EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS欧洲药剂学与生物药剂学杂志
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS(英文缩写 EUR J PHARM BIOPHARM),ISSN 0939-6411,eISSN 1873-3441,中文译名:欧洲药剂学与生物药剂学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.589 | Q1 |
| 2022 | 4.900 | Q1 |
| 2023 | 4.400 | Q1 |
| 2024 | 4.300 | Q1 |
| 2025 | 5.000 | Q1 |
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 最新收录文献
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1. Making Pharmaceutical Administration Evidence Cumulative: What PBPK Teaches Us About Building Knowledge Across Products.
PMID:期刊:日期:2026-10-01Pharmaceutical administration studies determine whether a medicine can be prepared, held, and delivered without unacceptable loss of quality. Their conclusions are essential to product instructions, yet the underlying evidence is difficult to use beyond the product and conditions originally tested. This letter contrasts that pattern with physiologically based pharmacokinetic modelling, a field in which system, drug, and study information are represented separately and the purpose and limits of model use are made explicit. Administration science does not require a PBPK model. It does, however, need records that preserve the relationships among product and formulation attributes, administration-system components, preparation and use conditions, measured outcomes, and the boundaries of the experiment. Standardized, structured records would not remove the need for product-specific studies. They would make previous work easier to interpret, reveal when further testing is necessary, and allow administration evidence to contribute to cumulative pharmaceutical knowledge.
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2. From the laboratory to the skin: translational potential of nanofibers in the treatment of cutaneous leishmaniasis - an overview and systematic approach.
PMID:期刊:日期:2026-10-01Cutaneous leishmaniasis (CL) remains a major global health challenge, particularly in low- and middle-income countries, due to the limitations of current therapies, including toxicity, high cost, invasive administration routes, and poor patient adherence. In this context, nanotechnology-based drug delivery systems, such as nanofibers, have emerged as promising alternatives to improve therapeutic outcomes. This study provides a comprehensive overview of CL, its epidemiology, clinical manifestations, and current pharmacological treatments, followed by a systematic and critical analysis of nanofiber-based platforms for its treatment. A structured search was conducted in PubMed, Web of Science, and Scopus databases, covering studies published between 2010 and 2026. Seventeen studies met the inclusion criteria and were analyzed in terms of polymer composition, fabrication techniques, physicochemical properties, and biological performance. The results demonstrated that polymeric nanofibers, particularly those produced by electrospinning and solution blow spinning, exhibit favorable characteristics, including high surface area, controlled drug release, biocompatibility, and enhanced local drug retention. Both in vitro and in vivo studies revealed significant antileishmanial activity, reduced cytotoxicity, and improved wound healing. Additionally, preliminary clinical findings highlighted their potential as safe and non-invasive therapeutic alternatives. Complementary bibliometric and patent analyses indicated increasing scientific and technological interest in this field, while highlighting key translational challenges related to standardization, scalability, regulatory approval, and clinical validation. Overall, nanofiber-based systems represent a promising translational strategy for the topical treatment of CL, offering advantages over conventional therapies and addressing key challenges associated with current clinical management.
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3. Applicability boundaries and method-selection strategies for the CMC determination of pharmaceutical surfactants.
PMID:期刊:日期:2026-10-01The Critical Micelle Concentration (CMC) is a crucial Functionality-Related Characteristic (FRC) for pharmaceutical surfactants, fundamentally determining solubilization and thermodynamic stability in formulation design-an indicator increasingly emphasized by global pharmacopoeias. However, a distinct regulatory gap persists: major compendia, including the Chinese Pharmacopoeia (ChP), the United States Pharmacopeia (USP), and the European Pharmacopoeia (EP), currently lack explicit, practical methods for CMC determination. Because different measurement techniques rely on distinct physical principles, they are highly susceptible to environmental factors, leading to significant discrepancies in measurement results. To systematically bridge this methodological gap, this study optimized three mainstream testing techniques for pharmaceutical surfactants across various structural types. These methods were meticulously developed based on practical measurement processes and statistical theory, thereby ensuring their applicability and reliability. Through comparative analysis, we identified the most suitable measurement methods for different categories of pharmaceutical excipients. Importantly, we systematically identified the factors that significantly influence the results of CMC measurement. Ultimately, this study establishes a structure-guided methodological decision framework comprising class-specific method-selection framework for CMC measurement within defined applicability boundaries, thereby providing a practical basis for the quality evaluation of pharmaceutical surfactants and the future development of functionality-related compendial specifications.
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4. Advanced delivery systems for sodium thiosulfate in cisplatin otoprotection.
PMID:期刊:日期:2026-10-01Cisplatin is an indispensable agent in pediatric oncology, yet its clinical utility is severely compromised by irreversible sensorineural hearing loss, which affects up to 60 % of young patients. Sodium thiosulfate (STS) has recently emerged as the gold-standard otoprotectant, but its systemic administration is constrained by a critical pharmacokinetic paradox: a mandatory 6-hour delay after cisplatin infusion is required to avoid interference with antitumor efficacy, creating a window of vulnerability during which the inner ear remains unprotected. This review systematically examines the engineering strategies developed to overcome the limitations of systemic STS delivery, with a focus on nanotechnology platforms and localized routes of administration. We highlight how the shift from systemic to intratympanic delivery enables high intracochlear concentrations of STS without compromising the antineoplastic action of cisplatin. Key innovations include: (i) lipid- and polymer-based nanoparticle systems that optimize transport across the round window membrane; (ii) in situ-forming hydrogels and microgels that resist Eustachian tube clearance through bioadhesion and provide sustained STS release; and (iii) noninvasive transtympanic strategies that use chemical permeation enhancers to bypass the tympanic membrane, transfer through the walls of the tympanic cavity. The synergy of stimuli-responsive nanocarriers and localized delivery protocols represents a transformative approach to otoprotection, offering the prospect of hearing preservation precisely during peak cochlear cisplatin exposure and thereby improving the quality of life for childhood cancer survivors.
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5. A smarter dermal filler: Antimicrobial protection and collagen stimulation with niacinamide.
5. 更智能的皮肤填充剂：烟酰胺具有抗菌保护和胶原蛋白刺激作用PMID:期刊:日期:2026-10-01Biological skin aging involves structural changes, including flattening of the epidermal-dermal junction and reduced collagen types I and III. Modern aesthetic medicine is shifting from volumetric enhancement toward regenerative dermal fillers, though risks of delayed inflammation or infection from post-procedural injections should be mitigated. Niacinamide is a well-established molecule that stimulates collagen synthesis, modulates inflammation and inhibits bacterial growth. We evaluated the biostimulatory, antimicrobial, anti-inflammatory, and safety profiles of a new niacinamide-enriched cross-linked hyaluronic acid dermal filler (HAR) compared to untreated controls and Belotero Balance® (commercial reference). Biostimulation was assessed ex vivo in human skin explants cultured for 8 days, using Masson's trichrome staining and collagen I/III immunostaining. Antibacterial activity against Gram-positive and Gram-negative bacterial models was assessed by monitoring growth, while anti-inflammatory properties were analyzed via TNF-α and IL-6 levels in LPS-stimulated macrophages. Safety and biocompatibility were evaluated against human dermal fibroblasts. HAR-treated explants displayed improved epidermal architecture and a denser collagen type I network. HAR inhibited bacterial growth (∼90% Gram-negative; ∼50% Gram-positive), significantly lowered IL-6 and TNF-α levels, and showed excellent biocompatibility with high fibroblast viability and minimal hemolysis. These findings highlight HAR as a multifunctional dermal filler combining essential structural support with regenerative, antibacterial, and anti-inflammatory benefits.
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6. Formulation development and optimization of sparfloxacin-loaded solid lipid nanoparticles integrated with microneedles for the treatment of biofilm-infected wounds.
PMID:期刊:日期:2026-10-01The efficient management of infected skin wounds is severely limited by the thick bacterial biofilm within the lesion, the intractable stratum corneum barrier of the perilesional skin, and the high toxicities of potent antibiotics. Sparfloxacin (SPFX) was withdrawn from the market due to its severe systemic side effects and UV-induced phototoxicity, while its severe hydrophobicity causes localized crystalline cytotoxicity upon topical application. To safely rejuvenate this potent drug, an integrated transdermal system combining photoshielding, SPFX-loaded solid lipid nanoparticles (SPFX-SLNs) with dissolving microneedles (MNs) was developed. This study primarily focuses on the systematic screening, formulation development, and optimization of SPFX-SLNs via Box-Behnken Design-Response Surface Methodology (BBD-RSM). The optimized nanocarriers exhibited a uniform size (86.85 ± 1.89 nm) and a two-fold higher antibacterial potency against Escherichia coli (E. coli) than free SPFX. Mechanistically, the solid lipid core locked SPFX in a safe amorphous state to preclude crystal-induced irritation, while functioning as a physical photoshield against UV activation. By depositing the nanomedicine exclusively into infected dermis, the MN platform minimized systemic drug exposure. In a rat model of E. coli-infected biofilm wounds, the formulated SPFX-SLNs MNs achieved over 50% (58.44%) wound closure within 3 days and near-complete re-epithelialization by day 11, and a 98.61% final closure rate by day 14. Ultimately, this work establishes a comprehensive formulation development strategy for a safety-enhanced, biofilm-penetrable nanomedicine-MN hybrid that successfully repurposes a clinically restricted antibiotic for advanced wound regeneration.
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7. Co-assembled rutin and rhein Hydrogel: A promising approach for reducing neutrophil extracellular traps in tissue repair.
7. 共组装芦丁和大黄酸水凝胶：一种在组织修复中减少中性粒细胞胞外陷阱的有前景的方法PMID:期刊:日期:2026-10-01Neutrophil extracellular traps (NETs) severely impede wound tissue repair in diabetic patients. All-natural small molecule self-gelling powder, integrating the advantages of hydrogels and powders, is expected to provide a timely and effective strategy for chronic wound management. However, the synthesis and application of the all-natural small molecule self-gelling powder are still in their infancy. This study prepared an innovative carrier-free self-gelling powder by co-assembling rhein (Rhe) and rutin (Rut) under an alkaline environment. These two natural small molecules were co-assembled into the RR gel through π-π stacking and hydrogen bonding interactions. Subsequently, the RR powder was obtained through lyophilization of the hydrogel, thereby combining hemostasis and pharmacological properties. Notably, RR powder still showed strong regenerative ability after undergoing a drying-hydration cycle, while maintaining excellent injectability and viscoelasticity. Moreover, the self-gelling RR powder not only achieved rapid and effective hemostasis but also significantly inhibited NETs, reduced inflammatory responses and promoted angiogenesis in diabetic wound through in-situ spraying, showing significant promotion of wound healing with no obvious toxic side effects. Together, this study provides a novel co-assembly strategy and application form for self-gelling materials derived from all-natural small molecules, offering a promising approach for tissue repair by reducing NETs.
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8. Formulation and stability design spaces for a new yellow fever vaccine.
PMID:期刊:日期:2026-10-01Yellow fever (YF) is a life-threatening disease that is entirely preventable through vaccination. The objective of this study was to formulate a freeze-dried presentation of a live-attenuated, Vero cell-based yellow fever vaccine (vYF) with improved manufacturability and enhanced shelf-life. Considering four critical quality attributes (i.e., glass transition temperatures and infectious titers at two time points), a comprehensive formulation screening was performed to identify an optimal combination of excipients, capable of protecting the virus during lyophilization while ensuring long-term stability of the vYF infectious titer. Overall, L-proline, urea, and poloxamer 407 demonstrated a stabilizing effect, and the application of an advanced kinetic model enabled prediction of a 60-month shelf-life at 5 °C for the formulated vaccine. Machine learning models were used to build both formulation and stability design spaces that defined global stabilizing regions within the explored concentration ranges of each excipient. This study demonstrates that the combination of systematic excipient screening and advanced analytics enables the selection of robust formulations with long-term stability within an accelerated development timeframe. The developed vaccine formulation has the potential for large-scale industrial production and can address substantial market demand in the coming years, representing a significant advancement in vYF technology.
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9. Ciliation and mucus secretion in an in vitro model of nasal mucosa based on CI-pNaEC cell line for preclinical drug testing.
PMID:期刊:日期:2026-10-01In preclinical development of nasal drug formulations, in vitro models of the nasal mucosa offer a viable alternative to animal testing. The novel cell line CI-pNaEC produces mucus and develops motile ciliation, thereby adequately emulating key characteristics of human nasal epithelium. In this study, ciliation and mucin secretion in CI-pNaEC was further investigated. Mucin expression was quantified and fluorescence recovery after photobleaching (FRAP) assays were used to evaluate the mucus diffusion barrier. In addition, the contribution of the mucus barrier to drug permeation was evaluated. The thickness of the CI-pNaEC-derived mucus and the diffusion barrier were within the ranges reported for healthy mucus. Cilia length in CI-pNaEC cultures corresponded to physiological conditions, although overall ciliation density remained lower than in vivo. However, coordinated mucus transport can be observed in some areas of the CI-pNaEC cultures, which could lead to mucociliary clearance with further optimization. These results highlight CI-pNaEC as a promising in vitro model for mimicking human nasal mucosa in the preclinical assessment of intranasal drug delivery systems.
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10. Design rules for externally triggered drug uncaging under optical and radiolytic regimes.
PMID:期刊:日期:2026-10-01Externally triggered prodrug activation can improve therapeutic index by decoupling systemic distribution from pharmacological activity. This review examines prodrug uncaging strategies enabled by electromagnetic radiation through the lens of activation physics and clinical constraints, spanning UV-visible-near-infrared photochemistry and ionizing radiation. Differences in clinical applicability arise from fundamentally contrasting activation physics and irradiation geometry. While recent reviews have cataloged externally triggered prodrug systems across multiple modalities, we instead organize the field by activation regime and evaluate these systems under clinically realistic constraints. In photochemical activation, direct light-chromophore coupling enables predictable bond cleavage through defined excited-state pathways, but effective application is constrained by tissue optics and beam-sample geometry. X- and γ-rays penetrate deeply into tissues, but their uncaging pathway is indirect via diffusible water radiolysis products, resulting in stochastic rather than deterministic cleavage chemistry. We evaluate these platforms using deliverability, irradiation geometry, dose efficiency under clinically realistic conditions, microenvironment dependence, and functional group compatibility. We conclude with practical design rules and a decision framework that aligns targeted pathology and treatment objectives with the appropriate trigger chemistry, payload selection, and delivery strategy under the governing activation physics.