Science China-Life Sciences中国科学：生命科学（英文版）
Science China-Life Sciences(英文缩写 SCI CHINA LIFE SCI),ISSN 1674-7305,eISSN 1869-1889,中文译名:中国科学：生命科学（英文版） 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 10.384 | Q1 |
| 2022 | 9.100 | Q1 |
| 2023 | 8.000 | Q1 |
| 2024 | 9.500 | Q1 |
| 2025 | 9.600 | Q1 |
Science China-Life Sciences 最新收录文献
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1. A CDC20 allelic series reveals stage-specific control of metaphase-to-anaphase transitions during mitosis and meiosis in rice.
PMID:日期:2026-09-22The metaphase-to-anaphase transition is a critically controlled checkpoint essential for precise chromosome segregation. In yeast and animals, cell division cycle 20 (CDC20) serves as an essential coactivator of the anaphase-promoting complex/cyclosome (APC/C), triggering the degradation of key substrates to initiate anaphase. Plants, however, often possess multiple CDC20 homologs, whose functional specificity remains poorly characterized. Employing CRISPR/Cas9 technology, we generated a series of cdc20 triple mutants in rice (Oryza sativa) and performed a systematic cytological analysis to investigate the functions of all three CDC20 genes. Complete loss of CDC20s' function resulted in gametophytic mitotic defects, ultimately causing bilateral gametophyte lethality. We obtained hypomorphic alleles specifically displaying disrupted meiosis without mitotic defects. The cdc20-triple-1 and cdc20-triple-2 mutants were arrested at metaphase I with normal chromosome alignment, but failed to remove sister chromatid cohesin 3 (SCC3) from chromosome arms. In contrast, the cdc20-triple-3 and cdc20-triple-4 alleles progressed through meiosis I but arrested at metaphase II, exhibiting aberrant spindles and chromosome missegregation. We further demonstrated that CDC20s regulated shugoshin 1 (SGO1) distributive pattern: SGO1 loaded normally in cdc20-triple-1 but persisted at centromeres and failed to detach, even when sister chromatids separated aberrantly. However, cdc20-triple-3 mutants showed normal SGO1 unloading, suggesting that timely SGO1 removal from centromeres depends on a CDC20-mediated metaphase I-to-anaphase I transition. Our findings reveal that rice CDC20 homologs play a critical role in controlling the metaphase-to-anaphase transition throughout both mitosis and meiosis, thereby ensuring tight regulation and enhancing genomic stability during sexual reproduction.
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3. Surface immunity releases an RNA-encoded safety lock on NLR activation.
PMID:日期:2026-09-21该文献暂无摘要。
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4. Intraputaminal AAV9 co-delivery of AADC and GDNF in severe AADC deficiency: first-in-human pediatric dose-escalation study.
PMID:日期:2026-09-21Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare, severe inherited neurotransmitter disorder causing combined monoamine depletion and severe motor, autonomic, and developmental impairment. Building on established intraputaminal AAV-mediated AADC replacement, we evaluated a next-generation dual-mechanism strategy that couples restoration of dopamine synthesis with neurotrophic circuit support by delivering an AAV9 vector co-expressing human AADC and glial cell line-derived neurotrophic factor (GDNF) in children with genetically confirmed severe AADC deficiency. Four children (36-59 months; 1 female, 3 males) without head control at baseline received a single bilateral MRI-guided intraputaminal infusion at one of three dose levels (2.0×10, 6.0×10, or 1.28×10 vector genomes) and were followed for 52 weeks. The primary endpoint was safety and tolerability. Key secondary outcomes assessed cerebrospinal fluid (CSF) monoamine metabolites, F-DOPA PET, motor development, and disease-related symptoms. Treatment was feasible and generally well tolerated, with no vector-related serious adverse events. Biomarker analyses provided convergent evidence of target engagement, including increased CSF metabolites and improved F-DOPA uptake, accompanied by improvements in motor function and symptom burden in most participants. By Week 52, one participant achieved full head control and independent sitting, and two achieved partial head control. These first-in-human findings support a dual-gene "enzyme restoration plus circuit support" paradigm and provide a strong translational rationale for further clinical development of this next-generation gene therapy for severe AADC deficiency. ClinicalTrials.gov registration: NCT05765981.
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5. A gustatory receptor mediates sucrose detection to enhance moth reproductive fitness.
PMID:日期:2026-09-20The mutualism between pollinators and flowering plants is a fundamental interaction in ecosystems, mediated by nectar rewards. Sucrose, a major component of floral nectar, is a key driver of pollinator foraging, yet the sensory mechanisms underlying sucrose detection are poorly defined. Here we demonstrate that the pollinator Mythimna separata exhibits a strong sex-independent preference for sucrose, which directly enhances reproductive fitness. We identify MsepGR5, a gustatory receptor expressed in antennal sensilla chaetica, as a key receptor mediating sucrose detection. Crucially, genetic ablation of MsepGR5 completely abolishes both sucrose-evoked neural responses and feeding behavior. Our findings uncover a dedicated gustatory pathway for sucrose detection and establish its critical role in reproductive success in M. separata.
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9. An innovative model for integrated traditional Chinese and Western medicine: state-target differentiation and treatment.
9. 一种中西医结合的创新模式：状态-靶点辨证论治PMID:日期:2026-09-15Facing the health challenges posed by global population aging and the increasing burden of chronic non-communicable diseases, Integrated Traditional Chinese and Western Medicine (ITCWM) in China has achieved notable progress over the past 70 years. However, the traditional "combination of disease and syndrome" model exhibits several limitations, including the disconnect between syndrome differentiation and disease stages, insufficient precision in the targeting of Chinese herbal medicines, inconsistencies in disease nomenclature between Traditional Chinese Medicine (TCM) and Western Medicine (WM), and fragmentation in diagnosis and treatment. The "state-target differentiation and treatment" (STDT) model, proposed in 2015, enables the organic integration of TCM's macroscopic state modulation and WM's microscopic targeting. Under the guidance of this theory, Tong Xiaolin classified diabetes into four stages: stagnation, heat, deficiency, and injury. This classification has been incorporated into the International Guideline for Diagnostic and Treatment Principles of Chinese Medicine in Diabetes, issued by the World Federation of Chinese Medicine Societies. By reconstructing the diagnostic and treatment system of ITCWM, reconstructing a modern system for Chinese herbal medicine, and promoting alignment between TCM and WM disease spectra, this approach facilitates the transformation of TCM from experience-based medicine to precision medicine. It also advances the internationalization of TCM and provides a "Chinese solution" for the development of ITCWM and global health governance.
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10. A sesterterpenoid derivative alleviates ulcerative colitis through targeting ProRS to suppress the NLRP3 inflammasome.
10. 一种二倍半萜衍生物通过靶向ProRS抑制NLRP3炎症小体来缓解溃疡性结肠炎PMID:日期:2026-09-15Ulcerative colitis (UC) is a prevalent inflammatory bowel disease that affects millions of people worldwide, for which no definitive cure currently exists. Herein, we report the discovery of a novel sesterterpenoid derivative, ColD14, with a complicated cage-like structure and contiguous stereogenic centers, which exhibits significant anti-NLRP3 inflammasome activity. Proteomic and biochemical studies identified glutamyl-prolyl tRNA synthetase (EPRS) as a direct target of ColD14. Both EPRS knockdown and pharmacological inhibition by ColD14 reduced NLRP3 inflammasome activation, underscoring the crucial role of EPRS in inflammatory processes. Mechanistically, through the molecular interaction with amino acid residues R1152, E1154, and R1278 at the ATP site, ColD14 inhibited prolyl-tRNA synthetase (ProRS) activity. This suppression triggered the amino acid response (AAR) pathway and consequently attenuated NLRP3 inflammasome activation via mitophagy regulation. In vivo, ColD14 activated the AAR signaling pathway, triggered mitophagy, and inhibited NLRP3 inflammasome activation, thereby alleviating DSS-induced colitis in mice. Taken together, our findings underscored the significance of EPRS in NLRP3 inflammasome activation and suggested that the EPRS inhibitor, ColD14, may be valuable in ulcerative colitis therapy via the EPRS-AAR-mitophagy axis.