross sections, which allow for rates on the order of 1-1,000 s-1 and, as a result, enable a variety of analytically useful measurements. Such applications rely on one or more of a variety of reaction mechanisms, such as proton transfer, electron transfer, metal ion transfer, and selective covalent bond formation. Electrodynamic ion traps make excellent reaction vessels for ion-ion reactions due to their ability to trap one or both polarities of ions, thereby allowing reactions to proceed with high reactant to product conversion. Understanding the underlying phenomena of ion-ion reactions, as well as the conditions under which they proceed, is essential to designing future experiments. This tutorial review summarizes the underlying phenomena of gas-phase ion-ion reactions and related practical considerations needed to optimize these reactions in an electrodynamic ion trap.
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7. New Analytical Technologies to Resolve, Interpret, and Understand Lipid Complexity.
PMID:日期:2026-05-01The rapid and continued development of mass spectrometry-based technologies has significantly increased the capability to study and characterize lipids while providing new insight into the complex roles of lipids throughout biology. These capabilities have included the ability to quantify, structurally characterize (including resolving isomers that pose significant challenges to lipidomics), and spatially map lipids within numerous complex organisms, revealing new capabilities in emerging areas such as single-cell analysis. With these rapid developments, several challenges have emerged, such as accurate lipid identification, incorrect and overinterpretation of mass spectrometry data and structural assignments, and the need for improved analytical and bioinformatics tools to understand lipidomics data at the pathway and systems levels. This review critically assesses analytical technologies used for lipidomics studies, along with current challenges and technological developments driving the field forward. By highlighting these challenges, and possible avenues to address them, this review emphasizes the excitement for the future of lipidomics and the need for continued development of analytical tools to enhance our understanding of lipid biology.
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8. Accelerating Diagnostics for Pandemic Preparedness.
PMID:日期:2026-05-01Diagnostics are central to pandemic preparedness, guiding surveillance, clinical care, and public health response. The COVID-19 pandemic exposed limitations in diagnostic infrastructure but also accelerated innovation across assay types, created accessible testing mechanisms, and demonstrated the value of public-private partnerships. This review outlines the critical roles diagnostics play across pandemic phases, from early detection to post recovery surveillance. We review the current diagnostic landscape for pandemic priority pathogens and unmet needs and challenges and examine recent advances in analytical technologies, including isothermal amplification, CRISPR-based methods, alternative sample types, and novel platforms, with a focus on their potential for rapid deployment and field use. We also explore the emergence of diagnostic accelerators and biorepositories that support assay validation and global test availability. For analytical chemists, pandemic preparedness presents a call to action: to develop, validate, and translate innovative tools that can adapt to meet urgent diagnostic needs during future health emergencies.
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9. The Next Generation of Protein Sequencing and Analysis Methods.
9. 下一代蛋白质测序和分析方法PMID:日期:2026-05-01Advances in protein sequencing and analysis are poised to transform proteomics through an ability to link sequence, structure, and function at scale, thereby accelerating biological discovery and biomedical innovation. However, interrogating proteins is uniquely challenging because they cannot be amplified, are composed of complex chemical structures, and exist across a vast landscape of proteoforms. Techniques such as mass spectrometry typically drive large-scale proteomics studies; however, a new generation of technologies is pushing the boundaries, promising new features such as de novo, single-molecule, and/or higher-throughput sequencing and analysis. While many strategies are still in an early stage, a few modalities, such as fluorosequencing, single-molecule sequencing, digital proteomics mapping, and nanopore-based protein sequencing, have now reached or are thought to be nearing commercial implementation. In this review, we evaluate the mechanisms, current progress, and remaining challenges of these technologies while also highlighting how recent innovations are converging toward a new generation of proteomic technologies.
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10. A Stable Isotope Tracing Primer for the Mass Spectrometrist.
PMID:日期:2026-05-01Metabolic function plays a key role in our understanding of both biological and pathophysiological processes. Metabolism is a complex combination of intrinsic processes and environmental cues across a heterogeneous mix of cell types. To investigate metabolism, stable isotope tracing is a versatile approach to assess metabolism across scales, including in cultured cells, animal models, and humans. From the first tracing studies over a century ago, the development and utility of these studies have gone hand-in-hand with technological advances in detecting these labeled atoms, particularly with mass spectrometry. In this review, we describe the instrumentation used to measure isotopically labeled metabolites and approaches to analyze and interpret stable isotope tracing data, and discuss current challenges and opportunities for discovery with these methods.