JOURNAL OF ORAL PATHOLOGY & MEDICINE口腔病理与医学杂志
JOURNAL OF ORAL PATHOLOGY & MEDICINE(英文缩写 J ORAL PATHOL MED),ISSN 0904-2512,eISSN 1600-0714,中文译名:口腔病理与医学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.539 | Q2 |
| 2022 | 3.300 | Q2 |
| 2023 | 2.700 | Q1 |
| 2024 | 2.300 | Q2 |
| 2025 | 2.300 | Q2 |
JOURNAL OF ORAL PATHOLOGY & MEDICINE 最新收录文献
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1. Papilliferous Keratoameloblastoma: What Is It, and Who Coined the Eponym?
PMID:期刊:日期:2026-09-24该文献暂无摘要。
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2. Effects of Infrared and Dual-Wavelength Photobiomodulation Therapy on Mandibular Bone Healing Following Radiotherapy and Tooth Extraction: An Experimental Study.
PMID:期刊:日期:2026-09-21Osteoradionecrosis (ORN) is a serious complication of head and neck radiotherapy characterized by impaired bone healing. Infrared photobiomodulation therapy (IR-PBMT) and dual-wavelength photobiomodulation therapy (Dual-PBMT) have been proposed as non-invasive approaches to enhance bone regeneration. Twenty-nine male Wistar-Albino rats were included. An experimental protocol designed to induce mandibular ORN was performed using a single 35 Gy radiation dose followed by mandibular molar extraction. Animals were allocated to four groups: control, radiotherapy plus extraction (RT + EX), RT + EX + IR-PBMT, and RT + EX + Dual-PBMT. IR-PBMT was performed using a 940 nm diode laser, whereas Dual-PBMT combined 632-650 nm red and 904-940 nm infrared wavelengths. Both PBMT protocols were applied extraorally for 14 consecutive days. Bone samples were evaluated histopathologically and immunohistochemically for alkaline phosphatase (ALP), bone morphogenetic protein-2 (BMP-2), osteonectin (ONC), and tartrate-resistant acid phosphatase (TRAP). The RT + EX group exhibited severe inflammation and tissue destruction, whereas both PBMT-treated groups showed reduced inflammation and partial epithelialization. Osteogenic marker expression was significantly lower and TRAP expression was significantly higher in the RT + EX group than in the control group (p < 0.05). Compared with the RT + EX group, both IR-PBMT and Dual-PBMT significantly increased ALP, BMP-2, and ONC expression and reduced TRAP expression (p < 0.05). ALP expression was significantly higher in the Dual-PBMT group than in the IR-PBMT group, whereas no significant differences between the two protocols were observed for BMP-2, ONC, or TRAP. Both IR-PBMT and Dual-PBMT improved the evaluated histological and bone-remodeling parameters following radiotherapy and tooth extraction. Because the control animals did not undergo tooth extraction, comparisons with the control group should be interpreted cautiously. Although Dual-PBMT produced a greater increase in ALP expression, the findings do not demonstrate the overall superiority of one PBMT protocol over the other. Both approaches may represent promising adjunctive strategies for mitigating radiation-associated impairment of mandibular bone healing.
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3. Inhibition of Aurora Kinase A Prevents Malignant Transformation in Oral Leukoplakia.
PMID:期刊:日期:2026-09-01Aurora Kinase A (AURKA), a highly conserved and potent kinase, is frequently overexpressed in diverse cancers. However, its role in the malignant transformation (MT) of oral mucosa remains poorly understood. This study investigated the expression pattern of AURKA and evaluated the therapeutic potential of its inhibitor in oral leukoplakia (OLK), the most representative oral potentially malignant disorder. Immunohistochemistry was performed on clinical samples (21 normal controls, 27 OLK, 23 MT of OLK) to examine AURKA expression and its correlation with clinicopathological characteristics. The inhibitory effect of targeting AURKA on tumor proliferation was verified in vitro using two oral squamous cell carcinoma (OSCC) cell lines. Additionally, the chemopreventive effect of the AURKA inhibitor Alisertib on MT was assessed using a 4-nitroquinoline oxide (4NQO)-induced mouse OLK model. AURKA expression levels positively correlated with the malignant progression of OLK. Significantly higher AURKA expression percentages were observed in non-homogeneous lesions (10.39% ± 4.28% vs. 3.53% ± 4.22% homogeneous, p < 0.001), lesions ≥ 2 cm (11.19% ± 4.55% vs. 4.69% ± 4.36% < 2 cm, p < 0.01), and lesions with high-risk dysplasia (12.10% ± 4.04% vs. 4.59% ± 4.12% low-risk dysplasia, p < 0.001). Targeting AURKA significantly inhibited the proliferation of OSCC cells in vitro. Furthermore, Alisertib treatment effectively suppressed oral mucosa carcinogenesis in the 4NQO model. Increased AURKA expression may represent an early molecular event in OLK carcinogenesis, and targeting AURKA with alisertib is a candidate for potential applications in the management of OLK.
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4. Predictors of Lesion Detection in a 12-Year Oral Cancer Screening Program: A Cohort Study in Northern Portugal.
PMID:期刊:日期:2026-09-01Oral cancer is a significant global public health issue, with high morbidity and mortality often linked to late diagnosis. This study evaluated a 12-year oral cancer screening program in northern Portugal to characterize its implementation and outcomes, identifying predictors of lesion detection. The program's outcomes were analyzed to assess its feasibility and contribution to early detection. A retrospective analysis of screening program data from 2012 to 2024 was conducted. Participants were recruited through community outreach and selection of high-risk groups in primary care settings. A standardized oral/oropharyngeal examination protocol was used to classify lesions as benign, suspicious, or malignant based on clinical examination. Demographic data and risk factors were recorded, and individuals with suspicious or malignant lesions were referred for specialized evaluation. A total of 10 433 participants were screened (median age 63 years; 64% female). Oral lesions were detected in 16.7%, with 6.1% classified as suspicious and 0.2% malignant. Current smoking (OR = 1.65; p < 0.001), former smoking (OR = 1.27; p = 0.010), and previous oncological disease (OR = 1.74; p < 0.001) were associated with lesion detection on multivariable logistic regression. Overall, 16.4% of participants were referred for specialized consultation. This large-scale screening program successfully reached a broad population, identifying a substantial number of potentially malignant lesions. The association with known risk factors supports the need for targeted screening strategies. Further research should integrate diagnostic confirmation, evaluate long-term patient outcomes, and assess cost-effectiveness to refine oral cancer screening policies and healthcare resource allocation.
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5. Inhibition of the EP300/Notch Signaling Pathway Regulates Proliferation and Apoptosis in Oral Squamous Cell Carcinoma.
PMID:期刊:日期:2026-09-01Oral squamous cell carcinoma (OSCC) is highly recurrent and metastatic; EP300 drives tumorigenesis, but its mechanism is unclear. EP300 expression was profiled in OSCC via databases, RT-PCR, and Western blot. Knockdown effects on proliferation (CCK-8, colony), cell cycle, and apoptosis (flow cytometry) were measured. EP300-Notch interplay was probed with Valproic acid, a Notch signaling activator (VPA) rescue assays. Our experimental results showed that EP300 was upregulated in OSCC Cell Lines. In addition, bioinformatics analysis showed that EP300 upregulation was significantly associated with poor prognosis of OSCC. Prior research and bioinformatics analyses have demonstrated a close relationship between EP300 and the activation of the notch signaling pathway in OSCC. After EP300 knockdown in OSCC cells treated with VPA, our results indicated that VPA could partially reverse the effects of EP300 knockdown on cell proliferation, cell cycle, apoptosis, and EMT processes in OSCC Cells. In this study, we observed that EP300 knockdown suppressed the Notch signaling pathway, consequently inhibiting OSCC cell proliferation, the cell cycle, and EMT while also promoting apoptosis. These findings suggest that EP300 is crucial for OSCC cell growth and development.
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6. Prognostic Value of Bcl-xL in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
6. Bcl-xL在头颈部鳞状细胞癌预后中的价值：系统综述和荟萃分析PMID:期刊:日期:2026-09-01Head and neck squamous cell carcinoma is a heterogeneous disease with poor survival outcomes. Bcl-xL regulates tumor cell survival and apoptosis and has been associated with metastasis and poor prognosis, although its overall role remains undeciphered. We systematically evaluated the prognostic value of Bcl-xL in head and neck squamous cell carcinoma following PRISMA 2020 guidelines. We identified 2241 reports from seven databases, of which 20 original studies with overall good quality (REMARK) and low bias (QUIPS) were included. An association between Bcl-xL levels and survival was rarely observed. However, high Bcl-xL levels correlated with increased risk of lymph node metastasis in 40% of studies. A study on oral tongue cancer identified a significant correlation between high Bcl-xL levels and decreased survival and lymph node metastasis. Current evidence does not support Bcl-xL as a general prognostic marker in head and neck squamous cell carcinoma. Nevertheless, Bcl-xL may have prognostic relevance in oral tongue cancer if further studies confirm the original finding.
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7. Oral Epithelial Dysplasia Information Needs Questionnaire (ODIN-Q): Responsiveness and Insights Into Patient Education.
PMID:期刊:日期:2026-09-01The Oral Epithelial Dysplasia Informational Needs Questionnaire (ODIN-Q) was developed to assess the informational needs of patients with oral epithelial dysplasia (OED), a precancerous disorder associated with an increased risk of malignant transformation. This study aimed to evaluate the responsiveness of the ODIN-Q following an educational intervention using a written patient information leaflet about OED. A prospective pre-post observational study was conducted at the Oral Medicine Unit at University College London Hospitals, between March 2023 and March 2025. Fifty patients with histologically confirmed OED completed the previously validated ODIN-Q before and after reading the leaflet. Differences between pre- and post-reading ODIN-Q scores were analysed using descriptive statistics and Cohen's d to determine effect sizes and responsiveness. Fifty participants (29 females, 21 males; mean age = 65 years) were included in the analysis. Overall ODIN-Q scores increased from 2.44 to 2.71, with a small overall effect size (d = 0.30; 95% CI: 0.01-0.59). The highest responsiveness was observed in the medical system and access to information domain (+0.42; +19%; d = 0.49; 95% CI: 0.19-0.79), followed by psychosocial aspects (+0.29; +12%; d = 0.38; 95% CI: 0.09-0.67) and physical aspects (+0.28; +11%; d = 0.36; 95% CI: 0.07-0.65). Other domains showed negligible to small responsiveness (investigative tests: d = 0.11; 95% CI: -0.18-0.40). The ODIN-Q demonstrates preliminary evidence of responsiveness to changes in patients' informational needs following educational interventions, supporting its potential use as a multidomain measure for evaluating and guiding patient-centred education in OED.
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8. Bridging the Health Literacy Gap for Patients With Oral Cancer: Readability Enhancement With AI Chatbots.
PMID:期刊:日期:2026-09-01Early diagnosis is crucial in improving oral cancer outcomes. Patient education materials support timely recognition and management. However, these resources are often written above recommended reading levels, beyond patients' health literacy and limiting accessibility. To assess the readability of available patient information on oral cancer by the NHS, to evaluate three large language models (LLMs; ChatGPT, Claude and Gemini) in simplifying texts while preserving their content, and to propose an improved leaflet based on UK materials, expert review and LLM adjustment to match average UK reading levels. Materials were collected from NHS-affiliated websites. Original and LLM-simplified texts were assessed using validated readability tools (FRES, FKGL, GFI, CLI and SMOG). Content fidelity was assessed using character 3-5-g cosine, sentence-content retention and latent semantic analysis (LSA). An expert review was applied to the proposed leaflet. LLM-revisions significantly improved readability across all five indices (p < 0.0001). Mean FRES of original texts was 66.4 ± 7.7, while Claude (81.6 ± 6.2) was the only model to surpass the 80 benchmark. Semantic similarity to source text remained high (LSA means 0.97 ± 0.04, 0.94 ± 0.09 and 0.96 ± 0.08; character 3-5-g cosine 0.85 ± 0.05, 0.80 ± 0.08 and 0.82 ± 0.08 for respective models). Baseline readability of the proposed leaflet was comparable to NHS materials (FRES 65.7); Claude increased this to 81.2. LLM-based simplification enhanced readability while preserving content fidelity. This approach can help enhance accessibility, particularly for populations disproportionately affected by oral cancer. With human oversight, it could be adopted at the policy level to standardise patient education and reduce health literacy disparities.
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9. Rapamycin Targets Cancer Stem Cells to Decrease Cisplatin Resistance in a Head and Neck Cancer Mouse Xenograft Model.
PMID:期刊:日期:2026-09-01Cisplatin is a common chemotherapeutic agent for advanced head and neck squamous cell carcinoma (HNSCC), but treatment success is often limited by resistance. Cancer stem cells (CSCs) are known contributors to this cisplatin chemoresistance in HNSCC. The mechanistic target of rapamycin (mTOR) pathway, which is frequently dysregulated in HNSCC, plays a crucial role via the PI3K/AKT/mTOR axis in maintaining CSC populations and promoting cancer proliferation. However, the specific effects of combining rapamycin, an mTOR pathway inhibitor, with chemotherapeutic agents on CSC maintenance and overall tumorigenicity remain unclear. We examined CSC gene expression in HNSCC cell lines (HSC4, SCC25, OT-1109) and evaluated the therapeutic potential of combining rapamycin, an mTOR pathway inhibitor, with cisplatin on CSC using a cell viability assay. The combination was further evaluated in an HSC4 mouse xenograft model. Tumor volume and animal weight were monitored throughout treatment. Xenograft tissue analysis via immunohistochemistry assessed stem cell markers (CD133 and ALDH1A1), proliferation markers (Ki-67), and mTOR pathway inhibition (pS6). Administration of low-dose cisplatin enriched the CD133 cell population but failed to decrease the tumor mass in HNSCC xenografts. In contrast, the combination of cisplatin and rapamycin significantly impeded tumor growth and minimized toxicity, concurrently reducing the population of CD133 tumor cells. These findings suggest that rapamycin enhances the mechanistic efficacy of cisplatin by specifically targeting and reducing cisplatin-induced stemness (CD133 CSC population). This study proposes a viable combination therapy for HNSCC involving an mTOR inhibitor and a platinum-based drug to overcome CSC-mediated resistance.
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10. Pg-Induced ATR Activation Promotes ESCC Progression via M2 TAM Polarization.
PMID:期刊:日期:2026-09-01Emerging evidence suggests that oral pathogens may contribute to the development of systemic malignancies. Porphyromonas gingivalis (Pg), a major periodontal pathogen, has been implicated in several cancers including esophageal squamous cell carcinoma (ESCC). However, the molecular mechanisms underlying this association remain unclear. This study aimed to investigate the impact of Porphyromonas gingivalis (Pg) on the growth of esophageal squamous cell carcinoma (ESCC) and its potential mechanisms. THP-1 cells were differentiated into M0 macrophages with PMA and divided into control group, Pg group, and Pg + siATR group. THP-1 cells were divided into three groups: control group, Pg group, and Pg + siATR group. The control and Pg groups were transfected with siNC, while the Pg + siATR group was transfected with siATR. After transfection, the Pg group and Pg + siATR group were incubated with 200 MOI pg. The control group was cultured normally. Cells and supernatants were collected, and macrophage polarization status was detected with qRT-PCR, Western blot, and flow cytometry. Macrophages treated differently were co-cultured with human esophageal squamous cell carcinoma cell line KYSE150. The proliferation, invasion, and apoptosis of KYSE150 were examined. KYSE150+shATR and KYSE150+shNC cell lines were constructed with a lentivirus system. Thirty male BALB/c mice aged 6-8 weeks were randomly divided into control group, pg group, and pg+shATR group, with 10 mice in each group. For the Pg and Pg+shATR groups, 200 μL Pg (1 × 10 CFU/mouse) was applied to the mandibular molars of mice four times a week for 1 month. The control group was treated with the vehicle (CMC) only. After 3 weeks of bacterial colonization, KYSE150+shATR cells (1 × 10 cells/mouse) were inoculated into the right axilla of mice in the Pg+shATR group, while KYSE150 + shNC (1 × 10 cells/mouse) were inoculated into the right axilla of mice in the control and Pg groups. Tumor volume was measured with calipers every 7 days. After 4 weeks of experimentation, D-luciferin potassium salt was injected intraperitoneally at 150 mg/kg, and bioluminescence imaging was performed after sodium pentobarbital anesthesia. The mice were euthanized post-imaging, and macrophage polarization in tumor tissues was examined with qRT-PCR, histopathological examination, and Western blot. In this study, we found that Pg could promote the polarization of M0 macrophages into M2 macrophages, while also promoting the malignant progression of KYSE150 cells. The expression levels of ATR, phosphorylated ATR (p-ATR), and M2 macrophage markers (CD206, Arg1, and VEGF) decreased when ATR was inhibited. In BALB/c mice, Pg-induced ATR activation promoted the growth of subcutaneously implanted tumors by recruiting M2-type TAMs. Experimental data also indicated an association between M2 polarization, decreased p-chik, and ATR. This study reveals that Pg can activate the ataxia-telangiectasia and Rad3-related protein (ATR) signaling pathway, inducing the polarization of M2 tumor-associated macrophages (TAM), thereby promoting the growth of ESCC. This provides a new theoretical basis for the prevention and treatment of ESCC.