JOURNAL OF HUMAN HYPERTENSION人类高血压杂志
JOURNAL OF HUMAN HYPERTENSION(英文缩写 J HUM HYPERTENS),ISSN 0950-9240,eISSN 1476-5527,中文译名:人类高血压杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.877 | Q3 |
| 2022 | 2.700 | Q3 |
| 2023 | 2.700 | Q2 |
| 2024 | 3.400 | Q2 |
| 2025 | 3.300 | Q2 |
JOURNAL OF HUMAN HYPERTENSION 最新收录文献
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2. Interaction between adiposity and genetic risk score on blood pressure traits in Mexican adults.
PMID:日期:2026-09-22Hypertension is a complex disease influenced by genetic and environmental factors, with obesity being a major risk factor. We aimed to evaluate the interaction between adiposity indicators and genetic risk on blood pressure traits in a Mexican population. This longitudinal study included 1424 adults from the Health Workers Cohort Study, with data collected in 2004-2006, 2010-2012, and 2016-2019. A genetic risk score (GRS) was computed by summing the risk alleles from six single nucleotide polymorphisms (SNPs) and categorized into tertiles. Analyses were performed using hybrid mixed-effects regression and Cox proportional hazards models, adjusting for potential confounders. Significant longitudinal associations were observed for body mass index (BMI), waist circumference, and body fat percentage (total and trunk) with higher systolic (SBP) and diastolic blood pressure (DBP) levels, both between- and within-subjects. A positive longitudinal interaction was also found between the GRS and each adiposity indicator on DBP. For example, with each unit increase in BMI over time, individuals in the highest GRS category had on average, higher DBP levels than those in the lowest GRS category (P = 0.001). Our longitudinal findings suggest a positive interaction between genetic factors and adiposity on blood pressure, underscoring the need to consider both aspects when addressing hypertension risk in the Mexican population.
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3. Can primary aldosteronism and acromegaly be etiological factors in non-obese patients with obstructive sleep apnea syndrome?
PMID:日期:2026-09-21Obstructive sleep apnea syndrome (OSAS) is strongly associated with obesity; however, a substantial proportion of patients are non-obese, raising the possibility of underlying endocrine etiologies. This study aimed to investigate the prevalence of primary aldosteronism (PA) and acromegaly in non-obese patients with OSAS and to evaluate the necessity of routine screening. Non-obese individuals, defined as those with a body mass index (BMI) < 30 kg/m², who were diagnosed with OSAS by polysomnography were prospectively evaluated. Clinical characteristics, comorbidities, plasma aldosterone-to-renin activity ratio (ARR), and insulin-like growth factor-1 (IGF-1) levels were assessed. Patients with elevated ARR underwent confirmatory saline infusion testing and adrenal imaging when indicated. Among 103 patients, biochemical evidence of PA according to the original study protocol was identified in 20 patients (19.4%), whereas post hoc application of the 2025 Endocrine Society screening criteria identified 29 patients (28.2%) with a screen-positive/probable PA phenotype. Hypertension was more frequent in patients with primary aldosteronism than in those without primary aldosteronism (70.0% vs. 24.1%). Adrenal adenomas were detected in 3.9% of the cohort. IGF-1 levels were within age- and sex-adjusted reference ranges in all patients, and no cases of acromegaly were identified. These findings suggest that screening for primary aldosteronism may be clinically warranted in non-obese patients with OSAS, whereas routine screening for acromegaly should be reserved for those with suggestive clinical features.
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4. Muscle microvascular reactivity and its associations with arterial stiffness and aortic pressures in postmenopausal women with abdominal obesity and hypertension.
PMID:日期:2026-09-17Hypertension is associated with obesity and vascular dysfunction in postmenopausal women (PMW). We examined the impact of obesity and hypertension on forearm muscle microvascular reactivity and its associations with macrovascular function and visceral adipose tissue (VAT) in PMW aged 50-69 years. They were classified by waist circumference (WC) and systolic blood pressure (SBP) as non-obese (PMW-NOB, n = 15) and obese non-hypertensive (PMW-OB, n = 17), and obese hypertensive (PMW-HTN, n = 17). Microvascular function was measured by near-infrared spectroscopy-derived tissue oxygen saturation indices (reperfusion magnitude [TSI], hyperemic response [TSI], and area under the curve [TSI]) during reactive hyperemia. Macrovascular function was assessed by aortic stiffness (carotid-femoral pulse wave velocity [cfPWV]) and pressures (SBP, pulse [PP], augmentation [AP], forward wave [Pf], and backward wave [Pb]) using arterial tonometry. Abdominal obesity was assessed by WC and dual-energy x-ray absorptiometry-derived VAT. WC and VAT, but not body mass index, were higher in PMW-HTN compared to PMW-NOB and PMW-OB (P < 0.01). TSI and TSI were lower in PMW-HTN compared to PMW-NOB and PMW-OB (P < 0.05). cfPWV, aortic SBP, PP, AP, Pf, Pb (all P < 0.05), and VAT (P < 0.01) were higher while plasma arginine was lower (P < 0.05) in PMW-HTN compared to PMW-NOB and PMW-OB. TSI and TSI were inversely associated with cfPWV, aortic pressures, and VAT (all P < 0.05). Our findings suggest that abdominal obesity with hypertension is characterized by micro- and macrovascular dysfunction in PMW. Greater VAT is associated with impaired microvascular reactivity, aortic stiffening, and increased aortic pressures.
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5. Association between physical activity score and incident hypertension among Chinese adults aged 65 years and older: a national prospective cohort study.
PMID:日期:2026-09-15Existing evidence on the association between physical activity and risk of incident hypertension is limited. This study aims to explore the relationship between physical activity and risk of incident hypertension in Chinese older adults. We analyzed the data of 3923 participants (median age 87 years) from the Chinese Longitudinal Healthy Longevity Survey. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of physical activity with risk of incident hypertension. Subgroup analyses of this association were conducted by age and sex. During a median follow-up of 2.7 years, 1479 participants developed incident hypertension. A higher physical activity score was associated with a lower risk of incident hypertension. Compared with the low-score group, the high-score group had a 23% lower risk of incident hypertension in the fully adjusted model (HR = 0.77, 95% CI: 0.66-0.91). Each standard deviation increment in the physical activity score was associated with a 9% lower risk of incident hypertension (HR = 0.91, 95% CI: 0.86-0.97; P for trend = 0.005). Subgroup analyses showed that similar associations were observed in participants aged ≥80 years and men. Higher daily physical activity is an independent protective factor for hypertension prevention in Chinese older adults. Promoting accessible daily physical activities may be of great significance in reducing the risk of incident hypertension in this population.
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6. Hypertensive heart disease and HFpEF:atrial functional valve regurgitation as the trigger of acute heart failure in a syndrome of exertional dyspnoea.
PMID:日期:2026-09-14Hypertensive heart disease (HHD) is widely regarded as the principal structural substrate underlying heart failure with preserved ejection fraction (HFpEF). Accordingly, contemporary models have largely focused on ventricular remodeling, myocardial fibrosis, microvascular abnormalities as the mechanisms linking chronic hypertension to heart failure (HF). However, current concepts increasingly recognize HFpEF as a syndrome predominantly characterized by impaired exercise tolerance and exertional dyspnea without tendency to congestion at rest, whereas the mechanisms responsible for progression to acute heart failure (AHF) remain incompletely understood. This distinction raises an important pathophysiological question: if hypertensive ventricular remodeling primarily accounts for a chronic exertional phenotype, what triggers the transition to acute congestion? We review the limitations of current epidemiological, imaging, and clinical trial data in addressing this question and discuss clinical observations suggesting that most episodes of acute heart failure with preserved or mildly reduced ejection fraction are associated with identifiable structural or haemodynamic abnormalities rather than isolated hypertensive remodeling. Based on these observations, we propose that progressive hypertensive atrial remodeling may represent an important mechanism linking stable HHD to decompensated AHF. Chronic atrial remodeling may promote atrial fibrillation and atrial functional mitral and tricuspid regurgitation. These lesions are dynamic and may become severe in patients with permanent atrial fibrillation or atrial fibrillation with a high ventricular response. When severe, they create a transient haemodynamic substrate for congestion that may partially regress following restoration of more favourable loading conditions. Rather than challenging the central role of HHD in HFpEF, this perspective extends the current pathophysiological framework by distinguishing the mechanisms responsible for chronic exertional symptoms from those precipitating AHF providing a rationale for future mechanism-oriented research.
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7. Cardiovascular frailty - an emerging frailty phenotype.
PMID:日期:2026-09-14With an ageing population worldwide, there is a corresponding increase in the prevalence of frailty. It is well established that there is a bi-directional relationship between frailty and cardiovascular morbidity and mortality. Different models have been developed to assess frailty in clinical practice exploring the physical phenotypes, cumulative deficits, social, vascular and cognitive aspects of frailty. However, no model as yet integrates the role of cardiovascular frailty in this context. This narrative review presents the concept of cardiovascular frailty, examining existing literature on how components of blood pressure dynamics in older adults, and vascular ageing affects frailty. These are discussed with emphasis on the oxi-inflammaging process that underpins both frailty and changes to blood vessels during the ageing process. Available literature is delineated on how these factors interact in ageing, and their resultant effect on cardiovascular frailty. Evidence is provided on the associations between arterial compliance and blood pressure in older adults with frailty. This is shown to be largely underpinned by oxi-inflammaging occurring at the cellular level, ultimately leading to progression of frailty and increase in cardiovascular-related morbidity and mortality. There is a growing need for a new phenotype- cardiovascular frailty which addresses the bi-directional relationship between frailty and the cardiovascular system and how these can be objectively assessed for clinical management.
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8. Comparison of telmisartan with losartan, valsartan, and candesartan on the risk of new-onset diabetes mellitus.
PMID:日期:2026-09-14Evidence remains limited on whether telmisartan with partial peroxisome proliferator-activated receptor-gamma (PPAR-γ) activity lowers new-onset diabetes mellitus (NODM) risk compared with non-PPAR-γ-active angiotensin II receptor blocker (ARB). We therefore evaluated the NODM risk of telmisartan compared with losartan, valsartan, and candesartan using real-world clinical data. We conducted a multicenter, retrospective, treatment-control cohort study using clinical data from 17 institutions between 2005 and 2023, covering 19 283 922 patients converted to a common data model. Adults newly prescribed telmisartan or other ARBs (losartan, valsartan, or candesartan) and taking the medication for ≥6 months were included, while patients with pre-existing diabetes were excluded. Propensity score matching (PSM) was performed, and hazard ratios (HR) were estimated using a Cox proportional hazards model. The primary outcome was incident NODM, defined by a diagnosis of diabetes (ICD-10), initiation of glucose-lowering medications, or HbA1c ≥ 6.5%. A total of 6 868 patients of new-users of telmisartan and 22 500 patients of other ARBs were included. In the overall population, telmisartan was associated with lower NODM risk (HR 0.87, 95% CI 0.80-0.94). After 1:2 PSM, there was no significant difference in the risk of NODM between telmisartan and other ARBs (10.61% [39.50/1 000 person-years] vs. 11.02% [40.42/1 000 person-years]; HR 0.97, 95% CI 0.88-1.08). Secondary analyses were also not significantly different. Overall, this study did not detect sufficient evidence that telmisartan reduces NODM risk compared with losartan, valsartan, or candesartan.
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9. Effect of chronic angiotensin system inhibitor treatment on cardiovascular adaptations to exercise training in adults with metabolic syndrome.
PMID:日期:2026-09-12Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) are commonly prescribed alongside exercise to manage hypertension in individuals with metabolic syndrome (MetS). However, whether chronic renin-angiotensin system (RAAS) inhibition modifies exercise-induced physiological adaptations remains unclear. In this prospective parallel-group study, 62 sedentary adults with MetS completed a 16-week supervised high-intensity interval training (HIIT) program. Participants were either chronically treated with ACEi or ARBs (antihypertensive medication group, AHM, n = 27) or not receiving pharmacological treatment (CONTROL, n = 35). Primary outcomes included changes in resting and exercise blood pressure (BP), MetS components, and cardiorespiratory fitness (CRF). Both groups showed significant improvements over time in cardiometabolic health (MetS Z-score: AHM -0.22 ± 0.42; CONTROL -0.30 ± 0.33; p < 0.001) and CRF (VO: AHM 3.9 ± 2.1; CONTROL 5.0 ± 3.1 mL·kg⁻¹·min⁻¹; p = 0.003), with no significant time × group interactions (all p > 0.05). Resting blood pressure decreased similarly in both groups (mean arterial pressure [MAP]: AHM -4.2 ± 8.7; CONTROL -6.5 ± 6.3 mmHg; p = 0.005; interaction p > 0.05). Exercise blood pressure responses also improved, with significant time effects for maximal MAP (p = 0.008) and submaximal diastolic BP (p = 0.047), without between-group differences (interaction p > 0.05). Chronic treatment with ACEi or ARBs does not appear to attenuate improvements in cardiometabolic health, BP, or CRF by 16 weeks of supervised HIIT in adults with MetS. These findings suggest that RAAS inhibition is compatible with structured exercise training, supporting HIIT as an effective adjunct therapy in individuals receiving antihypertensive medication. However, the absence of significant interactions should be interpreted in the context of limited power to detect small-to-moderate differences.
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10. Atherosclerosis prediction with large language models via prompt engineering.
PMID:日期:2026-09-07Atherosclerosis remains difficult to detect in its early stages due to its often asymptomatic nature. While artificial intelligence, particularly Large Language Models (LLMs), has shown significant promise for diagnostic support, optimal strategies for leveraging their capabilities in clinical risk prediction remain unclear. This study evaluated LLMs for atherosclerosis risk prediction using prompt engineering through mutual information-based feature selection and similarity-based case retrieval. Utilizing a large Japanese health checkup cohort (n = 117 698), with cardio-ankle vascular index (CAVI) as an atherosclerosis indicator, we evaluated Llama-3.1-Swallow-8B-Instruct-v0.1 performance across various configurations using F1 scores. We compared four case extraction methods, including Random Selection, Mahalanobis Distance, Cosine Similarity, Euclidean Distance, and feature selection from Zero-shot (no cases) to 4-shot, 6-shot, and 10-shot settings. The integration of mutual information-based feature selection with similarity-based case extraction improved F1 scores across all in-context learning settings. Cosine similarity-based selection achieved the highest F1 score in the 4-shot setting (0.715 ± 0.023) and 6-shot settings (0.719 ± 0.022), while Euclidean distance-based selection yielded the best F1 scores in the 10-shot (0.724 ± 0.017) settings. These combinations consistently outperformed the random selection baselines, which yielded significantly lower F1 scores (4-shot: 0.461 ± 0.017; 6-shot: 0.475 ± 0.023; 10-shot: 0.462 ± 0.029). Our findings demonstrate that combining feature selection with similarity-based case retrieval enhances the ability of LLMs to predict atherosclerosis risk. The substantial improvement in F1 scores over baseline methods suggests that optimized prompt engineering is crucial for clinical application of LLMs in cardiovascular risk assessment.