JOURNAL OF NEUROENDOCRINOLOGY神经内分泌学杂志
JOURNAL OF NEUROENDOCRINOLOGY(英文缩写 J NEUROENDOCRINOL),ISSN 0953-8194,eISSN 1365-2826,中文译名:神经内分泌学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.870 | Q2 |
| 2022 | 3.200 | Q3 |
| 2023 | 3.300 | Q2 |
| 2024 | 4.100 | Q1 |
| 2025 | 5.000 | Q1 |
JOURNAL OF NEUROENDOCRINOLOGY 最新收录文献
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1. Prolactinomas in the transition from adolescence to young adulthood: A multicentre, retrospective study from the TALENT group.
PMID:日期:2026-10-01Prolactinomas in the transition age present unique challenges; treatment strategies and long-term outcomes in this population remain incompletely characterised. This is a multicentre, retrospective study of 110 consecutive patients (33 males) with prolactinomas, aged 15-25 years, across five Italian referral centres (2010-2025). Clinical, hormonal, radiological, and treatment-related parameters were assessed at diagnosis and at follow-up. At diagnosis, the median age was 20 years; median prolactin 177 ng/mL [49-6646]; 55% of patients had micro-tumours. Male patients presented with larger tumours, higher prolactin levels, and greater invasiveness (p < .001 for all comparisons). Cabergoline was first-line therapy in 95%, achieving prolactin normalisation in 75% and significant tumour shrinkage (≥50% volume and/or diameter reduction) in 66% of patients. Partial resistance (biochemical and/or radiological) occurred in 40% of patients. Treatment discontinuation occurred in 48% of cases; 61% of patients discontinuing cabergoline after prolonged normalisation experienced recurrence, which was predicted by younger age at diagnosis (OR 0.67/year, p = .040) and shorter treatment duration (OR 0.95/month, p = .050), the latter showed 93% sensitivity for recurrence at 45.5 months. Adverse events occurred in 12%, leading to treatment discontinuation in 6%. Surgery was required in 17%, achieving long-term remission in 31%, while 21% of surgical cases required radiotherapy. At last follow-up (median 72 months), 73% remained on cabergoline while 25% achieved complete radiological resolution. Transition-age prolactinomas demonstrate high cabergoline resistance rates and frequent recurrence after discontinuation. Treatment duration ≥45.5 months before withdrawal may reduce recurrence risk. Surgical remission is achievable, especially in non-invasive tumours, although multimodal therapy is often required for disease control.
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2. Genetic landscape of a neonatal hypogonadotropic hypogonadism series: Novel variants and phenotypic spectrum.
PMID:日期:2026-10-01To describe clinical presentation and genetic findings in a cohort of infants with congenital hypogonadotropic hypogonadism (CHH) diagnosed before 2 years of age. From a large cohort of patients who underwent next-generation sequencing (NGS) for CHH between 2019 and 2025, we identified all patients tested at ≤2 years of age. Genetic analysis consisted of a targeted CHH gene panel, followed by a CPHD-NGS panel. In one remaining patient with neurodevelopmental defects, whole-exome sequencing was performed. Phenotypic data were collected through the GENHYPOPIT registry. Twelve male infants (1.5% of the total cohort) met the inclusion criteria; one additional patient via familial screening was included, for a total of 13 patients. All had micropenis; four had associated cryptorchidism (bilateral in half of cases). CHH was biologically confirmed during mini-puberty in 10 infants, at a median age of 6.8 weeks. Seven of these 10 infants received gonadotropin therapy, at an average of 4.1 months. MRI revealed bilateral olfactory bulb agenesis in five cases. A pathogenic or likely pathogenic variant was identified in 7 of 12 patients (58%), involving TACR3 (n = 2), ANOS1, FGFR1 (including two novel variants), SOX10, GLI2 (through the CPHD panel), and SOX11 (identified by exome sequencing). A genetic cause was identified in 58% of cases, a diagnostic yield higher than reported in pubertal cohorts. Early genetic diagnosis allowed anticipatory monitoring for syndromic manifestations and associated pituitary deficiencies-particularly relevant for FGFR1 and GLI2 variant carriers at risk of CPHD. Our findings support the inclusion of GLI2 and SOX11 in targeted HH gene panels.
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3. Predictors of in vitro response to somatostatin and dopamine receptor-targeted treatments are lacking in clinically non-functioning pituitary tumors.
PMID:日期:2026-10-01Clinically non-functioning pituitary neuroendocrine tumors (NF-PitNETs) lack effective medical therapies, and the role of somatostatin receptor ligands (SRLs) and dopamine agonists (DAs) in this setting is controversial. We evaluated the in vitro response of NF-PitNETs to multiple SRL and/or DA treatments, focusing on the role of receptor expression and tumor characteristics in driving tumor response. Forty-four NF-PitNET primary cultures were treated (72 h, 10 nM) with octreotide (OCT), pasireotide (PAS), OCT + PAS, BIM-53097 (D2R agonist), BIM-53097 + PAS, and BIM-23B065 (SSTR2/SSTR5/D2R preferential ligand) to evaluate cell proliferation inhibition. Tumors were considered responders to a treatment when a ≥20% reduction in cell proliferation was observed (vs. control); responder tumors to at least one tested condition were classified into the "responder group" for further analysis. Somatostatin (SSTRs) and dopamine type 2 receptor (D2R) expression were evaluated through immunohistochemistry. Data on radiological invasiveness, proliferation indices (Ki67%, mitoses), and p53 immunostaining were collected. Tumor grade was determined using Trouillas and PANOMEN-3 classifications. Median patient age at surgery was 60.3 years (IQR 49.7-70.7), 29 were males (71%). Overall, no significant in vitro inhibition of cell proliferation was observed [ranging from -4.2% (OCT and PAS) to -7.4% (BIM-53097 + PAS)]. However, 13 cultures (30%) were included in the "responder group" [mean inhibition ranging from -18.6% (OCT) to -27.7% (BIM-53097 + PAS)]. D2R was the most expressed receptor (median IRS 8, IQR 6-8), followed by SSTR1 and SSTR2 (median IRS 4, IQR 3-6); SSTR3 and SSTR5 expression was low. In the whole cohort, OCT and PAS efficacy directly correlated with SSTR2 (p = .013 and p = .027, respectively). D2R and SSTR2 expression was higher in responders vs. non-responders to BIM-23B065 (p = .017 and p = .042, respectively). ROC curve analysis discriminates BIM-23B065 responders based on D2R and SSTR2 expression with acceptable ability (AUC = 0.784 and AUC = 0.743, respectively). However, the "responder group" did not differ significantly from the "non-responder group" with respect to patient demographics, tumor clinical-pathological characteristics, receptor expression, and grading. In conclusion, we confirm the limited efficacy of SRL and DA treatment in NF-PitNETs. D2R and SSTR2 can discriminate tumors responsive to BIM-23B065. As concerns the other tested compounds, none of the tumor parameters evaluated demonstrated robust predictive value for NF-PitNET in vitro response.
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4. Ethanolamine plasmalogens increase luteinising hormone pulsatility and are associated with GPR61 expression in bovine gonadotrophin-releasing hormone neurons.
PMID:日期:2026-10-01Pulsatile secretion of luteinising hormone (LH) reflects episodic activity of hypothalamic gonadotrophin-releasing hormone (GnRH) neurons and is essential for reproductive function. Plasmalogens are ether phospholipids enriched in neuronal membranes; however, their role in neuroendocrine regulation of reproduction remains unclear. We examined the effects of ethanolamine and choline plasmalogens on LH pulsatility in vivo and investigated GPR61 expression in bovine hypothalamic tissues and relevant cell lines. The oestrous cycles of 15 Holstein heifers were synchronised, and blood samples were collected at 10 min intervals for 8 h. Ethanolamine plasmalogens, choline plasmalogens or vehicle were administered intravenously. LH concentrations were measured by radioimmunoassay, and LH pulses were identified using the Pulsar algorithm. GPR61 expression was examined by RT-PCR, Western blotting and immunofluorescence in bovine hypothalamic tissues and in cell lines. LH pulse frequency showed a significant treatment × time interaction (p < .01) and increased after ethanolamine plasmalogen administration (Holm-adjusted p = .0084), whereas no significant changes were observed after choline plasmalogen or control treatments. Mean LH concentrations showed a significant effect of time (p < .01), whereas neither the treatment effect nor the treatment × time interaction was significant. LH pulse amplitude was unaffected. GPR61 was expressed in GnRH neurons in the bovine hypothalamus, including the preoptic area, arcuate nucleus and median eminence, and was also detected in GT1-7 and LβT2 cells. Ethanolamine plasmalogens are associated with increased LH pulsatility in vivo and GPR61 expression in GnRH neurons, suggesting a potential role for plasmalogen composition in the neuroendocrine regulation of reproduction.
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5. Effects of combined nutritional interventions on the natural history of X-linked adrenoleukodystrophy in female carriers.
PMID:日期:2026-09-01Female carriers of X-linked adrenoleukodystrophy (X-ALD) frequently develop neurodegenerative phenotypes resembling adrenomyeloneuropathy. However, evidence supporting disease-modifying nutritional strategies remains limited. We evaluated the effects of Aldixyl®, a derivative of Lorenzo's Oil, and dietary interventions on neurological progression, very-long-chain fatty acids (VLCFAs) levels, adrenal function, and systemic safety in X-ALD women. We conducted a single-center retrospective longitudinal study including ABCD1 heterozygous women followed at Bambino Gesù Children's Hospital between 2001 and 2025. Neurological disability was measured by Adult ALD Clinical Score (AACS), Expanded Disability Status Scale (EDSS), and Timed 25-Foot Walk (T25-FW). Outcomes were compared between patients treated with Aldixyl® plus dietary prescriptions (group A) and those receiving diet-only (group B). Thirty-six patients were included (mean age 41.6 years), 36.1% were neurologically symptomatic at baseline (mean AACS 2.7 ± 2.6). Median C26:0 levels were mildly elevated (1.59 μmol/L). Group A (n = 20) was older and more neurologically impaired at baseline than group B (n = 16) (AACS 3.45 vs. 0.38). Over a median follow-up of 69 months, neurological progression was significantly slower in group A according to AACS (LS mean difference -2.26) and EDSS (-1.03), while T25-FW did not change. Aldixyl® exposure was associated with sustained VLCFA reduction (β = -0.40 μmol/L). Adrenal function and metabolic parameters remained stable, although a mild, uncomplicated decrease in platelet count was observed. In female X-ALD carriers, Aldixyl® is associated with sustained VLCFA reduction and signals suggestive of a more favorable neurological trajectory, while preserving adrenal function and demonstrating an acceptable safety profile. These findings warrant confirmation in prospective, controlled studies.
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6. Voltage-gated calcium channel activity of gonadotropin-releasing hormone (GnRH) neurons is altered by age and by prenatal androgen exposure in female mice.
PMID:日期:2026-09-01Polyendocrine metabolic ovarian syndrome (PMOS), a common cause of infertility, is marked by persistently high luteinizing hormone (LH) pulse frequency, presumably driven by high-frequency GnRH pulses. Prenatally androgenized (PNA) mice mimic neuroendocrine PMOS symptoms including high LH-pulse frequency. GnRH neurons from adult PNA mice have a higher spontaneous firing rate than those from vehicle (VEH) mice; this is reversed in peripubertal mice despite more excitatory inputs at both ages. We hypothesized voltage-gated Ca currents (I) help set intrinsic excitability of GnRH neurons and are altered by development and/or PNA treatment. Whole-cell patch-clamp measurements were made of GnRH neuron I and excitability in 3 week-old and adult VEH and PNA mice. PNA treatment increased I density and depolarized the I-half-inactivation potential at both ages. In adults, the half-activation potential of the Ca conductance was depolarized, and the half-inactivation time of the fast I component was increased regardless of PNA treatment. There was an age-related change in firing response to current injections driven primarily by more firing in 3 week-old VEH mice; 3 week-old PNA mice had adult-like responses. Blocking small-conductance Ca-activated K current with apamin increased GnRH neuron firing rate except in adult PNA mice. Apamin changed the post-spike-train membrane response from hyperpolarization to depolarization; during development, this net effect of apamin was smaller in PNA mice. In summary, GnRH neurons from PNA mice have increased I and altered I kinetics. Ca-activated K currents are less prominent in GnRH neurons from adult PNA mice, perhaps contributing to their increased spontaneous firing activity.
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7. Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice.
PMID:日期:2026-09-01Stress impairs reproduction, at least in part, by inhibition of Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells and suppression of gonadotropin secretion. However, the mechanism for this inhibition is not clear. Neuropeptide Y (NPY) is a pleiotropic molecule that is produced in neurons throughout the brain and mediates several physiological processes including energy homeostasis and stress responses. Centrally administered NPY elicits variable effects on luteinizing hormone (LH) secretion, which vary with species, gonadal status, and the site of infusion. Therefore, our objective was to determine the in vivo action of central NPY administration on LH pulses in mice. Frequent blood samples were collected and assayed for LH concentrations from male and female mice that received a central injection of NPY or saline (control). Additional studies were performed in which NPY or saline treated animals received a kisspeptin challenge to evaluate direct effects on GnRH cells, or tissue collection to evaluate transcripts associated with KNDy cells. Intracerebroventricular injection (ICV) of NPY robustly suppressed LH pulses in ovariectomized (OVX) female and gonadectomized (GDX) male mice. However, the same treatment in gonad-intact males yielded variable responses, and analysis in estradiol-replaced OVX female mice revealed an unexpected suppression of LH following brief isoflurane exposure. In assessment of KNDy neurons, we found a statistically significant increase in the abundance of mRNA encoding dynorphin in micro-punches of the arcuate nucleus 1 h after ICV injection of NPY. In further support of the hypothesis that NPY impairs KNDy cells, we found that animals pretreated with NPY or saline had the same response to exogenous kisspeptin, suggesting gonadotropin-releasing hormone neurons and gonadotrope cells remain fully responsive to stimulation. We conclude that NPY is sufficient to suppress LH secretion in OVX female and GDX male mice and that this suppression is likely mediated by the KNDy cells in the arcuate nucleus.
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8. Parental state dynamically reshapes auditory processing of offspring vocalizations in zebra finches.
8. 父母状态动态地重塑了斑胸草雀后代发声的听觉处理PMID:日期:2026-09-01Parental care is critical for offspring survival. For many species, including humans, auditory cues unique to dependent offspring, such as baby cries, elicit the necessary behavior from parents to care for young. Despite this, we know little about how the brain encodes auditory cues specific to offspring. Zebra finches are an excellent model to study this. Zebra finches are biparental, meaning both male and female parents raise the young and rely on auditory cues (begging calls) to elicit chick feeding responses (parental behavior). Begging calls also become individually identifiable by the parents, necessitating higher-order learning/association neural processes. It is well established that the caudomedial nidopallium (NCM), a higher-order region of secondary pallial cortex (analogous to the mammalian secondary auditory cortex), is involved in the perception of complex auditory signals in birds. It is unknown, however, if/how NCM responds to offspring begging calls. To begin testing this, we used high density silicon probes to record single-unit in vivo electrophysiology activity in the NCM of adult parenting and non-parenting zebra finches exposed to playbacks of their own chick's begging calls (parents only), novel age-matched begging calls (parents and non-parents), as well as novel adult male song and pure tone controls. Our results show that NCM neurons in parents respond more strongly (i.e., higher evoked firing rates) to both their own and novel chick begging calls and have higher baseline (spontaneous) firing rates in narrow spiking units relative to non-parents. Furthermore, NCM neurons in parenting females tend to show more selective responses towards their own chick begging calls, whereas those in males do not show similar levels of selectivity. These results provide preliminary evidence that NCM responses are altered during parenting and lay essential groundwork for future studies on how auditory responses may elicit parental behavior.
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9. Early-life environmental enrichment reduces anxiety and induces sex-dependent neuroplasticity in hypothalamic oxytocin and vasopressin neurons.
PMID:日期:2026-09-01Early-life experiences critically shape neuroendocrine systems involved in emotional and social behaviours. The oxytocin (OXT) and vasopressin (AVP) systems are particularly sensitive to environmental influences during the perinatal period, a developmental window characterized by high neural plasticity. However, the long-term effects of perinatal environmental enrichment (PEE) on hypothalamic OXT and AVP neuroplasticity and their relationship with emotional behaviour remain poorly understood. Therefore, this study investigated whether PEE induces persistent behavioural, structural, and neurochemical changes in OXT and AVP neurons in male and female mice. Male and female mice reared in either PEE or non-enriched environment (NE) conditions were evaluated in adulthood using the elevated plus maze, light/dark box, and sociability/social novelty preference tests. Morphometric analyses assessed soma and nuclear size, as well as OXT and AVP immunoreactivity in neurons of the paraventricular nucleus (PVN) of the hypothalamus. PEE reduced anxiety-like behaviour, as evidenced by increased open-arm exploration in the elevated plus maze, particularly in males, and reduced latency to enter the light compartment in the light/dark box. These behavioural effects were accompanied by reduced soma and nuclear dimensions of AVP neurons in PEE males, as well as increased nuclear size and OXT immunoreactivity in both sexes. Correlation analyses showed that smaller AVP neuronal profiles were associated with reduced anxiety-related behavioural measures, whereas larger OXT neuronal dimensions were associated with reduced risk-assessment behaviours. Perinatal environmental enrichment induces long-lasting, sex-dependent structural and neurochemical plasticity in hypothalamic OXT and AVP systems, which may contribute to the enduring modulation of anxiety-related behaviours.
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10. Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice.
PMID:日期:2026-09-01Pulsatile gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1 neurons via neurokinin B (NKB) signaling through TacR3. However, discrepancies between ex vivo and in vivo pharmacology limit mechanistic understanding of how TacR3 activation regulates pulsatile hormone release. We developed and synthesized a photoswitchable TacR3 agonist (azo-senktide) and characterized its photochemical and pharmacological properties using UV-Vis spectroscopy, TacR3-expressing HEK293T cells, electrophysiology in mouse hypothalamic slices, and in vivo optofluidic delivery combined with light stimulation to assess LH secretion in freely moving mice. Azo-senktide reversibly photoisomerized between inactive (trans) and more potent (cis) conformations. In cells, light activation enhanced TacR3-mediated Ca signaling. In brain slices, photostimulation depolarized and increased firing of Kiss1 neurons through a mechanism consistent with the established TacR3-TRPC5 signaling pathway. In vivo, optical activation of azo-senktide in the arcuate nucleus elicited a time-locked LH pulse at an intermediate dose, whereas lower or higher doses were ineffective, indicating a nonlinear, dose-dependent response. These findings demonstrate that temporally gated TacR3 activation via photoswitchable azo-senktide evokes an increase in LH, revealing that neurokinin B signaling in the Kiss1 network depends on activation dynamics, reconciles inconsistencies, and establishes photopharmacology as a powerful approach for probing neuroendocrine timing mechanisms.