EUROPEAN JOURNAL OF PEDIATRICS欧洲儿科学杂志
EUROPEAN JOURNAL OF PEDIATRICS(英文缩写 EUR J PEDIATR),ISSN 0340-6199,eISSN 1432-1076,中文译名:欧洲儿科学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.860 | Q1 |
| 2022 | 3.600 | Q1 |
| 2023 | 3.000 | Q1 |
| 2024 | 2.600 | Q1 |
| 2025 | 2.900 | Q1 |
EUROPEAN JOURNAL OF PEDIATRICS 最新收录文献
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1. Respiratory morbidity at age 4 across COVID-19 and pre-pandemic birth cohorts: the role of atopic risk.
PMID:日期:2026-10-05The COVID-19 pandemic dramatically reduced early-life respiratory viral exposures, yet the long-term respiratory consequences for pandemic-born children remain unclear. We aimed to compare respiratory morbidity at age 4 between children born during versus before the pandemic and assess whether atopic risk modifies this association. This single-center birth cohort follow-up study included children born in February-March 2020 (COVID-19 cohort) and pre-pandemic controls born during the same period in 2019. Respiratory outcomes at age 4 were assessed using a structured telephone questionnaire (The International Study of Wheezing in Infants). The primary outcome was composite respiratory morbidity (CRM), defined as use of a short-acting bronchodilator (SABA), inhaled and/or oral corticosteroids, and/or emergency room visits for respiratory symptoms. Of 588 eligible children, 329 (55.9%) completed follow-up (139 COVID-19, 190 controls); baseline characteristics, including atopy prevalence, were comparable between cohorts. CRM during the fourth year of life was significantly more common in the COVID-19 cohort (39.6% vs. 27.4%, p = 0.02). In stratified analyses, CRM was markedly higher among atopic-risk pandemic-born children (atopic subgroup: n = 47 COVID-19, n = 68 controls) (66% vs. 27.9%, p < 0.001), but not among non-atopic children (26.1% vs. 27%). Multivariable logistic regression confirmed a significant COVID-19 cohort × atopy interaction for CRM (OR 5.04, 95% CI 1.83-13.89, p = 0.002), while neither factor alone was independently associated with the outcome. Birth during the COVID-19 pandemic was associated with increased preschool respiratory morbidity, particularly among children with atopic risk. These findings suggest that altered early-life microbial exposures may modify respiratory morbidity trajectories according to host atopic susceptibility. • Children born during the COVID-19 pandemic had fewer respiratory infections and wheezing episodes in infancy due to reduced viral circulation. • Atopic predisposition is among the strongest risk factors for recurrent wheezing and persistent asthma in preschool children. • Pandemic-born children show significantly higher composite respiratory morbidity at age 4, but exclusively among those with atopic risk (OR 5.04). • Neither pandemic birth nor atopy alone predicts excess morbidity-only their combination does, suggesting host susceptibility shapes long-term respiratory trajectories.
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2. Spinal pain prevalence in childhood and socioeconomic patterns: a comparative study in four European birth cohorts.
PMID:日期:2026-10-03The aim of this study was to examine the prevalence and socioeconomic patterns of spinal pain in children and adolescents across different European contexts. We used individual participant data from four population-based birth cohorts from Denmark, Portugal, Italy, and Finland. Data on anatomical location, frequency, intensity, and pain-related functional limitations of spinal pain in children aged 7-18 years were analysed. Maternal educational level at birth was used as an indicator of the child's socioeconomic background. Socioeconomic patterns in spinal pain were quantified by the slope and relative indices of inequality. The prevalence of spinal pain varied from 4.6% (previous 3 months) in Portuguese 7-year-old boys to 92.3% (previous 12 months) in Danish 18-year-old girls. Prevalence increased with age, and females reported more pain than males. Among children reporting spinal pain, approximately 59% experienced frequent pain, 59% intense pain, and 35% pain-related functional limitations, with notable differences across cohorts and age groups. We found no consistent socioeconomic gradient in the prevalence of spinal pain. However, among children reporting spinal pain, socioeconomic differences were more apparent in pain frequency, intensity, and daily-life functional limitations, although the direction and magnitude of these gradients varied across cohorts. Spinal pain is common in children and adolescents, but no consistent socioeconomic pattern was observed in its occurrence. Spinal pain appears prevalent across all socioeconomic groups, with inequalities emerging more clearly in the frequency, severity, and functional impact of pain, although these patterns varied across settings. • Paediatric spinal pain is common, but prevalence estimates vary widely across studies. • Evidence on socioeconomic inequalities in childhood spinal pain is mixed and inconsistent. • Prevalence varies markedly across cohorts reflecting both methodological and contextual differences. • Inequalities in pain frequency, intensity, and daily-life impact are more apparent than those in spinal pain prevalence.
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3. Prevalence of chronic conditions among children and adolescents-register data and self-reports.
PMID:日期:2026-10-03The purpose of this study is to estimate the prevalence of chronic health conditions (CHCs) among children and adolescents in Denmark using data from national population registers and survey data from self-reports. The data originated from two sources: (1) the Danish national registers and (2) two nationally representative surveys. A 20% random sample of all children born between 1994 and 2013 (N = 263,864) was drawn from the Danish national registers and included records of in- and out-patients in public hospitals, in primary health care or indicated prescriptions. Self-reported health conditions were obtained from the two nationally representative surveys (N = 70,534). Chronic conditions were classified by experienced clinicians across the range of physical and mental health conditions in the International Classification of Diseases, 10th revision (ICD-10). In the register data, the overall prevalence of CHCs increased with age in both sexes, from 9.3% to 14.6% among 1-10-year-olds and from 18.3% to 22.0% among 11-20-year-olds, mainly due to an increased frequency of mental disorders with age. The prevalence of self-reported CHCs was 28.4% among 11-15-year-olds, 14.6% of whom reported being affected in their daily lives. Among 16-20-year-olds, the prevalence of self-reported CHCs was 34.2%, and 15.3% reported being affected in their daily lives. The inclusion of both register-based and survey data allowed the study to capture different groups of children and adolescents. Furthermore, the choice of method used to estimate the prevalence of CHCs depends strongly on the data source, the case definition, and the context of the healthcare system. • The prevalence of chronic health conditions (CHCs) found among children and adolescents varies due to methodological variability and use of definitions. • Using national registries, this study has explored the prevalence of physical and mental health conditions across all ICD-10 diagnoses among children and adolescents referred to a hospital. • In the register data, the prevalence of CHCs varied between 9.3% and 18.3% in the child population; in the youth population, 22% were diagnosed with a condition classified as chronic. • Self-reported data from 11-15-year-olds and 16-20-year-olds showed prevalences of 28.4% and 34.2%, respectively, including CHCs not necessarily exceeding the threshold of clinical referral.
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4. Adjunctive mild controlled hypothermia for moderate necrotizing enterocolitis in very low birth weight infants: a prospective cohort study with external contemporaneous controls.
PMID:日期:2026-10-03Necrotizing enterocolitis (NEC) is a severe condition in preterm infants. Few therapies are available to slow disease progression or reduce the need for surgery. This study aims to assess if mild controlled hypothermia as an adjunctive treatment reduces surgical intervention in preterm infants with NEC. A single-center intervention was conducted from 2019 to 2023 and compared with an external, contemporaneous prospective cohort study. Infants weighing less than 1500 g with moderate NEC were enrolled. One center administered mild hypothermia and served as the intervention cohort. The other seven centers served as contemporaneous controls and provided standard care. The intervention group received mild controlled hypothermia. This targeted a core esophageal temperature of 35.5 °C (± 0.5 °C) for 48 h after NEC diagnosis, in addition to standard medical management. The control group received standard care and maintained normothermia. The primary outcome was the need for surgical intervention due to NEC. All-cause mortality was analyzed using subdistribution hazard ratios (SHR) for competing risks. Inverse probability of treatment weighting (IPTW) adjusted for baseline differences to strengthen causal inference. Among 285 preterm infants, 92 were in the intervention group. This group required fewer surgical interventions (14.13% vs. 46.11%; adjusted relative risk [aRR], 0.30; 95% confidence interval [CI], 0.17-0.53) and showed lower mortality risk (0.59; 95% CI, 0.38-0.93) compared to the control group (n = 193). The incidence of severe neurological outcomes was similar between groups; informative missingness was addressed using deterministic MNAR sensitivity analyses. Conditional inference tree analysis identified hypothermia as the primary protective factor against surgery. Mild controlled hypothermia may reduce the need for surgical intervention and improve survival rates, indicating its potential as a promising adjunctive therapy. • Necrotizing enterocolitis (NEC) affects preterm very low birth weight (VLBW) infants with sufficient severity to require surgical intervention. Mortality rates reach 50% in the most vulnerable subgroups. Current medical management has not demonstrated efficacy in halting disease progression or reducing the need for surgery. • Preclinical and pilot studies suggest that adjunctive mild hypothermia (35.5 °C) reduces intestinal inflammation and oxidative stress in NEC. However, no adequately powered multicenter trial has evaluated its clinical effectiveness as an adjunctive therapy. • Adjunctive mild hypothermia was associated with decreased rates of surgical intervention and reduced all-cause mortality. • Exploratory analyses indicated that adjunctive mild hypothermia was the factor most strongly associated with avoidance of surgery.
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5. Therapeutic value of continuous subcutaneous insulin infusion with electrolyte supplementation for pediatric diabetic ketoacidosis.
5. 持续皮下胰岛素输注联合电解质补充对小儿糖尿病酮症酸中毒的治疗价值PMID:日期:2026-10-02Pediatric diabetic ketoacidosis (DKA) is life-threatening; traditional IV insulin risks hypoglycemia and electrolyte issues. We evaluated the efficacy and safety of continuous subcutaneous insulin infusion (CSII) combined with electrolyte supplementation in DKA. Sixty-six patients were randomly assigned to the study group (CSII + electrolyte supplementation) or control group (intravenous insulin infusion + electrolyte supplementation). Overall efficacy, time to pH normalization, target blood glucose achievement, urine ketone clearance, levels of BUN, creatinine, potassium, FPG, 2hPG and sodium, inflammatory markers, acid-base balance indicators, and adverse reactions were compared. Study group had higher overall efficacy (χ = 5.121), shorter time to pH normalization, target blood glucose achievement, and urine ketone clearance (t = 8.023, 7.712, 7.438), lower BUN, creatinine, FPG, 2hPG, sodium, CRP, TNF-α, and IL-6 levels (t = 8.893, 15.816, 5.865, 12.267, 4.542, 3.626, 2.615, 5.746), higher serum potassium, CO₂CP, and blood pH levels (t = 9.737, 4.220, 17.78), and lower blood lactate levels (t = 6.922) and adverse reaction rates (χ = 4.243) than the control group (all P < 0.05). CSII with electrolyte supplementation improves pediatric DKA treatment outcomes by regulating blood glucose and electrolytes, alleviating inflammation and acidosis, and reducing adverse reactions during treatment. • Pediatric diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes mellitus. • Traditional intravenous insulin infusion is the standard treatment but carries risks of hypoglycemia, hypokalemia, and other electrolyte disturbances. • Electrolyte supplementation is routinely used alongside insulin therapy to correct dehydration and metabolic imbalances in DKA. • This study provides clinical evidence that continuous subcutaneous insulin infusion (CSII) combined with electrolyte supplementation is more effective than conventional intravenous insulin therapy in pediatric DKA. • CSII-based regimen achieved faster pH normalization, blood glucose control, and urine ketone clearance, with better improvements in renal function, inflammatory markers, and acid-base balance. • The CSII group also showed lower rates of adverse reactions, suggesting that this approach may offer a safer and more efficient alternative for managing pediatric DKA.
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6. Lower-limb joint hypermobility and associations with physical performance in school-aged children: a cross-sectional study.
PMID:日期:2026-10-02Lower-limb joint hypermobility has been associated with alterations in physical function; however, its independent relationship with physical performance in asymptomatic school-aged children remains unclear. This study investigated the association between lower-limb joint hypermobility and physical performance and determined whether these associations persisted after adjustment for potential confounding variables. A cross-sectional study was conducted in 165 school-aged children aged 4-13 years. Lower-limb joint hypermobility was assessed using the Lower Limb Assessment Score (LLAS). Participants were classified as non-hypermobile (LLAS < 7; n = 120) or hypermobile (LLAS ≥ 7; n = 45). Physical performance was evaluated using the Youth Fitness International Test (YFIT) battery, including the 20-m sprint, handgrip strength, and standing long jump. Group comparisons were performed using the Mann-Whitney U test, and multivariable linear regression analyses adjusted for age, sex, BMI-for-age standard deviation score (BMI-SDS), and weekly sports participation frequency were conducted. In the unadjusted analyses, children with lower-limb joint hypermobility demonstrated significantly slower 20-m sprint times (median [IQR]: 5.40 [4.90-6.10] vs. 5.00 [4.48-5.47] s; p = 0.005; r = 0.22), lower handgrip strength (9.80 [6.65-14.40] vs. 13.70 [10.40-16.75] kg; p < 0.001; r = 0.28), and shorter standing long jump distances (1.19 [1.00-1.32] vs. 1.30 [1.15-1.46] m; p = 0.002; r = 0.24). However, lower-limb joint hypermobility was not independently associated with any physical performance outcome after adjustment for age, sex, BMI-SDS, and weekly sports participation frequency (20-m sprint: p = 0.861; handgrip strength: p = 0.868; standing long jump: p = 0.389). Lower-limb joint hypermobility was associated with poorer physical performance in unadjusted analyses but was not an independent determinant of physical performance after accounting for demographic, anthropometric, and lifestyle factors. Longitudinal studies are needed to clarify these associations throughout childhood. • Joint hypermobility is common in children and may be associated with musculoskeletal symptoms and functional limitations. •Previous studies have reported inconsistent findings regarding the relationship between joint hypermobility and physical activity levels. • Children with lower-limb joint hypermobility demonstrated poorer physical performance in unadjusted analyses. •After adjustment for age, sex, BMI SDS and sports participation frequency, lower-limb joint hypermobility was not independently associated with physical performance. •Demographic and lifestyle factors explained a substantial proportion of the variability in physical performance.
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7. Early-onset neonatal sepsis and neonatal antibiotic exposure in Hungary a nationwide population-based study.
PMID:日期:2026-10-02Neonatal sepsis remains a challenge in perinatal medicine. We aimed to estimate incidence of culture positive early-onset sepsis (CP-EOS), causative pathogens and overall antibiotic exposure in newborn infants in Hungary. Retrospective national registry analysis (2020-2023). Data were mainly collected from the Hungarian National Perinatal Registry covering all level II-III neonatal intensive care units (NICUs) in Hungary. The number of livebirths in each gestational age group was provided by Hungarian Central Statistical Office. Overall CP-EOS incidence was 0.41/1,000 livebirths (0.20/1,000 ≥ 35 weeks gestation, 7.0/1,000 < 35 weeks gestation). Main pathogens were Escherichia coli (33.3%) and Group B streptococci -GBS (24.5%). Ten of 49 (20.4%) infants with E. coli sepsis died. No GBS related mortality occurred. Lumbar puncture was only performed in 30/147 (20.4%) of the CP-EOS cases. No cases of isolated meningitis occurred in the absence of CP-EOS. Newborns presenting with respiratory distress in the first 72 h were five times more likely to receive antibiotics (OR 4.9 CI 4.6-5.2) than infants without respiratory distress. Overall, 63.9% of NICU-treated neonates received antibiotics for a median (IQR) duration of 5 (3-8) days. A minimum of 3.2% of all neonates in Hungary received antibiotics, acknowledging that some more neonates are treated on postnatal wards and Level I NICUs which are not included in the perinatal registry. A substantial number (15.6%) of blood cultures were taken without subsequent antibiotic commencement. Our results provide the first national incidence estimates for CP-EOS in Central-Eastern Europe. The study identified high antibiotic use with a concurrently relatively low EOS incidence. The results support implementing new strategies to reduce unnecessary antibiotic exposure in the newborn period. • Neonatal early-onset sepsis (EOS) causes substantial neonatal morbidity, prompting widespread, frequent empirical antibiotic use. • Unnecessary early-life antibiotic exposure shifts the infant gut microbiota and increases risks for long-term adverse health outcomes. • This first nationwide Central-Eastern European study reveals a low EOS incidence (0.41/1,000 live births) but high NICU antibiotic exposure (63.9%) in Hungary. • Escherichia coli has overtaken GBS as the leading EOS pathogen, causing significant mortality primarily in preterm infants.
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8. Parental and grandparental age in relation to Down syndrome risk and congenital heart disease in affected children: a case-control study in Peru.
PMID:日期:2026-10-02This study aimed to assess the association between grandparental age and the risk of Down syndrome and evaluate the relationship between paternal age and congenital heart disease (CHD) among affected children in Peru. A retrospective case-control study was conducted at a national pediatric referral center in Peru, including 290 participants (145 cases with free trisomy 21 and 145 controls without genetic disorders). Logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Parental ages were higher in cases than in controls, but there were no significant differences in grandparental ages. Maternal age was the strongest risk factor for Down syndrome (OR = 1.16 per additional year; 95% CI: 1.09-1.23). No significant association was found between maternal grandmother's age and Down syndrome (OR = 0.96 per additional year; 95% CI: 0.91-1.02). Paternal age ≥ 32.6 years (categorical analysis based on the Liu-derived cut-off) was associated with an increased risk of congenital heart disease in the presence of FT21, compared with a reference group combining FT21 without CHD and healthy controls (aOR = 3.64; 95% CI: 1.96-6.77). In this Latin American cohort, maternal age remains the primary risk factor for Down syndrome, with no evidence supporting an effect of maternal grandmother's age at the birth of the mother. Notably, advanced paternal age was independently associated with higher odds of congenital heart disease among children with Down syndrome. These findings warrant confirmation in independent populations before being considered for clinical application. • Advanced maternal age is the main established risk factor for Down syndrome. • The maternal grandmother's age at the birth of the mother remains uncertain, with inconsistent evidence. The contribution of paternal age to congenital heart disease in affected individuals has been insufficiently studied. • In this case-control study from a Latin American population, the maternal grandmother's age at the birth of the mother was not associated with DS • Advanced paternal age was independently associated with higher odds of congenital heart disease among children with Down syndrome.
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9. Vitamin B12 in early childhood: a phenotype-guided approach to deficiency and unexpectedly elevated concentrations.
PMID:日期:2026-10-02Vitamin B12 deficiency can cause preventable but potentially irreversible neurological injury in infancy, whereas unexpectedly elevated total vitamin B12 creates a different diagnostic challenge. This review outlines a phenotype-guided approach to both findings, emphasizing the mother-infant dyad. Infant deficiency commonly reflects low maternal status, including unrecognized malabsorption despite an omnivorous diet. Neurological manifestations may precede anemia or macrocytosis. Methylmalonic acid and total homocysteine therefore help resolve borderline or clinically discordant vitamin B12 results, although interpretation requires age-specific reference intervals and consideration of renal function. Symptomatic infants generally require prompt parenteral replacement, while selected asymptomatic infants with nutritional deficiency may respond to supervised oral treatment. Newborn screening can identify affected mother-infant dyads but does not exclude deficiency developing later during breastfeeding. Elevated total vitamin B12 most commonly reflects supplementation or altered transport, clearance, or assay characteristics, and should not be equated with toxicity. Persistent unexplained elevation warrants targeted clinical and laboratory assessment. Integrating clinical phenotype, maternal evaluation, functional biomarkers, and cautious interpretation of elevated concentrations may reduce delayed treatment and unnecessary investigations in infancy and early childhood. • Infant vitamin B12 deficiency may cause irreversible neurological injury without macrocytic anemia. • Maternal vitamin B12 status strongly influences fetal stores and breastfed-infant risk. • A phenotype-led framework integrates infant deficiency, maternal assessment, newborn screening, and unexpectedly elevated vitamin B12. • Functional biomarkers help distinguish intracellular deficiency from isolated high total vitamin B12, which is not equivalent to toxicity.
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10. Value-based neonatology (VBN): a new ethical paradigm for newborn care.
PMID:日期:2026-10-02A few months ago, the Lancet Commission on the Future of Neonatology laid the foundations for boosting research and development in this field, ensuring modern, effective neonatal medicine. Worried about curing neonates as it was done 20 years ago, the Commission document provides a long list of actions for the various stakeholders. Several ethical issues arise in the background, which may go unnoticed, particularly by clinicians busy with routine clinical care. This review highlights some issues, explains the ethical reasoning behind the Lancet Commission document, and promotes the adoption of "Value-Based Neonatology". The value-based approach is already being used in other medical specialties, and we set out the framework for its application in neonatal medicine here.Conclusion: We believe that the full introduction of VBN in neonatal clinical care and research will help changing practicing, because it would be hopefully useful to optimise resource allocation and eventually decrease the areas of uncertainties.