Cell Host & Microbe细胞·宿主与微生物
Cell Host & Microbe(英文缩写 CELL HOST MICROBE),ISSN 1931-3128,eISSN 1934-6069,中文译名:细胞·宿主与微生物 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 31.316 | Q1 |
| 2022 | 30.300 | Q1 |
| 2023 | 20.600 | Q1 |
| 2024 | 18.700 | Q1 |
| 2025 | 23.200 | Q1 |
Cell Host & Microbe 最新收录文献
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1. A commensal-derived sugar protects against obesity by regulating immunometabolism.
PMID:日期:2026-09-23Obesity is a worsening global epidemic that is partially regulated by the microbiota through unknown factors. We discovered a human commensal bacterium, Clostridium immunis, which prevents and treats obesity in mice by secreting a phosphocholine-modified exopolysaccharide. Loss- and gain-of-function bacterial mutants involving the phosphocholine biosynthesis locus (licABC) revealed that the phosphocholine moiety is required to protect against metabolic disease. This C. immunis exopolysaccharide decreases small-intestinal and visceral fat levels of IL-22, which increases metabolic activity specifically in visceral adipose tissue; C. immunis lacks activity against obesity when IL-22 or group 3 innate lymphoid cells, predominant secretors of IL-22, are absent. Importantly, phosphocholine biosynthesis genes are less abundant in humans with obesity or hypertriglyceridemia, suggesting conserved functions of bacterial phosphocholine. These results define a bacterial molecule-and its key structural motif-that provides immunometabolic control of obesity. More broadly, they highlight a clinically translatable strategy to reduce visceral fat.
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2. Dietary pectin remodels commensal bacterial surfaces to promote IgA-mediated protection from intestinal inflammation.
PMID:日期:2026-09-17Diet-microbe interactions shape mucosal immunity, yet how dietary cues drive strain-specific immunoglobulin A (IgA) responses remains poorly understood. Here, we show that dietary pectin induces a microbiota-dependent high-IgA phenotype in gnotobiotic mice mono-colonized with Bacteroides uniformis (B. uniformis). This effect is mediated by a pectin-responsive rcsC-associated regulatory program that remodels the bacterial surface. Comparative lipidomics identifies the glycosphingolipid HexCer (34:0) as a dominant feature of the remodeled bacterial surface. HexCer is recognized by the C-type lectin receptor CLEC4E on intestinal neutrophils, and CLEC4E deficiency abrogates IgA induction. Downstream of CLEC4E, neutrophil-derived APRIL (a proliferation-inducing ligand) promotes IgA class switching and enhances IgA coating of bacteria in vivo. This IgA response increases the mucosal association of B. uniformis and confers protection against colitis. Together, these findings uncover a diet-responsive bacterial program that generates an immunogenic glycosphingolipid signal to engage innate sensing and shape the mucosal IgA repertoire, thereby reinforcing mutualistic colonization.
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3. The rice circadian clock orchestrates the rhizosphere microbiome to synchronize nitrogen supply with plant demand.
PMID:日期:2026-09-09Improving nitrogen use efficiency (NUE) is pivotal for sustainable agriculture but is limited by spatiotemporal mismatches between soil N supply and crop N demand. Here, we show that the rice circadian clock component Nhd1 coordinates rhizosphere microbial activity with plant diurnal N uptake. Nhd1 drives a rhythmic root exudation program: quercetin 3-gentiobioside peaks during the day against a constitutive baseline of baimaside secretion, both of which upregulate core microbial N-cycling genes to boost ammonium bioavailability. This Nhd1-orchestrated exudation rhythm aligns microbial N turnover with peak plant N demand. A synchronized microbial community engineered to match this diurnal N release pattern increased grain yield and NUE in field trials, with far greater benefits in cultivars harboring weak versus strong Nhd1 alleles. Our work uncovers a mechanism by which the plant circadian clock directly coordinates rhizosphere microbial functions to optimize N acquisition, thus providing a tractable strategy for sustainable crop production.
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4. Microbial indole-3-acetamide alleviates polycystic ovary syndrome through HIF-2α-ceramide signaling.
PMID:日期:2026-09-09Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease and metabolic disorder in women that is marked by abnormalities in adipose tissue and gut microbial dysbiosis. However, it remains unclear whether and how the gut microbiota affects adipose tissue, thereby leading to the development of PCOS. Here, we find that intestinal Collinsella aerofaciens and its metabolite indole-3-acetamide (IAM) are significantly reduced in PCOS patients. Mechanistically, we demonstrate that C. aerofaciens produces IAM through an IAM synthase, which activates the adipose hypoxia-inducible factor 2α (HIF-2α) signaling pathway and promotes adipose ceramide degradation, thereby ameliorating the PCOS phenotype. A constructed IAM-producing engineered probiotic ameliorates PCOS in a mouse model. Together, our findings elucidate the link between gut dysbiosis and adipose tissue dysfunction in PCOS, while suggesting the potential of IAM as a treatment for PCOS.
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6. Toward medical countermeasures against hantaviruses.
PMID:日期:2026-09-09Hantaviruses are zoonotic threats that can cause hemorrhagic fever with renal syndrome and severe cardiopulmonary syndrome. Despite disease severity, there are no approved vaccines or therapeutics available for the prevention or management of hantavirus infections. Here, we discuss advances in the development of vaccines, neutralizing antibodies, and small-molecule antiviral therapeutics.
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7. A Hippo-thesis: Can bacteria turn back reproductive time?
7. 一个Hippo假说：细菌能否逆转生殖时间？PMID:日期:2026-09-09Fertility declines with age, partly because the endometrium ages alongside the oocyte. In this issue, Li et al. show that Lactobacillus gasseri and its exopolysaccharide reduce endometrial senescence and improve implantation in aged mice. Although senescence markers responded similarly in human endometrial cells, effects on human pregnancy rates remain unclear.
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8. Holding the granuloma together: Fibroblasts contain mycobacterial infection.
PMID:日期:2026-09-09Genetic variation in leukotriene A hydrolase (LTA4H) influences tuberculosis severity, but underlying mechanisms remain unclear. In this issue, Hughes et al. identify LTA4H-dependent fibroblasts at the granuloma periphery that regulate eicosanoid signaling, thereby limiting mycobacterial dissemination. These findings reveal a fibroblast-mediated link between host genetic susceptibility, granuloma organization, and bacterial containment.
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9. Interferon family feud determines immunity to mycobacteria.
PMID:日期:2026-09-09The immune response to Mycobacterium tuberculosis (Mtb) infection leverages the interferon system. In this issue of Cell Host & Microbe, Fattinger and colleagues provide compelling evidence for a previously suspected antagonism of type I interferons and interferon-γ as an important determinant of susceptibility against Mtb infection.
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10. Pulling the strings: Endobacteria manipulate fungal mycotoxin production.
PMID:日期:2026-09-09In an overlooked but common phenomenon, bacteria colonize fungi and change how the eukaryotic microbe inhabits niches. In this issue, Wei et al. present a comprehensive look at an endofungal bacterium, identifying a mechanism to change plant disease outcomes through antagonism of beneficial soil microbes.