Esophagus食管
Esophagus(英文缩写 ESOPHAGUS-TOKYO),ISSN 1612-9059,eISSN 1612-9067,中文译名:食管 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.671 | Q3 |
| 2022 | 2.400 | Q4 |
| 2023 | 2.200 | Q3 |
| 2024 | 3.800 | Q2 |
| 2025 | 5.800 | Q1 |
Esophagus 最新收录文献
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3. Long-term nutritional outcomes after esophagectomy following induction chemotherapy versus chemoradiotherapy for T4b esophageal cancer.
PMID:日期:2026-09-20The long-term impact of preoperative treatment on nutritional recovery after esophagectomy remains unclear. Although neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACRT) followed by surgery are established strategies for advanced esophageal cancer, their differential effects on postoperative weight loss have not been well characterized. This study aimed to compare long-term nutritional outcomes between esophagectomy after induction chemotherapy and after induction chemoradiotherapy in patients with T4b esophageal cancer. We retrospectively analyzed 86 patients with T4b esophageal cancer who underwent conversion surgery after induction treatment at six institutions between 2009 and 2021. Patients were categorized into a chemotherapy group (CT group, n = 51) and a chemoradiotherapy group (CRT group, n = 35). Longitudinal changes in body weight, lymphocyte counts, serum albumin levels, and prognostic nutritional index (PNI) were evaluated up to 24 months postoperatively. Postoperative weight loss was significantly greater in the CRT group than in the CT group, particularly at 9 and 12 months postoperatively (-13.4% vs. -9.6%, P = 0.011; -13.8% vs. -9.3%, P = 0.022). Weight loss persisted until 12 months after esophagectomy in the CRT group, whereas gradual recovery was observed after 6 months in the CT group. Lymphocyte counts were consistently lower in the CRT group from preoperation through 24 months postoperatively (all P < 0.05). Serum albumin levels did not differ significantly between groups. One year after surgery, deterioration in PNI was significantly greater in the CRT group (P < 0.001). Esophagectomy following induction chemoradiotherapy was associated with greater long-term weight loss and impaired nutritional recovery compared with surgery following chemotherapy alone. These findings highlight the need for intensified nutritional surveillance and intervention in patients treated with preoperative CRT.
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4. Tumor-associated calcium signal transducer 2 expression as a promising therapeutic target in esophageal squamous cell carcinoma: a combined the Cancer Genome Atlas and an institutional cohort.
PMID:日期:2026-09-20Esophageal squamous cell carcinoma (ESCC) has a poor prognosis, and new therapeutic targets are required. Antibody-drug conjugates (ADCs) are a promising therapeutic modality that selectively delivers cytotoxic payloads to tumors via cell-surface antigens. Tumor-associated calcium signal transducer 2 (TROP2, TACSTD2) has shown therapeutic potential as an ADC target in several malignancies; however, its clinical significance in ESCC remains unclear. An institutional cohort of ESCC patients treated at Kindai University was retrospectively evaluated by immunohistochemistry (n=70) and RNA sequencing (n=27). TACSTD2 copy number alterations, RNA expression, and survival were analyzed using the Cancer Genome Atlas (TCGA) ESCC dataset. IHC was assessed in both resected and biopsy specimens, including metastatic lesions. Survival analyses were performed, stratifying patients by cohort-specific median TACSTD2 expression levels. Immunohistochemistry analysis demonstrated uniformly strong TROP2 expression in all evaluable primary and metastatic lesions. In the TCGA dataset, TACSTD2 mRNA expression was consistently high, irrespective of copy-number status, and was comparable to or higher than that observed in non-small cell lung cancer and breast cancer, tumor types in which TROP2-targeted ADCs are clinically active. The TACSTD2 high-expression group showed a trend toward worse overall survival in both the institutional and the TCGA cohort, whereas disease-free survival was similar. TROP2/TACSTD2 is strongly and consistently expressed in ESCC at the protein and RNA levels, despite infrequent gene amplification, supporting its feasibility as a therapeutic target. High expression shows a trend toward poorer overall survival, warranting validation in larger cohorts.
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5. Randomized trial comparing esophageal resection versus substitution alone for corrosive esophageal strictures.
PMID:日期:2026-09-20To compare perioperative safety and long-term functional outcomes of esophageal resection versus substitution-alone in patients with corrosive esophageal strictures refractory to endoscopic dilatation. This prospective, single-center, open-label, parallel-group, non-inferiority randomized controlled trial was conducted at a tertiary referral center in India. Patients aged 14-60 years with corrosive esophageal strictures unresponsive to serial dilatation were included. Participants were randomized in a 1:1 ratio to either esophageal resection or substitution-alone group. The primary outcome was incidence of postoperative pulmonary complications (PPC) within 30 days. Secondary outcomes included operative parameters, postoperative morbidity, mortality, and health-related quality-of-life (HRQOL) assessed using the Gastrointestinal-Quality-of-Life-Index (GIQLI). Between September 2012 and December 2023, 143 patients were randomized (resection, n=69; substitution-alone, n=74), and all were analyzed. PPC occurred in 11.6% of the resection group and 8.1% of the substitution-alone group (absolute risk difference, 3.5%; 95% CI -6.3% to 13.3%); the prespecified non-inferiority criterion was not met. Mediastinal dissection time was significantly longer in the resection group (48 ± 28 vs 22 ± 8 min; p < 0.001). However, total operative duration, blood loss, cervical anastomotic leak rates, recurrent laryngeal nerve palsy, and length of hospital stay were comparable between groups. One mortality (0.7%) occurred in the resection group due to a colo-colic anastomotic leak. At 12-months, mean GIQLI scores were higher following resection (118.6 ± 11.2 vs. 111.2 ± 12.8; p=0.08). Esophageal resection and substitution-alone were associated with comparable perioperative outcomes in patients with corrosive esophageal strictures. Although formal non-inferiority of esophageal resection was not established, no significant difference in PPC was observed. The higher HRQOL scores following resection should be considered exploratory. Clinical Trials Registry of India (CTRI/2015/10/006237).
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6. Impact of educational pamphlet in achalasia care: education as therapy among Pakistani patients.
PMID:日期:2026-09-20Achalasia, a rare disease, requires symptomatic self-management that can be achieved by educating patients. Pakistan continues to struggle with low health literacy, resulting in a meagre understanding of disease management, for which educational materials have shown promising improvements in knowledge and symptom resolution. This study aims to investigate the impact of educational intervention on Pakistani achalasia patients, for their disease and associated symptoms management. A prospective observational study involving 84 Pakistani achalasia patients was conducted at Center for Liver and Digestive Diseases, Holy Family Hospital, Rawalpindi. Participants received educational pamphlet covering disease information, diagnostic tests, treatment options, and dietary recommendations. Baseline data, including demographic details and health measures, were collected, followed by an educational session. One month later, follow-up assessments evaluated changes in symptoms, HRQoL, and feasibility of pamphlet. Data analysis was performed using SPSS version 25.0. The educational pamphlets significantly improved health outcomes post-follow-up. Subgroup analysis suggested that intervention was broadly effective across demographic groups, while regression analysis confirmed that pamphlet intervention was strong predictor of symptom improvement (p < 0.001) and patient satisfaction. Correlation analyses revealed that higher education levels were associated with greater improvements in both Eckardt and ASQ scores, while employment status showed weak associations with health outcomes. The educational pamphlet had a significant impact on improving symptom management and patient satisfaction with achalasia, demonstrating its effectiveness in enhancing disease understanding and self-management. Future research should focus on the long-term effects and explore additional strategies to enhance disease self-management in diverse populations.
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7. Respiratory sarcopenia defined by paraspinal muscle mass and peak expiratory flow predicts postoperative pneumonia after esophagectomy for esophageal cancer: a comparison with sternocleidomastoid muscle mass.
7. 以椎旁肌质量和峰值呼气流速定义的呼吸肌少症预测食管癌食管切除术后 postoperative pneumonia：与胸锁乳突肌质量的比较PMID:日期:2026-09-20Sarcopenia is a predictor of postoperative pneumonia after esophagectomy. Recently, respiratory sarcopenia has been proposed as a predictor of postoperative pneumonia that captures respiratory vulnerability more directly than sarcopenia. Respiratory sarcopenia is defined by decreased respiratory muscle strength (RMS) and respiratory muscle mass (RPM). As RPM does not have an established assessment method, previous studies used skeletal muscle mass at L3, including the psoas major (PM) and paraspinal (PS) muscles. However, this may not accurately reflect respiratory muscle status. Therefore, we focused on the sternocleidomastoid (SCM) muscle, an accessory respiratory muscle. We investigated which muscle mass measure for defining respiratory sarcopenia shows the strongest association with postoperative pneumonia after esophagectomy: SCM at C3, PM at L3, or PS at L3. We reviewed 500 patients who underwent radical subtotal esophagectomy from 2007 to 2024. Based on preoperative CT, muscle mass was calculated as the areas of the three muscles normalized by height squared. RMS was assessed by percent predicted peak expiratory flow (%PEF). Respiratory sarcopenia was defined as low %PEF and low muscle mass. Univariable and multivariable logistic regression evaluated factors associated with postoperative pneumonia. Eighty patients (16.0%) developed postoperative pneumonia. In multivariable analysis, respiratory sarcopenia defined by PS mass was associated with postoperative pneumonia after adjustment for covariates (OR: 2.76, 95% CI 1.32-5.79, P = 0.007). SCM- and PM-based definitions were not significantly associated with postoperative pneumonia. Respiratory sarcopenia defined by decreased %PEF and PS mass is associated with postoperative pneumonia after esophagectomy.
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8. Local triamcinolone acetonide injection for the prevention of pharyngeal deformity following endoscopic submucosal dissection of superficial pharyngeal neoplasms.
PMID:日期:2026-09-20Extensive mucosal resection following endoscopic submucosal dissection (ESD) for hypopharyngeal neoplasms can result in scar contracture and pharyngeal deformity, potentially increasing the risk of aspiration pneumonia. This study aimed to evaluate the efficacy and safety of local triamcinolone acetonide (TA) injection for preventing post-ESD pharyngeal deformity. This retrospective cohort study included 388 patients who underwent ESD for hypopharyngeal neoplasms between 2011 and 2026. Patients were divided into those who received local TA injection after ESD (TA group, n = 65) and those who did not (control group, n = 323). Post-ESD pharyngeal deformity was classified into four grades based on endoscopic findings. The piriform sinus was subdivided into three subfields according to the extent of the mucosal defect. The TA group had a significantly lower deformity severity and fewer grade ≥ 2 deformities than the control group (both p < .001). Significant preventive effects were observed only in the piriform sinus (both p < .001). Among mucosal defects involving multiple piriform sinus subfields, both outcomes were significantly lower in the TA group for mucosal defects involving two (p < .001 and p = .046, respectively) and three (both p < .001) subfields. Similar findings were observed after propensity score matching. No adverse events related to TA injection were observed. Local TA injection may be an effective and safe strategy for preventing post-ESD pharyngeal deformity, particularly in mucosal defects involving multiple piriform sinus subfields.
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9. Improved operative mortality after esophagectomy in patients aged ≥ 75 years over a decade: a nationwide Japanese retrospective cohort study.
PMID:日期:2026-09-20Esophagectomy is associated with substantial morbidity and mortality, particularly in older patients. Although minimally invasive surgery (MIS) has been widely adopted, its contribution to improve operative outcomes in this population remains unclear. This study aimed to evaluate temporal trends in short-term outcomes after esophagectomy in patients aged ≥ 75 years and determine whether the increasing adoption of MIS contributed to improved operative mortality. Using the Japanese National Clinical Database, we analyzed patients aged ≥ 75 years who underwent radical esophagectomy for esophageal cancer between 2014 and 2024. The primary and secondary endpoints were operative mortality and severe postoperative complications (Clavien-Dindo grade ≥IIIa), respectively. Multivariable logistic regression analyses were performed, including sensitivity analyses additionally adjusted for MIS. Among 7,678 patients, patient complexity increased over time, with higher proportions of octogenarians, patients with American Society of Anesthesiologists Physical Status ≥ 3, and patients receiving preoperative chemotherapy. Open thoracotomy decreased from 53.1% to 6.5%, whereas robot-assisted esophagectomy increased from 0% to 34.8%. Operative mortality decreased from 4.7% to 2.4%, with a risk-adjusted odds ratio (OR) of 0.49 (95% confidence interval [CI] 0.35-0.67; P < 0.001). Risk of severe postoperative complications remained unchanged (adjusted OR = 1.12, 95% CI 0.98-1.29; P = 0.11). Mortality reduction remained significant after adjustment for MIS (OR = 0.58, 95% CI 0.41-0.83; P = 0.003). Despite increasing patient complexity, operative mortality after esophagectomy in older patients improved substantially over the past decade. This improvement was unlikely to be explained by the increasing use of MIS alone and may reflect broader advances in perioperative management and other system-level factors. These findings have important implications for surgical care in aging populations worldwide.
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10. Comparison of Respiratory function recovery after esophagectomy: a retrospective analysis of surgical approaches.
PMID:日期:2026-09-20Esophagectomy for patients with esophageal cancer is a highly invasive procedure that can lead to substantial postoperative pulmonary impairment. Minimally invasive approaches, such as video-assisted thoracoscopic surgery (VATS) and robot-assisted minimally invasive esophagectomy (RAMIE), have been introduced to improve postoperative outcomes. This study aimed to assess the impact of surgical approach on postoperative pulmonary function recovery. A retrospective analysis was conducted on patients who underwent esophagectomy between 2006 and 2023. Patients were categorized into three groups: open esophagectomy (OE), VATS, and RAMIE. Pulmonary function was assessed using vital capacity (VC) and forced expiratory volume in one second (FEV1.0) at one, three, six, and 12 months postoperatively. Multivariate logistic regression was performed to identify independent factors influencing respiratory function decline. In all approaches, the VC and FEV1.0 decreased at one month postoperatively, followed by gradual recovery. Compared with OE, RAMIE showed a significantly better VC than OE at one month postoperatively (p = 0.04), whereas VATS showed a significantly better FEV1.0 at one month (p = 0.03). By 12 months, respiratory function recovery was comparable among all groups. Postoperative pulmonary complications (PPCs) were identified as a significant risk factor for long-term pulmonary function decline (p = 0.044). Minimally invasive approaches, particularly RAMIE and VATS, contribute to preserving postoperative respiratory function at one month. However, respiratory function recovery is similar across all surgical techniques at one year. Preventing PPCs is crucial for improving respiratory function outcomes. Further prospective studies are needed to validate these findings and refine surgical strategies.