TRENDS IN BIOCHEMICAL SCIENCES生物化学趋势
TRENDS IN BIOCHEMICAL SCIENCES(英文缩写 TRENDS BIOCHEM SCI),ISSN 0968-0004,eISSN 1362-4326,中文译名:生物化学趋势 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 14.264 | Q1 |
| 2022 | 13.800 | Q1 |
| 2023 | 11.600 | Q1 |
| 2024 | 11.000 | Q1 |
| 2025 | 14.400 | Q1 |
TRENDS IN BIOCHEMICAL SCIENCES 最新收录文献
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1. The protein tyrosine phosphatase interactome: beyond catalytic activity.
1. 蛋白质酪氨酸磷酸酶相互作用组：超越催化活性PMID:日期:2026-10-02Protein tyrosine phosphatases (PTPs) are increasingly recognized as regulators of signaling networks rather than mere antagonists of kinases. Interactome-level analyses reveal that many PTPs function as scaffolds that organize spatially constrained signaling complexes, thereby influencing context-dependent signaling outputs. Focusing on representative nonreceptor PTPs (SHP-2, PTPN23, and PTPN13) and receptor PTPs (PTPRM and PTPRK), this review integrates methodological advances that enable increasingly detailed mapping of PTP-centered interactomes. Across cancer, neurobiology, and immune signaling, changes in these assemblies link scaffold function to disease phenotypes. This framework highlights PTP scaffold functions beyond catalysis and emerging therapeutic strategies targeting protein-protein interactions and scaffold-dependent mechanisms.
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2. Cell-free RNA fragmentomics: rethinking the biology of RNA liquid biopsies.
2. 无细胞RNA片段组学：重新思考RNA液体活检的生物学PMID:日期:2026-10-01Cell-free RNA (cfRNA) is emerging as a promising analyte for liquid biopsy because it captures dynamic changes in gene expression across tissues and disease states. However, interpretation of cfRNA profiles remains limited by the lack of a unifying framework describing how extracellular RNAs are released, processed, and stabilized. Here, we propose that concepts from cell-free DNA fragmentomics provide a useful lens to interpret cfRNA biology and introduce the concept of cfRNA fragmentomics. We argue that many cfRNAs originate as intracellular ribonucleoprotein complexes that undergo extracellular ribonuclease processing, generating stable fragmented RNAs associated with proteins and other carriers. Under this framework, informative cfRNA signatures may arise not only from diseased tissues but also from indirect systemic responses to disease.
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3. PABMB: connecting molecular biosciences across the Americas.
3. PABMB：连接美洲各地的分子生物科学PMID:日期:2026-10The Pan-American Association for Biochemistry and Molecular Biology (PABMB) has promoted scientific exchange, education, and research in the molecular biosciences across the Americas for more than five decades. By linking national societies operating in markedly different scientific environments, PABMB provides a regional framework for meetings, training, researcher mobility, and international collaboration, with particular emphasis on early-career scientists.
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4. HAT trick: how histones open the door to gene expression.
4. HAT技巧：组蛋白如何开启基因表达之门PMID:日期:2026-10该文献暂无摘要。
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5. Kinesins as dynamic drug targets: structural insights and emerging therapeutic strategies.
5. 驱动蛋白作为动态药物靶点：结构洞察与新兴治疗策略PMID:日期:2026-09-22Kinesins are essential for intracellular organization and cell division, and their involvement in disease has generated interest in their therapeutic potential. However, pharmacological studies have focused on a limited subset of kinesins and have mainly targeted the conserved motor domain. Advances in cryogenic electron microscopy and artificial intelligence-based structure prediction are revealing new opportunities for selective modulation. These approaches show that specific kinesin families may be inhibited by targeting conformational states induced by nucleotide and microtubule binding. They have also identified regulatory sites outside the motor domain, including stalk and tail interfaces that control autoinhibition, cargo binding, and localization. These insights redefine kinesins as dynamic, multidomain machines and highlight opportunities for selective, mechanism-guided therapeutic strategies.
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6. Evolutionary assembly of the flagellar cage: repurposing a Type IV pili subcomplex.
PMID:日期:2026-09-22Flagella, the major motility organelles in bacteria, display great diversity and complexity in their motor structures. Aside from the classical model with a simple motor, the functions of the components of complex motors are beginning to be explored. Recently, flagellar motors in Campylobacterota were found to have homologs of Type IV pili (T4P). Here, we review how these homologs form a peripheral cage structure in the motor, enclosing stator units and influencing motor assembly and function. We highlight structural features, including conformational variability and a proposed two-step assembly process, and synthesize evidence for their possible origin via exaptation of T4P components in the common ancestor of Campylobacterota. This work focuses on the evolution, structure, and functional integration of a co-opted subcomplex, shedding light on the re-engineering of nanomachines.
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7. Cable bacteria use extracellular electron transfer.
7. 电缆细菌利用胞外电子传递PMID:日期:2026-09-15Recent work by Aiyer and colleagues demonstrates that cable bacteria can conserve energy and grow under anoxic conditions by transferring electrons to electrodes via extracellular electron transfer. This transfer is both direct and riboflavin-mediated. Two distinct outer cell-surface redox centers, likely outer-membrane cytochromes, are involved in the electron transfer.
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8. SNOR: a path for ribosome recovery after hibernation.
8. SNOR：核糖体休眠后恢复的途径PMID:日期:2026-09-14Cellular dormancy requires ribosomes to be reversibly silenced yet preserved. Gluc et al. identify Shwachman-Bodian-Diamond syndrome domain-containing hibernation factor (SNOR), a fission yeast hibernation factor induced specifically by perturbed glucose homeostasis. Rather than driving translational shutdown, SNOR maintains dormant ribosomes in a state competent for rapid reactivation.
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9. Selection regimes, not just cold environments, shape cold-active cellulases.
9. 选择机制，而不仅仅是寒冷环境，塑造了冷活性纤维素酶PMID:日期:2026-09-10Cold-active cellulases have traditionally been discovered in persistently cold environments, but examples from autolytic mushrooms, gut microbiomes, and biomass-decomposition systems suggest they are not exclusive adaptations to chronic cold. We propose that diverse ecological selection regimes may also favor enzymes that relieve catalytic bottlenecks.
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10. Pyruvylation expands the redox repertoire of lysine acylation.
10. 丙酮酰化扩展了赖氨酸酰化的氧化还原反应范围PMID:日期:2026-09-07Song et al. establish lysine pyruvylation (Kpy) as an acylation response to glycolytic flux and pyruvate availability, detect pyruvyl-CoA, implicate histone acetyltransferase 1 and p300 as writers and sirtuin 3 as an eraser, and link promoter-associated histone Kpy to transcriptional regulation, defining a distinct C3 acylation alongside lactylation at the redox-coupled pyruvate-lactate node.