Fitoterapia植物疗法
Fitoterapia(英文缩写 FITOTERAPIA),ISSN 0367-326X,eISSN 1873-6971,中文译名:植物疗法 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.204 | Q3 |
| 2022 | 3.400 | Q2 |
| 2023 | 2.500 | Q3 |
| 2024 | 2.600 | Q3 |
| 2025 | 2.900 | Q2 |
Fitoterapia 最新收录文献
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1. Evaluation of the effect of plant resins on antimicrobial activity: a comprehensive review of mechanisms and applications.
PMID:日期:2026-09-24Natural resins are substances of plant origin secreted by plants in response to biological or environmental aggression. Rich in bioactive compounds such as terpenes, flavonoids, phenolic acids, and alkaloids, they have been used since ancient times for their therapeutic properties. This review focuses on natural resins, including plant-derived resins such as propolis, frankincense (incense), myrrh, gum arabic, mastic, dragon's blood, guggul, tragacanth, and asafoetida, as well as the insect-derived resin shellac, which represents an exceptional case among natural resins. Comparing their effectiveness against bacteria, fungi, viruses, and parasites, and identifying their mechanisms of action. Data were collected from PubMed, ScienceDirect, Google Scholar, and Web of Science. The information was organized according to resin type, targeted microorganism or parasite, study type (in vitro, in vivo, or clinical), mechanism of action, and observed efficacy. The studied resins exhibited various antimicrobial and antiparasitic effects, including bacterial and fungal inhibition and antiviral and antiparasitic actions. The main mechanisms of action include membrane disruption, biofilm inhibition, immune modulation, and enzyme inhibition. Among them, propolis and frankincense are characterized by a broad spectrum of activity, whereas other resins show more specific effects. In conclusion, natural resins represent a promising source of bioactive compounds for the development of new therapeutic applications owing to their diverse mechanisms and broad antimicrobial and antiparasitic potential.
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3. Three previously undescribed indole alkaloids from the fruits of Brucea javanica (L.) Merr. with their tyrosinase inhibitory activity.
PMID:日期:2026-09-23Brucea javanica (L.) Merr. (Simaroubaceae) is a widely recognized medicinal plant in traditional Chinese medicine, noted for its rich variety of structurally diverse secondary metabolites. As part of our ongoing phytochemical investigation on the fruits of this species, three undescribed indole alkaloids, named Yadanziindoles A-C (1-3), were isolated and identified. Their structures were elucidated based on extensive spectroscopic data (HRESIMS, 1D and 2D NMR). Structurally, compounds 1 and 2 feature a C-2 2-hydroxypropan-2-yl substituent and differ in the oxidation state of the C-3 functionality, whereas compound 3 possesses a distinct, highly oxidized C-2 acyl side chain. In bioactivity assays, compounds 1 and 2 exhibited promising tyrosinase inhibitory activity. To gain deeper insights into the molecular basis of the observed activity, we conducted molecular docking studies to characterize their binding interactions with the target enzyme. These findings suggest that these indole derivatives represent a promising template for the development of novel tyrosinase inhibitors.
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4. Stilbenoids from the bark of Hopea odorata: antioxidant and antidiabetic activities.
PMID:日期:2026-09-22Two previously undescribed tetrameric stilbenoids, named hopearatols A (1) and B (2), were isolated from the bark of Hopea odorata Roxb., along with 17 known stilbenoids. Their structures were elucidated by HRESIMS and NMR spectroscopic analyses, while the absolute configuration of hopearatol A (1) was determined by ECD calculations combined with DP4+ probability analysis. To our knowledge, hopearatol A (1) represents the first tetrameric stilbenoid featuring a cyclobutane-containing core embedded within a complex polycyclic framework. Both ethyl acetate and methanol extracts exhibited high total phenolic content (TPC), with values of 223.4 ± 2.8 and 264.0 ± 3.2 mg GAE/g, respectively. Selected compounds were evaluated for their antioxidant (DPPH) and α-glucosidase inhibitory activities. The newly isolated compounds 1 and 2 showed low DPPH radical scavenging activity but displayed considerable α-glucosidase inhibition relative to acarbose (IC = 109.7 ± 0.8 and 174.0 ± 8.1 μM, respectively, vs. 913.7 ± 19.6 μM). Notably, 15 emerged as the most potent compound, demonstrating stronger radical scavenging capacity than ascorbic acid (IC = 36.3 ± 1.3 μM vs. 86.5 ± 1.2 μM) and remarkable α-glucosidase inhibition (IC = 27.9 ± 1.8 μM).
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5. Cinchonain Ib alleviates the cerebral ischemia-reperfusion injury by regulating mitophagy through AKT/mTOR signaling pathway.
PMID:日期:2026-09-21Cinchonain Ib has demonstrated numerous potential pharmacological properties. However, its therapeutic efficacy against cerebral ischemia-reperfusion (IR) injury and underlying molecular mechanisms remained elusive. The mitophagy has been widely studied and demonstrated to play a critical role in the pathogenesis of IR, and currently therapeutic drugs were inefficient. This study aimed to investigate the effects of cinchonain Ib against IR and elucidate its underlying mechanism. We explored the role of cinchonain Ib using neuroblastoma (N2a) cell exposed to oxygen-glucose deprivation/reperfusion (OGD/R), and mice subjected to middle cerebral artery occlusion (MCAO). The results indicated that cinchonain Ib supplementation effectively ameliorated IR injury due to the mitigations of cell death and mitophagy through AKT/mTOR signaling pathway. In MCAO mice model, cinchonain Ib administration significantly reduced neuronal death, enhanced neurological recovery, and attenuated mitophagy. Furthermore, in the N2a-induced OGD/R model, cinchonain Ib exerted an inhibitory effect on the cell death, mitochondrial reactive oxygen species and mitophagy. Western blot analysis revealed that cinchonain Ib inhibited the activation of the AKT/mTOR signaling pathway, consequently attenuating mitophagy and mitigating the IR injury. Overall, our data indicated that cinchonain Ib was a promising therapeutic agent for early prevention and treatment of ischemic stroke.
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6. Experimental and computational evaluation of bioactive secondary metabolites from Trewia nudiflora stem bark.
PMID:日期:2026-09-21Trewia nudiflora L. (Euphorbiaceae) stem bark is traditionally used in Ayurvedic medicine for treating pain and gastrointestinal disorders, yet its bioactive constituents and underlying mechanisms remain unvalidated. This study aimed to isolate bioactive secondary metabolites from the methanol stem bark extract (MeOH-extract) of T. nudiflora and systematically evaluate its antidiarrheal, analgesic, thrombolytic, and membrane-stabilizing activities. Secondary metabolites were isolated via column chromatography and structurally characterized using H and C NMR. In vivo antidiarrheal (castor oil-induced), central (tail-immersion), and peripheral (acetic acid writhing) analgesic profiles were evaluated in Swiss albino mice. In vitro thrombolytic and membrane-stabilizing assays were complemented by in silico molecular docking and ADMET profiling against five validated protein targets. Stigmasterol and (5α)-gitoxigenin 3-(α-L-rhamnopyranoside) were isolated as known constituents, providing chemotaxonomic confirmation, while the novelty lies in their integrated pharmacological and in silico characterization. . The MeOH extract significantly reduced diarrheal feces by up to 60.46% (400 mg/kg), prolonged tail-immersion latency by 217.65%, and inhibited abdominal writhing by up to 65.39%. The extract showed 23.10% clot lysis and 89.14% hemolysis inhibition, while stigmasterol and gitoxigenin preferentially targeted μ-opioid (-5.856 kcal/mol) and EP2 receptors (-5.649 kcal/mol), respectively.ADMET profiling confirmed favorable oral absorption for stigmasterol (HIA = 96.4%, log BB = 0.80, LD₅₀ = 890 mg/kg) and flagged gitoxigenin's narrow cardenolide safety margin (Toxicity Class II; LD₅₀ = 41 mg/kg). These findings provide phytochemical and mechanistic support for the ethnomedicinal claims of T. nudiflora and identify both compounds as pharmacological leads warranting further investigation.
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7. Investigating potential quality markers of Stellariae Radix on correlations among absorbed blood components, signature metabolites and pharmacodynamic indicators.
7. 基于吸收入血成分、特征代谢物与药效指标相关性探究银柴胡的潜在质量标志物PMID:日期:2026-09-21Stellariae Radix is a representative medicinal herb that is used clinically for treating yin deficiency fever, bone-steaming fever, and infantile malnutrition fever, but its quality control has not been fully investigated; however, this technique relies solely on single evaluation indicators of pharmacopeia and noncharacteristic ingredients. This study aimed to predict potential quality markers (Q-markers) of Stellariae Radix to establish a scientific and reasonable quality evaluation system. Our study established an integrated strategy that progressed from chemical characterization using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) to bioactivity-guided screening via Pearson correlation analysis and culminated in the final selection of the most relevant quality markers by modeling their nonlinear relationships with efficacy using a back-propagation neural network (BP-NN) algorithm. First, the chemical constituents of Stellariae Radix were characterized via UPLC-Q-TOF-MS. By integrating a deficiency-heat syndrome rat model and serum pharmacochemistry-metabolomics, the absorbed constituents, metabolites and related biomarkers of Stellariae Radix were further elucidated. Subsequently, Pearson correlation analysis between the differentially expressed metabolites and blood-absorbed components revealed eight bioactive constituents linked to specific biomarkers. The five candidate Q-markers, namely, curcumenol, stellarine C, dichotomine B, dichotomine A, and wogonin, were selected via BP-NN analysis on the basis of their correlation with heat-clearing efficacy. Overall, the integrated approach combining UPLC-Q-TOF/MS-based metabolomics with Pearson correlation analysis and BP-NN is an effective tool for investigating the efficacy of Stellariae Radix, and these five components could be considered potential quality markers.
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8. Modified Hu-lu-ba-wan and its active component trigonelline ameliorate diabetic renal tubular injury via enhancing PACS2-regulated mitochondria-endoplasmic reticulum contacts and mitophagy.
8. 加减胡芦巴丸及其活性成分葫芦巴碱通过增强PACS2调控的线粒体-内质网接触和线粒体自噬改善糖尿病肾小管损伤PMID:日期:2026-09-18Mitochondrial dysfunction and impaired mitophagy in proximal tubule epithelial cells are central to the pathogenesis of Diabetic Kidney Disease (DKD). The mechanisms of Modified Hu-lu-ba-wan (MHLBW), a clinically validated herbal formula for DKD patients, remain to be explored. This study aimed to investigate the renal protective effects of MHLBW against DKD, identify its bioactive component and elucidate the underlying mechanisms. The efficacy of MHLBW was evaluated in DKD mice. Transcriptomics, chemical profiling analysis, and serum metabolomics were employed to uncover the mechanisms of MHLBW and to identify its active components. Molecular docking (MD) and dynamics simulations were conducted to predict the binding affinity between the identified component, trigonelline (TRL), and its putative target, Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2). Gene silence in vitro experiments were further performed for mechanism verification. MHLBW treatment significantly ameliorated hyperglycemia and renal injury in db/db mice. MHLBW restored mitochondrial morphology and function, enhanced mitochondria-endoplasmic reticulum contacts (MERCs), and activated Pink1/Parkin-mediated mitophagy in renal tubules, an effect associated with increased PACS2 expression. Chemical profiling analysis and serum metabolomics identified TRL as a key component of MHLBW. TRL replicated the benefits of MHLBW in HK-2 cells. MD and dynamics simulations demonstrated stable binding between TRL and PACS2. Crucially, knockdown of PACS2 abolished the protective effects of TRL on MERCs and mitophagy. MHLBW and TRL can alleviate diabetic renal proximal tubular damage by targeting PACS2 to enhance MERCs and promote Pink1/Parkin-mediated mitophagy, indicating that MHLBW represents a promising therapeutic formula for DKD.
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9. Four new chemical constituents from the stems of Syringa oblata Lindl.
PMID:日期:2026-09-15This study investigated the chemical constituents and biological activities of the stems of the Mongolian medicinal plant Syringa oblata Lindl. Through chromatographic separation and spectroscopic analysis, 30 compounds were isolated from the aqueous fraction, including four new and ten first-reported in Syringa species. Using human breast cancer MCF-7 cells as the research subject, the in vitro anti-tumor activity of the isolated compounds was evaluated by the CCK-8 method. In addition, among the 30 compounds detected by the DPPH method, nine showed strong antioxidant activity, with half maximal inhibitory concentration (IC₅₀) values lower than that of vitamin C. These results provide a scientific basis for the medicinal use of the stems of Syringa oblata Lindl.
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10. Huangqi Guizhi Wuwu decoction suppresses experimental autoimmune encephalomyelitis by promoting PINK1/Parkin-mediated mitophagy and inhibiting microglial pyroptosis.
10. 黄芪桂枝五物汤通过促进PINK1/Parkin介导的线粒体自噬和抑制小胶质细胞焦亡改善实验性自身免疫性脑脊髓炎PMID:日期:2026-09-15Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Huangqi Guizhi Wuwu Decoction (HGWD), a classic traditional Chinese medicine formula, exerts protective effects against MS, yet the underlying mechanism involving mitophagy and microglial pyroptosis remains poorly elucidated. This study investigated the ameliorative effects of HGWD on experimental autoimmune encephalomyelitis (EAE) and its molecular mechanism. HGWD components were identified via UHPLC-Q-Orbitrap HRMS, and potential anti-MS targets were predicted by network pharmacology and molecular docking. EAE mice and LPS-stimulated microglia were treated with HGWD, with mitophagy inhibitor 3-MA and PINK1 siRNA used for mechanism validation. Assessments included clinical scoring, histopathology, Western blotting, immunofluorescence, ELISA, transmission electron microscopy and mitochondrial function assays. A total of 59 constituents were identified; network pharmacology revealed core pyroptosis-related targets (IL-1β, IL-18, NLRP3, CASP1) in MS, and molecular docking confirmed strong binding affinities between key active components and these proteins. HGWD significantly alleviated EAE clinical severity and reduced demyelination by enhancing PINK1/Parkin-mediated mitophagy, improving mitochondrial function, and inhibiting microglial pyroptosis, which was validated in vitro. Notably, both 3-MA and PINK1 silencing abolished HGWD's protective effects. This study first confirms that HGWD treats EAE via the PINK1/Parkin mitophagy-pyroptosis axis, providing theoretical evidence for its clinical translation and quality control.