TRENDS IN MOLECULAR MEDICINE分子医学趋势
TRENDS IN MOLECULAR MEDICINE(英文缩写 TRENDS MOL MED),ISSN 1471-4914,eISSN 1471-499X,中文译名:分子医学趋势 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 15.272 | Q1 |
| 2022 | 13.600 | Q1 |
| 2023 | 12.800 | Q1 |
| 2024 | 13.800 | Q1 |
| 2025 | 18.100 | Q1 |
TRENDS IN MOLECULAR MEDICINE 最新收录文献
-
1. Genomic newborn screening, a healthcare system transformation.
PMID:日期:2026-09-23Genomics has revolutionised the diagnosis of rare diseases and is now set to transform prevention through integration with newborn screening programmes. This will identify a broader range of severe, treatable diseases while creating the potential for data reuse across the lifetime. However, for effective population-wide implementation, a shift in the healthcare system to support preventive rather than reactive healthcare will need to occur. In addition, potential harms need to be identified and minimised. This review covers key components of this system shift including parental consent and choice, data workflows and reporting, education, and health-economic impact. Utilising digital technology and global collaboration will be integral to successful evidence generation at scale and to the integration of genomics into public health.
-
2. The splicing axis of aging: mechanisms and therapeutic opportunities.
PMID:日期:2026-09-21Aging is characterized by progressive loss of molecular fidelity that compromises stem-cell function and tissue homeostasis. Aging transcriptomes show widespread disruption of RNA processing, including increased intron retention, cryptic splice-site usage, and altered RNA quality control. These changes arise from somatic mutations as well as accumulated transcriptional, metabolic, and proteostatic stress. Importantly, similar splicing abnormalities are observed in age-associated diseases such as clonal hematopoiesis and neurodegeneration, overlapping with physiological aging states. Here, we synthesize mechanistic, stem-cell, and longevity studies to define declining RNA-processing fidelity as a unifying contributor to aging across systems. We propose the 'splicing axis of aging' as a framework linking RNA-processing dysfunction to tissue decline and outline emerging therapeutic strategies to restore spliceosome integrity and RNA homeostasis.
-
3. Pulsatile farnesoid X receptor activation rewires liver disease pharmacology.
PMID:日期:2026-09-15Nuclear receptor agonists face a dilemma: sustained receptor activation improves efficacy but inevitably exacerbates mechanism-based toxicity. Zang et al. challenge this by demonstrating that transient, physiologically synchronized farnesoid X receptor activation maintains efficacy while minimizing adverse effects, introducing temporal control of signaling as a new precision-therapeutic paradigm.
-
4. hPSC models in cancer mechanisms and therapeutic discovery.
PMID:日期:2026-09-15Despite major advances in cancer genomics and immunotherapy, the field remains limited by experimental models that fail to faithfully recapitulate human tumor initiation, genetic context, and immune-tumor interactions. Traditional animal and immortalized cell models often lack predictive power for therapeutic response and toxicity. Recent advances in human pluripotent stem cell (hPSC) technology have transformed this landscape, enabling the generation of patient-specific cancer models, multicellular organoids and assembloids, and scalable immune effector cells. These platforms now permit mechanistic dissection of tumorigenesis, reconstruction of human tumor microenvironments, and development of off-the-shelf immunotherapies. This review will synthesize these emerging findings, define key technological and biological gaps, and outline future directions for integrating hPSC-based modeling into precision oncology and translational cancer research.
-
5. Extracellular vesicles redefine glioma detection.
PMID:日期:2026-09-03Robinson et al. challenge the reliance on neurosurgery for glioma diagnosis by integrating multi-omic profiling of plasma extracellular vesicles with machine learning. Across independent cohorts, these biomarkers discriminate between glioma and controls and enable longitudinal tracking of tumor burden, establishing a clinically relevant foundation for minimally invasive diagnosis, monitoring, and stratification.
-
6. The niche-metabolism axis: reprogramming tumor-associated macrophages for precision immunotherapy.
PMID:日期:2026-08-18Tumor-associated macrophages (TAMs) critically modulate solid tumor progression and immunotherapy resistance, yet their profound context-dependent heterogeneity defies the traditional M1/M2 dichotomy. In this review, we propose the 'niche-metabolism axis' framework, deconstructing the tumor microenvironment into dynamically interacting functional niches (e.g., hypoxic cores and tertiary lymphoid structures). Within these niches, specific physicochemical stresses substantially influence localized TAM metabolic reprogramming. Metabolites such as lactate and lipids act not merely as substrates but as signaling mediators and epigenetic donors, shaping TAM phenotypes. Consequently, TAMs acquire spatial metabolic imprints and evolve into 'ecosystem engineers' that actively remodel the immune microenvironment. This framework highlights that therapeutic paradigms should shift from nonselective TAM depletion to niche-specific metabolic-epigenetic reconstruction, providing a precise roadmap for designing next-generation engineered macrophage therapies.
-
7. Emerging therapeutic opportunities targeting nonclassical MHC-I molecules.
PMID:日期:2026-08-17Nonclassical major histocompatibility complex class I (MHC-I) molecules, including human leukocyte antigen E (HLA-E), HLA-F, HLA-G, MHC-I-related protein 1 (MR1), and the CD1 family, constitute a conserved antigen-presenting system that regulates immune surveillance, tissue homeostasis, and tolerance through specialized interactions with innate and unconventional T cells. Although these molecules have long been implicated in cancer, infection, autoimmunity, and transplantation, their distinct immunobiology and therapeutic potential have largely been considered in isolation. Recent advances in structural immunology, single-cell and spatial profiling, engineered immune cell technologies, and early clinical studies have established nonclassical MHC-I pathways as tractable targets for immunotherapy. In this review, we synthesize the biology, disease-associated functions, and therapeutic targeting of these molecules, integrating immune checkpoint blockade, antibody-based therapeutics, and MR1- and CD1-restricted cellular immunotherapies into a unified framework. We further highlight shared immunological principles, emerging clinical translation, and opportunities for universal, off-the-shelf immune interventions.
-
8. Formicitoxins: membrane-targeting antifungal peptides from carpenter ant venoms.
PMID:日期:2026-08-14Fungal infections cause millions of deaths, yet clinical antifungals span only three drug classes. Koch et al. discover formicitoxins-35 venom peptides from carpenter ants-which are the first from any formicine species. Two outperform voriconazole in vitro and delay infection in vivo. Formicitoxins disrupt fungal membranes independently of existing drug targets.
-
9. RNA translational control in skeletal development, homeostasis, and disease.
9. 骨骼发育、稳态和疾病中的RNA翻译调控PMID:日期:2026-08-14[中文摘要] 骨骼的发育、维持与修复需要精确控制蛋白质的生成，然而mRNA水平往往与蛋白质丰度相关性较差。翻译是将mRNA转化为蛋白质的过程，但其在骨骼生物学中的作用远不如转录调控那样被充分理解。近年来翻译组学（translatomics）的进展开始揭示翻译调控如何参与骨骼发育、稳态与修复。本文总结了跨骨骼谱系、发育阶段及疾病状态下的翻译控制，并讨论了研究mRNA翻译的新兴方法以及靶向翻译通路的潜在治疗机会。理解翻译调控如何塑造骨骼健康与疾病，将为骨骼缺陷的精准干预开辟新途径。
[英文摘要] Skeletal development, maintenance, and repair require precise control of protein production, yet mRNA levels often correlate poorly with protein abundance. Translation is the process through which mRNA is converted into protein, but its role in skeletal biology remains much less understood than that of transcriptional regulation. Recent advances in translatomics have begun to reveal how translational regulation contributes to skeletal development, homeostasis, and repair. Here, we summarize translational control across skeletal lineages, developmental stages, and disease settings. We also discuss emerging approaches for studying mRNA translation and potential therapeutic opportunities that target translational pathways. Understanding how translational regulation shapes skeletal health and disease will open new avenues for precise interventions for skeletal defects.
-
10. Tumor metaboception: local PGE2 signals global decline.
PMID:日期:2026-08-13Cancer cachexia has long been attributed to circulating factors. Cross et al. now show that, in liver kinase B1 (Lkb1)-mutant lung tumors, local prostaglandin E2 acts on vagal neurons to drive anorexia and wasting, accelerated by fat. Defining metaboception as neural sensing of local signals-a new therapeutic concept.