VIRUS GENES病毒基因
VIRUS GENES(英文缩写 VIRUS GENES),ISSN 0920-8569,eISSN 1572-994X,中文译名:病毒基因 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.198 | Q4 |
| 2022 | 1.600 | Q4 |
| 2023 | 1.900 | Q3 |
| 2024 | 1.900 | Q3 |
| 2025 | 2.000 | Q3 |
VIRUS GENES 最新收录文献
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1. Molecular characterization and complete genome of a putative novel Vigna Yellow Mottle Soymovirus infecting wild red cowpea (Vigna angularis var. nipponensis).
PMID:日期:2026-10-01Wild red cowpea (Vigna angularis var. nipponensis) plants exhibiting systemic chlorotic mottles and mosaic patterns on trifoliate leaves were identified during a virus survey in South Korea. High-throughput sequencing of symptomatic leaf samples generated contigs related to members of the genus Soymovirus (family Caulimoviridae). The complete circular double-stranded DNA genome was subsequently determined and validated by PCR amplification and Sanger sequencing. The virus genome is 8,892-nt in length and was tentatively named Vigna yellow mottle soymovirus (VYMSV). Its genomic organization, including primer binding sites, gene arrangement, and open reading frame (ORF) sizes, is largely consistent with those of other soymoviruses, except that ORFI is split into three segments (Ia, Ib, and Ic). The genome contains 10 putative ORFs encoding a movement protein, a coat protein, a replicase polyprotein, a translational activator, and proteins of unknown functions. Pairwise nucleotide sequence comparisons of the reverse transcriptase and RNase H region showed 69.9% identity with Soybean chlorotic mottle virus, consistent with ICTV species demarcation criteria; phylogenetic analysis further corroborated a close evolutionary relationship. Based on these molecular and phylogenetic data, VYMSV represents a putative novel species belonging to the genus Soymovirus. This study expands the known diversity of soymoviruses infecting wild legumes and provides genomic resources for future detection and epidemiological investigations.
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2. Epidemiological trends of HCV subtypes in China.
PMID:日期:2026-10-01While China has made notable progress toward the World Health Organization's goal of hepatitis elimination, substantial challenges continue to persist. In recent years, the prevalence of hepatitis C virus (HCV) in China has remained high. Understanding the distribution and trends of HCV genotypes is crucial for effective disease management. This study systematically analyzes the distribution and changes in various HCV subtypes across China, utilizing data from 29,874 cases identified through high-quality detection methods in 123 articles published between 1994 and 2024. Our findings indicate that the five most prevalent HCV subtypes are 1b, 3b, 6a, 2a, and 3a. The 1b subtype is primarily found in Guangdong (26.71%), Heilongjiang (25.16%), Yunnan (8.42%), Guizhou (6.85%) and Hubei (5.52%). The 2a subtype is concentrated in Heilongjiang (55.85%), Guangdong (8.35%) and Yunnan (6.7%), while subtypes 3b, 3a, and 6a are more common in southern provinces such as Yunnan, Guizhou, and Guangdong. Importantly, the distribution of subtypes in Southern and Southwestern China differs significantly from other areas, with genotypes 3 and 6 comprising over 50% of cases. This study highlights the need for ongoing surveillance and targeted strategies in HCV management to adapt to the evolving landscape of viral genotypes in China.
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3. The relationship between mutations in reverse transcriptase region of hepatitis B virus and progression of liver disease.
PMID:日期:2026-10-01The specific objective of this study was to investigate mutations of Hepatitis B virus (HBV) reverse transcriptase (RT) region in Chinese HBV-infected patients at different stages and their association with the progression of liver disease. HBV RT regions in serum samples were amplified and sequenced from 384 patients with chronic HBV infection, including 100 asymptomatic carriers (ASC), 101 chronic hepatitis B, 96 liver cirrhosis, and 87 hepatocellular carcinoma (HCC). Further analysis of genotyping and AA substitution within RT was performed by the online HBV genotyping tool and MEGA7.0 software. A logistic regression model was used to explore the relationship between RT mutations and advanced liver disease (ALD). The mutation rate gradually increased from ASC to HCC (P for trend < 0.05). Logistic regression analysis showed that one RT site mutation, rtS106A/C, was significantly associated with the ALD. Multivariate regression analysis confirmed that two RT mutations, rtH55R/Q/K and rtS137T/Q/E, were independent risk factors for HBV-related HCC. The current study reveals that mutations within the RT region might be associated with the progression of HBV-related liver diseases and might serve as predictive biomarkers for patients with HBV infection at high risk of developing HCC.
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4. Molecular epidemiology of human rhinovirus in coastal China: genotyping and epidemic trends in Daishan (2022-2023).
PMID:日期:2026-10-01To investigate the positive rate and molecular epidemiological characteristics of human rhinovirus (HRV) in influenza-like illness (ILI) cases in Daishan, Zhejiang Province. Throat swab specimens from ILI cases were collected from a hospital in Daishan, Zhejiang Province, between January 2022 and December 2023. Real-time PCR was performed to identify 14 common respiratory pathogens. Nested PCR was performed to amplify the VP4/VP2 gene sequences of HRV-positive specimens. Phylogenetic analyses were conducted based on the VP4/VP2 regions of HRV. A total of 1,255 specimens were collected. The overall positive rate for respiratory pathogens was 54.34% (682/1,255), with HRV detected in 7.57% (95/1,255) of the cases. Three genotypes of HRV were identified, encompassing 25 serotypes, including 15 types of HRV-A, 5 types of HRV-B, and 5 types of HRV-C. HRV was one of the main pathogens causing respiratory tract infections in Daishan, Zhejiang Province, from January 2022 to December 2023. The prevalence of HRV was complex, with HRV-A being the predominant genotype, while HRV-A, HRV-B, and HRV-C were co-prevalent. Continuous monitoring of HRV infections is recommended.
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5. Molecular evidence of two begomoviruses and a novel DNA-B infecting Duranta erecta variegata in Pakistan.
PMID:日期:2026-10-01Rapidly evolving begomoviruses are a serious threat to cash crops worldwide. Perennial plants often harbor these viruses for a long time, making them accessible to crop plants. Perennial ornamental plants Duranta erecta variegata (Variegated Sky Flower) were found with typical begomoviral symptoms, including leaf curling, leaf deformation, and leaf shortening in the plant nurseries of Faisalabad, Pakistan, in 2021. Begomovirus and its associated satellite molecules of ~ 2.8 and ~ 1.4 kb, respectively, were amplified using rolling circle amplification (RCA). Sanger sequencing of cloned molecules revealed the presence of rose leaf curl virus (RoLCuV, Begomovirus rosae) accompanied by a novel recombinant DNA-B, tentatively named "rose leaf curl virus DNA-B," along with hollyhock yellow vein alphasatellite (HYVA, Gosmusatellite alceae). Another plant sample showed the presence of agriculturally important papaya leaf crumple virus (PaLCrV, Begomovirus papayae). To our knowledge, this is the first report of RoLCuV, a novel DNA-B, PaLCrV, and HYVA infecting D. erecta variegata in Pakistan.
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6. Genome sequence analysis of baculoviruses from the noctuid moths Eudryas unio and Autographa gamma indicates that they are isolates of Betabaculovirus xecnigri, a species of slow-killing granuloviruses.
PMID:日期:2026-10-01Complete genome sequences were determined for three uncharacterized betabaculoviruses (Baculoviridae: Lefavirales) from noctuid moth species. These viruses included Eudryas unio granulovirus 1112 (EuunGV-1112), Eudryas unio granulovirus 1229 (EuunGV-1229), and Autographa gamma granulovirus Darmstadt (AugaGV-Darmstadt). Analysis of the features and open reading frame (ORF) contents of the genome sequences indicated that all three viruses were closely related to Helicoverpa armigera granulovirus (HearGV; Betabaculovirus helarmigerae) and Xestia c-nigrum granulovirus (XecnGV; Betabaculovirus xecnigri), two betabaculoviruses that kill larvae slowly and appear to suppress alphabaculovirus replication in coinfections. Phylogenetic inference with whole genome or core gene alignments grouped the EuunGV isolates in a clade with XecnGV. This clade was contained within a larger clade with AugaGV. Pairwise nucleotide distance estimation confirmed that AugaGV and the EuunGV isolates are viruses of Betabaculovirus xecnigri. Five ORFs were found to be unique to the EuunGV/AugaGV/HearGV/XecnGV group of betabaculoviruses, though what role the products of these ORFs play in the unusual features of their pathology remains to be determined. PCR analysis of cadavers from bioassays of AugaGV and EuunGV indicated that these viruses are able to infect and replicate in larvae of Helicoverpa zea and Spodoptera frugiperda, species which are susceptible to HearGV.
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7. Molecular characterization and recent spread of dengue virus type 3 lineage III_B.3.2 in Brazil: in silico analysis of protein motifs and epidemiology.
PMID:日期:2026-10-01The dengue virus (DENV) belongs to the Flaviviridae family and is responsible for a febrile arbovirus disease of global relevance. In Brazil, there has been endemic circulation of the four viral serotypes since the last century, with DENV-3 being frequently associated with more severe clinical conditions and major epidemics. This study aimed to perform the motif characterization of DENV-3 strains circulating in Brazil and its epidemiology. We obtained cases information by serotype from DATASUS/TABNET from 2013 to 2025. Furthermore, 184 complete genomes of Brazilian samples available in the GenBank and GISAID databases were analyzed with the genome reference sequence of DENV-3 (NC_001475.2). The sequences were edited and analyzed with the MAFFT, BioEdit, Nextclade, and GeneDoc software to identify lineages and amino acid motifs and were subsequently submitted to phylogenetic analyses in the IQ-Tree and FigTree programs. The results indicated a historical predominance of serotype one, but with a considerable increase in DENV-2 and DENV-3 cases in 2024 compared to the previous year. By December 2025, DENV-3 cases had already surpassed those of DENV-1 for that year. Nine amino acid motifs were identified throughout the genome, especially sites of N-myristoylation, casein kinase II phosphorylation, protein kinase C phosphorylation, and N-glycosylation. The predominant lineages were 3III_C.2 and 3III_C.2.2 until 2022, when lineage 3III_B.3.2 was introduced in Brazil, being associated with the increase in cases. This genotype presented substitutions and the absence of protein motifs compared to previous lineages, suggesting that such alterations contributed to its replicative success.
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8. Mitochondrial cytochrome b motif architecture predicts host-specific genomic vulnerability across vertebrate species.
PMID:日期:2026-10-01Mitochondrial DNA (mtDNA) plays a pivotal role in cellular bioenergetics, immune regulation, and evolutionary adaptation, making it a uniquely informative genomic system for studying host-pathogen interactions. The cytochrome b (cyt b) gene, one of the most conserved mitochondrial protein-coding loci, is widely recognized for its utility in species identification, phylogenetics, and molecular evolution [1-3]. However, its potential role in shaping comparative host susceptibility to infectious diseases remains underexplored. In this study, we re-analyzed PCR-RFLP-derived mitochondrial cyt b restriction profiles targeting CCNNGG, GTAC, AGCT, TTAA, and CGCG motifs across seven vertebrate hosts: cattle, buffalo, pig, goat, rabbit, chicken, and quail. These motif architectures were compared with documented susceptibility patterns for Pasteurellosis, foot-and-mouth disease (FMD), Rinderpest, and Sarcoptes scabiei infestation [4, 6, 7]. The integrated motif matrix revealed distinct host-specific restriction profiles and four comparative genomic vulnerability clades. The findings support a model in which conserved mitochondrial motif architecture may reflect evolutionary genomic signatures relevant to pathogen-host range and susceptibility. The study is intended as a comparative genomic framework and does not claim direct causality between single restriction motifs and disease outcome.
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9. Genetic diversity and evolutionary analysis of HIV-1 among migration populations: a five-year cross-sectional molecular epidemiology study.
PMID:日期:2026-10-01It is crucial to conduct strict surveillance on the diversity of HIV-1 to aid the generation of evidence-based biomedical and behavioral prevention programs to HIV/AIDS. In the current study, the social demographic characteristics, HIV-1 viral diversity among migration populations between 2017 and 2021 were investigated comprehensively and were compared with those in the previous five-year, between 2012 and 2016. Epidemiological investigation indicated that the male-to-female ratio decreased from 10.34:1 to 5.12:1, indicating significantly more female were infected when compared to the previous five years (p = 0.004). Moreover, an inversion on both the gender and nationality was found when comparison between study participants from southeastern ports and northwestern ports (p < 0.05) during the ten-year study period. Molecular epidemiology study revealed that two subtypes C/BC and CRF01_AE dominated, with the emerging of novel unique recombinant forms, including CRF01_AE/C/BC, CRF03_AB/C/BC, A/D, CRF01_AE/C, CRF08_BC/B, CRF01_AE/B, and B/CRF01_AE/C between 2017 and 2021. In addition, a significant higher proportion of drug-resistant viruses was found among this population when compared with the previous five-year (p < 0.001). In conclusion, the altered social demographic characteristics, co-circulation of CRF01_AE, C/BC recombinants, multiple URFs, and increasing amount of multiple drug-resistant viruses, indicated a new trend of the HIV-1 molecular epidemic in this population, which called for enhanced public health responses and prioritization of resources.
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10. Functional contribution of Epstein-Barr virus BARF1 residues 35-39 to viable cell maintenance under serum deprivation and tumor formation.
PMID:日期:2026-09-16Epstein-Barr virus (EBV) BamHI-A rightward frame 1 (BARF1) is a viral oncogene implicated in epithelial malignancies, but the determinants of its transforming activity remain incompletely defined. We generated BARF1 truncation constructs and targeted mutants to examine the contribution of residues 35-38 and adjacent Ser39 in BALB/c 3T3 fibroblasts using serum deprivation, tumorigenicity, BCL-2 expression, and molecular docking assays. Deletion of residues 35-38 in full-length BARF1 reduced viable cell maintenance under severe serum deprivation, whereas Ser39-to-Ala substitution in the BARF1 1-56 background markedly reduced the viable cell advantage of this fragment. Neither mutant produced detectable tumors during the 28-day observation period. Full-length BARF1 induced tumors in all animals, whereas BARF1 1-56 retained partial tumor-forming activity. BARF1 1-46 maintained higher viable cell numbers under serum-limiting conditions but produced no detectable tumors, suggesting a contribution of residues 47-56 to tumor formation. BCL-2 remained detectable in both non-tumor-forming mutants. Exploratory docking predicted a more favorable score and distinct positioning for the wild-type 35-39 peptide relative to the catalytic subunit of cAMP-dependent protein kinase A (PKA) than for the mutant peptides; however, this analysis does not demonstrate Ser39 phosphorylation or PKA-dependent BARF1 activity. Overall, these findings support a functional contribution of the BARF1 region encompassing residues 35-39 to viable cell maintenance under serum deprivation and tumor formation. Because construct-level BARF1 protein abundance, stability, secretion, and localization were not assessed, the observed phenotypes cannot be attributed solely to the altered residues.