Boletin Medico del Hospital Infantil de Mexico墨西哥儿童医院医学公报

Boletin Medico del Hospital Infantil de Mexico(英文缩写 B MED HOSP INFANT M),ISSN 0539-6115,eISSN 1665-1146,中文译名:墨西哥儿童医院医学公报 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。

2026 年数据 · 影响因子
0.700
JCR 分区
Q4
CAS 分区
B4
近一年发文量
38
本站 PubMed 收录统计

发文量统计区间:2025-10-01 至 2026-09-30,按本站收录文献的发表日期统计。

ISSN: 0539-6115 · eISSN: 1665-1146 · 缩写: B MED HOSP INFANT M ·中文: 墨西哥儿童医院医学公报

期刊介绍

选择期刊介绍栏目

期刊简介

《Boletin Medico del Hospital Infantil de Mexico》是墨西哥城儿童医院主办的综合性儿科医学期刊,以西班牙语发表,面向儿科医师、住院医师及相关研究人员。内容涵盖儿科各亚专业、儿童公共卫生与临床病例,强调临床实践与本地流行病学特点的结合,在拉丁美洲儿科界具有一定影响力。

研究方向

主要刊载儿科临床研究、病例报告、综述、短篇通讯及临床实践指南,涉及新生儿、儿童感染、营养、内分泌、呼吸、神经及外科等方向,也关注儿童保健政策与医院管理经验。

期刊特色

研究取向偏重临床实用与病例积累,论文多基于单中心经验,方法学要求适中,适合儿科临床医师、基层儿科工作者及研究生参考,尤其便于了解拉美地区儿科疾病谱与诊疗实践。

投稿难度

投稿难度总体中等偏易,但需注意语言与格式规范,建议以西班牙语撰写并突出临床价值与本地相关性;病例报告应有明确教学意义,研究类稿件需说明伦理与统计方法,避免仅凭分区判断录用可能。

历年影响因子趋势

JCR 数据年份影响因子JCR 分区
2021未收录N/A
20220.900N/A
20230.600Q4
20240.500Q4
20250.700Q4

Boletin Medico del Hospital Infantil de Mexico 最新收录文献

  1. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    1. Mexican version of the Autism Behavior Checklist: validity and reliability.

    作者:
    Lilia Albores-Gallo, Karen L Varela-Orozco, Ofelia Roldán-Ceballos, Claudia List-Hilton, Ana P Maurer
    日期:
    2026

    The Autism Behavior Checklist (ABC) evaluates symptoms in individuals with Autism Spectrum Disorders (ASD) within a school setting. The purpose of this study was to evaluate the validity of the ABC Mexican version. Participants were children (n = 133, aged 2-17). All parents were interviewed with the autism diagnostic interview-revised (ADI-R) to confirm an ASD diagnosis and then answered the ABC checklist. The sample for the ABC test-retest analysis consisted of 19 parents with unaffected typically developing children between 2 and 17 years old. Children and adolescents (n = 133) with a mean age of 6.9 years (standard deviation [SD] 3.7), 83.5% were males. The ABC total mean score was 69.3 (SD 25). The Internal consistency through the Cronbach Alfa coefficient was α = 0.83 < p = 0.001 for the 57 ABC items. The 10-day test-retest reliability showed a Pearson correlation coefficient of r = 0.98, p < 0.001. The Spearman correlation coefficients between the ABC subscales and the ADI-R ranged from (rs = 0.494) to (rs = 0.816). Criterion validity with a cutoff of 30 resulted in a sensitivity of 87% and a specificity of 37%. The best Kappa coefficient was 0.285 between the ABC and the ADI-R. The Mexican ABC has good psychometric properties. Further studies should investigate its value in educational settings.

  2. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    2. Clinical aptitude: two educational strategies for its development in cardiology residents. Quasi-experimental design.

    作者:
    Félix A Leyva-González, Gress M Gómez-Arteaga, Alberto Lifshitz-Guinzberg, Francisco J F Gómez-Clavelina, Lilia Degollado-Bardales, Eduardo Almeida-Gutiérrez, Karina Lupercio-Mora, Juan Verdejo-París, Daniel Manzur-Sandoval, Enrique Gómez-Álvarez, Julieta D Morales-Portano, Félix A Leyva-Salas, Martha A Gómez-Arteaga, Rosalba I Leyva-Salas, Víctor A Ayala-Angulo
    日期:
    2026

    Esta indagación en nuestro medio representa el primer trabajo multicéntrico en cardiología, mediante el que se pretende determinar los efectos de dos estrategias educativas: participativa vs. tradicional, con respecto al desarrollo de la aptitud clínica en residentes de cardiología de tres sedes académicas. Diseño cuasiexperimental, multicéntrico. Se estudió toda la matrícula. Se construyó un instrumento que evaluó la variable aptitud clínica mediante ocho indicadores y 170 ítems; la validez conceptual/de contenido y confiabilidad se valoró por cinco cardiólogos con experiencia docente e investigación educativa. Estrategia educativa participativa: cada sesión se desarrolló en tres fases con guías de discusión estructuradas. Estrategia educativa tradicional: cada sesión se efectúo en dos fases. Las sesiones se realizaron una vez por semana (2 horas). Duración total: 20 sesiones. El instrumento de medida se aplicó en la 1.ª y 20.ª sesión. Por año de residencia, en la calificación global de los indicadores se estimaron diferencias estadísticas entre medición inicial y final, resultando significativas en las tres sedes. Por indicador se realizó este mismo análisis y el resultado fue el mismo. Una estrategia educativa participativa vs. estrategia tradicional tiene mayores efectos en el desarrollo de la aptitud clínica en residentes de cardiología en la sede experimental. This investigation represents the first multicenter study in cardiology in our setting, through which it is intended to determine the effects of two educational strategies: participatory vs. traditional, with respect to the development of clinical aptitude in cardiology residents at three academic sites. Quasi-experimental, multicenter design. The entire enrollment was studied. An instrument was built that assessed the variable “clinical aptitude” by means of eight indicators and 170 items; conceptual/content validity and reliability were assessed by five cardiologists with teaching and educational research experience. Participatory educational strategy: each session was developed in three phases with structured discussion guides. Traditional educational strategy: each session was conducted in two phases. Sessions were held once a week (2 hours). Total duration: 20 sessions. The measurement instrument was applied in the 1 and 20 session. By year of residency, statistical differences were estimated in the overall rating of the indicators between the initial and final measurements, were found to be significant at all three sites. By indicator, the same analysis was performed and the result was the same. A participatory vs. traditional educational strategy has greater effects on the development of clinical aptitude in cardiology residents at the experimental site.

  3. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    3. Initial impact assessment of the current PAIDOS clinical care model for school-age children living with obesity in Mexico.

    作者:
    Salvador Villalpando-Carrión, M José Adame-Vivanco, Daniela Felgueres-Nacach, Montserrat Remís-Colín, Fuentes-Balderrama Jaime
    日期:
    2026

    Given the increasing prevalence and public health burden of childhood obesity in Mexico, the development of multidisciplinary evidence-based clinical care models is urgent. The PAIDOS clinical care model was active from 2011 to 2013 in the Mexican Children's Hospital. This model was redesigned and launched in 2015 as a more comprehensive and holistic protocol. This updated model consists of six in-hospital sessions aimed at engaging the nutritional, physical, psychological, and family elements associated with childhood obesity. Participants in this model were 119 children and adolescents from 7 to 16 years of age (X̅ = 11.91, standard deviation = 2.32, 66% male, with a body mass index [BMI] ≥ 95 percentile). Repeated measure analysis of covariances exhibits significant reductions in BMI at post-test, as well as maintenance at the 6-month follow-up. Negative self-esteem presented a significant decrease at post-test, while other dimensions of depression displayed significant changes only for girls. The current PAIDOS clinical care program shows promise as it is effective in reducing and maintaining BMI. Future directions are discussed.

  4. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    4. Effectiveness of the "Golden Hour" program in preventing sepsis in pediatric patients with acute lymphoblastic leukemia.

    作者:
    Mónica V Cárdenas-Monsibaiz, Enrique Villarreal-Ríos, Karla E Margain-Pérez, Liliana Galicia-Rodríguez, Jesús González-Aparicio
    日期:
    2026

    La iniciativa «Hora Dorada» se propone para reducir complicaciones graves en pacientes oncológicos pediátricos con neutropenia febril. Se refiere a la administración de antibiótico de amplio espectro en la primera hora de la atención en el servicio de urgencias. Los pacientes con leucemia linfoblástica aguda son de alto riesgo por la inmunosupresión prolongada. El objetivo fue determinar la administración de antibiótico dentro de los primeros 60 minutos como factor asociado a menor incidencia de sepsis en pacientes con leucemia linfoblástica aguda. Diseño de cohorte retrospectiva en expedientes de pacientes pediátricos con diagnóstico de leucemia linfoblástica aguda. Los grupos se integraron en función del tiempo de administración del antibiótico posterior al ingreso a triaje. En el grupo con administración oportuna (≤ 60 minutos) se estudiaron 44 pacientes y en el grupo con atención tardía (> 60 minutos), 11 pacientes. El diagnóstico de sepsis utilizó de referencia los criterios de Phoenix. El tiempo triaje-administración de antibiótico se midió en minutos. El análisis estadístico incluyó regresión logística simple y cálculo de probabilidad de ocurrencia del evento. El 54.5% del grupo con atención tardía desarrolló sepsis, en el grupo con atención oportuna la incidencia fue del 22.7% (p = 0.038). El modelo de regresión logística reportó significancia (p = 0.004). La probabilidad de desarrollar sepsis fue del 49.1% a los 80 minutos, el 35.5% a los 60 minutos y el 56% a los 90 minutos. La administración de antibiótico dentro de los primeros 60 minutos se asoció con menor incidencia de sepsis en pacientes con leucemia linfoblástica aguda. The “Golden Hour” initiative is intended to reduce serious complications in pediatric oncology patients with febrile neutropenia, and it refers to the administration of broad-spectrum antibiotics within the first hour of care in the emergency department. Patients with acute lymphoblastic leukemia are at high risk due to prolonged immunosuppression. The objective was to determine the administration of antibiotics within the first 60 minutes as a factor associated with a lower incidence of sepsis in patients with acute lymphoblastic leukemia. Retrospective cohort design in the records of pediatric patients diagnosed with acute lymphoblastic leukemia, with groups organized based on the time of antibiotic administration after triage admission. In the timely administration group (≤ 60 minutes), 44 patients were studied, and in the delayed care group (> 60 minutes), 11 patients. The diagnosis of sepsis used the Phoenix criteria as a reference. The time between triage and antibiotic administration was measured in minutes. The statistical analysis included simple logistic regression and calculation of the probability of the event occurring. Fifty-four percent of the late-care group developed sepsis, while in the timely-care group the incidence was 22.7% (p = 0.038). The logistic regression model reported significance (p = 0.004). The probability of developing sepsis was 49.1% at 80 minutes, 35.5% at 60 minutes, and 56% at 90 minutes. Antibiotic administration within the first 60 minutes was associated with a lower incidence of sepsis in patients with acute lymphoblastic leukemia.

  5. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    5. Experience of a third-level hospital teaching the laparoscopic percutaneous extraperitoneal closure technique to residents for pediatric inguinal hernia repair.

    作者:
    Ricardo M Ordorica-Flores, Hector M Ibarvo-Gracia, Cristian Zalles-Vidal, Salvador Montoya-Alvarez, Arturo Minor-Martínez, Fernando Pérez-Escamirosa, Jaime Nieto-Zermeño
    日期:
    2026

    This study aims to present the experience of a third-level hospital teaching inguinal hernia repair through the laparoscopic percutaneous extraperitoneal closure (LPEC) method to pediatric surgery residents. This study was performed by the Department of Pediatric Surgery of a third-level hospital of clinical care. Eleven residents received pediatric inguinal hernia repair training based on the LPEC method using a Tuohy needle. The mean time of four metrics was used to measure trainees' performance during the inguinal hernia repair procedure through the LPEC method, alongside approval of the procedure by an expert surgeon. Operative times between the first and last surgeries were evaluated using the paired t-student test. A total of 50 repairs were performed, including 45 unilateral repairs (31 right and 14 left hernias) and 5 bilateral repairs. The follow-up period for all patients was 12 months with no significant complications, no recurrence, and without post-operative hydrocele. The results showed statistically significant differences for umbilical trocar insertion time (p = 0.018), inguinal hernia repair time (p < 0.001), umbilical trocar site closure time (p = 0.029), and the total surgical procedure time (p < 0.001) metrics. The mean time in the last surgical repair procedure was 19.7 ± 5.9 min. All pediatric surgery trainees adequately acquired the skills to perform the inguinal hernia repair through the LPEC method. This study provides our experience in implementing this technique in a third-level hospital.

  6. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    6. Position statement of the Mexican Academy of Pediatrics regarding strategies to prevent respiratory syncytial virus infection in Mexico's pediatric population.

    作者:
    Rosa M Wong-Chew, María Del C Espinosa-Sotero, Ana E Limón-Rojas, María G Miranda-Novales, Martha J Avilés-Robles, José I Castillo-Bejarano, Sarbelio Moreno-Espinosa, Rodrigo Romero-Feregrino, Socorro A Anzures-Gutiérrez, Fortino Solórzano-Santos, Antonio Luévanos-Velázquez, Patricia Saltigeral-Simental, Mónica Reyes-Berlanga, Claudia Del C López-Enríquez, Denisse Vaquera-Aparicio, Mariana Merlo-Palomera, Leticia Belmont-Martínez
    日期:
    2026

    El virus sincicial respiratorio (VSR) constituye una de las principales causas de infección respiratoria aguda baja, bronquiolitis, neumonía y hospitalización en niños, con mayor riesgo de gravedad en menores de seis meses, prematuros, pacientes con displasia broncopulmonar, cardiopatías congénitas, inmunocompromiso y otras comorbilidades. En México, la evidencia disponible muestra una carga clínica relevante y una estacionalidad predominante de septiembre a marzo. El desarrollo de nuevas estrategias preventivas ha transformado el abordaje del VSR, particularmente mediante la vacunación materna con vacuna bivalente de proteína F prefusión y la inmunoprofilaxis pasiva con anticuerpos monoclonales de acción prolongada. El presente posicionamiento de la Academia Mexicana de Pediatría revisa la evidencia epidemiológica, clínica y de efectividad en vida real sobre las estrategias disponibles para la prevención de la enfermedad por VSR en población pediátrica. La vacunación materna entre las 32 y 36 semanas de gestación permite la transferencia transplacentaria de anticuerpos y confiere protección al lactante durante los primeros meses de vida. Por su parte, los anticuerpos monoclonales, especialmente el nirsevimab, han demostrado reducciones significativas en infección respiratoria baja, hospitalización, ingreso a cuidados intensivos y enfermedad grave asociada a VSR, con un perfil de seguridad favorable. Con base en la carga de enfermedad, la estacionalidad nacional, la disponibilidad de productos preventivos y las condiciones del sistema de salud mexicano, la Academia Mexicana de Pediatría propone una estrategia complementaria y progresiva que integre vacunación materna e inmunoprofilaxis con anticuerpos monoclonales, priorizando inicialmente a lactantes de alto riesgo y ampliando de manera gradual la cobertura hacia todos los lactantes susceptibles. Respiratory syncytial virus (RSV) is one of the leading causes of acute lower respiratory tract infection, bronchiolitis, pneumonia, and hospitalization among infants and young children, with the highest risk of severe disease observed in infants younger than six months, preterm infants, and children with bronchopulmonary dysplasia, congenital heart disease, immunocompromising conditions, and other underlying comorbidities. In Mexico, available evidence demonstrates a substantial clinical burden and a predominant seasonal circulation from September to March. In recent years, the development of novel preventive strategies has transformed the approach to RSV prevention, particularly through maternal immunization with a bivalent prefusion F protein vaccine and passive immunoprophylaxis with long-acting monoclonal antibodies. This position statement from the Mexican Academy of Pediatrics reviews the epidemiological, clinical, and real-world effectiveness evidence regarding currently available strategies for the prevention of RSV infection in the pediatric population. Maternal vaccination between 32 and 36 weeks of gestation promotes transplacental antibody transfer and provides protection to infants during the first months of life. Monoclonal antibodies, particularly nirsevimab, have demonstrated significant reductions in lower respiratory tract infection, hospitalization, intensive care unit admission, and severe RSV-associated disease, with a favorable safety profile. Based on disease burden, national seasonality, availability of preventive products, and the characteristics of the Mexican health care system, the Mexican Academy of Pediatrics proposes a complementary and progressive strategy integrating maternal vaccination and monoclonal antibody immunoprophylaxis, initially prioritizing high-risk infants and gradually expanding coverage to all susceptible infants. Implementation should consider efficacy, safety, cost-effectiveness, operational feasibility, equity, and timely access.

  7. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    7. Septic shock secondary to disseminated coccidioidomycosis: case report.

    作者:
    Gerardo F Ramos, M A Elisa Vásquez-Sandoval, Rodrigo García-Pérez
    日期:
    2026

    La coccidioidomicosis es una infección endémica en el norte de México causada por Coccidioides immitis y Coccidioides posadasii. Su principal manifestación es en los pulmones, aunque cerca del 1% puede tener afectación de otros órganos, lo que se conoce como coccidioidomicosis diseminada. De forma infrecuente, estos casos pueden cursar con choque séptico. En pediatría, esta forma de expresión está infraestudiada, pero se ha asociado con elevada mortalidad. Se presenta el caso de una paciente de 16 años que acudió por una lesión ulcerativa en región cervical acompañado de fiebre y pérdida de peso de 2 meses de evolución. Durante su estancia desarrolló choque séptico refractario aunado a endocarditis y tuvo fallo multiorgánico con un desenlace fatal. Debe considerarse esta micosis como causa de choque séptico en zonas endémicas donde no existe una causa específica. Coccidioidomycosis is an endemic infection in northern Mexico caused by Coccidioides immitis and Coccidioides posadasii. Its main manifestation is in the lungs, although approximately 1% may affect other organs, which is known as disseminated coccidioidomycosis. Rarely, these cases can present with septic shock. In pediatrics, this form of expression is understudied but has been associated with high mortality. We describe the case of a 16-year-old female who presented with an ulcerative lesion in the cervical region accompanied by fever and weight loss that had lasted 2 months. During her stay, she developed refractory septic shock combined with endocarditis and suffered multiorgan failure with a fatal outcome. This mycosis should be considered as a cause of septic shock in endemic areas where there is no specific etiology.

  8. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    8. Inflammatory indices predictors of presence, severity and mortality of necrotizing enterocolitis: an observational study.

    作者:
    Gloria P Sosa-Bustamante, Alejandro Covarrubias-Gil, Diana L Colmenero-Carrera, Ulises P Villalpando-Sosa, Arturo M Reyes-Sosa, Carlos Paque-Bautista, Paulina P Reyes-Sosa, Joselin Chavero-Espínola, Alexis D Arroyo-Tovar, Aurelia Del C Ramos-Jiménez, Arturo Reyes-Hernández, Alma P González
    日期:
    2026

    La enterocolitis necrosante (ECN) es una enfermedad grave en recién nacidos pretérmino (RNPT) que requiere de biomarcadores predictores. Los índices neutrófilo/linfocito (INL), plaqueta/linfocito (IPL) e inmunidad/inflamación sistémica (IIS) han mostrado utilidad en entidades neonatales. El objetivo de la investigación fue evaluar los índices inflamatorios como predictores de presencia, gravedad y mortalidad en ECN en RNPT. Estudio observacional, retrospectivo. Se incluyeron RNPT de 26-36 semanas de gestación, con biometría hemática completa, distribuidos en dos grupos, con ECN (n = 85) y sin ECN (n = 85). Se registraron datos clínicos y hematológicos de los RNPT, así como la evolución y desenlace para los casos de ECN. Se incluyeron 170 RNPT con edad gestacional de 32.5 (RIC: 31-34) semanas y peso de 1,402.5 g (RIC: 1,170-1,691 g), 52% hombres y 48% mujeres. Para ECN, la sensibilidad fue para INL 48%, IPL 8% e IIS 34%; especificidad del 98% de INL, IPL e IIS. Para ECN quirúrgica, sensibilidad del INL del 66%, IPL 20% e IIS 58%; especificidad del 95% de INL, IPL e IIS. Para ECN grave, sensibilidad del INL del 60%, IPL 15% e IIS 45%; especificidad del 90% de INL y 93% de IPL e IIS. El INL y el IIS demostraron ser predictores de diagnóstico, gravedad y desenlace quirúrgico de ECN, aunque no para mortalidad. Pueden ser marcadores de bajo costo y accesibles desde unidades de primer nivel hasta áreas neonatales especializadas. Necrotizing enterocolitis (NEC) is a serious disease in preterm newborns (PTNBs) that requires predictive biomarkers. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immunity-inflammation index (SII) have proven useful in neonatal conditions. The study objective was to evaluate inflammatory indexes as predictors of NEC presence, severity and mortality in PTNBs. Retrospective, observational study. PTNBs at 26-36 weeks’ gestation with complete blood count were included and divided into two groups: those with NEC (n = 85) and without NEC (n = 85). Clinical and hematological data were recorded from participants, along with the course and outcome for those with NEC. One hundred seventy PTNBs infants with a gestational age of 32.5 (IQR: 31-34) weeks and a weight of 1,402.5 g (IQR: 1,170-1,691 g) were included, 52% male and 48% female. For NEC, sensitivity was 48% for the NLR, 8% for PLR, and 34% for SII; specificity was 98% for NLR, PLR, and SII. For surgical NEC, sensitivity was 66% for NLR, 20% for PLR, and 58% for SII; specificity was 95% for NLR, PLR, and SII. For severe NEC, sensitivity was 60% for NLR, 15% for PLR, and 45% for SII; the specificity was 90% for NLR, and 93% for PLR and SII. NLR and SII were shown to be predictors of diagnosis, severity, and surgical outcome of NEC, although not for mortality. They can be low-cost, and accessible markers from first-level units to specialized neonatal areas.

  9. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    9. Pityriasis lichenoides chronica in a Mexican pediatric series: clinical-epidemiological profile and therapeutic approach.

    作者:
    Juan A Godínez-Chaparro, Helena Vidaurri-de la Cruz, Ixchel R Ramírez-Ricarte, Óscar G Aguirre-Félix
    日期:
    2026

    Pityriasis lichenoides chronica (PLC) is a rare dermatosis in children, with limited epidemiological data restricting its clinical and therapeutic characterization. A retrospective case series was conducted at two tertiary care hospitals in Mexico City. Electronic records of patients younger than 18 years of both sexes with a diagnosis of PLC confirmed by histopathology were included in the study. The study period was from January 2017 to March 2025. Thirty-five confirmed cases were analysed (51.4% female and 48.6% male). The mean time to diagnosis was 2.4 years after lesion onset. The median disease duration was 24 months (interquartile ranges 9-49), with recurrence in 67.5% of cases. The most common sites were the trunk and extremities (65.7%), with predominance of erythematous-squamous papules and plaques (48.6%) that, upon resolution, left hypopigmented macules in 80% of patients. Phototherapy was used in 25.7% and oral methotrexate (MTX) in 22.9% of cases. In patients with prolonged disease duration (> 36 months), higher recurrence rates, longer MTX use, and, in some cases, greater use of phototherapy were observed. Pediatric PLC in a Mexican case series showed a chronic and recurrent course, with a low rate of resolution. The high frequency of recurrences and therapeutic variability, including MTX and phototherapy in prolonged cases, highlights the need for standardized treatment protocols.

  10. JCR分区: Q4 CAS分区: B4 影响因子: 0.7

    10. Randomized controlled, double blind trial of use of vancomycin catheter-lock to prevent Gram-positive bloodstream infection in neonates.

    作者:
    Carlos López-Candiani, Silvestre García-de la Puente, José L Arredondo-García
    日期:
    2026

    Central lines are more frequently used in infant newborns; they offer advantages but are related to traumatic complications, obstruction and infection. Antibiotics in catheter locks may decrease infections. The aim of this work was to evaluate the efficacy of vancomycin catheter lock to prevent Gram-positive bloodstream infection. Randomized controlled doubled blind trial in newborn with central catheter in first 48 hours. Parents informed consent was obtained. Two groups were formed: experimental group with vancomycin catheter lock twice a day for 30 minutes and control group with normal saline solution catheter lock. Primary outcome was Gram-positive bacterial bloodstream infection. Trial was approved by the project review committees of the National Institute of Pediatrics. Sixty-one patients were included, with mean gestational age of 34.9 weeks of gestation and 2,044 g of weight. Mean stay of catheter was 14.6 days and parenteral nutrition 12 days. It was lower suspicion of sepsis in experimental group (25 vs. 34.5%), fewer bloodstream infections (3.1 vs. 13.8%) and lower infection density per 1,000 catheter/days (2.3 vs. 4.6), but none of these were statistically significative. Vancomycin catheter-lock diminished bloodstream infections at 25% respect control group and 50% density infection per 1000 catheter/days, without being statistically significant.

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