CURRENT PROTEIN & PEPTIDE SCIENCE当代蛋白质与多肽科学
CURRENT PROTEIN & PEPTIDE SCIENCE(英文缩写 CURR PROTEIN PEPT SC),ISSN 1389-2037,eISSN 1875-5550,中文译名:当代蛋白质与多肽科学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.118 | Q3 |
| 2022 | 2.800 | Q3 |
| 2023 | 1.900 | Q4 |
| 2024 | 2.000 | Q4 |
| 2025 | 2.400 | Q3 |
CURRENT PROTEIN & PEPTIDE SCIENCE 最新收录文献
-
1. Structural and Functional Mechanisms of Human Serum Albumin in Drug Binding and Transport: Implications for Albumin-Based Nanocarrier Design - A Systematic Review.
PMID:日期:2026-09-09Albumin is a widely used nanoparticle drug delivery system due to its biocompatibility, stability, and inherent targeting capabilities. The aim of this systematic review is to highlight the structural and functional role of albumin in drug binding, stability, and targeting, with particular emphasis on the therapeutic implications. A comprehensive search of electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, was conducted according to the PRISMA guidelines. Relevant literature was screened based on predetermined criteria for inclusion and exclusion. Data were extracted and synthesized qualitatively. A total of 4,754 records were retrieved, and 76 studies were included in this review after the screening and assessment of their eligibility. The results showed that albumin plays a role in the stabilization of nanoparticles via steric and electrostatic interactions, improves the encapsulation efficiency of drugs, and increases the systemic circulation of nanoparticles. The targeting mechanisms of albumin, including the mechanisms of gp60-mediated transcytosis and SPARC-mediated tumor retention, have also been effective in the improvement of drug delivery and efficacy. From the results, it is evident that albumin plays a critical role in the improvement of nanoparticle formulations compared to synthetic stabilizers. From the results of this review, it is evident that albumin nanoparticles have a great future in the improvement of drug targeting and delivery.
-
2. Design, Synthesis, and Biological Evaluation of Lipidated Pentapeptide Derivatives Containing Unnatural Amino Acids.
PMID:日期:2026-08-31The development of novel peptide-based therapeutics offers a promising strategy to overcome the limitations associated with conventional antibacterial drugs. This study aimed to design and synthesize a new series of lipidated pentapeptide derivatives containing unusual amino acids and to evaluate their antibacterial and antifungal potential. A series of lipidated pentapeptides incorporating unconventional amino acids was designed and synthesized to enhance structural diversity, membrane interaction, amphiphilicity, and resistance to enzymatic degradation. Lipophilic moieties were introduced to improve peptide stability and biological performance. The synthesized compounds were characterized using standard analytical techniques and evaluated for their antibacterial and antifungal activities against selected Gram-positive and Gram-negative bacterial strains and pathogenic fungi. Several lipidated pentapeptide derivatives exhibited promising antibacterial activity against both Gram-positive and Gram-negative bacteria. In addition, notable antifungal activity was observed against pathogenic fungal strains. The results demonstrated that lipidation significantly enhanced the antimicrobial efficacy of the peptides. Among these peptide derivatives, compound 6a exhibited antibacterial activity against E. coli with MIC = 150 μg/mL, whereas compound 6b showed activity against S. aureus with MIC = 250 μg/mL. Compound 6c demonstrated the strongest antifungal activity against Candida albicans (MIC = 40 μg/mL), while compound 6e showed activity against Aspergillus niger (MIC = 80 μg/mL). The findings highlight peptide lipidation as an effective structural modification strategy to improve membrane interaction, bioactivity, and enzymatic stability of antimicrobial peptides. The incorporation of unusual amino acids further contributed to enhanced resistance against degradation, supporting their therapeutic potential. This study demonstrates that lipidated pentapeptide derivatives represent promising candidates for next-generation antimicrobial agents. Peptide lipidation emerges as a valuable approach for developing stable and potent peptide-based therapies to combat bacterial and fungal infections.
-
3. Structural Transitions of β-lactoglobulin Aggregates Observed Under Controlled Heat Treatment.
3. 在受控热处理下观察到的β-乳球蛋白聚集体的结构转变PMID:日期:2026-07-24β-Lactoglobulin (β-Lg), the major whey protein in bovine milk, readily undergoes structural transitions leading to amyloid fibril formation under acidic conditions and elevated temperatures. This study investigated the influence of different thermal treatment conditions on the aggregation and fibrillation behavior of β-Lg at pH 2. β-Lg solutions were subjected to three different thermal conditions: stepwise heating from 35o C to 90o C for 12h (Sample A), cyclic heating and cooling from 35o C to 90o C for 24h (Sample B), and constant heating at 90o C for 24h (Sample F). Untreated β-Lg served as the control (Sample M). Structural and morphological changes induced by these treatments were characterized by using intrinsic tryptophan fluorescence spectroscopy, Thioflavin T (ThT) fluorescence assay, circular dichroism (CD) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM). Spectroscopic and microscopic analyses revealed that stepwise heating (Sample A) promoted amyloid fibril formation, whereas constant heating (Sample F) resulted in extensive aggregation and the development of highly ordered β-sheet-rich fibrillar structures. In contrast, cyclic heating and cooling (Sample B) produced reduced fibril formation, partial retention of native β-Lg structural changes, and distinct aggregate morphologies. Fluorescence, CD, FTIR, and microscopic analyses consistently indicate that Sample F represents the most advanced fibrillar state, while Sample B remained in a partially unfolded and hydrated state with limited changes in the structure. The observed differences in aggregation and fibrillation behavior demonstrated that thermal treatment strongly influences the balance between structural rearrangement and irreversible protein aggregation. Controlled thermal cycling appears to modulate the aggregation pathway by stabilizing intermediate conformational states and limiting the formation of highly ordered amyloid assemblies. The method of heating plays a critical role in determining the structural change of βLg. While prolonged heating promotes extensive fibrillation and aggregation, controlled heatingcooling cycles reduce the extent of amyloid formation and preserve partially native-like structural characteristics. These findings provide valuable insights into the thermal regulation of β-Lg aggregation and may contribute to the development of processing strategies for controlling protein selfassembly in food and biomaterial applications.
-
5. Exploring Neurological Disorder Therapeutics: The Progress and Future Prospects of Proteins and Peptides Derived from Blue Foods.
PMID:日期:2026-07-06Neurological illnesses continue to be a major global health challenge and require novel and safe therapeutic strategies. Blue foods like marine fish, algae, and invertebrates consist of many bioactive proteins/peptides that might provide multiple benefits for maintenance of a healthy brain, including neuroprotection, reduction of inflammation, and reduction of oxidative stress. This review looks at both recent advances made with blue food bio-molecules and their potential future roles in therapeutic targeting for neurological disorders. This study is designed as a narrative review, aiming to comprehensively summarize and critically analyze existing literature on marine-derived bioactive peptides and their neuroprotective potential. Literature searches were conducted from January 2009 to March 2025 using PubMed and other biomedical databases. Available preclinical evidence suggests that marine-derived proteins and peptides may exert neuroprotective effects through multiple mechanisms, including activation of antioxidant defense pathways via Nrf2-mediated signaling, modulation of NF-κB-associated neuroinflammatory responses, regulation of serotonergic and dopaminergic neurotransmission, and attenuation of amyloid-β aggregation. Experimental studies conducted in animal models have reported improvements in cognitive performance, reductions in oxidative stress biomarkers, and decreased production of pro-inflammatory cytokines following administration of marine protein hydrolysates. Clinical translation of marine-derived bioactive peptides remains challenging due to the following factors: standardization of extraction, bioavailability, batch-to-batch variability, allergenic potency, and complex regulatory requirements. Ongoing new approaches using nano-formulation, synthetic biology, and Artificial Intelligence (AI) in the discovery of peptides hold the promise of enhancing their stability, targeting, and scalability. However, in order to validate the therapeutic utility of these approaches, it will require large, well-designed clinical studies.
-
6. Significance of Proteomics in Cancer: Current Approaches and Trends in Biomarker Discovery.
PMID:日期:2026-07-03Proteomic data, including protein identification, expression profiles, and modifications, have gained significant relevance in the molecular sciences. The mechanistic investigations on the growth and metastasis of tumours, for instance, cancer proteomics, have provided crucial information for the discovery of treatment targets as well as therapeutically helpful indicators. Several cancer proteome databases have evolved worldwide. The incorporation of proteomics studies alongside new omics is vital, as it generates a wealth of information about targets, molecular pathways, and modulators. Various bioinformatic tools can be used to analyse and process these records, producing pertinent information. The objective of this review is to provide a general overview of cancer proteomics and recent developments in proteomic methods. This compilation aims to provide insights into the current proteomics research being conducted on various types of tumors, where proteomic applications are still in their infancy. This study encompasses proteomics applications, ranging from biomarker identification to molecular pathway characterization, facilitated by technological advancements. Additionally, it discusses international developments in proteomics methods for translational research. The ongoing advancement in this sector is anticipated to deliver valuable data on a scale beyond what has ever been observed, as it is a fundamental technique in translational research.
-
7. Therapeutic Peptides as Targeting Vectors and Smart Therapeutics: Emerging Trends and Future Perspectives.
PMID:日期:2026-06-12Ever since the first monumental discovery in 1921, peptide science has evolved into the field of therapeutic peptides (TPs), whose unique biochemical properties bridge the gaps associated with small molecules and biologics. Despite the fascinating therapeutic potential of TPs, such as lower immunogenicity, targeting specificity, binding affinity, favorable safety profiles, relatively easy synthesis, chemical flexibility, and diversity in physiological functions, the use of TPs in clinical settings is hampered by their shortcomings. Persistent issues such as poor oral bioavailability, susceptibility to enzymatic degradation, and short in vivo half-life limit their clinical application. This review provides a comprehensive overview of the evolving landscape of peptide therapeutics, with emphasis on innovative strategies to overcome the aforementioned challenges. Key advancements include peptide-drug conjugates (PDCs), peptide-nanoparticle conjugates (PNCs), synergistic peptide combinations, stimuli-responsive smart peptide systems, multifunctional peptides, as well as peptide-directed delivery of genetic products such as CRISPR technology and RNA therapeutics. In particular, the review focuses on the latest cutting-edge innovations in TP applications such as cancer theranostics, immunotherapy, gene delivery systems, and precision nanomedicine. Moreover, the integration of artificial intelligence (AI)-driven models in tumor diagnostics, treatment decisionmaking, peptide design, and peptide discovery has served as a pivotal advancement in the utilization of bioinformatic technologies for enhanced diagnostic precision and improved treatment efficiency through machine learning. Highlights of current advances and future directions in this review aim to provide research and translational insights into therapeutic peptide design, delivery, and nextgeneration peptide-based therapeutics.
-
8. Innovative Protein Nanostructures and Hybrid Systems for Enhanced Encapsulation and Controlled Delivery of Bioactive Agents.
PMID:日期:2026-06-12Encapsulation technology is vital in food, pharmaceutical, and biomedical fields for protecting and delivering sensitive bioactive compounds. Proteins, due to their biocompatibility, biodegradability, and functional diversity, are increasingly used as carriers to enhance stability, bioavailability, and controlled release of bioactives. However, environmental factors such as pH, ionic strength, and enzymatic degradation can limit protein performance. This article reviews novel structural designs and modification strategies for protein-based delivery systems to improve encapsulation efficiency, stability, and targeted delivery of bioactive compounds. The study covers a range of protein architectures, including self-assembled nanostructures, protein nanoparticles, micelles, hydrogels, and hybrid protein-polymer systems. Techniques such as coacervation, crosslinking, and stimuli-responsive mechanisms are discussed to enhance delivery properties. Encapsulation efficiency, protection against degradation, controlled release, and bioavailability enhancement are analyzed. Novel protein structures, such as self-assembled nanocages and hybrid composites, demonstrated superior encapsulation and protection of bioactives against environmental and gastrointestinal degradation. Cross-linking and stimuli-responsive carriers enable targeted and controlled release. Encapsulation techniques such as spray drying, enzymatic cross-linking, and protein-polymer conjugation improve the mechanical and chemical stability of delivery systems. Codelivery platforms and surface functionalization further improve targeted absorption and therapeutic efficacy. Applications span the food, nutraceutical, pharmaceutical, and biomedical sectors, demonstrating promising results in enhancing the stability of functional ingredients, improving drug delivery, and advancing tissue engineering. Innovative protein-based delivery systems with tailored structural modifications offer enhanced encapsulation, protection, and controlled bioactive release, overcoming traditional limitations. Continued advancements in protein engineering and nanotechnology are crucial for optimizing these systems for clinical and industrial use, though challenges such as scalability and enzymatic degradation remain to be addressed.
-
9. Nanotherapeutic Interventions in Diabetic Wound Healing: Biomarker- Guided Mechanisms and Translational Prospects.
PMID:日期:2026-06-10Diabetes mellitus is a chronic metabolic disorder that is frequently complicated by impaired wound healing, resulting in diabetic foot ulcers, amputations, and long-term disability. Conventional wound management strategies often fail due to persistent inflammation, oxidative stress, vascular dysfunction, and neuropathy. Recent advances in nanotechnology and biomarker research have emerged as promising approaches to improve diabetic wound healing outcomes. A comprehensive literature review was conducted using PubMed, ScienceDirect, Elsevier, Web of Science, and Google Scholar to identify relevant studies published up to January 2025. Peerreviewed original research articles and reviews were screened using keywords related to diabetic wound healing, nanotherapeutics, nanoparticles, biomarkers, tissue engineering, and clinical translation. Nanotherapeutic systems, including metallic nanoparticles, polymeric nanoparticles, nanofibres, lipid-based carriers, hydrogels, and bioengineered exosomes, have demonstrated antimicrobial, pro-angiogenic, anti-inflammatory, and antioxidant effects in preclinical and clinical studies. These systems promote accelerated wound closure, enhance collagen deposition, improve angiogenesis, and reduce the inflammatory burden. Additionally, emerging biomarkers, such as microRNAs, cytokines, and angiogenic factors, provide valuable insights into wound progression, therapeutic response, and tissue regeneration. The integration of biomarker monitoring with nanocarrier-based delivery systems supports a personalised and adaptive wound care strategy. The combined application of nanotherapeutics and biomarker-based diagnostics addresses key pathological barriers in diabetic wound healing and offers improved therapeutic precision. However, translational challenges remain, including biosafety concerns, long-term toxicity, regulatory complexities, and variability in clinical outcomes. Nanotechnology-based therapeutics integrated with biomarker-driven assessment represent a promising and evolving paradigm for DM wound management, with the potential to enhance healing efficiency and support personalised treatment approaches; further large-scale clinical validation is warranted.
-
10. Recent developments in intein-mediated protein splicing and their applications in bioengineering.
PMID:日期:2026-06-09Inteins are self-excising protein elements that catalyze their own removal from host polypeptides and mediate the ligation of the surrounding exteins, generating mature and functional proteins without the requirement for external cofactors or energy sources. Since their discovery, inteins have attracted considerable interest due to their unique catalytic mechanisms, structural diversity, and broad applicability. Extensive progress in deciphering the molecular basis of cis- and trans-splicing inteins has facilitated the rational design and engineering of improved variants with enhanced efficiency, controllability, and substrate tolerance. These advances have significantly expanded their practical utility. Distinctive features such as compact architecture, high fidelity of splicing, orthogonal activity, minimal cytotoxicity, and irreversible function position inteins as powerful molecular tools in biotechnology and biomedicine. Their applications are increasingly diverse, ranging from fundamental protein engineering tasks such as protein purification, site-specific modification, and selenoprotein production to more translational uses, including microbial drug targeting, intein-based biosensing, targeted gene delivery, and therapeutic gene editing. In addition, conditional inteins, engineered to respond to environmental or molecular cues, are opening new avenues in synthetic biology and biomedicine, enabling precise control over protein function in complex cellular contexts. This review provides a comprehensive overview of intein biology, classification, and mechanistic insights, followed by a discussion of recent developments in their biotechnological and biomedical applications. Particular attention is given to challenges that continue to limit broader adoption, such as incomplete splicing, extein compatibility issues, and context-dependent efficiency. Finally, we highlight emerging opportunities in the field, including the computational design of orthogonal intein libraries, integration with high-throughput screening methods, and the incorporation of artificial intelligence to accelerate intein engineering and application discovery. Collectively, these developments underscore the transformative potential of inteins as versatile molecular tools poised to impact diverse areas of life sciences and therapeutic innovation.