International Journal of Pharmaceutics国际药剂学杂志
International Journal of Pharmaceutics(英文缩写 INT J PHARMACEUT),ISSN 0378-5173,eISSN 1873-3476,中文译名:国际药剂学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 6.510 | Q1 |
| 2022 | 5.800 | Q1 |
| 2023 | 5.300 | Q1 |
| 2024 | 5.200 | Q1 |
| 2025 | 6.000 | Q1 |
International Journal of Pharmaceutics 最新收录文献
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2. Fluorinated radiopharmaceuticals sorption onto plasticized polyvinyl chloride automated injector tubings: implications for patient dosing.
PMID:日期:2026-10-05The use of automated injectors for the administration of radiopharmaceuticals limits staff exposure and optimises the dose administered to patients, but many of these devices are only validated for a limited number of radiopharmaceuticals. The objectives of this study were to investigate the physicochemical phenomena occurring during the manipulation of fluorinated radiopharmaceuticals when in contact with injector tubings and to quantify and qualify the interactions between the radiopharmaceuticals and the tubing materials. For six of the radiopharmaceuticals tested, the measured doses reached 97.64 ± 0.24% of the programmed dose. These results indicate an absence of sorption phenomena and validate their use on the injector. In contrast, the three most lipophilic molecules caused the injector to malfunction, resulting in significant residual activity in the tubing of up to 67%. These results were confirmed by activimeter measurements and positron emission tomography images. from electronic microscopy results showed an alteration of the inner surface of the tubings that came into contact with lipophilic radiopharmaceuticals; however, this modification did not drastically alter the surface Zeta potential. Infrared spectroscopy confirmed the composition of the tubings as being plasticized polyvinyl chloride (PVCp), and plasticizer identification and quantification showed the presence of di-(2-ethylhexyl) adipate (reaching 37.5%) and di-(2-ethylhexyl) phthalate (more than 20%). A clear improvement was observed when co-extruded polyethylene / PVPp tubings were used. Unlike lipophilic radiopharmaceuticals, which exhibit sorption behaviour dependent on the presence of plasticizers, the tested hydrophilic radiopharmaceuticals demonstrated minimal interaction with PVCp tubing and can be reliably administered using the automated injector.
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3. PEGylated curcumin for cigarette smoke-induced oxidative stress: From nasal epithelial cells to fast- dissolving microneedle patches.
PMID:日期:2026-10-05Oxidative stress induced by inhaled oxidants, particularly cigarette smoke, contributes to the development of several acute and chronic respiratory diseases through oxidative damage and epigenetic alterations. Curcumin (CUR), a well-characterized natural polyphenol with potent antioxidant and anti-inflammatory properties, is considered a promising agent for modulating oxidative stress-related signaling pathways and epigenetic mechanisms; however, its poor aqueous solubility and bioavailability limit its clinical application. Therefore, in the present study, PEGylated curcumin (PEG-CUR) was investigated as a modified CUR formulation for subsequent incorporation into a dissolving microneedle-based intranasal delivery system. Exposure to cigarette smoke condensate (CSC) resulted in significant alterations in the expression of oxidative stress-related genes (SEPP1, NCF2, SFTPD, CCL5, and PTGS1) in nasal epithelial cells. However, pretreatment with CUR and PEG-CUR mitigated these gene expression changes. Both treatments also reduced global DNA methylation, with PEG-CUR showing a more pronounced effect than CUR. Following the demonstration of the beneficial effects of PEG-CUR, we developed PEG-CUR-loaded dissolving microneedle patches (PEG-CUR-DMNPs) as a localized intranasal delivery platform designed to facilitate PEG-CUR delivery through rapid dissolution of the microneedle tips. The mechanical robustness and penetration capability of the patches were initially evaluated using Parafilm® and ex vivo rat dorsal skin models. To further confirm their appropriateness for intranasal use, PEG-CUR-DMNPs were subsequently tested on ex vivo sheep nasal mucosa to evaluate microneedle penetration and dissolution kinetics. Overall, these results indicate that PEG-CUR-DMNPs represent a promising approach for localized intranasal drug delivery targeting oxidative stress-related respiratory diseases.
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4. Physicochemical and in vitro characterisation of antifungal PVA/chitosan composite wet-spun fibres loaded with hydroxypropyl-γ-cyclodextrin/amphotericin B complexes.
PMID:日期:2026-10-05Chronic wounds infected by Candida albicans impose a significant clinical burden, yet topical amphotericin B (AMB) delivery is constrained by low aqueous solubility. Wet-spun poly(vinyl alcohol) (PVA)/chitosan fibres loaded with an AMB/hydroxypropyl-γ-cyclodextrin (HP-γ-CD) inclusion complex were developed as a sustained-release antifungal wound dressing. Phase solubility analysis confirmed inclusion complex formation with an apparent stability constant of 36.1 × 10 M⁻ in distilled water (AL-type profile, R = 0.9984), characterised by Fourier-transform infrared spectroscopy (FTIR), H NMR, and scanning electron microscopy (SEM). IC-SE-1 achieved ∼ 354-fold and ∼ 136-fold solubility enhancement in distilled water and phosphate-buffered saline (PBS, pH 7.4), respectively, while fully retaining antifungal activity (MIC = 1 µg/mL; p = 0.112 vs. pure AMB). The complex was incorporated into fibres at four PVA:chitosan ratios and crosslinked with tripolyphosphate and glutaraldehyde. Formulation P6C4 (PVA 60%:chitosan 40%) demonstrated the most favourable overall performance, with the highest water-holding capacity (346.51 ± 4.10%), swelling (463.40 ± 11.12%), tensile strength (18.47 ± 2.18 MPa), and elongation (431.57 ± 52.22%). Woven fibres maintained inhibition zones against C. albicans from day 2 to day 7, with AMB release exceeding the MIC throughout, while haemolysis remained below 5% (ASTM F756-08). HP-γ-CD complexation enables sustained above-MIC AMB delivery from a dual-crosslinked biopolymeric dressing, providing in vitro proof-of-concept for Candida-infected chronic wounds, pending cytotoxicity and in vivo validation.
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5. Elucidating the release and permeation mechanisms of emulsion-type cataplasms from a structural perspective.
PMID:日期:2026-10-05Drug release and permeation play crucial roles in the therapeutic efficacy of cataplasms. However, due to the lack of research on the mechanisms underlying drug release and permeation, achieving optimal release and permeation characteristics through trial-and-error methods is inefficient. Therefore, we aimed to investigate the mechanisms of drug release and permeation in emulsion-type cataplasms from a structural perspective.Cataplasms with varied crosslinking densities, drug loadings, and drug types were prepared; drug release and permeation studies were performed using Franz diffusion cells, while the microstructural evolution of both the cataplasms and the skin was characterized via scanning electron microscopy, differential scanning calorimetry, Fourier-transform infrared spectroscopy, and histology.It was revealed that drug release essentially occurred as the drug escaped from structural constraints through the swelling of the crosslinked network. Drug permeation was demonstrated to be governed by four synergistic mechanisms: (1) the physical contact established by the intimate adhesion between cataplasms and the skin; (2) the influence of drug release amount on drug permeation behavior; (3) stratum corneum hydration induced by water-mediated keratin swelling; (4) disruption of the stratum corneum lipid structure resulting from L-menthol. In addition, this study revealed that the acidity and basicity of the drug itself constituted a key determinant of drug permeation. Overall, the present work is expected to provide a scientific basis for the rational design of cataplasms, improve research and development efficiency, and further promote advances in this field.
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6. Microfluidic processing of coarse emulsions: a scalable approach for nanoemulsion preparation in dermal drug delivery.
PMID:日期:2026-10-05Nanoemulsions are increasingly explored to enhance dermal drug delivery due to their nanoscale size. Microfluidic processing for nanoemulsion generation has attracted much attention but requires extensive optimisation. This study leverages 3D printed microfluidic chips for size reduction of a premixed emulsion as a scalable approach to fabricate cationic oil‑in‑water nanoemulsions loaded with ibuprofen (2%w/w) for dermal delivery. Phase inversion composition (PIC) and homogenisation were used as benchmark methods. Nanoemulsions comprising ethyl oleate, Tween® 80 and cetyltrimethylammonium bromide were optimised using PIC (∼33 nm) and subsequently used to prepare premixed emulsions (∼84 nm). Microfluidisation effectively reduced the droplet size of premixed coarse emulsions (∼57-67 nm), achieving size reduction comparable to that obtained using conventional homogenisation (∼62 nm). Varying the microchannel geometry in microfluidic chips and the flow rate did not significantly affect the nanoemulsion properties. Nanoemulsions prepared by homogenisation remained <200 nm for 3 months at 40°C and 12 months at 25°C, but they were less stable than those prepared via PIC and microfluidisation. Nanoemulsions produced via PIC exhibited higher skin permeation of ibuprofen (∼14 µg) compared with microfluidisation (∼10 µg) and homogenisation (∼7 µg). Microchannel processing improved nanoemulsion stability and skin delivery compared with homogenisation, offering scalable, energy-efficient continuous manufacturing, although PIC remained superior overall.
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7. A curve-based framework for dissolution profile modeling and formulation optimization.
PMID:日期:2026-10-05We present a unified framework for dissolution profile modeling and formulation optimization to identify formulation settings that reproduce a target dissolution profile. In generic drug development, the reference formulation is often unavailable or proprietary, making the underlying release behavior difficult to verify in advance. The proposed framework integrates parametric dissolution models and functional data analysis using functional principal component analysis (FPCA) within a candidate-based formulation-space exploration workflow. Curve similarity is quantified using the integrated squared difference, with the regulatory similarity factor f used as an additional evaluation metric. The framework was evaluated using two extended-release dissolution datasets exhibiting different release behaviors. Results demonstrated that model performance depends on the relationship between the modeling approach and the underlying dissolution characteristics. The parametric approach achieved strong performance when the dissolution behavior was well represented by the assumed model structure, whereas FPCA provided a flexible alternative when the underlying release behavior was not adequately described by a predefined model. The proposed framework enables systematic identification of candidate formulations and provides a flexible strategy for dissolution-guided inverse formulation design under uncertain release behavior.
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8. A dual functional hybrid lipid-polymeric nanoparticle co-loaded coenzyme Q10 and siRNA TNFα for anti-inflammatory skin therapy.
PMID:日期:2026-10-05Inflammatory skin diseases, such as psoriasis, lead to significant humanistic and economic burdens, mainly psychosocial impacts due to the relapsing papulosquamous characteristic of the disease. Due to the extensive skin lesions, topical therapies remain the main form of treatment. However, their effectiveness is limited by poor skin penetration. In addition, single-target mechanisms limit the simultaneous modulation of inflammatory and oxidative pathways involved in the pathogenesis of psoriasis and other skin diseases. To overcome these limitations, we developed hybrid lipid-polymeric nanoparticles (HLPNs) for the co-delivery of coenzyme Q10 (CoQ10), an endogenous antioxidant with anti-inflammatory properties, and small interfering RNA (siRNA) targeting TNFα, a central pro-inflammatory cytokine. HLPNs exhibited particles of 150-250 nm with low polydispersity (0.08-0.16), and high CoQ10 encapsulation efficiency (>85%). The presence of poly(allylamine hydrochloride) reversed the zeta potential (-27 to + 20 mV), enabling high siRNA binding efficiency and RNase protection. Structural analysis (ATR-FTIR, DSC, PXRD) confirmed successful CoQ10 incorporation into the lipid matrix and its amorphous conversion. HLPNs enhanced CoQ10 penetration into the stratum corneum (2-4.5-fold) and viable epidermis/dermis (4.7-7.5-fold) compared to solution, while confocal microscopy demonstrated improved siRNA skin delivery. In cell culture, HLPN-siRNA complexes promoted robust siRNA uptake in keratinocytes and macrophages. Therapeutic efficacy was validated in LPS-stimulated RAW264.7 macrophages, where HLPN_CoQ10-siTNFα significantly suppressed TNFα (3-6.5-fold), IL-6 (2-2.7-fold), and IL-1β (1.3-3-fold) secretion, while preserving CoQ10's antioxidant capacity and reducing reactive oxygen species (1.3-1.5-fold). Collectively, these findings show that the dual lipid-polymeric nature of HLPNs enables combinatorial delivery of antioxidant and RNAi therapies, offering a promising strategy for complex inflammatory skin disorders.
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10. Smart thermo/pH‑responsive Janus nanogel for synergistic chemo-magnetic hyperthermia therapy inducing caspase‑mediated apoptosis in the BALB/c 4T1 breast cancer model.
PMID:日期:2026-10-05Effective treatment of aggressive breast tumors remains challenging due to poor drug selectivity, systemic toxicity, and limited therapeutic synergy. Here, a thermo/pH‑responsive magnetic Janus nanogel was employed as a smart platform for on‑demand co‑delivery of 5‑fluorouracil (5‑Fu) and quercetin (Qu) combined with magnetic hyperthermia. Drug release behavior under acidic and hyperthermic conditions was investigated, followed by evaluation of cellular uptake and cytotoxicity in 4T1 breast cancer cells. Therapeutic efficacy was further assessed in BALB/c mice bearing orthotopic 4T1 tumors under alternating magnetic field (AMF)-induced hyperthermia. Tumor growth, histopathological alterations, hepatotoxicity, and the expression of apoptosis‑related genes (Bax, Bcl‑2, p53, caspase‑3, caspase‑8, and caspase‑9) were analyzed. The Janus nanogel exhibited dual-stimuli-responsive release of 5-Fu and Qu and showed enhanced in vitro cytotoxicity in the nanoformulated co-delivery system. In vivo, treatment with drug‑loaded nanogels combined with AMF produced pronounced tumor regression (p < 0.01) and extensive apoptotic cell death. Gene expression analysis indicated activation of both intrinsic and extrinsic apoptotic pathways, reflected by upregulation of Bax, p53, and caspases together with an increased Bax/Bcl‑2 ratio. No significant hepatotoxicity was observed. The integration of dual‑drug chemotherapy with magnetic hyperthermia using a thermo/pH‑responsive Janus nanogel provides a synergistic and safe therapeutic strategy for aggressive breast cancer. These findings highlight the potential of stimuli‑responsive nanocarriers for advanced combination cancer therapy.