ANALYTICAL SCIENCES分析科学
ANALYTICAL SCIENCES(英文缩写 ANAL SCI),ISSN 0910-6340,eISSN 1348-2246,中文译名:分析科学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.967 | Q4 |
| 2022 | 1.600 | Q4 |
| 2023 | 1.800 | Q3 |
| 2024 | 2.000 | Q3 |
| 2025 | 2.000 | Q3 |
ANALYTICAL SCIENCES 最新收录文献
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2. A highly sensitive electrochemical sensor based on poly(alizarin red)/gold nanoflowers/molybdenum disulfide composite for the detection of methotrexate.
PMID:期刊:日期:2026-10-01A sensitive electrochemical sensor for the detection of methotrexate (MTX), a widely used anticancer and anti‑autoimmune drug, was constructed. MTX monitoring is of great significance for reducing toxic side effects and guaranteeing clinical medication safety. The sensor was based on a glassy carbon electrode (GCE) modified with a nanocomposite of molybdenum disulfide (MoS) nanosheets loaded with gold gold nanoflowers (AuNFs), followed by the electrochemical polymerization of alizarin red (AR) to form a stable polymeric film (PAR) on its surface. The MoS nanosheets were prepared via liquid-phase exfoliation, and the AuNPs were deposited onto them via electrodeposition. The morphology of the modified electrode (PAR/Au@MoS/GCE) was characterized by scanning electron microscopy (SEM), and its electrochemical properties were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The synergistic effect of the nanocomposite and the conductive polymer significantly enhanced the electrocatalytic activity towards MTX oxidation. Under optimized conditions, the oxidation peak current of MTX at the modified electrode was nearly six times higher than that at a bare GCE. The sensor exhibited a linear response to MTX concentrations ranging from 0.4 to 38.6 µM, with a low detection limit of 0.027µM (S/N = 3). The sensor demonstrated excellent reproducibility, stability, and selectivity. Its practical applicability was successfully validated by determining MTX content in commercial tablet formulations with satisfactory recoveries.
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3. {"_":"Modified QuEChERS strategy based on dynamic in-situ assembly of aminated single-walled carbon nanotubes and magnetic FeO nanoparticles for pesticide residue analysis in Rhizoma Polygonati.","sub":["3","4"]}
PMID:期刊:日期:2026-10-01Accurate quantification of pesticide residues is critical to ensure the quality and safety of Rhizoma Polygonati, a well-recognized medicine-food homologous herb widely applied in functional food development. Strong matrix interference in gas chromatography-tandem mass spectrometry (GC-MS) detection and notable quantitative bias are frequently induced by the abundant pigments, polysaccharides, saponins and endogenous components in the herbal matrix. Conventional PSA and C adsorbents in standard QuEChERS protocols exhibit restricted purification capacity for this complex matrix, while most documented magnetic carbon-based adsorbents demand tedious pre-synthesis procedures that may block the active adsorption sites of nanomaterials. A modified QuEChERS-GC-MS method coupled with dynamic in-situ assembly strategy was established for 12 pesticide residues in Rhizoma Polygonati. Without pre-synthesis of any composites, in-situ functional synergy between NH-SWCNTs and magnetic FeO nanoparticles was achieved during the dispersive solid-phase extraction (d-SPE) step. Superior purification performance to conventional adsorbents was obtained by this system, with the matrix effect range of target pesticides narrowed from -31.4%-64.3% to -25.3%-36.7%. Favorable linearity (R ≥ 0.9990), acceptable spiked recoveries (86.2%-106.5%) and stable precision (RSD ≤ 15.20%) were validated through systematic method validation, providing a feasible and robust analytical protocol for pesticide residue monitoring in Rhizoma Polygonati and other complex herbal matrices.
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4. {"_":"Applicability of HILIC-SPE pretreatment for the quantitation of N-Ethyl-2'-deoxyguanosine in LC-ESI/MS/MS.","sup":["2"]}
PMID:期刊:日期:2026-10-01DNA adducts analysis is crucial for elucidating the mechanism of mutagenesis and carcinogenesis induced by various chemical compounds. Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-MS/MS) is commonly employed to determine DNA adduct. Pretreatment is essential in DNA adduct analysis due to a significant concentration disparity between normal 2'-deoxynucleosides (dNs) and DNA adducts. The level of DNA adducts is typically assessed by the ratio of DNA adducts to normal 2'-deoxyguanosine (dG) when the DNA adducts originate from dG. Consequently, the determination of dG and DNA adducts is necessary for accurate evaluation. Reversed-phase (RP)-solid-phase extraction (SPE) is the first choice for pretreatment of DNA adducts analysis. This pretreatment using RP-SPE effectively enriches DNA adducts while removing a substantial amount of dNs, particularly thymidine (T) and 2'-deoxyadenosine (dA), which may suppress the ionization of DNA adducts in the electrospray ionization (ESI) process. However, two separate measurements are required to determine the concentrations of dG and DNA adducts, as dG is removed during the SPE process. Therefore, an SPE method that simultaneously extracts dG and DNA adducts is desirable. In this study, we investigated the applicability of hydrophilic interaction chromatography (HILIC)-type SPE sorbents developed by our team, for the pretreatment of DNA adduct analysis. N-ethyl-2'-deoxyguanosine (EtdG), an acetaldehyde-derived DNA adduct, was selected as a model DNA adduct. By optimizing the washing and eluting solutions, dG and EtdG were simultaneously extracted from the sample solution while eliminating T and dA. This pretreatment method enables the simultaneous measurements of dG and DNA adducts concentration, thereby enhancing the accuracy and rapidity of the DNA adducts analysis.
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5. Nitrogen-doped carbon nanodots as a biocompatible FRET donor for caspase-3 detection and chemotherapy response evaluation in osteosarcoma cell lysates.
PMID:期刊:日期:2026-10-01Osteosarcoma is a highly aggressive bone malignancy requiring precise tools for early diagnosis and effective evaluation of chemotherapy efficacy. Here, we report an "off-on" fluorescent nanosensor based on nitrogen-doped carbon nanodots (N-CNDs) for the sensitive and selective detection of caspase-3 activity, a key apoptosis executor. The sensor is constructed by conjugating carboxyl-functionalized N-CNDs with a BHQ1-labeled peptide substrate containing the caspase-3-specific DEVD cleavage motif. In the absence of caspase-3, fluorescence is quenched via FRET. Upon caspase-3 activation, the peptide is cleaved, releasing BHQ1 and restoring fluorescence. The nanosensor exhibits high sensitivity (detection limit of 0.0106 U/mL), excellent selectivity, and robust performance in complex biological media. As a proof-of-concept application, it detects elevated caspase-3 activity in osteosarcoma cell lysates (MG-63) compared to normal osteoblast lysates (hFOB1.19) and enables quantitative, dose-dependent assessment of apoptosis induced by cisplatin and doxorubicin directly in cancer cell lysates. With its current format, this cell-lysate-based platform provides a practical and sensitive tool for preclinical drug screening and rapid comparison of chemotherapeutic potency, while laying a foundation for future adaptation toward live-cell and in vivo imaging applications.
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6. Activated carbon-coated particles as adsorbent for packed columns in gas chromatography.
PMID:期刊:日期:2026-10-01This study reports the first development of gas chromatographic columns packed with activated carbon (AC)-coated adsorbent particles. The AC-coated adsorbent particles were prepared by coating an AC layer on solid support particles using a vacuum carbon coater. Glass beads, diatomite, a porous polymer, and activated alumina particles were investigated as the support materials. The AC layer was uniformly coated on the surface of each support material, achieving a thickness of approximately 300-400 nm after 500 coating cycles. The AC-coated particles were packed in a stainless steel tube with an inner diameter of 1.0 mm and a length of 1.0 m to prepare a packed capillary column. The retention performance of the AC-coated particle-packed columns was evaluated using a capillary gas chromatograph coupled with a flame ionization detector. Strong retention for typical low-molecular-weight organic compounds, including methane, ethane, and propane, was observed. The retention power increased with increasing number of AC-coating cycles and support surface area. The theoretical plate numbers were lower for adsorbents coated on nonporous and low-porous supports, and higher for supports with a large specific surface area. The results demonstrated that the present AC-coating method readily affords AC adsorbents with high retention for typical volatile compounds.
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7. Raman scattering spectroscopic analysis on the structural changes in the micelles of a CTAB-NapTS system.
PMID:期刊:日期:2026-10-01Condensed micelle solutions are ubiquitously seen and utilized in foods, medicine, oil recovery, and so on. It is well-known that micelles formed from ionic surfactants drastically change their aggregate morphologies from spherical to short, rigid rod-like, and occasionally to long, winding worm-like structures as the concentration of the co-existing salts is varied. In general, these large-scale morphological changes induced by additive salt have been directly assessed by X-ray or neutron scattering spectroscopies. However, industrial processes are often carried out under open-system and atmospheric conditions, thus they show transient and dynamic changes of their structures and resultant viscoelastic properties according to the environmental changes. Here we examined whether Raman scattering spectroscopy is applicable for detecting such large-scale morphological changes in micelles by monitoring the corresponding changes occurring in the local packing environment of neighboring surfactant alkyl chains. As a representative micelle-salt system, cetyltrimethylammonium bromide (CTAB) and sodium p-toluene sulfonate (NapTS) were studied by varying their concentration ratio. As a result, it was proposed that the CH twisting and scissoring modes were useful indices to discriminate the morphological changes in micelles. These results provide a useful index for monitoring the transient structural changes of micelle solutions and elucidating the mechanism of the resultant changes in viscoelastic properties in situ and on-site monitoring.
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8. Solvent-based post-processing to fill layer gaps in FFF-printed polypropylene fluidic chips and their application to flow injection analysis.
PMID:期刊:日期:2026-10-01The development of new analytical tools remains a powerful approach in analytical chemistry, and three-dimensional (3D) printing has gained increasing popularity as a manufacturing technique in recent years. The fabrication of experimental tools using 3D printers has attracted attention in many fields. However, objects fabricated by fused filament fabrication (FFF) may contain gaps between printed paths, and which can cause leakage when liquid is introduced. In this study, solvent-based post-processing was performed in order to fill layer gaps in FFF-printed polypropylene fluidic chips. As methods, a compression process and solvent-based post-processing were applied. In the compression process, a polypropylene fluidic chip was compressed using a compression tool while being heated. After this compression process, solvent-based post-processing was conducted. The post-processed chip was used to measure peak profile during flow-injection measurement. As a result, peak profiles were obtained, and no leakage from the chip was observed during the measurements.
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9. A bromocresol green electropolymerized film-modified pencil graphite electrode for sensitive differential pulse voltammetric detection of tinidazole.
PMID:期刊:日期:2026-10-01A novel and highly sensitive electrochemical sensor based on an electropolymerized bromocresol green (BCG) film-modified pencil graphite electrode (poly(BCG)@PGE) was developed for the determination of tinidazole (TNDZ). The electropolymerization of BCG on the electrode surface significantly enhanced the electrochemical response toward TNDZ by improving electron-transfer kinetics and increasing the effective surface area. The fabrication and surface characteristics of the modified electrode were systematically investigated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and Fourier-transform infrared spectroscopy (FT-IR). The electrochemical behavior of TNDZ was studied using CV and differential pulse voltammetry (DPV). Key experimental parameters affecting sensor performance, including the pH of the electrolyte solution, monomer concentration, and number of electropolymerization cycles, were optimized. Under the optimized conditions, the proposed sensor exhibited a wide linear dynamic range (LDR) from 0.4 to 500 µM for TNDZ determination, with a high sensitivity of 1402 µA·mM·cm and a low limit of detection (LOD) of 0.11 µM. The practical applicability of the developed voltammetric sensor was successfully demonstrated by the determination of TNDZ in artificial blood, pharmaceutical formulation, and spring water samples. The obtained results showed satisfactory recoveries with high precision and accuracy, confirming the reliability and potential applicability of the poly(BCG)@PGE sensor for sensitive electrochemical monitoring of TNDZ in complex matrices.
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10. Analysis of trace gold in sub-microliter samples by surface-enhanced laser-induced breakdown spectroscopy using porous silicon with a single laser shot.
PMID:期刊:日期:2026-10-01Surface-enhanced laser-induced breakdown spectroscopy (SELIBS) using porous silicon (Si) is an attractive technique for liquid analysis in terms of requiring only microvolume samples, simple pretreatment, and a low plasma generation threshold. These features make SELIBS particularly suitable for industrial process monitoring, such as wet metal recovery processes. In our previous studies, we have analyzed sample solutions with volumes of approximately 10 µL by accumulating multiple spectra measured over the spread area of the sample. Reducing the volume of sample solutions and enabling rapid analysis remain important challenges for practical applications. In this study, we demonstrate single-shot analysis of trace gold (Au) in sub-microliter solution samples by SELIBS using porous Si, representing a step toward practical use. The emission line of Au was successfully observed using only 0.5 µL of sample and a single laser shot with an energy of 2.0 mJ. A calibration curve for Au was built using the Au intensity normalized by the Si intensity in the Au concentration range of 0.5-5.0 ppm (mg/L). From this calibration curve, a coefficient of determination of 0.997 was obtained. The limit of detection was estimated to be 0.48 ppm based on the Au intensity. The relative errors of predicted Au concentrations in additionally analyzed samples using the Au/Si calibration curve were approximately 10%. The proposed method has a potential for in-situ monitoring of wet metal recovery processes.