Vascular Health and Risk Management血管健康与风险管理
Vascular Health and Risk Management(英文缩写 VASC HEALTH RISK MAN),ISSN 1176-6344,eISSN 1178-2048,中文译名:血管健康与风险管理 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 未收录 | N/A |
| 2022 | 2.900 | N/A |
| 2023 | 2.600 | Q2 |
| 2024 | 2.800 | Q2 |
| 2025 | 3.200 | Q2 |
Vascular Health and Risk Management 最新收录文献
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1. MiR-375 Targeting PDK1 Regulates the Wnt/β-Catenin Pathway in Lower Extremity Arteriosclerosis Obliterans.
1. MiR-375靶向PDK1调控下肢动脉硬化闭塞症中的Wnt/β-catenin通路PMID:日期:2026-01-01Lower extremity arteriosclerosis obliterans (LEASO) is a severe peripheral arterial disease characterized by chronic inflammation, lipid deposition, and vascular remodeling. MicroRNA-375 (miR-375) has emerged as a regulatory molecule in vascular pathology, but its role in LEASO remains unclear. This study investigated whether miR-375 regulates the Wnt/β-catenin signaling pathway by targeting pyruvate dehydrogenase kinase 1 (PDK1), and its impact on LEASO progression. Clinical samples (arterial tissues and blood) were collected from 10 LEASO patients and 10 trauma-related amputation controls. Histology, qPCR, Western blot, and ELISA were used to evaluate molecular and inflammatory markers. Animal models of atherosclerosis (LDLR-/- mice) and LEASO (SD rats) were established, with Wnt/β-catenin pathway inhibition as intervention. In vitro, vascular smooth muscle cells (VSMCs) were transfected with miR-375 mimics/inhibitors, and functional assays were performed. Dual-luciferase reporter assays confirmed the interaction between miR-375 and PDK1. Compared with the control group, miR-375 expression was markedly downregulated in LEASO tissues, reaching only 50.3% of the control level (P=0.008). By contrast, the mRNA and protein expression levels of PDK1, Wnt3a and β-catenin were significantly increased. A strong positive correlation was observed between PDK1 expression and Wnt signaling activity (r=0.91, P=0.012). Dual-luciferase reporter assay verified that miR-375 directly bound to the 3'-untranslated region (3'-UTR) of PDK1 mRNA, and suppressed PDK1 expression by 78% (P<0.001).In vascular smooth muscle cells (VSMCs), miR-375 overexpression suppressed cell proliferation and migration by 41.5% and 17.3%, respectively. Nevertheless, simultaneous PDK1 overexpression reversed these inhibitory biological effects. Notably, miR-375 upregulation inhibited the PDK1-Wnt/β-catenin signaling cascade and alleviated pathological phenotypes both in vitro and in vivo. However, endogenous miR-375 reduction was accompanied by compensatory and nonlinear alterations of molecular profiles under certain in vitro conditions, such as oxidized low-density lipoprotein (ox-LDL)-stimulated VSMCs.In vivo experiments demonstrated that restored miR-375 expression reduced atherosclerotic plaque area by 41.5%, decreased the secretion of pro-inflammatory cytokines including interleukin-6 (IL-6) and interleukin-1β (IL-1β), and enhanced plaque stability. Conversely, miR-375 knockdown aggravated intracellular lipid deposition and systemic inflammatory responses. miR-375 suppresses LEASO progression by targeting PDK1 and downregulating Wnt/β-catenin signaling. Restoring miR-375 expression represents a promising therapeutic strategy for LEASO.
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2. Short-Term 24-h Systolic Blood Pressure Variability and Subclinical Target-Organ Damage in White-Coat Hypertension: A Retrospective Cross-Sectional Study.
PMID:日期:2026-01-01To compare subclinical target-organ damage (TOD) across normotension (NT), white-coat hypertension (WCH), and mild-to-moderate hypertension (HT), and examine the association of 24-h systolic blood pressure (SBP) variability with concurrent TOD in untreated WCH. This single-center retrospective cross-sectional study included 267 hospitalized participants who underwent ambulatory blood pressure monitoring between 2012 and 2021 (91 NT, 93 WCH, 83 HT). TOD markers were compared across groups. Within WCH, multivariable models assessed 24-h SBP variability in relation to any TOD, left ventricular hypertrophy (LVH), left ventricular mass index (LVMI), and microalbuminuria (MA), adjusting for age, sex, body mass index, and 24-h mean SBP. Any TOD occurred in 26.4%, 52.7%, and 71.1% of NT, WCH, and HT participants, respectively (P<0.001). Within WCH, any TOD occurred in 35.5%, 64.5%, and 58.1% across increasing variability tertiles; the unadjusted between-tertile comparison was not statistically significant (P=0.056). Continuous 24-h SBP variability was associated with any TOD (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.05-1.52), LVH (OR 1.30, 95% CI 1.08-1.60), LVMI (β=2.23 g/m, 95% CI 0.33-4.12), and log-transformed MA (β=0.105, 95% CI 0.052-0.157). The area under the receiver operating characteristic curve was 0.613 for the base model and 0.678 after adding 24-h SBP variability, with better overall fit of the extended model (likelihood-ratio P=0.009). WCH showed an intermediate prevalence of any TOD between NT and mild-to-moderate HT. Within WCH, higher 24-h SBP variability was associated with concurrent TOD after accounting for 24-h mean SBP and basic clinical factors, and may provide Supplementary Information when interpreted alongside mean ambulatory blood pressure. These single-center cross-sectional findings do not establish temporal or causal relationships and require confirmation in prospective multicenter studies.
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3. Temporal Changes in Hospital-Captured 90-Day Care After Venous Thromboembolism: A 16-Year Electronic Health Record Cohort Study.
PMID:日期:2026-01-01Direct oral anticoagulants (DOACs) have simplified treatment for venous thromboembolism (VTE), but fewer mandatory monitoring visits may reduce opportunities for structured reassessment. We evaluated temporal changes in hospital-captured documentation of post-VTE care processes during the transition to DOAC-based treatment, including initial anticoagulation, clinical follow-up, laboratory monitoring, and selective imaging reassessment. We conducted a single-center retrospective electronic health record cohort study using routinely collected vascular surgery outpatient and inpatient records from Peking University People's Hospital between 2009 and 2024. Patients with VTE-related evidence and a definable hospital-captured index date were included. Treatment eras were prespecified as 2009-2014, 2015-2019, and 2020-2024. The study-defined documentation measure comprised therapeutic anticoagulation within 14 days and clinical follow-up, laboratory monitoring, and selective VTE-related ultrasound or imaging reassessment within 15-90 days. Among 5998 patients with a definable hospital-captured index VTE-related event, the median age was 64.0 years, and 55.3% were female. Documented anticoagulation within 14 days increased from 34.1% in 2009-2014 to 58.0% in 2020-2024. Within 15-90 days, clinical follow-up was documented in 1483 patients (24.7%), laboratory monitoring in 366 (6.1%), and VTE-related ultrasound or imaging reassessment in 578 (9.6%). All four prespecified domains were documented in 149 patients (2.5%) overall and in 3.2% during 2020-2024. In multivariable analysis, the 2020-2024 era, pulmonary embolism presentation, and upper-extremity or catheter-related VTE were associated with higher odds of four-domain documentation completion. In this 16-year electronic health record cohort, hospital-captured documentation of early anticoagulation increased, whereas documentation of 90-day follow-up processes remained infrequent; incomplete documentation or care delivered outside the hospital system may have contributed. These findings highlight opportunities to strengthen continuity and traceability of post-VTE management through timely clinical review and individualized decisions regarding treatment duration, safety monitoring, and selective imaging when clinically indicated.
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4. Sex as a Modifier of Health-Related Quality of Life, Illness Acceptance, and Psychological Distress in Patients After Aortic Aneurysm Repair: A 2-Year Prospective Study.
PMID:日期:2026-01-01Women constitute a minority of patients undergoing aortic aneurysm repair, yet available data suggest a worse quality of life and a higher burden of perioperative anxiety in this group. Prospective, multi-timepoint data comparing the sexes in Polish clinical centres are virtually absent. We assessed whether sex modifies quality of life, illness acceptance, and psychological distress over 2 years following aortic aneurysm repair. In this prospective, single-centre cohort study, 150 consecutive patients (113 men, 37 women; mean age 69.9, SD 8.1 years) treated for aortic aneurysm between 2021 and 2024 completed the WHOQOL-Bref, the Acceptance of Illness Scale (AIS) and the Hospital Anxiety and Depression Scale, Polish modified version (HADS-M), immediately after surgery and at 6 months, 1 year and 2 years. The cohort was unrestricted with respect to aneurysm extent and repair modality. The primary analysis used generalised estimating equations including sex, time and the sex-by-time interaction, adjusted for age, repair modality, urgency of admission, ischaemic heart disease and partnered status. A prespecified sensitivity analysis was restricted to infrarenal aneurysms treated by standard endovascular repair (n=94). Immediately after surgery, women scored lower than men in all four WHOQOL-Bref domains: physical 52.7 vs 60.2 (p=0.013), psychological 58.4 vs 68.1 (p=0.001), social relationships 59.0 vs 69.6 (p<0.001) and environmental 62.8 vs 67.5 (p=0.037); anxiety was higher in women (8.7 vs 7.1; p=0.035). After adjustment, the early deficit remained significant for the psychological domain (adjusted difference -9.26, 95% CI -15.54 to -2.98; p=0.004) and the social relationships domain (-9.85, 95% CI -15.95 to -3.74; p=0.002) but not for the physical or environmental domains, and the crude anxiety difference did not survive adjustment (p=0.253). Significant sex-by-time interactions indicated convergence in all domains except social relationships, for which the adjusted female deficit persisted across follow-up (-6.86, 95% CI -12.27 to -1.44; p=0.013). At 2 years no woman remained in the low illness-acceptance category compared with 20.5% of men (p=0.037); this categorical comparison rests on small and unstable cell counts and is presented as descriptive only. The sensitivity analysis reproduced and strengthened these findings. Women undergoing aortic aneurysm repair report a lower quality of life in the early postoperative period, and the deficit in the social relationships domain is the one that persists over 2 years after adjustment. In the absence of a preoperative baseline and with a small female subgroup, these observations are hypothesis-generating and support the routine, sex-stratified capture of patient-reported outcome measures in aortic practice.
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5. Risk Factors and Clinical Outcomes for Patients with Venous Thromboembolism in Kenya: Findings from the HEART Registry.
PMID:日期:2026-01-01Venous thromboembolism (VTE) encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE) poses a significant burden despite advances in diagnostic and therapeutic options. The risk factors and clinical outcomes of VTE are dynamic, highlighting the need for more comprehensive studies, especially in sub-saharan Africa. This study aimed to identify risk factors and clinical outcomes in three major tertiary centers in Kenya. The HEART Registry was developed in 2021 and recruited patients with VTE prospectively over three years from three facilities in Kenya. Patients' demographics, risk factors for VTE, hospital course, and clinical outcomes over six months were obtained. Descriptive statistics were used to summarize the data, presenting the findings as frequencies, percentages, medians, and interquartile ranges. No pre-specified inferential or comparative analyses were planned, consistent with the descriptive registry design. A total of 422 patients with VTE were prospectively enrolled. The median age was 46.5 years notably younger than typically reported in Western populations. DVT was the most common presentation (54%) followed by PE (38.4%). A substantial proportion of patients (49.5%) did not have any identifiable risk factors (unprovoked VTE). The most common acute-phase treatment was low molecular weight heparin (57.5%), followed by warfarin (28.6%). Direct oral anticoagulants recommended as first line therapy by current international guidelines were available but underutilized reflecting access constraints. Only 1.7% of participants received thrombolytic therapy. The median length of hospital stay was eight days. In the acute phase, 10.4% (n=31) of admitted participants died. At six-month follow-up, death occurred in an additional 39 patients. A substantial proportion of VTE patients in Kenya had no identifiable risk factors which is a pattern consistent with global data on unprovoked VTE. This highlights the need for caution in attributing VTE solely to preventable causes. VTE associated acute and six month mortality was high, driven predominantly by underlying comorbidities. Preventing VTE in acute medical conditions remains a major area of concern and future prospective studies are needed to identify novel population specific risk factors and optimize outcomes in this setting.
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6. Short-Term Efficacy and Safety of Topical Sirolimus Gel in Pediatric Superficial Microcystic Lymphatic Malformations: A Single-Center Interventional Study of 30 Patients.
PMID:日期:2026-01-01To evaluate the efficacy and safety of 0.2% topical sirolimus gel for pediatric superficial microcystic lymphatic malformations (LMs). This single-center interventional study included 30 pediatric patients (14 males and 16 females; aged 2-15 years) with superficial microcystic lymphatic malformations. All patients received 0.2% topical sirolimus gel twice daily for 12 weeks according to a predefined treatment and follow-up protocol. Clinical efficacy was assessed at baseline and week 12 using clinical examination, standardized photography, symptom scores, and available imaging findings, together with a four-grade physician-assessed response scale. Adverse events were monitored throughout treatment, and blood sirolimus concentrations were measured at weeks 4 and 12. All patients showed lesion reduction, with an overall response rate of 96% (29/30). At week 12, efficacy was graded as IV in 10 patients, III in 11, II in 8, and I in 1. Among patients with pain symptoms, pain scores decreased significantly after treatment (2.88 ± 0.78 vs 1.18 ± 0.88; P < 0.05). In 10 patients with measurable lesions, maximum lesion diameter decreased significantly from 3.22 ± 1.36 cm to 1.89 ± 1.33 cm (P < 0.05). Only mild local adverse effects were observed, and blood sirolimus concentrations remained below 2.0 ng/mL in all patients. Topical sirolimus gel demonstrated favorable efficacy and safety for pediatric superficial microcystic LMs.
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7. Public Awareness of Stroke Risk Factors, Warning Symptoms, Prevention Measures, and Stroke Management Among Adults in Two Major Cities in Yemen: A Cross-Sectional Study.
PMID:日期:2026-01-01Stroke remains a major global health challenge and a leading cause of mortality and long-term disability worldwide. In low-income, conflict-affected countries such as Yemen, the burden is amplified by fragile healthcare systems and limited access to preventive and acute care services. Hence, this study addresses a critical awareness gap by assessing awareness of stroke risk factors, symptom recognition, prevention strategies, and stroke management among adult community members in two major urban cities in Yemen. A cross-sectional survey design was employed using paper-based questionnaire. Participants were recruited through convenience sampling. Data analysis included descriptive statistics, non-parametric tests, correlation analysis, and bivariate logistic regression analysis. Our study revealed a high level of overall recognition-based awareness was observed among surveyed participants (87.9%; 95% CI: 84.7-91.1%). Specific areas of high recognition included obesity or overweight (89.4%) and high blood pressure (86.2%) as risk factors, dizziness/loss of balance (79.1%) as a symptom, and taking prescribed medications (87.2%) and regular medical checkups (86.9%) for prevention. Awareness of immediate medical care (87.7%) and future prevention medications (85.9%) also stood out in stroke management domain. A personal or family history of chronic diseases was strongly associated with greater overall stroke awareness score (p<0.001), as was a history of stroke itself (p=0.03). Bivariate regression analysis highlighted significant associations between high awareness and education level for symptoms, prevention, and stroke management domains scores (p <0.001). Despite the encouraging overall awareness, the findings highlight areas where targeted public health interventions may be warranted, particularly for less recognized aspects of stroke awareness. These should focus on reinforcing awareness, particularly concerning less recognized symptoms, and addressing disparities linked to socio-economic factors. These findings highlight the need for targeted stroke awareness interventions in urban settings, while underscoring the importance of further nationally representative studies. This study sheds light on the current level of stroke awareness and offers vital insights for policymakers and medical professionals to create culturally appropriate and successful educational campaigns.
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8. Refractory Kawasaki Disease in Infants Complicated with Giant Coronary Artery Aneurysms and Takayasu Arteritis: A Rare Case Report and Literature Review.
PMID:日期:2026-01-01Kawasaki disease (KD) is a common acute systemic vasculitis in children.10% to 20% of children present with refractory KD, and a few critically ill children may develop Kawasaki disease shock syndrome (KDSS) or macrophage activation syndrome (MAS). Coronary artery aneurysm (CAA) is the most serious complication of KD, and giant coronary artery aneurysm (GCAA) has an extremely poor prognosis. Takayasu arteritis (TAK) is a chronic granulomatous vasculitis mainly involving the aorta and its branches. It is extremely rare in infants, with no specific early symptoms and prone to delayed diagnosis. The combination of infant KD and TAK is extremely rare, as there is overlap in vascular involvement, making it difficult to differentiate clinically. This article reports the case of a 45-day-old male infant diagnosed with refractory KD, accompanied by KDSS and MAS. After conventional treatment, the condition relapsed and progressed to a GCAA, and subsequently TAK occurred. The complete clinical diagnosis and treatment process of the case will be elaborated in detail here. At the same time, based on the literature review, the diagnosis and treatment of this disease are analyzed to guide clinical practice.
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9. Stent Retriever-Assisted Embolic Protection During Recanalization of Chronic Internal Carotid Artery Occlusion with Contralateral Carotid Stenosis: A Case Report.
PMID:日期:2026-01-01Chronic internal carotid artery occlusion (CICAO) with contralateral stenosis confers high stroke risk, particularly when thrombocytopenia complicates dual antiplatelet therapy (DAPT). We report a single case of staged carotid revascularization in which a stent retriever was used as a temporary distal protection device during CICAO recanalization after hematologic optimization. A 69-year-old woman with chronic hepatitis B-related thrombocytopenia (20-68 × 10/L) presented with progressive imbalance (NIHSS 3, mRS 2). Imaging revealed bilateral parieto-occipital infarcts, chronic left ICA occlusion, and severe right ICA stenosis (80% North American Symptomatic Carotid Endarterectomy Trial (NASCET)). After eltrombopag therapy increased platelet counts to >300 × 10/L, DAPT was initiated. Revascularization was performed in two stages: right ICA stenting with distal filter protection, followed 14 days later by left CICAO recanalization using a Catch Mini stent retriever (Balt, Montmorency, France) as temporary embolic protection and dual-stent reconstruction (proximal Wallstent (Boston Scientific, Marlborough, MA, USA) and distal braided Leo+ stent (Balt, Montmorency, France)). Both procedures were completed without periprocedural complications. At 6 months, CTA demonstrated distal re-occlusion of the cavernous (C4) segment; however, the patient remained clinically stable (NIHSS 0) without recurrent ischemic events. The stent retriever-assisted approach was technically feasible in this single carefully selected patient and may offer a solution to the inherent limitation of conventional embolic protection devices in CICAO recanalization; however, its protective efficacy cannot be established without post-procedural imaging, which was not obtained in this case.
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10. Associations of Patient Morphology and Venous Anatomy with Early Changes in Upper-Extremity Venous Blood Flow Following PICC Placement in Patients with Cancer: A Prospective Cohort Study.
PMID:日期:2026-01-01Ultrasound evaluation of target vein diameter before peripherally inserted central catheter (PICC) placement is recommended to control the catheter-to-vein ratio, but early hemodynamic changes after PICC placement remain incompletely characterized. This study evaluated the associations of patient morphology and baseline venous anatomy with early changes in upper-extremity venous blood flow velocity after PICC insertion. In this prospective single-center cohort study, 519 adult patients with cancer requiring PICC insertion were enrolled. Body mass index (BMI), arm circumference, baseline vascular depth, and baseline vascular diameter were recorded before catheterization. Time-averaged mean venous blood flow velocity was measured by Doppler ultrasound before insertion and on day 1 after insertion under identical conditions. Multivariable linear regression was used to identify factors independently associated with day-1 flow velocity and with the change in flow velocity. All 519 patients completed baseline and day-1 assessments. Mean blood flow velocity decreased from 14.87 ± 4.42 cm/s at baseline to 14.28 ± 4.87 cm/s on day 1 (mean difference, -0.59 cm/s; 95% CI, -1.08 to -0.10; p = 0.017); the effect size was small (Cohen's dz = -0.10) and the clinical significance of this change is uncertain. The mean catheter-to-vein ratio was 30.8% ± 6.6%, and 36.4% of patients exceeded a ratio of 33%. In multivariable analyses, baseline vascular diameter was independently associated with both day-1 flow velocity (adjusted β, 7.25 cm/s per cm; 95% CI, 2.85-11.64; p = 0.001) and the change in flow velocity (adjusted β, 8.33 cm/s per cm; 95% CI, 3.18-13.48; p = 0.002), with smaller veins showing lower post-insertion velocities and greater reductions. Body mass index was independently associated with day-1 flow velocity (adjusted β, 0.24 cm/s per kg/m; 95% CI, 0.10-0.38; p = 0.001). Patient morphology and venous anatomy were associated with different patterns of early hemodynamic change after PICC insertion. This study evaluated hemodynamic changes only; catheter-related thrombosis was not assessed, and no conclusions regarding thrombosis risk can be drawn. The observed velocity reduction was small and of uncertain clinical significance. These findings are hypothesis-generating, and future studies incorporating thrombosis endpoints are needed.