Current Opinion in Virology病毒学新见
Current Opinion in Virology(英文缩写 CURR OPIN VIROL),ISSN 1879-6257,eISSN 1879-6265,中文译名:病毒学新见 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 7.121 | Q1 |
| 2022 | 5.900 | Q1 |
| 2023 | 5.700 | Q1 |
| 2024 | 5.100 | Q1 |
| 2025 | 5.500 | Q1 |
Current Opinion in Virology 最新收录文献
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1. Non-coding RNAs: cross-kingdom regulators of plant-virus-vector interactions in complex agroecosystems.
1. 非编码RNA：复杂农业生态系统中植物-病毒-载体互作的跨界调控因子PMID:日期:2026-09-29Plant viruses depend on insect vectors for dissemination in complex agroecosystems and often exploit plant and insect physiology to enhance transmission. This review synthesizes recent advances in understanding cross-kingdom exchange of non-coding RNAs (ncRNAs) as a central mechanism shaping plant-virus-vector interactions and broader agroecosystem dynamics. ncRNAs are exchanged among plants, insect vectors, and viruses via the phloem, insect saliva, and external plant surfaces through exudates. These molecules can suppress plant antiviral and anti-insect plant responses, modulate vector biology and behavior, and shape associated microbial communities, including endosymbionts and the plant microbiome. Despite rapid progress, key gaps remain in validating functional targets, identifying transport mechanisms, and demonstrating the ecological relevance of ncRNA exchange in agricultural and natural systems. Elucidating these processes will inform intervention strategies, including RNAi-based vector control and microbiome engineering approaches.
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2. Editorial overview: Novel vaccine adjuvants: advances in mechanism, design, and translation.
2. 编辑概述：新型疫苗佐剂：机制、设计与转化进展PMID:日期:2026-09-22该文献暂无摘要。
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4. Leveraging plant virus-vector molecular interactions for innovative vector and disease control.
4. 利用植物病毒-媒介分子互作进行创新的媒介和病害防控PMID:日期:2026-08-19Although insect-transmitted plant viruses cause substantial global crop losses, knowledge of the molecular mechanisms underlying their transmission is limited. Recent advances in omics technologies, high-resolution tissue-specific profiling, and protein-protein interaction prediction are rapidly improving our ability to identify vector proteins that mediate virus acquisition, retention, and transmission. These approaches provide critical insights into the molecular mechanisms underlying virus-vector interaction. The integration of molecular discovery with the all-important functional validation of genes involved in virus-vector interactions provides a foundation for the development of next-generation strategies to block plant virus transmission and improve vector management. With a focus on hemipteran vectors, this review summarizes recent progress in elucidating plant virus-vector molecular interactions and their potential use in innovative strategies for virus and vector control. These strategies include 1) the use of viral coat proteins for the delivery of insecticidal proteins into the insect hemocoel, 2) RNA interference or genome editing to disrupt the initial association of a virus with its vector or target other vector genes required for plant virus transmission, and 3) peptides or virus-derived components that compete with viruses for receptor binding in vector tissues.
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5. Innate immunity-mediated inflammation and immunopathogenesis in HSV-1-infected encephalitis.
5. 单纯疱疹病毒1型感染性脑炎中固有免疫介导的炎症与免疫发病机制PMID:日期:2026-08-14[中文摘要] 单纯疱疹病毒1型脑炎（HSE）尽管已有有效的抗病毒治疗，仍是中枢神经系统一种毁灭性的病毒感染。越来越多的证据表明，疾病结局并非仅由病毒复制决定，而是取决于脑内固有免疫的校准方式。儿童HSE宿主易感性的研究已鉴定出脑内固有的抗病毒机制，即定位于中枢神经系统（CNS）的固有免疫通路，使脑内驻留细胞能够感知并限制HSV-1感染，尤其是TLR依赖的干扰素反应、神经元相关的限制因子及其他CNS驻留的固有免疫机制。宿主固有免疫反应最初有助于限制病毒，而过度的或未能消退的激活则可促进炎症放大和长期神经损伤。与此同时，HSV-1介导的免疫重塑可能削弱抗病毒控制并改变随后的炎症轨迹。本文据此将HSE论述为一种动态的免疫病理性疾病，其中保护性固有免疫可转变为致病性神经炎症。基于这些观察，我们提出宿主导向的治疗策略应从统一的免疫调节转向基于病毒控制、抗病毒能力、炎症持续性和组织修复的阶段特异性免疫再校准。
[英文摘要] HSV-1 encephalitis (HSE) remains a devastating viral infection of the central nervous system despite effective antiviral therapy. Increasing evidence indicates that disease outcome is not determined by viral replication alone but by how innate immunity is calibrated within the brain. Studies of host susceptibility in childhood HSE have identified brain-intrinsic antiviral mechanisms, referring to central nervous system (CNS)-localized innate immune pathways that enable resident brain cells to sense and restrict HSV-1 infection, particularly TLR-dependent interferon responses, neuron-associated restriction factors, and other CNS-resident innate immune mechanisms. Host innate immune responses initially contribute to viral restriction, whereas excessive or unresolved activation can promote inflammatory amplification and long-term neurological injury. In parallel, HSV-1-mediated immune remodeling may weaken antiviral control and alter the subsequent inflammatory trajectory. Here, HSE is discussed as a dynamic immunopathological disorder in which protective innate immunity can transition into pathogenic neuroinflammation. Building upon these observations, we propose that host-directed therapeutic strategies should shift from uniform immune modulation toward stage-specific immune recalibration on the basis of viral control, antiviral competence, inflammatory persistence, and tissue repair.
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6. Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system.
6. 分子缠斗：涉及人类疱疹病毒、小泛素样修饰蛋白（SUMO）与宿主免疫系统之间复杂的相互作用PMID:日期:2026-07-29SUMOylation regulates critical cellular processes, including DNA repair, transcription, and immune responses. Human herpesviruses (HHVs) have evolved mechanisms to hijack the SUMO pathway, promoting viral replication, immune evasion, and establishment of latency. This review explores how HHVs manipulate the host SUMOylation machinery, detailing key viral proteins and their effects, as well as antiviral defense mechanisms.
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7. Molecular dialogues in plant rhabdovirus-host interactions.
7. 植物横纹病毒与宿主相互作用中的分子对话PMID:日期:2026-07-15Plant rhabdoviruses comprise a group of economically important pathogens that exhibit a complex dual-host infection cycle across plants and insect vectors, relying on exquisitely adapted cross-kingdom infection and survival strategies. In this review, we summarize recent advances in understanding plant rhabdovirus-host interactions, with a focus on the molecular basis underlying viral manipulation of host functions. We highlight key host factors or subcellular structures hijacked by plant rhabdoviruses to support robust viral replication and intracellular transport. We further explore the diverse counter-defense mechanisms deployed by plant rhabdoviruses to evade or suppress host immunity, including RNA silencing, phytohormone signaling cascades, and autophagy-mediated degradation. Finally, we discuss the intimate insect-virus interfaces, detailing how viral effectors modulate vector feeding behaviors, physiology, and innate immune responses to facilitate persistent, propagative transmission. Collectively, these advances establish an integrated framework for understanding the cross-kingdom pathogenesis of plant rhabdoviruses and provide insights for developing innovative crop protection strategies.
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8. Mass mortality events in aquatic mammals caused by avian influenza viruses.
8. 禽流感病毒导致的水生哺乳动物大规模死亡事件PMID:日期:2026-07-13In recent decades, mass mortality events (MMEs) among aquatic mammals have been caused by morbillivirus or avian influenza virus (AIV) infections. Thus far, AIV infections have been predominantly associated with direct or indirect contact with infected birds, while mammal-to-mammal AIV transmission has not been formally proven in most cases. However, amino acid changes in the HA or PB2 RNA segments previously identified as 'mammalian-adapting mutations' have been documented during AIV epizootics in aquatic mammals. Such mutations are known to increase infectivity and/or virulence of AIV in mammalian species, including humans. Epizootics caused by low-pathogenic AIV (LPAIV) are typically self-limiting respiratory disease outbreaks. In contrast, the ongoing panzootic caused by highly pathogenic AIV (HPAIV) subtype A(H5N1) clade 2.3.4.4b is associated with severe neurological disease and mortality in infected pinniped and cetacean species. The available serological data suggest that enzootic circulation of AIV in aquatic mammals is limited. LPAIV-specific antibodies have been detected in pinniped species only during documented flu outbreaks and have then decreased to undetectable levels, while no AIV-specific antibodies have been detected following recent HPAIV A(H5N1) infections. Since direct interventions in wild pinnipeds are limited, AIV surveillance and investigations into the genetic and phenotypic characteristics of AIVs associated with MMEs in aquatic mammals will be essential to better understand the risk that these viruses pose to often endangered animal populations, as well as to public health.
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9. The discovery and development of small molecule immune potentiators (SMIPs) as next-generation vaccine adjuvants, the creation of AS37.
9. 作为下一代疫苗佐剂的小分子免疫增强剂（SMIPs）的发现与开发，即AS37的创制PMID:日期:2026-07-10Aluminum salts remain the most widely used adjuvants in licensed vaccines, but their tendency to favor Th2-dominant humoral responses limits their usefulness when robust Th1, T follicular helper (Tfh), and cellular responses are required. Small-molecule immune potentiators (SMIPs) targeting Toll-like receptor 7 (TLR7) offer a rational way to complement aluminum, provided systemic exposure is tightly controlled. This review re-examines the discovery and development of AS37, a phosphonate-modified benzonaphthyridine TLR7 agonist that is stably adsorbed onto aluminum hydroxide through ligand exchange. We discuss why a TLR7-focused approach was selected, how the adsorption chemistry was validated, and how alum-TLR7 compares with alum alone, MF59, other prominent adjuvants, and related alum-bound TLR7/8 platforms such as Algel-IMDG/Alhydroxiquim-II. Across preclinical studies, AS37 and related alum-TLR7 formulations enhance antibody magnitude and quality, bias CD4+ responses toward Th1 immunity, and promote Tfh- and germinal-center-associated biology. Mechanistic benchmarking in nonhuman primates (NHP) shows increased recruitment and activation of antigen-presenting cells, particularly plasmacytoid dendritic cells, restricted antigen delivery to draining lymph nodes, and a type I interferon-associated program not seen with alum alone. Early human data from a meningococcal C conjugate vaccine show acceptable reactogenicity at lower and intermediate doses together with a transient dose-dependent interferon signature, expanded Tfh responses, and increased memory B cells, but the clinical evidence base remains limited to early-phase studies. AS37 should therefore be viewed as a distinct TLR7-focused, phosphonate-enabled implementation within a broader class of alum-combination innate immune potentiators, with remaining uncertainties around optimal dose, intracellular delivery mechanisms, and comparative clinical performance.
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10. Linking vector biology, transmission, and genome architecture in southeastern orthotospoviruses.
10. 东南部正番茄斑萎病毒属病毒中媒介生物学、传播与基因组结构的关联PMID:日期:2026-07-09[中文摘要] 正托孢病毒（Orthotospoviruses）通过蓟马介导的持久增殖型传播，持续对美国东南部的特色作物和行栽作物构成重大威胁。本文综合阐述了番茄斑萎病毒（TSWV）和大豆叶脉坏死病毒（SVNV）的发生与生物学特性，并结合凤仙花坏死斑病毒、花生环斑病毒和番茄褪绿斑病毒（TCSV）的相关背景进行讨论。TSWV寄主范围广泛且具有全球重要性，而SVNV已知寄主范围较窄，但仍在各大豆产区持续扩展。比较基因组分析提示二者具有不同的进化模式：TSWV在S和M片段的基因间区表现出更大的结构可塑性，而SVNV则保留了更为保守的基因间区架构和发夹结构。这些差异为比较正托孢病毒的发生提供了框架，但其流行病学意义在不同病毒—媒介系统中仍未能得到均衡阐明。防控策略同样出现分化：番茄和辣椒中的单基因抗性屡次被克服抗性的TSWV变异株所突破，而靶向全部五个病毒开放阅读框的多基因发夹结构构建体则对TSWV和TCSV提供更广泛的保护。综合而言，这些比较揭示了基因组架构和媒介生物学如何塑造美国东南部正托孢病毒的发生与防控。
[英文摘要] Orthotospoviruses remain major threats to specialty and row crops in the southeastern United States through thrips-borne, persistent-propagative transmission. We synthesize the emergence and biology of tomato spotted wilt virus (TSWV) and soybean vein necrosis virus (SVNV), with context from impatiens necrotic spot virus, groundnut ringspot virus, and tomato chlorotic spot virus (TCSV). TSWV has a broad host range and global importance, whereas SVNV has a narrower known host range but continues to expand across soybean-producing regions. Comparative genomic analyses suggest distinct evolutionary patterns: TSWV shows greater structural plasticity in the S and M segment intergenic regions, whereas SVNV retains more conserved intergenic architectures and hairpin structures. These differences provide a framework for comparing orthotospovirus emergence, but their epidemiological significance remains unevenly resolved across virus-vector systems. Management has likewise diverged, with single-gene resistance in tomato and pepper repeatedly overcome by resistance-breaking TSWV variants, while multigenic hairpin constructs targeting all five viral ORFs provide broader protection against TSWV and TCSV. Together, these comparisons highlight how genome architecture and vector biology shape orthotospovirus emergence and management in the Southeast.