JOURNAL DE MYCOLOGIE MEDICALE医学真菌学杂志
JOURNAL DE MYCOLOGIE MEDICALE(英文缩写 J MYCOL MED),ISSN 1156-5233,eISSN 1773-0449,中文译名:医学真菌学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.746 | Q2 |
| 2022 | 3.600 | Q2 |
| 2023 | 2.200 | Q3 |
| 2024 | 1.800 | Q4 |
| 2025 | 2.400 | Q3 |
JOURNAL DE MYCOLOGIE MEDICALE 最新收录文献
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1. Locally disseminated phaeohyphomycosis caused by Neoscytalidium dimidiatum in an immunosuppressed patient.
1. 免疫功能抑制患者中由二色新柱孢引起的局部播散性暗色丝孢霉病PMID:日期:2026-09-23Phaeohyphomycosis is considered an uncommon disease, and associated with occupational exposure, being more prevalent in inlands populations from tropical areas of Central and South America. It is caused by dematiaceous fungi, saprophytes that may be found in the soil, plants, as well as in humid and dusty areas, in household environments. They comprise a large group, including more than 150 species and 70 genera implicated in human diseases. The main species involved in phaeohyphomycosis are Alternaria, Cladosporium and Exophiala. Herein, we report an uncommon case of locally disseminated subcutaneous pheohyphomycosis in an immunosuppressed patient caused by Neoscytalidium dimidiatum, and successfully treated with itraconazole.
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2. Diagnostic performance of the EurobioPlex DermaScreen multiplex PCR assay for routine dermatophyte detection in clinical practice: a single-center comparative study.
PMID:日期:2026-09-16Rapid and accurate diagnosis of dermatophytosis is essential for appropriate treatment and antifungal stewardship. However, fungal culture lacks sensitivity and requires prolonged incubation, potentially delaying targeted therapy. We evaluated the diagnostic performance of the EurobioPlex DermaScreen multiplex PCR assay in routine laboratory practice compared with direct microscopic examination (DE) and fungal culture. This single-center pragmatic study included 1383 specimens for epidemiological analysis and 134 consecutive clinical samples for diagnostic evaluation. PCR results were compared with fungal culture as the primary reference standard and with a composite reference (culture and/or positive DE) in secondary analysis. Sensitivity, specificity, predictive values, and Cohen's kappa (κ) were calculated. Paired proportions were compared using McNemar's test. The overall culture positivity rate was 22.9%, with Trichophyton rubrum representing 68.5% of isolates. Using culture as reference, PCR sensitivity was 96.2% (95% CI 80.4-99.9) in DE-positive and 88.2% (95% CI 63.6-98.5) in DE-negative specimens. In DE-negative samples, negative predictive value reached 96.4% (95% CI 87.7-99.6). Agreement between PCR and culture was fair (κ = 0.21-0.39), with significant discordance by McNemar testing (p ≤ 0.006), mainly due to PCR-positive/culture-negative results. Using the composite reference (n = 57), PCR sensitivity was 89.5% (95% CI 78.5-96.0). In routine practice, multiplex PCR demonstrated high sensitivity and strong rule-out capacity, particularly in DE-negative specimens. Integration into specimen-adapted diagnostic algorithms may facilitate earlier diagnostic decision-making. These findings support the complementary use of multiplex PCR alongside conventional mycological methods in selected clinical contexts.
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3. Cyphellophora adelaidensis sp. nov. isolated from a chronic elbow infection, Australia.
3. 从澳大利亚一例慢性肘部感染中分离出的阿德莱德杯盘菌新种（Cyphellophora adelaidensis sp. nov.）PMID:日期:2026-09-15The genus Cyphellophora belongs to the order Chaetothyriales, family Cyphellophoraceae, and accommodates various species that have previously been reported as a cause of infection in humans. Here, we report a case of presumptive dermal phaeohyphomycosis of the elbow from a patient in Adelaide, Australia. Biopsies showed fungal growth on culture but subsequent molecular identification by ITS sequencing could not resolve the identity, with a low similarity match to Cyphellophora pauciseptata (89.3% similarity) observed. Hence, the isolate was subjected to nanopore genome sequencing to enable multi-gene phylogenetic analysis. The de novo genome assembly was found to consist of 23 nuclear fragments (size range 16,678-4716,474 bp) totalling 26,281,485 bp with a coverage of 17X, the mitochondrial genome was 29,902 bp in size and had a coverage of 277X. Ab initio gene annotation reported 11,251 genes and a GC-content of 54.17%. To define the phylogenetic placement, the ITS and LSU ribosomal DNA, BT2 and RPB1 loci were extracted from the assembled genome and compared to available sequence data from NCBI GenBank. The isolate was found to represent a distinct genetic lineage within the Cyphellophora, which we describe here as a new species, Cyphellophora adelaidensis.
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5. Intrathecal and systemic antifungal therapy for Candida auris central nervous system infection following gunshot wound-related neurotrauma.
5. 枪伤相关神经创伤后耳念珠菌中枢神经系统感染的鞘内和全身抗真菌治疗PMID:日期:2026-09-07Candida auris (C. auris) is an emerging fungal pathogen increasingly associated with healthcare-associated infections. Central nervous system (CNS) involvement is rare, and optimal management strategies remain undefined. We report a 13-year-old boy who developed a CNS infection caused by C. auris following firearm-related cranial trauma complicated by dural defect and cerebrospinal fluid (CSF) leakage. Despite systemic antifungal therapy with liposomal amphotericin B and voriconazole, cerebrospinal fluid cultures remained persistently positive. Intrathecal caspofungin was initiated because of ongoing microbiological growth and inflammatory CSF findings. Following initiation of intrathecal caspofungin as an adjunct to ongoing systemic therapy, serial CSF cultures subsequently became negative; no procedure-related adverse effects were documented. However, whether microbiological clearance was attributable to the intrathecal route, the cumulative effect of combination systemic therapy, or both cannot be determined from a single case. Nevertheless, this case underscores the therapeutic challenges of C. auris CNS infections and adds to the limited literature on adjunctive intrathecal caspofungin use in pediatric patients.
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6. Current understanding of epidemiology and diagnosis method of candidemia in Indonesia: A review.
6. 印度尼西亚念珠菌血症的流行病学与诊断方法的最新认识：一篇综述PMID:日期:2026-08-27Candidemia is an important but under-characterised bloodstream infection in Indonesia, occurring in a context of expanding populations at risk, emerging antifungal resistance and gaps in prevention and control. An estimated 7.7 million Indonesians (2.89% of the population) are affected by serious fungal diseases annually; this figure is not an estimate of candidemia incidence. The epidemiology of candidemia is complex, with various Candida species contributing to the disease burden. Early and accurate diagnosis is crucial for appropriate antifungal therapy. Conventional blood culture remains the reference method for diagnosing candidemia; however, the availability and routine use of CHROMagar Candida, VITEK and advanced diagnostic platforms across Indonesia have not been systematically characterised. Potential diagnostic approaches include serological assays, mass spectrometry, and molecular methods such as real-time PCR and sequencing. Frequently reported species in Indonesian studies include C. tropicalis, C. albicans and C. parapsilosis, although study populations and case definitions vary. Indonesian evidence for C. auris is limited to one molecularly confirmed archived isolate and other isolate reports lacking sufficient specimen, confirmatory or patient-level data to determine the number of affected patients or the national clinical burden. Where available, molecular methods may aid identification when phenotypic methods are inconclusive; results should be interpreted alongside culture findings and clinical data.
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7. Genotyping and antifungal susceptibility of Candida albicans isolated from patients with vulvovaginal candidiasis in Ha Noi city, Vietnam.
7. 越南河内市外阴阴道念珠菌病患者分离的白色念珠菌基因分型及抗真菌药物敏感性研究PMID:日期:2026-08-11[中文摘要] 本研究旨在确定从越南育龄妇女外阴阴道念珠菌病患者中分离的白色念珠菌菌株的抗真菌药物敏感性特征及ABC基因型。共收集93株从越南育龄妇女外阴阴道念珠菌病患者中分离的白色念珠菌菌株，采用针对25S rDNA的PCR方法进行ABC基因型鉴定。抗真菌药物敏感性试验依据美国临床和实验室标准协会文件（M27-A3和M27M44S-ED3）采用肉汤微量稀释法进行。共鉴定出三种不同的白色念珠菌基因型。其中，基因型A（72.04%）最为常见，其次为基因型C（18.28%）和基因型B（9.68%）。对氟康唑、伊曲康唑、伏立康唑、两性霉素B和5-氟胞嘧啶的耐药率分别为7.52%、13.98%、7.52%、9.68%和23.66%。唑类药物和两性霉素B耐药主要见于基因型C，而氟胞嘧啶耐药主要与基因型A相关。越南外阴阴道念珠菌病妇女中白色念珠菌的基因型分布与全球其他研究结果较为一致，均以基因型A为主要基因型。基因型与抗真菌药物耐药模式之间存在明显关联，唑类药物和两性霉素B耐药主要见于基因型C，氟胞嘧啶耐药则以基因型A为主。这些发现提示，确定基因型和抗真菌药物敏感性特征对于指导临床管理和抗真菌耐药监测具有重要意义。
[英文摘要] This study aimed to determine the antifungal susceptibility profiles and ABC genotypes of Candida albicans strains isolated from Vietnamese women of reproductive age with vulvovaginal candidiasis. A total of ninety-three C. albicans strains isolated from Vietnamese women of reproductive age with vulvovaginal candidiasis were determined for ABC genotypes using PCR targeting the 25S rDNA. Antifungal susceptibility testing was carried out based on the broth microdilution method in accordance with the Clinical and Laboratory Standards Institute documents (M27-A3 and M27M44S-ED3). Three different genotypes of C. albicans were identified. Among these genotypes, genotype A (72.04%) was the most frequent, followed by genotype C (18.28%) and genotype B (9.68%), respectively. The resistance rates to fluconazole, itraconazole, voriconazole, amphotericin B, and 5-flucytosine were 7.52%, 13.98%, 7.52%, 9.68%, and 23.66%, respectively. Azole and amphotericin B resistance predominated in genotype C, whereas flucytosine resistance was mainly associated with genotype A. The genotype distribution of C. albicans among Vietnamese women with vulvovaginal candidiasis was quite consistent with findings from other studies worldwide, in which genotype A was the predominant genotype. Distinct associations were observed between genotypes and antifungal resistance patterns, with azole and amphotericin B resistance mainly found in genotype C and flucytosine resistance predominating in genotype A. These findings suggest that determining genotypes and antifungal susceptibility profiles is important for informing clinical management and antifungal resistance surveillance.
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8. Onychomycosis in France, SFMM survey: Laboratory practices for the diagnosis in 2023 and epidemiology in 2019-2022.
8. 法国甲真菌病，SFMM调查：2023年诊断实验室实践及2019-2022年流行病学PMID:日期:2026-08-05Onychomycosis is a widespread superficial fungal infection worldwide, linked to dermatophytes and to a lesser extent to pseudodermatophytes or other moulds but also to yeasts. A retrospective national online survey was conducted in 2023 by the Société Française de Mycologie Médicale on the onychomycosis diagnostic process and culture identification results between 2019-2022. Among the 30 responses received for the practices part, it appeared that all laboratories used at least two culture media for this analysis (Sabouraud chloramphenicol and Sabouraud chloramphenicol-cycloheximide), 60% of them used mass spectrometry for fungal identification and 23.3% associated it with panfungal molecular sequencing. For the epidemiology part of the survey, data from 31 participants were collected. Identifications of fungal cultures from nails were obtained in 20,862 cases showing 79.8% of dermatophytes, among them 84.8% of Trichophyton rubrum. Pseudodermatophytes were responsible for 281 onychomycoses (1.4%), with 68.0% of Neoscytalidium hyalinum. This fungus was found in particular in the Martinique, a French territory in the Caribbean, where it has been reported twice as frequent as T. rubrum. Yeasts and moulds were found in 10.3% and 8.5% of the nail cultures, respectively, but the data collected for these fungi in this survey did not allow to separate onychomycosis from fungal colonisation or contamination (except Candida albicans, classically retained as a pathogen of the nails mainly from the hand). Finally, from 2015 to 2022, 24 cases of invasive fungal infections originating from nail infection were reported, including three related to dermatophytes, confirming that onychomycosis, rarely, can become life-threatening.
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9. Diversity in polar lipid signatures and phenotypes of terbinafine susceptible and resistant clinical isolates of Trichophyton rubrum.
9. 红色毛癣菌对特比萘芬敏感和耐药临床分离株的极性脂质特征及表型多样性PMID:日期:2026-08-03Terbinafine (TBF) remains a frontline therapeutic agent for dermatophytosis; however, resistance in Trichophyton rubrum is emerging as a significant clinical challenge. Here we present the mass spectrometry based lipidomic signatures of select clinical isolates of T.rubrum and draw attention to lipidomic changes related to TBF resistance. While there was no change in sterol content, an extensive lipid remodeling in PGL molecular species was observed. For example, a decreased unsaturation index, LPS/PS ratio, and LPA/PA ratio was observed in TBF resistant isolate. These changes were balanced by an increased odd fatty acyl containing and saturated -PGL molecular species, LPG/PG ratio, and LPI/PI ratio in TBF resistant isolate. Among SLs, PCer(t18:0/18:0(2OH)) species showed significant decrease in TBF resistant isolate. Additionally, decreased DAG and increased TAG contents point to the fact that lipid biosynthesis shifts from polar lipid synthesis towards TAG synthesis in the resistant isolate, while making necessary adjustments in PGL and SL molecular species to maintain membrane homeostasis and keep the sterol synthesis at optimum levels. Further, upon correlating the variations with phenotypes and enzymatic activities, a compensatory adaptation of stress in resistant isolates of T. rubrum is evident. Together, these datasets should be useful to understand the role of lipid homeostasis in the underlying mechanisms of TBF resistance and emphasize the potential lipid biosynthetic pathways to develop therapeutic interventions.
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10. Oral Candida infection and colonization in pediatric patients with cancer: risk factors, species distribution, and antifungal susceptibility.
10. 儿童癌症患者的口腔念珠菌感染与定植：危险因素、菌种分布及抗真菌药物敏感性PMID:日期:2026-07-30[中文摘要] 口腔念珠菌病是儿童癌症患者常见的机会性真菌感染，可导致严重的侵袭性感染。为有效管理和治疗口腔念珠菌病，解决危险因素、准确鉴定念珠菌菌种并提供合适的局部或全身抗真菌治疗至关重要。本研究纳入2024年4月至9月期间所有年龄≤18岁的癌症患者。进行了口腔检查并采集微生物拭子。采用传统方法和分子方法进行菌种鉴定。依据临床与实验室标准研究所指南，研究了六种常用药物的体外抗真菌活性。在102例儿童癌症患者中，39例（38.2%）培养阳性。在培养阳性的患者中，9例（23.1%）被诊断为口腔念珠菌病，而30例（76.9%）表现为口腔念珠菌定植。年龄或性别与口腔念珠菌病之间未发现统计学显著关联，而地塞米松和头孢他啶则显著相关。在获得的41株念珠菌分离株中，白念珠菌最常见（51.2%），其次为都柏林念珠菌（21.9%）、非洲念珠菌（12.1%）、热带念珠菌（7.3%）、光滑念珠菌（2.4%）、马克斯克鲁维酵母（2.4%）和库德里阿兹威毕赤酵母（2.4%）。两性霉素B和卡泊芬净对所有念珠菌分离株表现出最高的体外活性。氟康唑对白念珠菌的耐药率最高，为28.6%。本研究为儿童癌症患者口腔念珠菌定植和感染相关的危险因素、分子流行病学和抗真菌药敏模式提供了有价值的见解。它还强调了持续监测抗真菌药敏模式的重要性，以支持该人群的抗真菌管理措施。
[英文摘要] Oral candidiasis is a common opportunistic fungal infection in pediatric cancer patients, which can lead to severe invasive infections. To manage and treat oral candidiasis effectively, it is vital to address risk factors, accurately identify Candida species, and provide suitable topical or systemic antifungal therapy. This study included all patients aged ≤ 18 years with cancer from April to September 2024. Oral examinations were conducted along with the collection of microbial swabs. Species identification was performed using both conventional and molecular methods. The in vitro antifungal activity of six common agents was investigated using the Clinical & Laboratory Standards Institute guidelines. Of the 102 pediatric patients with cancer, 39 (38.2%) had positive cultures. Among those with a positive culture, 9 patients (23.1%) were diagnosed with oral candidiasis, while 30 (76.9%) exhibited oral Candida colonization. No statistically significant link was found between age or gender and oral candidiasis, while dexamethasone and ceftazidime were significantly associated. Among 41 obtained Candida isolates, C. albicans was the most common (51.2%), followed by C. dubliniensis (21.9%), C. africana (12.1%), C. tropicalis (7.3%), N. glabratus (2.4%), K. marxianus (2.4%), and P. kudriavzevii (2.4%). Amphotericin B and caspofungin demonstrated the highest in vitro activity against all Candida isolates. Fluconazole showed the highest resistance rate at 28.6% for C. albicans. This study provides valuable insights into risk factors, molecular epidemiology, and antifungal susceptibility patterns associated with oral Candida colonization and infection in pediatric cancer patients. It also underscores the importance of continued surveillance of antifungal susceptibility patterns to support antifungal stewardship efforts in this population.