CHEMISTRY & BIODIVERSITY化学与生物多样性
CHEMISTRY & BIODIVERSITY(英文缩写 CHEM BIODIVERS),ISSN 1612-1872,eISSN 1612-1880,中文译名:化学与生物多样性 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.745 | Q3 |
| 2022 | 2.900 | Q3 |
| 2023 | 2.300 | Q3 |
| 2024 | 2.500 | Q3 |
| 2025 | 2.900 | Q3 |
CHEMISTRY & BIODIVERSITY 最新收录文献
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1. Development of Dithioacetal-Modified Dihydropyrimidone Derivatives with Potential Anti-Inflammatory Activity for Inflammatory Bowel Disease.
PMID:日期:2026-09-01Inflammatory bowel disease (IBD) is a chronic autoimmune disorder, and the development of novel anti-inflammatory small molecules is crucial for advancing therapeutic options. In this study, we designed and synthesized a series of novel dihydropyrimidinone derivatives containing dithioacetal groups. Through in vitro safety assessments and anti-inflammatory screening, we identified several compounds with promising biological activities. Notably, compound D3 exhibited exceptional anti-inflammatory effects, demonstrating an IC of 1.2 µM in inhibiting NO secretion. Mechanistic investigations revealed that D3 inhibits the activation of the MAPK/NF-κB signaling pathway, thereby reducing the expression of LPS induced pro-inflammatory proteins and the secretion of NO. In vivo, compound D3 effectively ameliorated DSS-induced acute colitis in mice, as evidenced by reductions in body weight loss and colonic adhesion. In conclusion, we have developed a series of promising anti-inflammatory small molecules that may offer significant therapeutic potential for IBD and contribute to the development of new anti-inflammatory drugs.
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2. Deep Eutectic Solvent Based Microwave and Ultrasound Assisted Extraction of Bioactive Compounds From Vitex agnus-castus: Optimization and Antioxidant/Antibacterial Evaluation.
PMID:日期:2026-09-01This study aimed to optimize microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE) of bioactive compounds from the leaves of Vitex agnus-castus using deep eutectic solvents (DES). Response surface methodology (RSM) was applied to determine optimal extraction conditions. ChCl:TetEG:HO was selected as the optimal DES for MAE, while ChCl:TriEG:HO was identified as the most suitable solvent for UAE. The physicochemical properties of DES, including FTIR spectra, viscosity, pH, and density, were characterized. Optimal MAE conditions were predicted as a microwave power of 293 W, an extraction time of 119 s, and a liquid-to-solid (L/S) ratio of 25.12, whereas optimal UAE conditions were 501.96 W, 23.27 min, and an L/S ratio of 70.08. Antioxidant activities (TAC, DPPH, and ABTS) of DES extracts were compared with those obtained using 70% ethanol under optimal MAE and UAE conditions. Phenolic and flavonoid compounds were quantified by HPLC, including caffeic, syringic, p-coumaric, and ferulic acids, as well as rutin, myricetin, quercetin, and kaempferol. In addition, the antibacterial activities of the extracts were evaluated. The results demonstrate the effectiveness of optimized MAE and UAE combined with DES for the comprehensive recovery of bioactive compounds from Vitex agnus-castus.
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3. Integrated Extraction of Tea Tree Oil and Polysaccharides From Melaleuca alternifolia Using Three-Phase Partitioning: Process Optimization, Techno-Economic Analysis, and Sustainability Evaluation.
PMID:日期:2026-09-01Conventional tea tree oil extraction approaches such as steam distillation are limited by excessive water and energy input, alongside the production of polysaccharide-rich waste residues. This study systematically explored the application of three-phase partition (TPP) method in Melaleuca alternifolia for integrated extraction of tea tree oil (TTO) and polysaccharides, addressing challenges in conventional methods. Using ammonium sulfate ((NH)SO) and tert-butanol (t-butanol), the TPP process operated under mild conditions (60°C). Through Box-Behnken Design optimization, TPP methods achieved 1.15% TTO and 5.57% polysaccharide yields rich in neutral pentoses. GC-MS analysis identified 32 volatile compounds in TPP-derived TTO, among which terpinen-4-ol (33.19%) served as the dominant bioactive constituent and satisfied the 30%-48% threshold specified in GB/T 26514-2011, while multiple minor terpene components fell outside the standard concentration ranges. A techno-economic evaluation revealed that the integrated process incurred a total direct material and electricity cost of 176.6 RMB for extracting 11.5 g of TTO and 55.7 g of polysaccharides, with t-butanol expenses constituting the majority (65.6%) of costs. Overall, this study is the first to establish a TPP process for simultaneous extraction of TTO and polysaccharides from M. alternifolia, offering a green, economically viable, and sustainable approach for industrial-scale bioactive compound recovery.
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4. Cinerascensosides A and B, Two New Cytotoxic Sulfated Saponins From the Sea Cucumber Holothuria cinerascens.
PMID:日期:2026-09-01Two new cytotoxic sulfated compounds, cinerascensosides A and B (1 and 2), alongside three described triterpene glycosides, holothurins A (3), B (4), and B (5), were separated from the sea cucumber Holothuria cinerascens. Their structures and absolute configurations were established through extensive spectroscopic analysis, DP4+ probability calculation, and ECD calculations. Furthermore, probable biosynthetic pathways of 1-5 were suggested. Among them, compound 4 exhibited the most potent cytotoxicity against the HepG2 cell line (IC = 2.60 µM), followed by compound 3 (IC = 2.80 µM). Compound 2 displayed cytotoxicity on the KB and SK-LU-1 cell lines (IC = 9.28 and 9.49 µM, respectively), whereas compound 3 exhibited potent activity (IC = 2.48 and 2.98 µM). Computational analyses, including molecular docking, network pharmacology, and molecular dynamics (MDs) simulations, collectively suggest a potential mechanism of action underlying the observed cytotoxic activity.
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5. Phytochemical Profile and Long-Term Physiological Effects of Green Coffee Bean Extract on Body Composition, Hematological Indices, and Liver Integrity in Experimental Rats.
PMID:日期:2026-09-01This study evaluated the 90-day effects of aqueous green coffee bean extract on body weight, anthropometric indices, hematological parameters, and hepatic morphology in Wistar rats, together with phytochemical characterization. Acute toxicity was also assessed. Adult Wistar rats (n = 24) were randomly allocated into four groups (n = 6/group): control (distilled water) and extract-treated groups receiving 150, 300, or 450 mg/kg body weight orally once daily for 90 consecutive days. Body weight was monitored weekly, while anthropometric, hematological, relative liver-weight, and histological assessments were performed at the end of treatment. Acute toxicity testing produced no mortality up to 5000 mg/kg. Compared with controls, extract-treated rats showed significant reductions in body-weight gain, body mass index, and specific body-mass gain (p < 0.005). RBC counts were significantly reduced in all treated groups while platelet count was significantly reduced at 450 mg/kg (p < 0.005). Histological examination showed preserved hepatic architecture, although mild cellular swelling and sinusoidal dilation occurred at 450 mg/kg. GC-MS identified caffeine, quinic acid, 2-hydroxy-6-methylbenzaldehyde, and n-hexadecanoic acid. Overall, 90-day exposure was associated with reduced weight gain and alterations in selected hematological indices, while no major structural hepatic damage was observed under the experimental conditions.
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6. Antioxidant Potential of Schistocerca gregaria (Orthoptera: Acrididae) Extract: HPLC Analysis, Molecular Docking, and Bioassays.
PMID:日期:2026-09-01Insects are emerging as a sustainable source of natural products in alternative and complementary medicine. This study evaluated the in vitro antioxidant activity and cytotoxic effects of methanolic extract of Schistocerca gregaria. Antioxidant activity was evaluated in the second, third, fourth, and fifth nymphal instars of S. gregaria. The results revealed that fifth nymphal instar exhibited markedly higher antioxidant capacity than the earlier instars with IC of 27.73, 74.71, and 34.32 µg/mL in the DPPH radical scavenging assay, FRAP and ABTS system, respectively for fifth nymphal instar of S. gregaria. Further characterization of the fifth nymphal instar methanolic extract was accomplished through HPLC leading to the identification of phenolic acids (chlorogenic, caffeic, and Ferulic acids), flavonoids (quercetin, apigenin, and kaempferol) with quercetin, apigenin, and chlorogenic as dominant constituents. Molecular docking study was performed to corroborate the in vitro results. Cytotoxicity testing on normal human skin fibroblasts indicated that the methanolic extract of the fifth nymphal stage was nontoxic up to 1000 µg/mL. No toxicity or mortality was observed at doses up to 4000 mg/kg.bw in zebrafish and 1500 mg/kg in mice. These findings confirm the antioxidant potential of S. gregaria nymphal extract with no in vitro or in vivo toxicity.
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7. Natural Lactone-Based Quorum Sensing Inhibitors Attenuate Virulence in Pseudomonas aeruginosa.
PMID:日期:2026-09-01Natural lactones represent a promising anti-virulence strategy against Pseudomonas aeruginosa by targeting quorum-sensing (QS) pathways. In this work, we investigate γ-caprolactone (Capro), γ-octalactone (Octa), γ-decalactone (GDL), δ-decalactone (DDL), and a laboratory-generated lactone mixture (Lx) as modulators of QS-regulated virulence. Treatment with γ-decalactone and engineered lactone formulations significantly downregulated rhlR expression (∼twofold) and suppressed pyocyanin and rhamnolipid production. At 48 h, lactone exposure reduced extracellular virulence factors by up to 74.81% (pyocyanin) and 49.08% (rhamnolipids), indicating effective disruption of quorum sensing signaling. Collectively, these findings demonstrate that biotransformation-derived lactones attenuate virulence programs in P. aeruginosa, highlighting their potential as quorum sensing inhibitors for managing biofilm-associated infections.
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8. Fungicidal Efficacy of Leaf Extracts From Khaya senegalensis (Desr.) A. Juss. Irrigated With Agricultural Drainage Water and Treated With Some Fertilizer Types.
PMID:日期:2026-09-01This study evaluated the bio-based chemical compounds and antifungal potential of leaf ethanolic extracts from 20-month-old Khaya senegalensis (Desr.) A. Juss. seedlings. Plants were irrigated with three water types: 100% Nile water (NW), 50% NW + 50% agricultural drainage water (ADW), and 100% ADW, and fertilized with NPK, seaweed extract (SE), microbial top strains (TS), or their combinations. The extracts were tested against plant pathogenic fungi, Botrytis fabae and Alternaria alternata. Rutin, gallic acid, and naringenin were the primary bioactive compounds. Under 100% NW, maximum concentrations reached 29.79, 6.87, and 13.039 mg/g extract, respectively. While 100% ADW caused severe abiotic stress and threshold failure in unfertilized plants, adding SE and TS biostimulants to the 50% ADW blend protected the leaf chemical profile (PC1 = 97.5%, PC2 = 1.5%). The highest fungal inhibition percentage (FIP) against B. fabae reached 54.8% using 50% NW + 50% ADW combined with NPK + TS. Against A. alternata, the maximum FIP was 85.6% at 3% with 100% ADW + NPK + TS. Minimum inhibitory concentrations were 0.75%-5% for B. fabae and 0.0625%-0.25% for A. alternata. Thus, K. senegalensis extracts offer a sustainable biopesticide resource for managing plant pathogens under marginal water irrigation.
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9. Synthesis, Characterization, and Biological Assessment of 2-Methoxynicotinonitrile Derivatives.
PMID:日期:2026-09-01This study presents the formation of 2-methoxy-3-cyanopyridine derivatives 3(a-g) that occurred while attempting to synthesize furo[2,3-b]pyridines. The structures of all newly synthesized compounds were confirmed by IR, H NMR, C NMR, 2D-NMR, HRMS, and crystal x-ray structure analysis. In the crystal structure of 3f, the molecules are connected by C-H···N≡C, C-Cl···O-C, and C-S···N≡C interactions to form layers, which are further connected through π···π and Cl···π interactions, consolidating a 3-dimensional structure. The antioxidant activities of all synthesized compounds were tested in a DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenger assay. Compound 3d displayed the highest level of activity with an IC of 57.47 ± 1.17 µg/mL. Moderate levels of antibacterial activity were found against Escherichia coli, Coagulase-Negative Staphylococci (CONS), and Streptococcus species. These findings indicate that the 2-methoxy nicotinonitrile is an adaptable scaffolding to provide both tunable electronic properties and potential antioxidant and antibacterial properties. This new synthetic conversion described here demonstrates a practical method for preparing structurally diverse cyanopyridines and provides a platform for further lead optimization toward future multifunctional bioactive compounds.
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10. Qualitative Analysis of Chemical Composition Changes Before and After Lactobacillus Fermented Ziziphi Spinosae Semen by LC-MS and Prediction of Fermentation Mechanism.
PMID:日期:2026-09-01This study aimed to screen dominant Lactobacillus strains for fermenting Ziziphi Spinosae Semen (ZSS), analyze chemical composition changes before and after fermentation, and speculate on the fermentation mechanism. Liquid fermentation of ZSS was conducted using Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus acidophilus, and Lactobacillus rhamnosus. HPLC was employed to determine the content of spinosin, 6'''-feruloylspinosin, jujuboside A, and jujuboside B. Total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity were measured using UV spectrophotometry. Principal component analysis (PCA) was employed to identify the optimal fermentation strain, and UPLC-Q-Exactive Orbitrap-MS technology was used for qualitative analysis of chemical components before and after fermentation. Results indicated L. plantarum as the optimal fermentation strain. UPLC-Q-Exactive Orbitrap-MS analysis revealed 41 chemical components in the unfermented sample, reduced to 30 post-fermentation. L. plantarum was hypothesized to catalyze enzymatic hydrolysis breaking C─O bonds, N─C bonds, acyl groups, and glucosyl groups, facilitating interconversion among compounds.