JOURNAL OF CLINICAL INVESTIGATION

JOURNAL OF CLINICAL INVESTIGATION(英文缩写 J CLIN INVEST),ISSN 0021-9738,eISSN 1558-8238 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。

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JOURNAL OF CLINICAL INVESTIGATION 最新收录文献

1. Rocky Mountain labs: NIAID's Montana campus.
   Karen Honey
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19244628
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2. Hoofbeats, zebras, and insights into insulin resistance.
   Robert A Hegele, Karen Reue
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19244606

   In this issue of the JCI, Semple and colleagues report phenotypic evaluation of patients with a germline mutation in the gene encoding serine/threonine kinase AKT2 (see the related article beginning o…

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3. DAMPs ramp up drug toxicity.
   Jacquelyn J Maher
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19244605

   The clinical syndrome of acetaminophen-induced liver injury represents the combined result of drug toxicity and a potent innate immune response that follows drug-induced cell death. In this issue of t…

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4. Glucocorticoids and neonatal brain injury: the hedgehog connection.
   Alberto Gulino, Enrico De Smaele, Elisabetta Ferretti
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19244604

   Glucocorticoids (GCs) play a critical role in neural development; however, their prenatal or neonatal therapeutic use can have detrimental effects on the developing brain. In this issue of the JCI, He…

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5. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.
   Avlin B Imaeda, Azuma Watanabe, Muhammad A Sohail, Shamail Mahmood, Mehdi Mohamadnejad, Fayyaz S Sutterwala
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19164858

   Hepatocyte death results in a sterile inflammatory response that amplifies the initial insult and increases overall tissue injury. One important example of this type of injury is acetaminophen-induced…

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6. Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism.
   Vivi M Heine, David H Rowitch
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19164857

   Glucocorticoids (GCs) are administered to human fetuses at risk of premature delivery and to infants with life-threatening respiratory and cardiac conditions. However, there are ongoing concerns about…

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7. Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium.
   Amy P Wong, Armand Keating, Wei-Yang Lu, Pascal Duchesneau, Xinghua Wang, Adrian Sacher
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19164856

   The bone marrow compartment is enriched in stem and progenitor cells, and an unidentified subpopulation of these cells can contribute to lung epithelial repair. Here we identify this subpopulation and…

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8. Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.
   Robert K Semple, Alison Sleigh, Peter R Murgatroyd, Claire A Adams, Les Bluck, Sarah Jackson
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19164855

   Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic steatosis. Increased hepatic lipogenesis contribut…

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9. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.
   Carrie E McCurdy, Jacalyn M Bishop, Sarah M Williams, Bernadette E Grayson, M Susan Smith, Jacob E Friedman
   The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19147984

   Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain po…

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10. PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
    Xiu Feng Hu, Jie Li, Scott Vandervalk, Zeping Wang, Nancy S Magnuson, Pei Xiang Xing
    The Journal of clinical investigation 2009 IF: 14.30 Q1 PMID: 19147983

    Provirus integration site for Moloney murine leukemia virus (PIM1) is a proto-oncogene that encodes a serine/threonine kinase with multiple cellular functions. Overexpression of PIM-1 plays a critical…

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